ライフサイエンスコーパス: binding site of

1 and genetic evidence support an overlapping binding site of 1 with the anti-cancer compound didemnin

2 and applied both to predict the genome-wide binding sites of 1312 TFs available from protein interac

3 the DNA-binding domains and a consensus DNA-binding site of 18 base pairs.

4 he D-helix of CD81, which coincides with the binding site of 1D6, a monoclonal anti-CD81 antibody kno

5 accurately predicted transcript levels using binding sites of 20+ regulators.

6 and DNA shape features surrounding the core-binding sites of 239 and 56 TFs extracted from in vitro

7 rest and that it partially overlaps with the binding site of 4EGI-1.

8 Detailed mapping of the binding site of a bactericidal antibody by hydrogen/deut

9 the pT1471 phosphate occupies the phosphate-binding site of a canonical pY complex, while Y1473 occu

10 tem, GABA was placed quasi-randomly near the binding site of a GABAA-R homology model, and atomistic

11 s, Ncd and KIFC3, to determine the potential binding site of a known KIFC1 ATPase inhibitor, AZ82.

12 T cells is a means of combining the antigen-binding site of a monoclonal antibody with the activatin

13 dues W(437)LAGLF(442), which encompasses the binding site of a neutralizing monoclonal antibody, mAb4

14 h a conserved tyrosine residue in the ligand-binding site of a subset of iLBPs.

15 Here we mapped genome-wide binding sites of a catalytically inactive Cas9 (dCas9) f

16 entially able to interact at two orthosteric binding sites of a heterodimer simultaneously, possibly

17 ectroscopy (SRCS) process to determine which binding sites of a molecule preferentially bind to a pla

18 t, after alignment, describe the genome-wide binding sites of a particular TF.

19 sly and cooperatively bind the CD4- and CCR5-binding sites of a single gp120 monomer of the HIV-1 env

20 y that binds adjacent to the heparan sulfate binding site of A27, likely affecting ligand binding.

21 -helixes alpha3 and alpha4 represent the Vif-binding site of A3H.

22 Disease-causing variations in the ATP-binding sites of ABCB4 cause defects in PC secretion, wh

23 ted patients who harbor mutations in the ATP-binding sites of ABCB4.

24 umanizing mutations in the vestibule-located binding site of AChBP to improve its suitability as a mo

25 its two-fold symmetry in the vicinity of the binding site of adamantyl inhibitors, and steric constra

26 e natural substrates bound to one of the two binding sites of ADK.

27 ted cells, suggesting that Nup214 is a major binding site of AdV during infection.

28 quence, deduced amino acid sequence, and IgE-binding sites of Aed a 3 were identified.

29 tive to Akt inhibitors which bind to the ATP binding site of Akt.

30 primary binding site of alphaXbeta2 and the binding site of alphaMbeta2 on iC3b.

31 bly, there is no overlap between the primary binding site of alphaXbeta2 and the binding site of alph

32 he N terminus of chECL1, suggesting that the binding site of ALV-J gp85 on chNHE1 is probably located

33 immunoprecipitation (iCLIP) to identify the binding sites of ALYREF, an mRNA export adaptor in TREX,

34 cytosolic leaflet enter the empty G-protein binding site of an activated beta2 adrenergic receptor a

35 tained in the lipidic cubic phase reveal the binding site of an endogenous porphyrin ligand and confo

36 gical catalysis within the natural substrate binding site of an enzyme that can be subjected to direc

37 tors, to identify a component of the odorant-binding site of an OR from the malaria vector, Anopheles

38 genes, all of which contain conserved miR159-binding sites of analogous complementarity.

39 The binding sites of anions and aromatic rings in SIFSIX mat

40 main linker of one molecule in the substrate binding site of another, attenuating the chaperone funct

41 The functional effects and binding sites of antibodies and fibronectin were consist

42 nalysis, we identified several P. gingivalis-binding sites of ArcA, which led to the discovery of an

43 The predicted binding site of ArgTX-636 is in the pore region of the N

44 rmethylated enhancer regions overlapped with binding sites of B cell-specific transcription factors (

45 odimer was formed involving the nucleic acid binding site of BolA and the C-terminal tail of Grx.

46 art of the C-terminal tail domain, the actin-binding site of both isoforms.

47 The integrity of the binding site of both LL-37 and actin is a prerequisite t

48 ired quasisynchronous adaptations in the Sia-binding sites of both lectin and esterase domains.

49 her than APC/C(Cdh1), and interacts with the binding sites of both the C-box and Ile-Arg tail motifs.

50 o 8.08+/-0.0610(4)L.mol(-1), at the warfarin binding site of BSA.

51 molecular modeling study demonstrated that A binding sites of BSA play the main role in the interacti

52 ness-instigating diterpene of Reb A into the binding sites of BSA.

53 and characterize its binding mode in the ATP binding site of Btk.

54 s cerevisiae) two-hybrid analysis to map the binding site of Bud23 on Ecm16.

55 id monolayers are used to characterize local binding sites of calcium in zwitterionic and anionic mod

56 rst molecular insights into the phospholipid binding site of calreticulin as a key anchor point for t

57 h affinity ligands on GC B-cells unmasks the binding site of CD22 relative to naive and memory B-cell

58 that favor competitive inhibition at the ATP binding site of CDK2 were identified and typically exhib

59 em is governed by two binding sites: The key binding site of CFTR (pS768) occupies one groove of the

60 th the active site of SIRT2 and the proposed binding site of chroman-4-one-based inhibitors.

61 nity labeling (PAL) was used to identify the binding site of chroman-4-one-based SIRT2-selective inhi

62 The binding site of class IIa deacetylases was previously ma

63 wild-type 46-residue peptides containing ATP-binding sites of Class I and II synthetases and those co

64 ate-dependent reduction of the dicarboxylate-binding site of complex II (site IIf); (b) pore opening

65 ion could be eliminated by mutating the SOX9-binding site of CRE2.

66 dependent manner and did not involve the PCh-binding site of CRP.

67 ions that are far from the regulatory Ca(2+)-binding site of cTnC.

68 the type of complexes formed may affect the binding sites of Cu(2+) available to catalyse the format

69 two reducing-end mannoses into the domain A binding site of CV-N than with the nonreducing end unit.

70 with CXCL12 that is possible due to the two binding sites of CXCR4.

71 previously been shown to contain the ICAM-1 binding site of DBLbeta domains, suggesting that the mAb

72 bearing implications for the so-far unknown binding site of delta on RNAP.

73 n for both drugs, whereas the other distinct binding sites of Dic and Nps remain unaffected.

74 y or by competition interactions, either for binding sites of dissolved organic carbon or for biotic

75 nd supposed to interact with the orthosteric binding site of dopamine receptors, was actually a negat

76 We determined the genome-wide binding sites of Dppa2 and find that Dppa2 operates outs

77 Mutations in the ubiquitin-binding site of Dss1 cause growth defects and accumulati

78 h correlates with deviations in the effector-binding site of E-RAS.

79 nificantly enriched for transcription factor binding sites of EBF1, EP300, and CEBPB (P < 5e-6).

80 reference compound (Erlotinib) into the ATP binding site of EGFR-TK domain (PDB ID:1M17) to elucidat

81 The N-terminal Cdc13-binding site of Est1 cooperates with the TLC1-Ku-Sir4 pa

82 The DNA-binding sites of estrogen receptor alpha (ERalpha) show

83 The discovery of the target and binding site of FR171456 within the target will aid furt

84 Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic

85 of the evolutionarily conserved galactoside-binding site of galectins has not been demonstrated.

86 centers on a dynamic hub near the nucleotide-binding site of Galphas, and radiates to helix alpha4.

87 boxy terminus were identified as the primary binding site of Gbetagamma.

88 ll molecules capable of interacting with the binding site of Gbetagamma.

89 a vaccine that specifically target the HVEM binding site of gD.

90 ype-associated SNPs were present in microRNA-binding sites of genes involved in energy metabolism and

91 JM2 binds the CD4-binding site of gp120 and neutralizes HIV-1 strains from

92 utralization spectrum, interact with the CD4 binding site of gp120, with a contact dominated by CDRH3

93 to other Hsp90 isoforms, the N-terminal ATP-binding site of Grp94 possesses a unique hydrophobic poc

94 Three nitrated tyrosines reside in the heme-binding site of hemopexin, and we found that one, Tyr-19

95 Ps are significantly over-represented in the binding sites of HNF4 and FOXA families of liver transcr

96 llosteric paths between catalytic and ligand binding sites of hPDI.

97 erent positions within the central substrate-binding site of hSERT, while no crosslinking is observed

98 The binding sites of hTMPK inhibitors were validated by phot

99 ation in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nit

100 The initial binding site of I2 in MFM-300(Sc), I2(I), is located nea

101 a cysteine-to-serine mutation in BTK at the binding site of ibrutinib in five patients and identifie

102 port the experimental determination of a GAG binding site of IL-10.

103 istinctly organized arrays of RNA polymerase binding sites of ill-defined function.

104 F) at selected positions in hSERT to map the binding site of imipramine, a prototypical tricyclic ant

105 revealed NLS2 primarily binds the major-NLS binding site of importin alpha, unlike NLS1 that associa

106 ese MT-interacting elements overlap with the binding site of importins on TPX2.

107 sitive hits exclusively when a ligand at the binding site of interest is displaced; it mitigates fals

108 bias in ChIP-seq is challenging because the binding sites of interest tend to be more common in high

109 We identified the inactivating Ca(2+) binding site of IP(3)R subunits as the primarily noise-s

110 In contrast, staurosporine binds at the ATP-binding site of IRE1alpha, resulting in a dimer consiste

111 to a monoglycopeptide shows that the GalNAc-binding site of its lectin domain is rotated relative to

112 portant for the stabilization (first calcium binding site) of its zymogenic form and the possible mod

113 Sequence analysis identified putative binding sites of known and novel transcription factors l

114 ealed specific RNA cleavages, localizing the binding sites of L7Ae to the RPR's catalytic and specifi

115 A peptide mimicking the binding site of laminin onto PrP(C) (Ln-gamma1) binds to

116 restingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains

117 m mice harboring a mutation at the PLCgamma1 binding site of LAT (Y136F) have impaired calcium flux a

118 The nucleotide-binding site of LegK4 contains an unusual set of residue

119 of mutations in both actin- and tropomyosin-binding sites of leiomodin affected its localization at

120 ynamic complex, we first mapped the adjacent binding sites of light chains MLC1 and ELC1 on the MyoA

121 ion NMR experiments, we were able to map the binding site of LOC14 as being adjacent to the active si

122 The ATP binding site of Lsh is in part required to promote stabl

123 technology such as ChIP-seq, the genome-wide binding sites of many proteins have been profiled under

124 not in those of Fmr1 KO neurons or when the binding site of miR125a, previously shown to bind PSD-95

125 roach, MBSTAR (Multiple instance learning of Binding Sites of miRNA TARgets), for accurate prediction

126 and (S)-17b, which bind within the substrate-binding site of MMP-13 and surround the catalytically ac

127 site shows structural similarity to the GTP-binding site of MoaA, suggesting that the viperin substr

128 bout the underlying molecular mechanisms and binding sites of modulatory compounds, we know just the

129 ug-like compounds able to target the antigen-binding sites of most or all patients in a stereotyped s

130 nt with its repressive function, the genomic binding sites of Myt1l are similar in neurons and fibrob

131 substitutions that are found in the 2nd SIA-binding site of NA proteins of avian-derived IAVs that b

132 , with striking parallels to the glutathione binding site of NaAtm1, a transporter that functions in

133 We developed RBDmap to determine the RNA-binding sites of native RBPs on a proteome-wide scale.

134 inding modes are made possible by the C-lobe-binding site of NCS-1, which adopts alternative conforma

135 The binding site of NF023, identified by NMR spectroscopy an

136 The allosteric binding site of NMS overlaps with the binding site of so

137 zed the specific amino acids involved in the binding site of nNOS-PDZ with dystrophin R16-17 using co

138 The binding sites of NRF-2 are conserved between rats and mi

139 both VEGFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NC

140 say showed that PL directly binds to the DNA binding site of nuclear factor-kappaB (NF-kappaB) p50 su

141 th regulatory (i.e., allosteric) Mg(2+)-dNTP-binding sites of nucleos(t)ide-metabolizing enzymes susc

142 ed CpGs downstream from SALL4 TSS are within binding sites of octamer-binding transcription factor 4

143 f neuronal genes, partially co-localizing at binding sites of OLIG2, a key activator of motor neuron

144 resent structural data that reveal the viral binding site of one of the first HIV-1-neutralizing anti

145 We mapped the genomic binding sites of one of these candidates and found enric

146 Here we report mapping of the HS-binding site of OPG.

147 that is unique from the previously described binding sites of other inhibitors.

148 ination with previous studies evaluating the binding sites of other protective antibodies, our result

149 ct binding modes to the choline/ethanolamine-binding site of P. falciparum choline kinase, reflecting

150 The WW domain of Rsp5 binds to the viral RNA-binding sites of p33 and p92 replication proteins and bl

151 The compounds bind competitively to the ATP binding site of p38alpha but unexpectedly with higher af

152 The E6-binding site of p53 is distal from previously described

153 mice lacking the extracellular neurotrophin binding site of p75 neurotrophin receptor.

154 tide sequence (I56-K68) overlapping with the binding sites of patients' serum IgEs.

155 ar docking studies suggested that the ligand binding site of PEDF-R interacts with the neurotrophic r

156 2 transmembrane domain; independent from the binding site of perampanel.

157 We map the binding site of PhnK on the complex using electron micro

158 Here we present the mutations in the ATP-binding site of PI3Kalpha to progressively transform the

159 ydrophobic binding cleft adjacent to the ATP binding site of PI3Kgamma, and achieves its selectivity

160 ressing a FRET-biosensor comprising the cGMP-binding sites of PKGIalpha.

161 s, alpha2AP can no longer bind to the lysine binding sites of plasmin(ogen) and is only a kinetically

162 Mutations of the arsenic-binding site of PML/RARA, but also PML, have been detect

163 at the information freely transfers from the binding site of preQ1 to the expression platform of the

164 ions in the canonical actin- or poly-proline-binding sites of profilin.

165 Furthermore, the structure revealed (i) the binding site of proMPO-processing proconvertase, (ii) th

166 that stolonidiol binds to the phorbol ester binding site of protein kinase C (PKC), induces transloc

167 ional suppressor mutations in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefu

168 lection of a nucleotide change at the miR172 binding site of Q contributed to subcompact spikes and f

169 dentified, we found several mutations in the binding sites of QS repressor, LsrR.

170 rmation of RapA, define the binding mode and binding site of RapA on RNAP, and show that the binding

171 ding site of RapA on RNAP, and show that the binding sites of RapA and sigma(70) on the surface of RN

172 tructural binding preferences and predicting binding sites of RBPs, which takes (predicted) RNA terti

173 od is less capable of identifying the longer binding sites of RBPs.

174 ore stable interactions at the secondary RNA binding sites of Rho, which reduced the lag in initiatin

175 In the two cAMP-binding sites of RIalpha, exocyclic phosphate oxygens of

176 r EDC/GEE, are used together to pinpoint the binding sites of rifamycin SV, doxycycline, and another

177 ions between m5C and micro RNA target sites, binding sites of RNA binding proteins, and N6-methyladen

178 ship between the methylation regions and the binding sites of RNA-binding proteins.

179 l structural changes that open the substrate binding site of Rv2466c allowing the release of the acti

180 dence that SA acts at or near the ubiquinone binding site of SDH to stimulate activity and contribute

181 Mutation within the IxM cargo-binding site of Sec24C led to a drastic reduction in sor

182 Individual binding sites of select KSHV gene products on PAN RNA we

183 faces the outside of the protein and is the binding site of several animal toxins, and the palm, a c

184 MARGE-cistrome can predict the binding sites of silenced transcription factors without

185 ific hypomethylated regions are enriched for binding sites of similar transcription factors, suggesti

186 steric binding site of NMS overlaps with the binding site of some allosteric, ectopic and bitopic lig

187 tent cyclic peptidomimetic bound to the iNOS binding site of SPSB2 with low nanomolar affinity (KD 29

188 The binding site of SSL3 overlaps those of TLR2 dimerization

189 of TLR2-glycans with the conserved Lewis(X) binding site of SSL3.

190 Disabling the binding sites of STAT5, NFIB and ELF5 in the proximal en

191 an SULT allosteric binding site-the catechin-binding site of SULT1A1 bound to epigallocatechin gallat

192 tructure of an NSAID allosteric site-the MEF-binding site of SULT1A1-is determined using spin-label t

193 Here, the catechin-binding site of SULT1A3, which sulfonates monoamine neur

194 The glycan-binding site of T1 sigma1 is located in the head domain

195 In contrast to T1 sigma1, the carbohydrate-binding site of T3 sigma1 is located in the tail domain,

196 The peptide binding site of TAP is located at the hydrophobic bounda

197 expression and genetic variation in microRNA-binding sites of target genes on growth and muscle quali

198 region homologous to the muscarinic receptor-binding site of Tau suggests that MAP2c also may regulat

199 C-terminal region of EBs and the microtubule-binding sites of tau.

200 ther cell types could be used to predict the binding sites of TFs of interest.

201 Notably, the regions around the binding sites of TFs that belong to the same TF families

202 by the binding of alternative factors to the binding sites of TFs whose activity has been ablated.

203 The overall architecture and NADP(+)-binding site of Tfu-FNO were highly similar to those of

204 and HS is strong, the conformational heparin binding site of TG2 is not conserved, suggesting that TG

205 unnel of RNAP aligns with the Shine-Dalgarno-binding site of the 30S subunit.

206 ibiting protein biosynthesis by blocking the binding site of the A-tRNA elbow, a mechanism not shared

207 effector-to junctions requires the vinculin binding site of the alpha-catenin sensor.

208 2A (SV2A) isoform has been identified as the binding site of the antiepileptic levetiracetam (LEV), m

209 cificity, CD-160130 did not bind to the main binding site of the arrhythmogenic KV11.1 blockers (the

210 raphic fragment screening to map the protein-binding site of the aspartic protease endothiapepsin by

211 that oxygen penetrates spontaneously the Qo binding site of the bc1 complex in the presence of an in

212 r KCa3.1 over KCa2.3, we first localized the binding site of the benzothiazoles/oxazoles to the CaM-B

213 ophore that is positioned in vicinity of the binding site of the binding protein using unnatural amin

214 an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible.

215 nd therefore is sensitive to changes in both binding site of the cation and chromophore orientation.

216 es had a high binding affinity for the oxLDL binding site of the CD36 receptor and participated in CD

217 -alpha3 loop directly interacts with the ATP-binding site of the CKI1 histidine kinase domain.

218 f the 3-benzazepin-1-ols into the ifenprodil binding site of the crystallized GluN1b/GluN2B N-termina

219 To test this hypothesis, we blocked the CD4 binding site of the envelope antigen and compared it to

220 ctrum of HIV-1 strains via targeting the CD4 binding site of the envelope glycoprotein gp120.

221 A triple mutation in the phosphopeptide-binding site of the forkhead-associated (FHA) domain dis

222 und 2 (Ki = 19 nM) binds within the aldehyde-binding site of the free enzyme species of ALDH2.

223 It is known that the Na(+) binding site of the GIRK1 subunit is defective, but the

224 es, which recognize the conserved coreceptor-binding site of the HIV-1 envelope glycoprotein (Env), c

225 h of VRC01, an antibody that targets the CD4 binding site of the HIV-1 envelope.

226 169R mutation located at the second receptor binding site of the HN protein contributed to a complex

227 nd the ligand binding site is similar to the binding site of the homologous receptors for the calcito

228 Gene conversion frequently spares the binding site of the hotspot-specifying protein PRDM9, wi

229 KC inhibitor that targets the diacylglycerol-binding site of the kinase.

230 tor and, conversely, binding to the receptor-binding site of the ligand.

231 omplexes can bind anionic species in the DIM binding site of the ligand.

232 We have now determined the cholesterol-binding site of the M2 protein in phospholipid bilayers

233 interact either with the phencyclidine (PCP) binding site of the N-methyl-d-aspartate (NMDA) receptor

234 ma1, and sigma2 receptors as well as the PCP binding site of the NMDA receptor.

235 no terminus and with the substrate/inhibitor-binding site of the opposite protomer at its carboxyl te

236 a structural model that places the receptor-binding site of the PDZ domain and membrane-binding surf

237 addition to a PIP3 molecule at the canonical binding site of the PH domain, we observe additional PIP

238 ereas the composition of the aromatic H3K4me-binding site of the PHD fingers appears to have no effec

239 n at the VWF A1 domain, corresponding to the binding site of the platelet glycoprotein Ibalpha (GPIba

240 Tumors with mutations in the SMAP-binding site of the PP2A A subunit displayed resistance

241 presence of ice-like water layers at the ice-binding site of the protein in aqueous solution at tempe

242 atic potential in the secondary quinone (QB) binding site of the reaction center (RC) of the photosyn

243 an avian-like glycine at the HA 228 receptor binding site of the reassortant H3N2 virus with 5 A(H1N1

244 he two most common are binding to the ligand-binding site of the receptor and, conversely, binding to

245 by ligands interacting with the orthosteric binding site of the receptor to incorporate concepts of

246 nd kinase domains and to the phosphotyrosine-binding site of the SH2 domain, respectively, inhibits t

247 site of a gene is regulated by a particular binding site of the TF.

248 trol for site-positioning paratopes (antigen binding site) of the antibody molecules.

249 (a) and an antibody targeting ligand-induced binding sites of the activated GPIIb/IIIa receptor (MBDu

250 omosome, constrained by interactions between binding sites of the chromosomal condensin complex, a ke

251 In this study we mapped the binding sites of the core transcription initiation facto

252 and deactivates both of the divalent cation-binding sites of the cTnC C-domain.

253 iation in mice, we characterised genome-wide binding sites of the forkhead/winged helix transcription

254 cers active in liver cells, enriched for the binding sites of the FOXA1, FOXA2 and HNF4A transcriptio

255 graft survival, estimated AA MMs at peptide-binding sites of the HLA-DRB1 molecule account for an im

256 teins in pressurised meat affected the water binding sites of the myofibrillar proteins and, thereby,

257 s in the structure of the sn-1 and sn-2 acyl-binding sites of the protein.

258 llosteric interactions between remote ligand binding sites of the protein.

259 engagement of the allosteric and orthosteric binding sites of the receptor.

260 nine nucleotides to the canonical nucleotide binding sites of the regulatory Bateman domain induces d

261 llicKZ, this protein associates with two RNA binding sites of the RNase E component of the Pseudomona

262 CRS regions (1) colocalize consistently with binding sites of the same RNA binding proteins (RBPs) or

263 romoters of repressed genes are enriched for binding sites of the serum-response factor (SRF).

264 H3K27ac after nerve injury are enriched for binding sites of the Sox10 and early growth response 2 (

265 lications of this finding on identifying the binding sites of the substrate and the subsequent mechan

266 ns of the FGF12-FGFR1c2 and FGF22-FGFR1c2 HS binding sites of the symmetric FGF2-FGFR2-HS2 signal tra

267 We noted that the ATP/inhibitor-binding sites of the TAM members closely resemble each o

268 these cavities corresponded to those of the binding sites of the template molecules.

269 ions of active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain

270 corresponded to the catalytic and substrate binding sites of the two enzymes.

271 Details with respect to the binding sites of the two inhibitors are provided on the

272 ilovirus family, which likely represents the binding site of their NPC1 receptor.

273 ynaptic membrane surface whenever the ligand-binding sites of their synaptic receptors are buried in

274 r dynamics simulation studies elucidated the binding site of these aniline-based influenza fusion inh

275 he area that corresponds to the rigid ligand-binding site of these bona fide folate receptors.

276 ophysical analyses revealed that two antigen-binding sites of these antibodies form a head-to-head di

277 In addition, we map the binding sites of these proteins using a combination of P

278 l analyses using agonists to map the odorant-binding sites of these receptors have been limited becau

279 ches to comprehensively map the identity and binding sites of these RNAs are lacking.

280 with novel mycobacterial alterations in the binding site of this drug.

281 DNA binding assays uncovered the DNA-binding site of ThrR and revealed that the repressor com

282 res of prototypical members bound to the ATP-binding site of TNNI3K reveal two anchoring hydrogen bon

283 clude is Avo3, occludes the FKBP12-rapamycin-binding site of Tor2's FRB domain rendering TORC2 rapamy

284 ification marks, chromatin accessibility and binding sites of transcription factors and co-activators

285 functional subsets in vivo were enriched for binding sites of transcription factors known to regulate

286 n is non-random, being strongly enriched for binding sites of transcription factors specifying chroma

287 , immune function, stem cell maintenance and binding sites of transcription factors that drive cellul

288 strate for the ATPase and that the substrate-binding site of TRIP13 is composed of subsites specific

289 small molecule ligands within the thyroxine binding site of TTR can stabilize the tetrameric integri

290 h revealing the ability of the two thyroxine binding sites of TTR to discriminate between different l

291 n be properly accommodated in the colchicine binding site of tubulin as well as in the ATP binding cl

292 toichiometry of K2hPg/VKK38, with the lysine-binding sites of two K2hPg domains anchored to two regio

293 sing synthetic Phl p 1-derived peptides, the binding sites of two ScFvs were mapped to the N terminus

294 nts by phage display that bind the back side binding site of Ubc9 and function as SUMO-based Ubc9 inh

295 ptic vesicles and possess a well defined ATP-binding site of undetermined function.

296 We determined the binding sites of unphosphorylated and phosphorylated MAP

297 The identification of similarities between binding sites of various proteins is a useful approach t

298 Here, we report the in vivo RNA binding sites of wild-type (WT) and reengineered forms o

299 ds to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the dev

300 stidine-rich motifs, which are the predicted binding site of Zn(2+) in the Zn-deficiency response.