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1 nt isothermal titration calorimetry data for binding of 11 tryptophan ligands to the homo-undecameric
2 was quantified as the difference in specific binding of [(11)C]raclopride (nondisplaceable binding po
7 of the new products were formed via covalent binding of 3-QCA with DOM molecules of above-average O/C
9 D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized f
10 O cell fibronectins were able to mediate the binding of a diverse panel of gp120 proteins to alpha4be
11 We have explored the interdependence of the binding of a DNA triplex and a repressor protein to dist
12 ty acids was found to play a key role in the binding of a glycolipid to the carbohydrate recognition
13 y can define the subunit topology and copper binding of a manganese oxidizing complex, and describe e
14 monomeric Delta123 predominantly blocked the binding of a non-neutralizing antibody to Delta123, whil
17 ption in vivo by analyzing motor defects and binding of a positron emission tomography (PET) radiolig
18 aper describes an assay that can profile the binding of a protein to ligands and can rank the affinit
20 is approach has broad potential to probe the binding of a variety of ligands to metal nanoparticles.
23 namics simulations, elucidating preferential binding of Abeta42 with the A2V and A2T hexapeptides com
24 gus Ashbya gossypii, we demonstrate that the binding of adenine and guanine nucleotides to the canoni
26 on of the signal transduction cascade, after binding of all investigated products to the receptor pre
28 y conformational changes associated with the binding of allosteric regulatory proteins, and show that
29 layers previously oxidized, and the covalent binding of amino-oligonucleotides to pure p-MBA monolaye
30 Synaptic dysfunction due to the disrupting binding of amyloid beta (Abeta) and tau oligomers is one
31 novel mechanism of MAPK activation requiring binding of an activator and also shows that MAPKs can be
32 onclude that phosphorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating e
33 differences from wild-type IL-23 except for binding of and signaling blockade by the 7B7 anti-IL-23
35 nding specificities, why lipid increases the binding of apoE to its receptor, and why specific residu
37 lysozyme demonstrate how nanomolar affinity binding of asymmetrical antigen is enabled through selec
38 s would disrupt critical interactions in the binding of ATP and thereby impair ATP-induced nucleotide
39 and its chaperone function are regulated by binding of ATP/ADP to mtHsp70's nucleotide-binding domai
40 inium-labeling of AtRALF1 indicated that the binding of AtRALF1 to intact roots is CML38-dependent.
44 for both alphavbeta5 and alpha5beta1, while binding of biotinylated cyclo[RGDfK] was very weak and o
46 d enabled identification of allele-dependent binding of both, transcription factors and coregulators
49 that the intragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORI
50 e structure of free CheR1, revealed that the binding of c-di-GMP induces dramatic structural changes
55 eriments revealed that FGF13 potentiates the binding of calmodulin to NaV1.5 and that phosphomimetic
56 affinity than Ca(2+)-free CaM (apoCaM); the binding of CaMKII peptide to CaM in return increases the
60 minal domain (NTD) with implications for the binding of certain adaptors, providing insight into how
64 ve mass spectra matching, the promiscuity of binding of cisplatin to ubiquitin is revealed, with 14 d
65 e increase in probe-to-probe spacing enables binding of cisplatin via the intrastrand GNG motif (N =
66 species in human-inflamed tissue and allows binding of complement factor 1q (C1q) and activation of
67 e central methylene considerably affects the binding of compound 1 analogues to PI3Kdelta enzyme.
69 noprecipitation analyses reveal constitutive binding of CREB to target gene promoters in the absence
70 ylation of CRMP-2, which results in elevated binding of CRMP-2 to microtubules and a concomitant incr
73 toplasmic relocalization of Cat L, decreased binding of CUX1 to Snail and the E-cadherin promoter, re
76 ing site provide the molecular mechanism for binding of dectin-2 to fungal mannans and also to bacter
77 biochemical influences that probably include binding of degraded hemoglobin, among other things, that
79 The vast majority of mutations do not affect binding of dynein to dynactin and BICD2 and are therefor
80 ys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys resid
81 n thus would be favorable for the postulated binding of E7 to phosphatidylethanolamine lipid headgrou
82 ed by a concerted transition model where the binding of each GABAergic drug additively and independen
83 structural and thermodynamic consequences of binding of each ligand to its allosterically coupled sit
84 Based on these results, we propose that the binding of each stator-unit is enhanced by the force it
86 hat ENb-TRAIL blocks EGFR signalling via the binding of ENb to EGFR which in turn induces DR5 cluster
87 cts also promoted the cytotoxic activity and binding of enterotoxin and beta toxin more strongly than
90 soform containing extradomain B enhances the binding of fibronectin through the RGD sequence to beta3
93 lected between 1979 and 2010 to block glycan binding of four pandemic GII.4 noroviruses isolated in t
98 TB domains are important for stabilizing the binding of Grb2 and Shc to the single-Tyr EGF receptors.
99 est whether this occurs in vivo, we used the binding of growth factor receptor bound 2 (GRB2) to phos
101 al His(64) residue to alanine promotes rapid binding of H2S and its efficient conversion to oxidized
102 absence of IRF4, chromatin accessibility and binding of Helios at PD-1 cis-regulatory elements were i
103 the effect of N-linked glycosylation on the binding of Herceptin to HER2 protein in breast cancer an
104 ilayer model, we show GTP-dependent membrane binding of hGBP1F In addition, we demonstrate nucleotide
106 of epigenetic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-gro
107 single domain antibody mimics the effect of binding of HIV integrase to LEDGF which is crucial for H
108 moter and enhancer activity and differential binding of HNF4alpha, a key regulator of expression of v
109 to, performing the separation function, the binding of HP-MBs and SG could be avoided while a low ba
110 than murine (m) PD-1 interactions, stronger binding of hPD-1 to hPD-L2 than hPD-L1, and comparable b
111 cytometry, we demonstrate a strong and quick binding of HRV types 16 and 1B to monocytes, and slower
118 The aim of this study was to evaluate the binding of IgE to five recombinant beta-conglutin isofor
119 maRIIB on myeloid cells and its differential binding of IgG subclasses controls the contributions of
120 ral and acidic pH, prevents the simultaneous binding of IgG, and reduces circulating IgG levels in pr
121 ha electrostatically repels the DNA, and the binding of IkappaBalpha appears to twist the NFkappaB he
122 lack Etv5 restored IL-10 production and the binding of IL-10-inducing transcription factors includin
123 n studied extensively for their roles in the binding of information and gaze function, respectively.
124 ctions, posttranslational modifications, and binding of inhibitors such as the p27 tumor suppressor p
128 understanding of the factors involved in the binding of KIR2DS1 and its inhibitory counterpart KIR2DL
130 ragmentation to give ethylene is promoted by binding of l-arginine in a nonoxidized conformation and
134 in its coiled-coil 1 domain that impedes the binding of linear (M1-linked) di-ubiquitin to its coiled
135 n the context of dynein alone, we found that binding of LIS1 to DDB does not strongly disrupt process
136 insic fluorescence enhancement observed upon binding of LM pectin to lysozyme was correlated with the
137 t, we show that direct, cell-cycle-regulated binding of M18BP1 to CENP-A nucleosomes recruits the Mis
138 NA structural alterations can promote direct binding of m6A-modified RNAs to low-complexity regions i
139 iquitination by MDM2, a process initiated by binding of MDM2 to the intrinsically disordered transact
142 sful remediation in coastal areas, permanent binding of mobile P in anoxic sediments may be needed to
143 ed an off-cycle pathway involving reversible binding of molecular oxygen to iridium, which contribute
144 providing the substrate for phase-dependent binding of mossy fiber spikes to repetitive theta-freque
147 ulated Raw 264.7 macrophages resulted in the binding of mu1A of the clathrin-coated vesicle AP-1 comp
148 infra-slow bursting enables integration and binding of multiple chemosensory stimuli over a prolonge
151 n the mutant CALR C terminus influences both binding of mutant CALR to MPL and activation of MPL sign
153 This analysis highlights that the strong binding of myosin Ic to actin is dominated by the ADP st
155 ectivity filter in which to test competitive binding of Na(+) These experiments disclosed a marked de
156 luciferase reporter assays revealed a direct binding of NANOG to a transcriptionally active site in a
157 g domains efficaciously blocked reticulocyte binding of native PvRBPs, suggesting that the human immu
158 ecovery phase from a hypoxic injury and that binding of neuronal uPA to astrocytic uPAR induces astro
164 analysis revealed that OA-NO2 increased the binding of Nrf2 to an antioxidant response element in th
165 obably because these mutations decreased the binding of NS1 to the cleavage and polyadenylation speci
167 ysis confirmed that clofibrate abrogates the binding of nuclear factor-kappaB to the PTPRZ1 and Wnt8a
168 scribe a detailed protocol based on covalent binding of nucleophilic groups on Wnt proteins to activa
170 nding domain (GluA2-LBD) are consistent with binding of one molecule of 11m per dimer interface, cont
173 comparable in oxLDL-loaded Mvarphis, yet the binding of p65/RelA (the prototypic NF-kappaB family mem
179 step in merozoite invasion is the essential binding of PfRh5/CyRPA/PfRipr complex to basigin, a step
182 nd is inhibited by mutations that compromise binding of phosphorylated Thr-348 to an allosteric bindi
184 Particular attention has focused on the binding of plasminogen (Plg) to bacterial surfaces, as i
187 ion is directed in part by sequence-specific binding of PRDM9, a polymorphic histone H3 (H3K4Me3) met
188 not allow discrimination between the initial binding of properdin and binding secondary to C3b deposi
190 jacent residues that facilitate the specific binding of proteins and modulate the global folding and
191 N)6](3-)/[Fe(CN)6](4-)) that is altered upon binding of PSMA with PSMA-Ab immobilized on N-AuNPs/ITO.
192 and enzyme activity are regulated in part by binding of purine nucleotides to an allosteric regulator
194 in, or phosphorylation site causes excessive binding of RAD51 to CFS loci and impairs CFS expression.
197 number of constraints, possibly through the binding of regulatory proteins in the trans-Golgi networ
198 pidly after folic acid injection, as did DNA binding of RelB and NFkappaB2, detected in nuclei isolat
199 sitive competition ELISA to measure integrin-binding of RGD-peptides in high-throughput without using
202 x to poly-Fe(vbpy)2(CN)2 followed by surface binding of salts of the cations and electrochemical redu
203 erologous SNARE proteins orchestrated by the binding of Sec1/Munc18 (SM) proteins to specific syntaxi
204 ar how the immune system reconciles receptor binding of self-proteins with self/non-self-discriminati
205 hancers regulate gene expression through the binding of sequence-specific transcription factors (TFs)
207 Previous in vitro studies suggested that binding of SH2 and PTB domains can enhance protein phosp
210 sis in embryonic stem cells showed extensive binding of Smad2/3/4 to GC-rich cis-regulatory elements.
213 ciated with Abeta localizing to synapses and binding of soluble Abeta aggregates to synapses requires
216 t-nCu exposure experiments indicate that the binding of SRE with nCu and dissolved Cu ions can signif
219 Notch signalling activity by inhibiting DNA-binding of Su(H), potentially affecting both activation
224 he promoter region of MLH1 as perturbing the binding of TFAP4 and consequently increasing DCLK3 expre
225 Thus, we demonstrated peptide-dependent binding of the activating NK cell receptor KIR2DS1, prov
228 ross EC-EC junctions in trans Except for the binding of the C-terminal angiopoietin domains to the Ti
233 which rearrangement of a flexible loop upon binding of the correct peptide substrate is required for
234 Glycan array analysis confirmed selective binding of the CRD to glycans that contain Manalpha1-2Ma
235 -mediated phosphorylation and 14-3-3 protein binding of the cytoplasmic amino-terminus of iRhom2 alte
246 main exerts negative allosteric control over binding of the N-terminal lectin domain to mannosylated
249 eral C3b-binding compounds to interfere with binding of the original C3b ligand that guided their dis
253 at this blocking activity may originate from binding of the peptide to a sequence of SdrC involved in
255 riments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and
257 as in the generally accepted P450 mechanism, binding of the primary substrate in the active-site trig
258 echanism could be inferred from the covalent binding of the proteasome-specific inhibitor epoxomicin
260 misfolding of chromatin fibre and block the binding of the regulator of chromatin condensation 1 (RC
261 n reduced expression of the gene through the binding of the repressive MYB transcription factor and,
262 noprecipitation experiments reveal increased binding of the repressor factor RE1-silencing transcript
264 and mass spectrometry, we further uncovered binding of the RNA-binding protein HuR to the -44 region
265 The kinetic association rate constant of the binding of the S339D/S340D mutant to the FERM domain of
266 H3K9ac serves as a substrate for direct binding of the SEC, as does acetylation of histone H4 ly
268 al at the RI, hypoxia-induced expression and binding of the splicing factor SRSF3, and increased bind
272 rsensitivity site to rs7692387 and predicted binding of the transcription factor ZEB1 rather to the n
274 ion to exploit therapeutically.Significance: Binding of the transcription factors NFIB and YBX1 to th
276 te with restoration of wild-type two-pronged binding of the UBXD1 adaptor protein that is impaired in
277 se a multidisciplinary approach to study the binding of the viral attachment protein G to its host re
278 idue of the N-terminal linker for inhibiting binding of the VWF A1 domain to GpIbalpha on platelets i
279 Significantly, Cripto-1 and Cryptic blocked binding of their cognate ligands to type I and type II T
282 of the splicing factor SRSF3, and increased binding of total and phospho-Ser2 RNA polymerase II spec
283 tment in Arabidopsis relies in large part on binding of trans-acting factors to cis-localized DNA seq
284 ant deactivating enhancers by disrupting the binding of transcription factors (TFs) in a given cellul
285 ise that stereospecific but necessarily weak binding of tropomyosin to F-actin is required for effect
287 dependent transcription is suppressed by the binding of two nucleoid associated proteins, IHF and Fis
292 s 1-101) pull downs showed sixfold-increased binding of vinculin and, to a lesser extent, alpha-actin
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