ライフサイエンスコーパス: binding selectivity

1 e and were correlated with the thermodynamic binding selectivity.

2 n mammalian cells by modulating trans-factor binding selectivity.

3 involved in endocytosis preserves interface binding selectivity.

4 palmitoylation of RPE65 controls its ligand binding selectivity.

5 s play a general role in Gcn5/PCAF substrate binding selectivity.

6 last five residues of NR2b contribute to the binding selectivity.

7 regation is correlated with G-quadruplex DNA binding selectivity.

8 ed calixarenes was screened for alkali-metal-binding selectivity.

9 Scalloped to create a wing cell-specific DNA-binding selectivity.

10 core module and results in the loss of tRNA binding selectivity.

11 a homologous RNase P RNA maintains the tRNA binding selectivity.

12 esidues in this region in determining ligand binding selectivity.

13 osal of a mechanism for beta 1/beta 7 ligand binding selectivity.

14 -1, directs its remarkable PtdIns(3,4,5)P(3) binding selectivity.

15 e densities promote a switch in carbohydrate-binding selectivity.

16 as sensitive methods for determining cation-binding selectivity.

17 ved in the control of arrestin stability and binding selectivity.

18 a typical bZIP heterodimer with altered DNA binding selectivity.

19 sulted in a significantly increased receptor binding selectivity.

20 , implying that ionic radius is important in binding selectivity.

21 , can be used to predict reversible covalent binding selectivity.

22 ted to these data to measure (11)C-LY2795050 binding selectivity.

23 receptors and those reversing benzodiazepine binding selectivity.

24 s with two cysteines, demonstrating arsenite binding selectivity.

25 nd, we propose, the BRC repeats regulate DNA-binding selectivity.

26 , and Oct4 confirms their role in regulating binding selectivity.

27 fic, where polymorphisms within TraA dictate binding selectivity.

28 Ps and NC-OMCPs also possess different anion binding selectivity.

29 Finally, the high binding selectivity, affinity, and fluorescence of yDNA

30 ligands, exhibit differences in their guest-binding selectivities and reactivity with tris(2-aminoet

31 Binding selectivities and stabilities of the complexes w

32 ding domain goes beyond simply providing DNA-binding selectivity and affinity (10-100-fold enhancemen

33 By combining this unique binding selectivity and asymmetric catalysis, we are abl

34 gand-protein binding interfaces that predict binding selectivity and demonstrate its effectiveness fo

35 These results clearly demonstrate the binding selectivity and enhanced affinity of side-by-sid

36 y of current screening collections, improved binding selectivity and frequency.

37 Finally, the combined effect of binding selectivity and inactivation selectivity was ass

38 23 (Trp in PTH and Phe in PTHrP) determines binding selectivity and position 5 (Ile in PTH and His i

39 In general, the binding selectivity and potency of [(3)H]NE reuptake inh

40 veal the structural basis for doublecortin's binding selectivity and provide insight into its role in

41 finity cleavage for the establishment of DNA binding selectivity and provides the information at a hi

42 or 10-fold, reversing the PTH2/PTH1 receptor binding selectivity and resulting in a high affinity int

43 in acetamide 6, which showed CCK-A receptor binding selectivity and sub-micromolar agonist activity

44 resent study provides direct evidence of MPO binding selectivity and tests the relationship of select

45 Binding selectivity and the effects of beta have been in

46 >40-fold delta over mu and delta over kappa binding selectivity, and exhibits delta receptor antagon

47 : D3R Ki = 6.84 nM, 1700-fold D3R versus D2R binding selectivity, and its metabolic stability in mous

48 it demonstrates only modest G-quadruplex DNA binding selectivity, and PIPER in pH 8.5 buffer is both

49 of MAP-PTHrP(1-36) was a determinant of R/RG binding selectivity, and PTH(1-14) bound selectively to

50 e GR LBD/10 complex provides a new basis for binding, selectivity, and anti-inflammatory activity and

51 ates (to confirm brain penetration, specific binding, selectivity, and kinetics), and third in human

52 e-binding pockets that may influence peptide binding, selectivity, and presentation.

53 Ets DNA binding, selectivity, and regulation have been extensive

54 he molecular mechanisms underpinning histone binding, selectivity, and regulation of these highly dyn

55 vide new insights into differences in ligand binding selectivity as well as unifying features of hist

56 ], have different levels of G-quadruplex DNA binding selectivity at pH 7 as determined by absorbance

57 t-antagonist benzodiazepine site ligand with binding selectivity at the alpha1 receptor.

58 protein can be designed that displays metal-binding selectivity based solely on coordination number

59 On the other hand, organic anion binding selectivity between Oat6 and Oat1 is influenced

60 were consistently greater (>2 muM), but the binding selectivity between symmetric and hemimethylatio

61 campus), and 14 (cerebellum), whereas in the binding selectivity (blockade) scan, all regional VT val

62 ificity is mediated in part through receptor binding selectivity brought about by alterations in the

63 ining duplexes or triplexes and on the metal binding selectivity but did not address the effect of th

64 termined that appropriate spacing can affect binding selectivity by 60-fold (20- x 3-fold).

65 ggest that DNA biosensors having only modest binding selectivity can also be used for fluorescence-ba

66 LXXLL motifs are the same and that receptor binding selectivity can be achieved by altering sequence

67 atterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed po

68 id inhibition potency and ex vivo plasma TTR binding selectivity data reveal that 2,6, 2,5, 2, 3,4,5,

69 of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection o

70 ing fibril inhibition potency and plasma TTR binding selectivity data.

71 was an exception, displaying excellent delta binding selectivity (delta Ki = 7 nM, mu/delta = 1900, m

72 of the C terminus and altered client peptide-binding selectivity, demonstrating the functional signif

73 The exceptional binding selectivity enables these inhibitors to occupy t

74 076 suggests rational approaches to modulate binding selectivity, enabling the design of multifunctio

75 Remarkable binding selectivities, even for homologous steroid pairs

76 few agents that display some (ca. 1000-fold) binding selectivity for 5-HT2A versus 5-HT2C receptors a

77 e an explanation for RNA G-quadruplex ligand binding selectivity for a group of naphthalene diimide l

78 e, it has proven challenging to achieve high binding selectivity for different isoforms of this prote

79 Binding selectivity for dopamine versus norepinephrine t

80 Binding selectivity for ER alpha was as high as 50-70-fo

81 Surprisingly, both compounds showed higher binding selectivity for FKBP52 versus FKBP12, in contras

82 lly used AT1R blocker losartan exhibits high binding selectivity for kidney AT1R and rapid metabolism

83 el an AMFE reflects a channel's preferential binding selectivity for one ion species over another.

84 Its use in generating a profile of DNA binding selectivity for several agents including distamy

85 e region in the delta receptor that confered binding selectivity for SUPERFIT by examining its bindin

86 and in the cloned transporter cells, and its binding selectivity for the DAT compared to the serotoni

87 transporter (NET) but in some cases retained binding selectivity for the DAT.

88 The unprecedented binding selectivity for the fetal muscle nAChR, coupled

89 riazolo[3,4-a]phthalazine 8 as a ligand with binding selectivity for the gamma-aminobutyric acid-A (G

90 the best compound features an unprecedented binding selectivity for the human telomeric DNA G-quadru

91 gonist ([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over the other th

92 Of those, eight exhibited excellent binding selectivity for TTR in human plasma (binding sto

93 combinations that provided enhanced receptor binding selectivities (>100-fold) and affinities (as low

94 x mimetics which reproduce their biophysical binding selectivity in a cellular context can be identif

95 idogenesis inhibitors that also display high binding selectivity in blood, it proves useful to system

96 have been established to govern RON2 ligand binding selectivity in other AMAs.

97 e indole ring did lead to improved CB 2/CB 1 binding selectivity in some cases (i.e., 7- 9, 15- 20).

98 mplex architectures of glycans can influence binding selectivity in unanticipated manners.

99 his precise variant to have altered receptor-binding selectivity in vitro.

100 We address ORC binding selectivity in vivo by mapping approximately 52,

101 ng with unlabeled MK-6240 to evaluate tracer binding selectivity in vivo.

102 ecific binding signals and confirmed its KOR binding selectivity in vivo.

103 e goal with the heterocycles is to design GC binding selectivity into heterocyclic compounds that can

104 Computationally, the prediction of binding selectivity is a challenge, and generally applic

105 dynamics calculations indicate that FTY720P binding selectivity is a function of the entropic contri

106 re than 500 SH3 domains in the human genome, binding selectivity is a key issue in understanding the

107 Binding selectivity is a requirement for the development

108 Thus, the in vitro KOR/MOR binding selectivity is about 36:1.

109 tRNA binding selectivity is affected in one but not in two ot

110 closely related molecules, it was shown that binding selectivity is an emergent property derived from

111 Structural comparisons indicate that this binding selectivity is determined by residues flanking t

112 Binding selectivity is determined by the nature of the s

113 We have observed that the substrate binding selectivity is more relaxed than the specificity

114 eceptors over alpha4beta2 receptors, but its binding selectivity is much greater at human than at rat

115 We further observed that the allosteric site binding selectivity is sensitive to inhibitor length as

116 The binding selectivity may arise in part from aspartic acid

117 The TTR binding selectivity, modification yield, and reaction ch

118 CpA dinucleotides and that this alternative binding selectivity modifies gene expression in the deve

119 en thermodynamic contributions affecting the binding selectivity, molecular dynamics free energy simu

120 These data suggest that mAChR antagonist binding selectivity needs to be re-examined in intact ce

121 structure suggests a basis for the different binding selectivity observed for the alpha1I and alpha2I

122 s spectrometry is used to evaluate the metal-binding selectivities of an array of novel caged macrocy

123 trometry is used to evaluate the heavy metal binding selectivities of five caged crown ethers and two

124 A rapid method for the screening of metal binding selectivities of host compounds in mixtures is p

125 and the characterizations of the nucleotide-binding selectivities of individual motifs.

126 oping this method for the rapid screening of binding selectivities of new synthetic ligands.

127 e proteomics method, we assessed the ATP/GTP binding selectivities of nucleotide-binding proteins at

128 lexes in the mass spectra correlate with the binding selectivities of the hosts.

129 m and have been shown to retain the distinct binding selectivities of the receptors from which they d

130 We also examined the binding selectivities of these proteins toward (S)GTP an

131 luorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respec

132 ate reductase (DHFR) that combine the enzyme-binding selectivity of 2,4-diamino-5-(3',4',5'-trimethox

133 d classified the cell lines according to the binding selectivity of 26,031 recovered tripeptide motif

134 ase content and placement also show a higher binding selectivity of 3 toward continuous AT-rich than

135 a possible structural interpretation for the binding selectivity of 4a and the lack of selectivity of

136 additional charge clamp that determines the binding selectivity of a coactivator and a distinct liga

137 We show that the binding selectivity of Bauhinia purpurea lectin switches

138 The F(-), Cl(-), and Br(-) binding selectivity of bis(p-nitroanilide)s of dipicolin

139 nsively, much less is known about the actual binding selectivity of BLM, that is, the obligatory step

140 N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated b

141 m channel is used to study the energetics of binding selectivity of Ca(2+) versus monovalent cations.

142 We present structural insights into the binding selectivity of CELF member 1 (CELF1) for GU-rich

143 the basis of molecular modeling, the ERbeta binding selectivity of compounds in this series appears

144 tihypertensive agent spironolactone, and the binding selectivity of cortisol over cortisone.

145 The phosphoinositide binding selectivity of Golgi coatomer COPI polypeptides

146 The in vitro binding selectivity of HuR is indicative of an ARE seque

147 ubstrates and is not inhibited, indicating a binding selectivity of LS for the catalytic site and OS

148 the structural and biochemical basis for the binding selectivity of NHERF1 PDZ domains.

149 hromatin structure in directing the promoter binding selectivity of Pdx1 in beta-cells and non-beta-c

150 Although binding selectivity of procyanidin B3 towards peptides c

151 g of Vestigial to Scalloped switches the DNA-binding selectivity of Scalloped.

152 We established in vivo binding selectivity of the anti-Abeta42 and anti-Abeta40

153 disclosed model where it is the noncovalent binding selectivity of the compounds, and not the alkyla

154 itively charged amino acids alters the sugar binding selectivity of the domain so that it now binds H

155 ur approach captures, in a single model, the binding selectivity of the PDZ domain family.

156 ntributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of th

157 (methyl and ethyl) increased the A(2B) AdoR binding selectivity of the xanthine derivatives while re

158 A method is presented here to evaluate the binding selectivity of these inhibitors to TTR in human

159 receptor domain specifies the signaling and binding selectivity of TIP39 for the PTH2 receptor over

160 ously, they provide a powerful way to assess binding selectivity on a proteome-wide scale and provide

161 d double-stranded DNA (ds-DNA) show that the binding selectivity pattern is similar when examined acr

162 -yloxy)butan-2-amine (7), showed an improved binding selectivity profile in favor of alpha(4)beta(2)

163 nist activity (IC(50) = 1.8 nM) and improved binding selectivity profile mu/kappa and mu/delta, when

164 No improvement in the binding selectivity ratio (SERT/DAT and NET/DAT) was fou

165 wed improvements in mu/delta and kappa/delta binding selectivity ratios as well as in the delta antag

166 C/N domain binding selectivity ratios ranged from 1 to 350, while r

167 I3K (EC(50) = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinase

168 )-27 showed > 2659- and > 2105-fold delta/mu binding selectivity, respectively.

169 otency and dramatically increased plasma TTR binding selectivity resulted.

170 the estradiol A-ring binding pocket and that binding selectivity results from differences in the inte

171 This binding selectivity revises the dogma in the field.

172 Comparison of ligand binding selectivity showed resemblance to that by the C1

173 te the structural features that confer CRTH2 binding selectivity, structure-activity relationship ana

174 Binding selectivity studies with the most potent (alpha/

175 phorylation of the cadherin reverses the TCF binding selectivity, suggesting another potential layer

176 ses, with 6 and 7 exhibiting somewhat higher binding selectivities than 8-10.

177 d lower binding potencies and delta receptor binding selectivities than their pyridine counterparts.

178 ve agents showed in many cases less dramatic binding selectivity than anticipated from published repo

179 (15a-d) displaying generally higher subtype binding selectivity than the bisphenolic analogues (15f-

180 Consistent with this binding selectivity, the signature domain of thrombospon

181 e domains; the use of induced fit to enhance binding selectivity; the imposition of fidelity at the l

182 The large binding selectivities, therefore, do not influence cleav

183 e easily extended to evaluate small molecule binding selectivity to any protein in a given biological

184 Selected polyphenols exhibited binding selectivity to different cellulose-based composi

185 ERs, three of which displayed over 100-fold binding selectivity to ERbeta over ERalpha.

186 aromatic ring is the prerequisite to display binding selectivity to Pt(111), while a neutral to posit

187 ering this cooperativity of Lrp binding, the binding selectivity to specific sites may increase to a

188 ion within this triplet, W976R, restored the binding selectivity to the general consensus sequence fo

189 ion of the other residue involved in agonist binding selectivity, to the corresponding residue in the

190 48-linked chains, UQ1-UBA shows little or no binding selectivity toward a particular chain linkage or

191 ge internal cavity, the cage exhibits a high binding selectivity toward C70 (K = 3.9x10(3) L mol(-1))

192 A 120-fold binding selectivity toward C70 (Kassoc = 1.81 x 10(7) M(

193 inverse agonist and antagonists that display binding selectivity toward the alpha5beta2gamma2 isoform

194 ds' terminal substituent correlated with its binding selectivity toward the alpha5beta2gamma2 versus

195 DCX's exquisite binding selectivity uncovers important insights into reg

196 TA buffer also demonstrated G-quadruplex DNA binding selectivity under these buffer conditions.

197 This binding selectivity was determined by the non-conserved

198 Binding selectivity was determined to a large part by th

199 10 with 2-pyridylmethoxy (compound 29), but binding selectivity was not enhanced (K(i): alpha 2 = 1.

200 zepine selectivity was reversed, yet peptide binding selectivity was unaffected.

201 veral compounds with combined D3/D4 receptor binding selectivity were also identified.

202 gree of polymerization of 10 (dp10) had high binding selectivity, while dp10 heparin and dp10 6-desul

203 lting, affect ssDNA binding: Y184A decreases binding selectivity, while Y189A and W193A decrease the

204 contrast, the enantiomers show only moderate binding selectivity with lysozyme.