ライフサイエンスコーパス: binding site

1 a flexible loop near the high-affinity zinc-binding site.

2 uencing the amino acid composition of the Ag binding site.

3 nding, indicating that they form an MAs(III) binding site.

4 origin sequence known to be a weaker ORC-DNA-binding site.

5 mon TdP-related blockers in the intra-cavity binding site.

6 in the amino acids that form the drug-target binding site.

7 e example of PerR lacking a structural metal-binding site.

8 yl group inserted deepest into the herbicide binding site.

9 l regions of the transporter and the central binding site.

10 eract with conserved residues within the ATP-binding site.

11 n the conformation of gp120 and the antibody binding site.

12 because of the existence of a second product-binding site.

13 access of the tethered ligand to the peptide-binding site.

14 only complementary components to the agonist binding site.

15 ions explore and coalesce around the initial binding site.

16 to an engineered cysteine near the dopamine binding site.

17 istinct, independently regulated, co-agonist-binding site.

18 fficiently to beta-tubulin at the colchicine binding site.

19 which was reduced after mutation of the Sp-1-binding site.

20 ated CBL by blocking the E2 approximately Ub binding site.

21 quence, but cluster into a small 3D putative binding site.

22 ethylation, is accommodated by BAF45C's H3K4-binding site.

23 nd structural plasticity within the receptor-binding site.

24 ChRs having a mutation(s) at the transmitter-binding sites.

25 established the regulatory function of these binding sites.

26 ompounds that link the primary and secondary binding sites.

27 that relatives exhibit highly conserved drug binding sites.

28 ly due to competitive binding at similar DNA binding sites.

29 are required to reveal potentially druggable binding sites.

30 (1)h interactions and identify their genomic binding sites.

31 ship study for novel ligands targeting these binding sites.

32 ttering (SAXS) data, and location of heparin-binding sites.

33 he mammalian genome contains hundreds of p53-binding sites.

34 tensity and increases accessibility of CREB1 binding sites.

35 hat include distinct 'footprint' patterns at binding sites.

36 rain are located within transcription factor binding sites.

37 not efficiently bind 20% of its coordinated binding sites.

38 3) domain contains an unusual cluster of YY1 binding sites.

39 with conserved genetic features and promoter binding sites.

40 hat Ln(3+) acts as an agonist of both Ca(2+)-binding sites.

41 Ms) and individual transcription factor (TF) binding sites.

42 uced computation time, especially for longer binding sites.

43 egard to the location of stabilizing protein binding sites.

44 an allosteric network that couples substrate-binding sites.

45 s of E-Syt1, only C2A and C2C contain Ca(2+)-binding sites.

46 ow-affinity binding sites, termed metastable binding sites.

47 cupancy across DNA regions far from specific binding sites.

48 exofacial (e2) and endofacial (e1) substrate-binding sites.

49 ovides a greater number of available kinesin binding sites.

50 se tissues and a genome-wide analysis of Dsx-binding sites.

51 key epithelial and EMT transcription factor binding sites.

52 n for epistasis between mutations across DNA-binding sites.

53 play an important role in stabilizing these binding sites.

54 gulated by intracellular pH, in part, at ATP-binding site 1 formed by the nucleotide-binding domains.

55 alytic glutamate of the canonical nucleotide binding site 2 was mutated to glutamine.

56 and we identified a specific palindromic DNA-binding site 5'-TTGATN4ATCAA-3' in these target sequence

57 The changes simultaneously switch the binding site affinities and the labilities of barriers o

58 Thus, binding site affinity and transcription factor levels ar

59 ndividual orthosteric contacts in the ligand binding sites, allowing us to rank the energetic contrib

60 Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encod

61 eceptor (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co

62 o conserved amino acids in the PKR eIF2alpha binding site and blocking PKR kinase activity.IMPORTANCE

63 ovided single-nucleotide resolution for each binding site and delineated a highly specific sequence a

64 ydrophobic residues surrounding the cofactor binding site and mutation of both residues negatively af

65 Determination of the Psb28 binding site and other biochemical evidence allow us to

66 est the potential existence of an additional binding site and provide new insights into GB1:IgG compl

67 polar residues that bridged over the Zn(2+) binding site and reached into a solvent accessible area.

68 These differences include a novel zinc-binding site and regions unique to the mammalian IP5 2-K

69 how that hAgo1 and hAgo2 have a single GW182-binding site and that miRNA binding increases hAgo's aff

70 eractions, ligands stabilize both the ligand binding site and the local secondary structure.

71 ce of allosteric coupling between the direct binding site and the NBD1:CL4 interface, thus enabling e

72 nnose residue ligated to Ca(2+) in a primary binding site and the nonreducing terminal mannose residu

73 Nonetheless, the evolution of the receptor-binding site and the stem region on HA is severely const

74 ochemical approaches, we identified two heme binding sites and a hemoglobin binding site in PfHDP.

75 TET2 colocalizes with EBNA2-EBF1-RBP-jkappa binding sites and can interact with EBNA2 by coimmunopre

76 This finding expands the universe of p53 binding sites and demonstrates that even isolated p53 ha

77 Published data reveal TET2 binding sites and hydroxymethylcytosine proximal to KLK3

78 s contain multiple transcription factor (TF)-binding sites and integrate the effects of each TF to co

79 for the predictions of metal ion and ligand binding sites and metal ion-dependent RNA stabilities.

80 ed the identification of potential inhibitor-binding sites and optimization of interactions of hits u

81 al enhancers, validated transcription-factor-binding sites and RNA motifs.

82 9-amino-acid protein containing five F-actin-binding sites and two G-actin-binding sites, and interac

83 avily enriched for AP-1 transcription factor binding sites and were frequently hypomethylated.

84 affinity binder reveal a highly preorganized binding site, and an overall architecture and ligand pla

85 nd the MyoA neck region adjacent to the MTIP-binding site, and both myosin light chains co-located to

86 onserved residues, particularly at the azole binding site, and heterologous expression of LmCYP51B an

87 n (domain II) containing a high-affinity Rev-binding site, and two or three additional domains.

88 g five F-actin-binding sites and two G-actin-binding sites, and interacts with wheat (Triticum aestiv

89 ied transcription factor Wilms tumor 1 (WT1) binding sites, and WT1 knockdown resulted in reduced SHM

90 ing PAR1 with an orthosteric-tethered ligand binding-site antagonist results in bleeding, possibly ow

91 Without Ca(2+) these binding sites are closed, precluding interactions with A

92 a prediction of which trans -acting factors binding sites are disrupted/created and links out to the

93 We show that CTCF binding sites are interwoven with enhancers within topol

94 ection of analytical window can impact which binding sites are titrated.

95 ther, our study defines enrichment of ALYREF binding sites at the 5' and the 3' regions of the mRNA i

96 pled channel of communication between the TA-binding site, ATPase site, and effector interaction surf

97 ng the large collection of Mn(II) and Mg(II) binding sites available in the protein data bank (PDB).

98 etecting communities of structurally similar binding sites based on the minimum description length pr

99 alyzed by constructing a weighted network of binding sites based on their structural similarities and

100 VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that i

101 pation of the adenine subpocket of the AcCoA binding site by an aromatic ring.

102 ion of the cAMP-binding site or distorts the binding site by making interactions with the binding poc

103 n peak calling algorithms that infer protein-binding sites by detecting genomic regions associated wi

104 Mutations of residues in the binding site can abolish c-di-AMP inhibition.

105 that spreading condensation from a specific binding site can take place in a path-independent manner

106 CeO2, and identifies surface features, H(+) binding sites, Ce(3+) locations, and O vacancies on (100

107 bsence of Ca(2+) and Ax culminated in target binding site closure.

108 This site appears to be part of a binding site cluster for this transcription factor on ex

109 p beginning at position 150) of the receptor-binding site common to this subgroup and a unique insert

110 an mRNA can be tuned by varying the ribosome binding sites controlling the recruitment of the ribosom

111 model, which takes input gene expression and binding sites data, either from ChIP-seq experiments or

112 CLCNKB mutations in barttin-binding sites, dimer interface or selectivity filter oft

113 subtype can bind sialic acid via a separate binding site distinct from the sialidase active site.

114 oviding access by TERT to this high affinity binding site during an early step in TERT-TER assembly.

115 -TTR with small molecules that occupy the T4 binding site eliminated the inhibitory capacity of the t

116 The E128K mutation in the IL1R-binding site enhanced integrin binding.

117 te the effect of pathogenic mutations in RBP binding sites, especially those related to splicing even

118 in complexes; additional independent tubulin binding sites exist in repeats two and three of the micr

119 we demonstrate how the detection of similar binding sites expands the space of opportunities for the

120 Simulations predict that a single FN-FN binding site facilitates either negligible fibrillogenes

121 kinase homology domain harbored an exclusive binding site for GCAP1 with similar affinities as the fu

122 This C-terminal tail displays the binding site for partner proteins and we report how it m

123 Previous studies have shown that the binding site for potentiating betaEST is in the C-termin

124 with other amino acid residues in the GERAMT-binding site for proper chaperone-dependent regulation o

125 SNP rs2227473 is located within a putative binding site for the aryl hydrocarbon receptor, a master

126 KNL1 on conserved MELT motifs to generate a binding site for the Bub3-Bub1 complex [4-7].

127 It affects a binding site for the miR-16 family and miR-103/miR-107 w

128 otein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, the

129 2149092 was predicted to disrupt a consensus binding site for the transcription factor ETS within an

130 metry (MS) can be used to map small-molecule binding sites for a rapidly aggregating protein.

131 We found that the binding sites for betaEST and dFBr communicate with the

132 lex, which correlated with the two suggested binding sites for GMF.

133 The sigma-holes are binding sites for Lewis bases, and binding energies corr

134 nce that repression of egl-1 is dependent on binding sites for miR-35 and miR-58 family miRNAs within

135 ne or two additional functionally equivalent binding sites for propofol, other than those modified by

136 expression, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome cofa

137 ence motifs enriched in the PREs are cognate binding sites for the identified transcription factors a

138 advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion protein SlmA an

139 A, adjacent to the guide region, function as binding sites for the snoRNP proteins including the enzy

140 Because of the presence in area IV of binding sites for transcription factors associated with

141 Among them there are multiple binding sites for transcription factors controlling the

142 oral lobar degeneration are enriched in CTCF-binding sites found in brain-relevant tissues, implicati

143 e the agonist, suggesting a distinct agonist-binding site from that found in TRPV1, a TRP channel fro

144 o identify canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked

145 ing filament barbed ends while three G-actin-binding sites (GABs) on other arms are available to recr

146 identification of nAChR allosteric modulator binding sites has been facilitated by using drugs develo

147 rs bind DNA only through specific, consensus binding sites has been recently questioned.

148 al, 7622 proteins from the scPDB database of binding sites have been evaluated using both a distance

149 In addition, we incorporated TF binding sites identified via large-scale in vitro assays

150 Furthermore, a binding site in a groove of the extracellular domain was

151 e of CaM bound to a peptide encompassing its binding site in AKAP79.

152 The method focused on a putative binding site in GPR39 for synthetic ligands and knowledg

153 the primary amino acid sequence in the SOD2-binding site in hsp70.

154 fied two heme binding sites and a hemoglobin binding site in PfHDP.

155 er, site directed mutagenesis of the miR-134 binding site in Sabin-1 IRES relieved miR-134-mediated r

156 Furthermore, Nedd8 binding site in Smurf is shown to be necessary for its u

157 o a DNA duplex sequence corresponding to its binding site in the IL-2 gene promoter.

158 Finally, we identify by molecular docking a binding site in the ion pore that we confirm by site-dir

159 vel mouse line, with deletion of the miR-223 binding site in the NLRP3 3' untranslated region, phenoc

160 sition 87 with alanine perturbs the chloride-binding site in the proton-exit channel.

161 ed to HeLa cells, RBDmap uncovered 1,174 RNA-binding sites in 529 proteins, many of which were previo

162 understanding of the topology of allosteric binding sites in AChBP and, by extrapolation, in the hum

163 biotin-labeled ghrelin to visualize ghrelin binding sites in coronal brain sections of amygdala.

164 Localizing ESRRA binding sites in cortical chromatin, we show that this n

165 represent the first analysis of OCRs and TF-binding sites in distinct populations of postmortem huma

166 Disruption of MIR1 binding sites in HBL1 showed an effect similar to that o

167 inding sites with known transcription factor binding sites in LCL GM12878 revealed substantial co-loc

168 ta-azipropofol, for direct identification of binding sites in mouse TRPA1.

169 Conversely, CTCF binding sites in NPCs are largely preexisting in pluripo

170 transcription factor hops between clustered binding sites in spatially restricted subnuclear regions

171 The ERalpha-binding sites in tamoxifen-associated endometrial tumors

172 However, ancient miRNAs and their binding sites in target genes are conserved during evolu

173 tein-1) activity and that the EGR1- and AP-1-binding sites in the CD44v6 promoter account for its res

174 dies to map the distribution of CRF receptor binding sites in the mouse brain.

175 alysis identified that several putative Klf5 binding sites in the promoter and first intron of Dmp1 a

176 nalysis of enriched transcription factor DNA-binding sites in the promoters of differentially express

177 uctural studies of the beta1AR define ligand-binding sites in the transmembrane helices and effector

178 seI hypersensitive and transcription factors binding sites in these regions.

179 ner, preventing its recruitment to canonical binding-sites in the promoters of Nanog, Oct4 and Sox2.

180 ulted from substitution T401A in the 2nd SIA-binding site, indicating that substrate binding via this

181 form of sTie2, which presents dimeric ligand binding sites, inhibits Angpt1 signalling at seventy-fol

182 al helicase cassettes, while 12 binds an RNA-binding site inside the N-terminal cassette.

183 Understanding the general principles of binding site interplay will pave the way for improved dr

184 To elucidate how the retigabine binding site is coupled to changes in voltage sensing, w

185 The structure of the THB-bound binding site is determined and confirms that THB binds t

186 Results demonstrated that a miR398 binding site is eliminated in AhCSD1-2.2 as a consequenc

187 This centrin-binding site is highly conserved within the first nuclea

188 cates that interaction with a particular ACh binding site is not the critical factor.

189 Cataloguing cholesterol-binding sites is a vital step in the effort to understan

190 The global organization of protein binding sites is analyzed by constructing a weighted net

191 petitive mode of action and a novel putative binding site; is weakly cytotoxic towards human primary

192 d P363S) have a higher affinity to their DNA binding sites, leading to a xylose catabolic activation

193 sPs and PtdInsPs interact with the polyanion-binding site located on an inner chamber wall of the enz

194 rough an activating and an inhibiting Ca(2+)-binding site located on the cytoplasmic side of the RyR

195 OEt at the GABAA receptor suggested that its binding site may be at the alpha + beta- subunit interfa

196 petition of the two RRs for their respective binding site mediated by only slight differences in bind

197 Multiple FN-FN binding site models predict a heterogeneous fibril popul

198 Finally, analysis of transcription factor-binding site motifs of differentially dysregulated genes

199 ced the activity of promoters harbouring NAC binding sites (NACbs).

200 nteraction energy is weak because only a few binding sites near the collision point contribute signif

201 he N terminus of chECL1, suggesting that the binding site of ALV-J gp85 on chNHE1 is probably located

202 ate-dependent reduction of the dicarboxylate-binding site of complex II (site IIf); (b) pore opening

203 ions that are far from the regulatory Ca(2+)-binding site of cTnC.

204 two reducing-end mannoses into the domain A binding site of CV-N than with the nonreducing end unit.

205 nd supposed to interact with the orthosteric binding site of dopamine receptors, was actually a negat

206 boxy terminus were identified as the primary binding site of Gbetagamma.

207 site shows structural similarity to the GTP-binding site of MoaA, suggesting that the viperin substr

208 both VEGFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NC

209 dence that SA acts at or near the ubiquinone binding site of SDH to stimulate activity and contribute

210 The glycan-binding site of T1 sigma1 is located in the head domain

211 r dynamics simulation studies elucidated the binding site of these aniline-based influenza fusion inh

212 ted patients who harbor mutations in the ATP-binding sites of ABCB4.

213 nalysis, we identified several P. gingivalis-binding sites of ArcA, which led to the discovery of an

214 molecular modeling study demonstrated that A binding sites of BSA play the main role in the interacti

215 nificantly enriched for transcription factor binding sites of EBF1, EP300, and CEBPB (P < 5e-6).

216 The DNA-binding sites of estrogen receptor alpha (ERalpha) show

217 bias in ChIP-seq is challenging because the binding sites of interest tend to be more common in high

218 tide sequence (I56-K68) overlapping with the binding sites of patients' serum IgEs.

219 ressing a FRET-biosensor comprising the cGMP-binding sites of PKGIalpha.

220 r EDC/GEE, are used together to pinpoint the binding sites of rifamycin SV, doxycycline, and another

221 ific hypomethylated regions are enriched for binding sites of similar transcription factors, suggesti

222 cers active in liver cells, enriched for the binding sites of the FOXA1, FOXA2 and HNF4A transcriptio

223 ions of active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain

224 Abeta, presumably as both bind at the sterol-binding site on Abcg4.

225 he complete energetic landscape of the Cdc42-binding site on ACK.

226 ealed that ciA-C2 partially occupies the SV2-binding site on HCA1, causing direct interference of HCA

227 Consistent with the location of the CSPG4-binding site on TcdB, we show that the anti-TcdB antibod

228 The linker-binding site on the SBD is a potential target for small

229 Surprisingly, Rac1 is not located at the binding site on the Sra1 subunit of the WRC previously i

230 Although the three inhibitors have distinct binding sites on Arp2/3 complex, they each induced an "o

231 L20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-

232 The integrin-binding sites on iC3b remain incompletely characterized.

233 ntify two, to our knowledge, new cholesterol-binding sites on the A2A adenosine receptor, a G-protein

234 not be explained by the distribution of GapR binding sites on the chromosome.

235 Their binding sites on the coat proteins are evolutionarily co

236 teractions between subunits as well as their binding sites on the Swr1 subunit.

237 The presence of these two channel-binding sites on VAMP721, one also required for SNARE co

238 Can1 mutants altered in the arginine-binding site or a cytosolic tripeptide sequence permanen

239 t TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making inte

240 Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhan

241 tation-sequencing analysis reveals that LSD1 binding sites overlap significantly with those bound by

242 These provide clues to elucidate the binding site parameters and mechanism of P-CAB inhibitio

243 on by CMPI and NS9283, indicating that their binding sites partially overlap.

244 valency can be adjusted to one or two biotin binding sites per immobilized SAv by choosing appropriat

245 nergy function improved transcription factor binding site prediction accuracy and dramatically reduce

246 ive energy function for transcription factor binding site prediction.

247 The results suggest that FGF12-FGFR1c2 binding site prefers a longer NS domain at the non-reduc

248 , e.g., PDX1, TCF7L2, and ADCY5 Importantly, binding sites previously identified by ChIP-seq for isle

249 by ClusterTAD have a high enrichment of CTCF binding sites, promoter-related marks, and enhancer-rela

250 e interaction networks (IINs), which map the binding sites proteins use for each interaction.

251 The specificity and geometry of the dectin-2-binding site provide the molecular mechanism for binding

252 functional similarities of the GP1 receptor binding site (RBS) of these viruses and the recent demon

253 ut was independent of the icilin and menthol binding site residue Y745 and, essentially, the N-termin

254 Introduction of two SIVmac316 CD4-binding site residues (G382R and H442Y) into the SIVmac2

255 und -260 and -230 mV, respectively, in the Q-binding site, respectively, suggesting that release of t

256 knocking down of CTCF or deletion of a CTCF binding site results in increased cell-to-cell variation

257 Deletion of the distal CTCF-binding site results in loss of Ramp3 expression in non-

258 The identification of this pore binding site sheds light on the mechanism of barbiturate

259 The ability to bind two distinct receptor binding sites simultaneously can allow the selective act

260 O pores show structural differences in their binding sites situated in the constriction region.

261 g modes: (SSB)30 and (SSB)60, defined by DNA binding site sizes of 30 and 60 nucleotides, respectivel

262 ycle is located on an alternative (ammonium) binding site, stabilizing the in situ generation of benz

263 rin attaches to the previously identified HS binding site, suggesting a functional role.

264 e than one modification, cluster in the heme-binding site, supporting a hierarchy of vulnerable amino

265 bserved, the mechanistic basis for homotypic binding site synergy is poorly understood.

266 volutionarily conserved transcription factor binding sites, taking advantage of the patterns observed

267 GPCRs have revealed transient, low-affinity binding sites, termed metastable binding sites.

268 e identified a linker region and a secondary binding site that are crucial for functionality.

269 facilitate the formation of an intracellular binding site that enhances G-protein coupling.

270 Spy1 lacks the cyclin-binding site that mediates p27 and substrate affinity, e

271 and encompasses a Myc-associated zinc finger-binding site that regulates KRAS transcription.

272 The labeling results reveal binding sites that are consistent with the known effects

273 s other than changes in transcription factor-binding sites that drive patterning.

274 pendent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPE

275 e chromatin marks or DNA-interaction protein binding sites, there is not yet an integrated software t

276 mods have alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, ABS2), Lmods lack TMB

277 comprise alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, and ABS2).

278 translation) lead to access of the substrate binding site to the alternate side of the membrane.

279 re repeats can initiate at subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (

280 Conservation of putative NusB/E binding sites upstream of Nus factor genes suggests that

281 ethod for prediction of transcription factor binding sites using an integrative energy function that

282 e, we identify and analyze more than 440,000 binding sites using ChIP-seq data for 20 DAPs in two hum

283 nzymes, which we find regulated by novel MYC-binding sites, validating an additional transcriptional

284 more, the exact biological function of these binding sites was confirmed by site-directed mutagenesis

285 Binding-site water is often displaced upon ligand recogn

286 nt elements: in addition to the known (main) binding site, we identified a linker region and a second

287 To better define the binding site, we used a series of decoy peptides derived

288 In one group, >50% of PR binding sites were co-occupied by ER, with a propensity

289 One monomer provides the SAM-binding site, whereas the conserved C-terminal tail of t

290 gions of subunits that contribute to the ACh binding site, whereas the lack of interface specificity

291 arkov model based on the presence of one IVM binding site, which described some effects of IVM on rat

292 Although it shares a binding site with other imide-based natural product tran

293 C3G interacted with two sets of binding sites with association constants Ka of 10(6) and

294 A comparison of EBNA3 binding sites with known transcription factor binding si

295 We identified a centrin-binding site within H. sapiens Prp40 homolog A (HsPrp40A

296 y of TRP channels and a well-defined calcium-binding site within the intracellular side of the S1-S4

297 spacing of HA ligands, which ought to bridge binding sites within or across the trimeric HA molecules

298 nce with its recruitment toward low-affinity binding sites within Teff cell cis-regulatory elements,

299 Furthermore, both binding sites within the ISS-N1 are important for splici

300 We identified ZEB1 binding sites within the LIF (stemness factor) promoter