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1 ant levels of recently proposed 'off target' binding sites for [(18)F]AV-1451, such as neuronal monoa
3 additional plant families and identified 715 binding sites for 501 genes conserved in dicots, monocot
4 y potential score, for accuracy in detecting binding sites for 75 vertebrate transcription factors.
6 sal that residues in this motif serve as the binding site for a divalent transition metal cofactor [e
8 c cleft between the domains might serve as a binding site for a potential host cell interaction partn
9 nding pocket in BGT1, which accommodates the binding site for a series of novel noncompetitive inhibi
11 incorporates competition between neighboring binding sites for a local pool of TF molecules explains
12 q analysis was used to determine genome-wide binding sites for a range of different TFs in multiple c
16 pha4, and alpha6 accessory subunits can form binding sites for ACh and NS9283 at interfaces with alph
17 specific RpL4 extension harbours overlapping binding sites for Acl4 and the nuclear transport factor
18 h is known to be phosphorylated as part of a binding site for activating 14-3-3 protein, but was crit
19 important role of beta-catenin and TCF4/LEF binding-sites for activating (alpha)-promoter, while act
20 cular modelling, we provide evidence for the binding site for adamantane derivatives and their putati
24 senchymal stem cell PCMs possess many unused binding sites for aggrecan, showing a 2.5x increase in P
25 g of this role, we have identified chromatin binding sites for AGO2 throughout the 45S region of the
26 on, docking calculations around the observed binding site for all three states of the receptor, inclu
27 the reaction rate and reduced the number of binding sites for allicin, whereas the number of non-cov
32 s may not be rare since such high numbers of binding sites for an anion are also found in analogous t
34 open sites at active enhancer regions and at binding sites for AP1-complex components, including c-Fo
35 mics enhanced sampling reveal three distinct binding sites for arginine vasopressin (AVP) within its
37 boxyl terminus of hClC-Kb is not part of the binding site for barttin, but functionally modifies the
40 thesized that this ACE mutation disrupts the binding site for blood components which may stabilize AC
41 r, but also as high affinity (KD </= 0.8 nM) binding site for both high molecular weight kininogen (H
42 5-bp consensus sequence GGC(GC)|(CG) as the binding site for both TGF-beta and BMP-activated Smads a
44 % of Dux-responsive genes contained ChIP-seq binding sites for both Dux and DUX4, and both proteins h
45 rved scaffold protein TOPBP1(Dpb11) provides binding sites for both pro- and anti-resection factors a
49 (TnC) as the Ca(2+)-binding moiety, has two binding sites for calcium ions, providing a linear respo
50 that the presence of high-nanomolar affinity binding sites for CaM at its universal gating brake and
52 more, phosphatidylinositol lipids occupy the binding site for capsaicin and other vanilloid ligands,
54 his SNP is on chromosome 8q24, adjacent to a binding site for CCAAT/enhancer-binding protein beta, a
56 tu neutron powder diffraction studies on the binding sites for CD4 within MFM-132a and MFM-115a revea
57 (E2RE), a region that contains at least two binding sites for cellular factors; one of these sites,
58 ive drug target carrying different potential binding sites for chemical modulators, particularly agon
59 n side chains was hypothesized as a possible binding site for chlorogenic acids in coffee melanoidins
61 We describe a completely novel allosteric binding site for class B receptors, providing an opportu
65 s situated at or near the negatively charged binding site for dihydrostreptomycin within the permeati
66 of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also invo
67 Because each receptor has a unique set of binding sites for downstream signaling partners and diff
69 now provides a three-dimensional view of the binding sites for drugs acting on sodium and calcium cha
73 ta(1-40) oligomers with multiple independent binding sites for EGCG with a Kd approximately 10-fold l
74 ch coincide with CCCTC-binding factor (Ctcf) binding sites, for example, the clustered protocadherin
75 y little phosphatidylserine (PS) but express binding sites for factor VIII (fVIII), casting doubt on
78 e show that the fourth helix constitutes the binding site for FlhA, a membrane protein at the export
80 tibodies (sABs) against LD2 and LD4 that are binding sites for focal adhesion kinase (FAK) and other
81 thin the previously determined fVa-dependent binding site for fXa (amino acid region 473-487 of FII).
84 GIRK2-4, and located within their C-terminal binding sites for Gbetagamma proteins that mediate membr
85 kinase homology domain harbored an exclusive binding site for GCAP1 with similar affinities as the fu
86 use models expressing SORLA variants lacking binding sites for GGA or retromer to query this concept
88 g the CD33 IgV domain, which is the antibody-binding site for GO, as well as diagnostic immunophenoty
90 ciency (Mac-1(-/-)) or mutation of the Mac-1-binding site for GPIbalpha have delayed thrombosis after
91 ble chromatin regions, as well as sex-biased binding sites for growth hormone-regulated transcription
94 us HSF sequence-binding elements (HSEs), the binding sites for heat shock factor-1 (HSF-1), located i
96 rotein footprinting to identify two separate binding sites for heparin interaction with Robo1: one bi
99 SOX9 binding peaks precisely overlapped with binding sites for histone-fold NF-Y transcription factor
100 the LARP7 family of proteins and defines the binding site for hLARP7 on the 7SK RNA, providing insigh
103 a indicate that polymeric C4BP with multiple binding sites for IAPP neutralizes lytic activity of IAP
105 ineered high-specificity M6P/IGF2R domain 11 binding site for IGF2 may improve therapeutic targeting
106 eceptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioa
108 r length counting and also indicate that the binding site for initiating NTP is located on p58C.
111 extremely hydrophobic, but in complex I the binding site for its redox-active quinone headgroup is a
113 sion of GAB2 but not by GAB2 mutants lacking binding sites for its effectors phosphatidylinositol 3-k
115 They find a progressive degeneration of binding sites for key transcription factors, mirroring t
116 s within cCpG-II and tCpG, which contain two binding sites for Kruppel-like transcription factors, in
120 hat contains the following two high affinity binding sites for LRP1: one is located within domains 1
121 BP-1c promoter in a region that contains two binding sites for LXRalpha and is known to be required f
128 view the regulatory roles of the 3'UTRome as binding sites for microRNAs or RNA binding proteins, or
129 renalase 3'-UTR (C/T; rs10749571) creates a binding site for miR-146a; consistently, miR-146a down-r
130 he 3'UTR of Kr-h1 mRNA contains a functional binding site for miR-2 family miRNAs (for miR-2, miR-13a
134 nce that repression of egl-1 is dependent on binding sites for miR-35 and miR-58 family miRNAs within
138 ed a preference in the enzyme's second metal binding site for Mn(II) over Mg(II), suggesting that T7
140 and CtrA and overlap with nearly all of the binding sites for MucR1, a regulator that controls the e
142 normal pigmentation and identify a critical binding site for Munc13-4 on Rab27a, revealing the molec
147 cessible regions were enriched for consensus binding sites for NFAT and Nr4a family members, indicati
148 n B7-H6 that is completely distinct from the binding site for NKp30, such that 17B1.3 does not block
152 w that most Ribi gene promoters also contain binding sites for one or more General Regulatory Factors
153 y a subset of sites; some of these sites are binding sites for other Polycomb repressive complex 1 (P
156 -type-specific and are strongly enriched for binding sites for p63, a master epidermal transcription
159 hromatin in hSSCs was strikingly enriched in binding sites for pioneer factors (NFYA/B, DMRT1, and ho
160 rug resistance Regulator (LmrR) as a generic binding site for planar coordination complexes that do n
164 revealed that in this setting, intravascular binding sites for platelets were exposed by neutrophils,
165 elements (CREs) comprised of combinations of binding sites for pluripotency TFs and measured their ex
166 rticularly weak splice sites and by upstream binding sites for Polypyrimidine Tract Binding protein (
168 sis and electrophysiology, we identified the binding site for potentiating dFBr on the top half of a
169 hed at mouse strain-selective adipose tissue binding sites for PPARgamma, a nuclear receptor for anti
170 with other amino acid residues in the GERAMT-binding site for proper chaperone-dependent regulation o
171 o gain insight into the number of functional binding sites for propofol and the energetic contributio
172 ne or two additional functionally equivalent binding sites for propofol, other than those modified by
175 t of beta-sheets and loops that serve as the binding site for PU.1, and also show that unlike other I
176 RNA, an extension of MotifMap which predicts binding sites for RBP motifs across human and mouse geno
177 s NMR and calorimetric techniques to map the binding site for Rem2 on human Cavbeta4a and measure its
180 expression, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome cofa
186 epigenetic inheritance of silencing requires binding sites for sequence-dependent activating transcri
187 revealed that the exon 11 sequences contain binding sites for serine/arginine-rich splicing factor 2
188 AngII-induced enhancers/SEs are enriched in binding sites for signal-dependent transcription factors
189 st that the loops and tails may offer unique binding sites for small micropollutants which are overse
191 izing antibodies (bNAbs) but can also expose binding sites for some types of nonneutralizing antibodi
192 tivity and identifies transcriptome-wide RNA binding sites for SONAR-predicted RBPs, revealing unexpe
195 ferentially expressed genes have a known DNA binding site for SR1, suggesting that they are likely di
197 n cyclotron resonance MS, we have probed the binding sites for ssDNA, using multiple substrates targe
198 form of Strep-Tactin that harbours a unique binding site for Strep-tag II and a single cysteine that
201 alphaCA possesses an additional, alternative binding site for sulfonamides that is not present in HCA
202 p in telomeric repeats, the longest reported binding site for synthetic, non-nucleic-acid-based, sequ
204 These data reveal a previously unappreciated binding site for targeted inhibition of BAX and suggest
205 s containing replication origins proximal to binding sites for Taz1, a component of the Shelterin tel
207 CdSe core and surface Cd adatoms serving as binding sites for terminal S atoms of the thiostannates
208 ructure-based mutational analyses mapped the binding site for the [GS]LFXG[ML]X[LV] motif to a conser
209 CXCR4 C-terminal domain (C-tail) also has a binding site for the actin-binding protein filamin A (FL
210 hic data show that the inhibitors occupy the binding site for the adenine ring of the ATP molecule an
211 SNP rs2227473 is located within a putative binding site for the aryl hydrocarbon receptor, a master
212 gene island and having a predicted promoter binding site for the As(III) oxidation regulator AioR.
215 D sequences, which shares homology with the binding site for the cellular NF-kappaB-repressing facto
216 croglobulin domain 4 of C3, which contains a binding site for the complement inhibitor compstatin and
217 hing data revealed the existence of the same binding site for the compounds on the enzyme molecule.
218 CATAC consensus sequence resembles the E-box binding site for the core circadian transcription factor
219 o-acid region of the nucleoporin Nup214 is a binding site for the major AdV capsid protein, hexon, an
221 t site, which was previously identified as a binding site for the NAM/ATAF1/CUC2 78 (NAC78) transcrip
222 the presence of low levels of H3K9me3 at the binding site for the PF3D7_1466400 AP2 transcription fac
223 se they bind to the sAC-specific, allosteric binding site for the physiological activator bicarbonate
225 eletion of exon 22, due to the creation of a binding site for the pre-mRNA processing protein hnRNP A
226 model in which the POTRA domains serve as a binding site for the preprotein as it emerges from the T
228 otein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, the
229 I and III in two different CaV isoforms as a binding site for the SH3 domains and report a crystal st
231 the best-characterized pause sequences is a binding site for the sigma(70) initiation factor that in
232 r function, however, required evolution of a binding site for the spatially restricted potent repress
234 poor inhibitors of the canonical galactoside-binding site for the tested galectins, with IC50 values
235 f the ternary complex reveals a noncanonical binding site for the toxin that adopts a novel conformat
236 23457 located in an evolutionarily conserved binding site for the transcription factor Cartilage pair
237 2149092 was predicted to disrupt a consensus binding site for the transcription factor ETS within an
238 This region of the promoter contained a binding site for the transcription factor hypoxia-induci
239 through rs7278468, which lies in a consensus binding site for the transcription repressor KLF10.
240 Methylation of SAP145 on Arg 508 generates a binding site for the Tudor domain of the Survival of Mot
241 This 'E-dimer-dependent epitope' is also the binding site for the viral glycoprotein prM during virus
242 that these phosphorylations create potential binding sites for the adaptor protein 14-3-3 that links
243 BV genome, overlapping previously identified binding sites for the B cell transcription factor PAX5.
245 pecific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, whi
246 g alpha-satellite DNA repeats, which contain binding sites for the DNA sequence-specific binding prot
247 ement dispersed 77 functional but suboptimal binding sites for the dosage compensation complex to a n
250 6me3 levels through changes in the number of binding sites for the histone methyltransferase Set2, th
251 ence motifs enriched in the PREs are cognate binding sites for the identified transcription factors a
253 NA binding by PPR repeats to infer candidate-binding sites for the maize protein PPR103 and its ortho
254 ctra for each isomer, clearly indicating the binding sites for the major conformers in the presence o
255 f microRNA promoters revealed enrichment for binding sites for the MAPK-driven ETS1 transcription fac
257 arrying Clk transgenes with deletions in the binding sites for the miRNA bantam have stochastic numbe
258 ion of the 128 genes was overrepresented for binding sites for the nuclear transcription factor kappa
259 advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion protein SlmA an
260 anding observation of high- and low-affinity binding sites for the prototypic inhibitor rolipram.
261 complex as a tethering complex with just two binding sites for the Rab7-like Ypt7 protein to determin
262 ional repressor compete for occupancy at DNA-binding sites for the regulation of common target genes.
263 al enhancers results mainly from clusters of binding sites for the same transcription factor, and it
265 yeast HO gene contains nine highly conserved binding sites for the SCB (Swi4/6-dependent cell cycle b
266 A, adjacent to the guide region, function as binding sites for the snoRNP proteins including the enzy
269 GapR target loci are especially enriched in binding sites for the transcription factors GcrA and Ctr
270 We found that robustness is encoded by many binding sites for the transcriptional activator Arrowhea
271 cond plasmid carrying a transgene flanked by binding sites for the transposase, into the cytoplasm of
272 e then conducted a ChIP sequence analysis of binding sites for the vitamin D receptor (VDR) across th
273 ors; in addition, we have mapped the precise binding site for these factors in the BAFF promoter.
274 o regulate PTEN and identify high-confidence binding sites for these miRNAs on the 3' UTR of protein
275 ), we have identified pathways that link the binding sites for these modulators to the Cys loop, a re
276 during active disease, in order to assemble binding sites for these TFs into synthetic promoters, wh
278 h was recently identified as a mitochondrial binding site for thiazolidinediones, including MSDC-0602
279 of use in clinical practice, the prototypic binding site for this class of drugs within pLGICs is ye
282 , leaving a cavity suggestive of a potential binding site for transcription-promoting small molecules
285 lacement with a sequence containing putative binding sites for transcription factors in, single-stran
286 red common cis-acting elements may represent binding sites for transcription factors responsible for
287 terminal (AF-1) domain of AR, which contains binding sites for transcription regulators, is not requi
289 allography lead to the identification of new binding sites for two derivatives and of a new crystal f
290 different timing classes each associate with binding sites for two transcription factors, GAGA-factor
291 to Tx7335 as wild-type, indicating that the binding site for Tx7335 is distinct from that of canonic
292 The data suggest that there is only one binding site for ubiquinol in cyt bo3 and that site corr
295 A removal depends on the availability of DNA binding sites for UvrD and/or the accessibility of the R
296 ined with Nanogold labeling reveals that the binding sites for vacuolar SNAREs and the Habc domain ar
298 the nanoparticle surface to provide tailored binding sites for virtually any class of substrate.
300 e dopamine transporter carries an endogenous binding site for Zn(2+), but the nature of the Zn(2+)-de
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