ライフサイエンスコーパス: binding specificity

1 abundance of neoantigens and greater mutant-binding specificity.

2 e coiled-coil and perhaps contributes to the binding specificity.

3 TFBSs in order to achieve genome-wide TF-DNA binding specificity.

4 ith a few residues in the motif endowing the binding specificity.

5 antibodies that do not change their antigen binding specificity.

6 ive DIMM binding sites contribute to its DNA binding specificity.

7 t of the antibody fragment (64)Cu-DOTA-B-Fab binding specificity.

8 tant for allosteric activation from receptor binding specificity.

9 calization but only minimally by altered RNA binding specificity.

10 ding, and ligand blot analysis confirmed the binding specificity.

11 t to the non-sulfated hyaluronan, confirming binding specificity.

12 -end pairing is a general determinant of AGO binding specificity.

13 nd H3.3 G90 as key determinants of UBN1-H3.3-binding specificity.

14 identical properties other than its antigen-binding specificity.

15 the HLA-presented peptide influence peptide binding specificity.

16 mode of deformation, consequently enhancing binding specificity.

17 Neu5Ac reveals the structural bases for its binding specificity.

18 2 complexes, while KIR2DL1 showed a broader binding specificity.

19 zed by proteins and is crucial for achieving binding specificity.

20 one-site and competitive ELISAs for oligomer binding specificity.

21 ctural variations that create differences in binding specificity.

22 cids that have an electrostatic influence on binding specificity.

23 ligand, contributing an important aspect of binding specificity.

24 ntisera competed with b12 for CD4bs-directed binding specificity.

25 ognize and bind DNA with different levels of binding specificity.

26 anisms through which homeodomains attain DNA binding specificity.

27 quence, is the major determinant of HDAg RNA binding specificity.

28 RRM adds affinity but does not contribute to binding specificity.

29 rtant determinants of Arg and Abl SH2 domain binding specificity.

30 the nucleotides that determine the TALE-DNA binding specificity.

31 and Oct1, a related protein with similar DNA-binding specificity.

32 latory codes and determinants of protein-DNA binding specificity.

33 modeling studies provided the basis for the binding specificity.

34 ily genes that share a similar paired domain binding specificity.

35 elucidate the factors controlling Gleevec's binding specificity.

36 ence features that accurately predict TF-DNA binding specificity.

37 uestion of what mechanism accounts for their binding specificity.

38 se findings and revealed avian-like receptor-binding specificity.

39 onal glycan-binding site, which broadens its binding specificity.

40 ith higher information content than the true binding specificity.

41 ced acute liver injury to determine its S1P1-binding specificity.

42 tly exhibit class I, class II, and class III binding specificity.

43 dentified PAD4 variants having enhanced TEM8 binding specificity.

44 tifs, and allows for the analysis of in vivo binding specificities.

45 cessful design and prediction of C2H2-ZF DNA-binding specificities.

46 to determine, predict and engineer their DNA-binding specificities.

47 -throughput approach into the modeling of TF binding specificities.

48 es us to match isoforms with their known DNA-binding specificities.

49 embers suggest that some of them evolved new binding specificities.

50 roved the prediction accuracy of homeodomain binding specificities.

51 is unclear how these variations affect HBGA binding specificities.

52 , with individual isoforms exhibiting unique binding specificities.

53 -DNA complexes are used to estimate relative binding specificities.

54 s that display common response regulator DNA-binding specificities.

55 homo- and heterodimers to measure their DNA binding specificities.

56 avior across viruses with different receptor binding specificities.

57 binding motifs that, in spite of limited DNA binding specificity, adopts crucial, specific roles when

58 led to E2F1 cistrome expansion and different binding specificity, alterations distinct from those obs

59 key determinants for biological activity and binding specificity, although the nature of interactions

60 tibodies results in induction of new antigen binding specificities and acquisition of binding polyrea

61 ants, suggested to be driven by altered HBGA binding specificities and antigenic drift.

62 ng HLA molecules for similarities in peptide binding specificities and binding pocket structure.

63 e set of natural C2H2-ZF proteins with known binding specificities and demonstrate that for >85% of t

64 transcription factor concentrations and DNA binding specificities and predicts precise gene expressi

65 ctural features refine the description of TF binding specificities and provide mechanistic insights i

66 The combinatorial chromatin-binding specificities and transcriptional activities of

67 physiological functions by regulating their binding specificities and transcriptional activities.

68 ntaining a variable Fab domain that mediates binding specificity and a constant Fc domain that bridge

69 orrectly identifies residues that confer DNA-binding specificity and accurately predicts binding moti

70 ure-based biophysical determinants for their binding specificity and affinity is of fundamental impor

71 The DNA-binding specificity and affinity of the dimeric human tr

72 bilization of the peptides but also on their binding specificity and affinity to the target molecules

73 tophan emanating toward I44(Ub) for enhanced binding specificity and affinity.

74 pen question whether the human protein's DNA-binding specificity and chromatin localization are conse

75 In order to dissect the receptors' binding specificity and enable structural studies, full-

76 eotides is distinct and that it reflects the binding specificity and genome occupancy of methylcytosi

77 lucidated the molecular basis underlying its binding specificity and high affinity.

78 ge of human disorders due to their exquisite binding specificity and high binding affinity.

79 s the molecular basis for pocket protein-E2F binding specificity and how cyclin-dependent kinases dif

80 to the study of in vivo transcription factor binding specificity and its relationship to cis-regulato

81 residues can be enough to alter activity or binding specificity and limit the functional resolution

82 the molecular prerequisites for higher level binding specificity and regulation, raising new question

83 f an epigenetic DNA modification on human TF binding specificity and reveals that many developmentall

84 in human cells using ChIP-seq to assess DNA-binding specificity and RNA-seq to measure the specifici

85 rmine brain penetration, brain distribution, binding specificity and selectivity (via the use of the

86 at in the cerebellum, thus demonstrating the binding specificity and selectivity of (18)F-LY2459989 i

87 A structure ('shape') is a determinant of TF binding specificity and since DNA shape has a significan

88 The binding specificity and stability of (18)F-GE180 was fur

89 the hydrophobic interactions to provide the binding specificity and strength in ribosome targeting o

90 GN-L-IO/DiR was fully characterized, and its binding specificity and subsequent internalization into

91 rtant for function despite the low intrinsic binding specificity and the complete lack of effect of d

92 dependent but convergent evolution of PUF4/5 binding specificity and the rewiring of the PUF4/5 regul

93 We also drive the intrinsic binding specificity and which correlation with amino aci

94 udicious strategies have blended design (for binding, specificity and active site modelling) with the

95 d its paralogue WelNDLY exhibit distinct DNA-binding specificities, and that, unlike WelNDLY, WelLFY

96 possibilities in terms of trimerization, DNA binding specificities, and transcriptional regulation.

97 significant improvements in target affinity, binding specificity, and enzymatic stability relative to

98 able di-residues that determine TAL effector binding specificity, and is independent of the transcrip

99 play significantly improved target affinity, binding specificity, and protection against 3'-exonuclea

100 nd PvRBP1a displayed a distinct reticulocyte-binding specificity, and their specific reticulocyte-bin

101 i-protein recognition codes in which new DNA-binding specificities are achieved by the assembly of mu

102 Data on TF-DNA binding specificities are essential for understanding ho

103 This analysis revealed that TF binding specificities are highly conserved between Droso

104 nd that SH2 domain proteins with overlapping binding specificities are unlikely to compete with one a

105 ties of homeodomains, the factors behind the binding specificity are still difficult to elucidate.

106 st as likely to have sites matching the TF's binding specificity as the targets implicated by ChIP.

107 Protein-binding specificity assays of C. parvum AP2 domains comb

108 used ChIP-seq to examine genome-wide CRISPR binding specificity at gRNA-specific and gRNA-independen

109 usly, we developed a method for modeling DNA binding specificities based on DNA shape features extrac

110 ession, we trained quantitative models of TF binding specificity based on protein binding microarray

111 We discovered mutual relationships among binding specificity, binding affinity, and structural pr

112 he 190V in HA does not affect virus receptor binding specificity but enhances binding affinity to hum

113 90V in the HA does not change virus receptor binding specificity but enhances virus binding affinity

114 8 virus has retained its avian-like receptor binding specificity, but could potentially establish inf

115 6E) has been reported to alter the substrate-binding specificity by shifting Glut5-mediated transport

116 However, subtle differences in binding specificities can be detected in vitro with the

117 aracterize how transcription factor (TF) DNA-binding specificity can change.

118 served, although underlying differential DNA binding specificity can dictate the recruitment of FOXK2

119 bind to specific DNA regions, although their binding specificities cannot account for their cell type

120 N37L in turn switches binding specificity: compared with the wild-type C. ther

121 ncreasing molecular size without loss of the binding specificity conferred by small cavity [Pd2(L)4](

122 istinct genomic regions, suggesting that DNA binding specificity contributes to functional difference

123 Using publicly available TF binding specificity data and DNaseI chromatin accessibil

124 on about the proteins and displays their DNA-binding specificity data in terms of k-mers, position we

125 n the context of a specificity tree based on binding specificities defined by peptide-phage binding s

126 ds SMYD2 in a U-shaped conformation with the binding specificity determined mainly by residues C-term

127 another by acquiring different intrinsic DNA-binding specificities, different preferences for half-si

128 The DNA binding specificities do not result from differences in

129 cell differentiation, is critical for EBNA3C binding specificity; EBNA3A and EBNA3B specificities are

130 tion weight matrices (PWMs) representing DNA-binding specificities for C2H2-ZF proteins.

131 ere we introduce a method for predicting DNA-binding specificities for Cys2His2 zinc fingers (C2H2-ZF

132 inding profiles (FBPs) represent the average binding specificity for a group of structurally related

133 me, approximately 24% of antibodies acquired binding specificity for divergent strains of HIV-1 gp120

134 revealed that the DivL PAS domains regulate binding specificity for DivK approximately P over DivK,

135 we screened 20 widely used lectins for their binding specificity for major pancreatic cell types, and

136 have designed variants of IbpA with inverted binding specificity for myo-inositol and D-ribose.

137 We validate the importance of DNA binding specificity for organ-specific gene regulation b

138 brational spectra and provide perspective on binding specificity for small-molecule ligands in intact

139 meric 'B' subunit made up of PltB, which has binding specificity for the N-acetylneuraminic acid (Neu

140 The same arrays enabled us to quantify binding specificity for these aptamers in parallel by co

141 s of the CBM 5/12 domain, representing a new binding specificity for this fold-family.

142 tion of I2BS protein in the rhesus brain and binding specificity for this radioligand.

143 (64)Cu-LLP2A and LLP2A-Cy5 demonstrated binding specificity for VLA-4 in an immune-competent mur

144 De novo prediction of their DNA-binding specificities from sequence alone would be a gre

145 allows ppGpp to bind to BipA and switch its binding specificity from ribosomes to small ribosomal su

146 orresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.

147 he galectin interacting with Gal-3BP and its binding specificity has not been identified and structur

148 For this reason, more complex models of binding specificity have been developed.

149 ssess, as previous systematic analyses of TF binding specificity have been performed using different

150 er, no genome-wide investigations into their binding specificity have been performed.

151 of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and

152 To understand the mechanisms that dictate binding specificity, HSF1 was purified as either a monom

153 dues from one Hox protein to another swapped binding specificities in vitro and gene regulation in vi

154 th nucleotide cofactors and modifies its DNA-binding specificity in a manner that stimulates DNA stra

155 alog has almost a 10-fold higher IGF-1R/IR-A binding specificity in comparison with native IGF-II.

156 show that the ion binding sites switch their binding specificity in E1 and E2.

157 1)C]11e) were generated and tested for NMDAR binding specificity in ex vivo autoradiography and brain

158 rface experiment to successfully demonstrate binding specificity in kinetic analysis biomechanics in

159 de constitutes a key signature providing PIC binding specificity in the human genome.

160 ful pathway for drug development focusing on binding specificity in the initial high-throughput scree

161 To identify the determinants of Chd1 binding specificity in the yeast genome, we investigated

162 However, CELF1's RNA binding specificity in vitro was not detectably altered

163 n vitro are not mutually exclusive, and that binding specificity in vivo remains to be demonstrated.

164 like factor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic transc

165 e number of Puf genes and alterations of RNA binding specificity including that: 1) Binding of Puf3 t

166 ubsequently, endocytic lectins with distinct binding specificities, including the Ashwell-Morell rece

167 ing with minimal interfaces, suggesting that binding specificity is an additional pressure for a scal

168 Binding specificity is determined by lysine 362 and alan

169 segregation, indicating that the lack of DNA binding specificity is detrimental to plasmid fitness in

170 novo motif analyses suggest that the lack of binding specificity is due to subsets of the finger doma

171 DNA-binding specificity is encoded at multiple levels, from

172 Binding specificity is further modulated by different bi

173 lar dichroism demonstrates that although the binding specificity is maintained the Kd values for the

174 ranscription factor dimerization impacts DNA-binding specificity is poorly understood.

175 though genogroup-dependent variation in HBGA binding specificity is structurally well characterized,

176 Brg1 helicase has dual nucleic-acid-binding specificities: it is capable of binding lncRNA (

177 s associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory dropl

178 est that polymorphisms that impact FOXP3 DNA-binding specificity may contribute susceptibility to aut

179 ant, we were able to build a heterodimer-DNA binding specificity model that has superior predictive p

180 improve the predictive power of quantitative binding specificity models across 27 transcription facto

181 assessing cooperativity when generating DNA binding specificity models for heterodimers.

182 r partners and its impact on heterodimer DNA binding specificity models is still lacking.

183 rface of yeast, we show that SELEX can yield binding specificity motifs and identify cleavable LHE ta

184 nd identifies which transcription factor DNA-binding specificities (motifs) are statistically overrep

185 solution chromatin accessibility, and TF-DNA binding specificities ('motifs').

186 and the other (ERalpha-G521R) with a ligand-binding specificity mutation, we herein demonstrate that

187 Substantial similarities in binding specificity, neutralization breadth and potency,

188 this process, we have characterized the DNA-binding specificities of 129 zinc finger sets from Droso

189 hensively by quantitatively assaying the DNA-binding specificities of 21 representative TALEs to appr

190 To address this, we determined the binding specificities of 242 Drosophila TFs, and compare

191 ein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs.

192 Toward this goal, we have used the DNA-binding specificities of 678 two-finger modules from bot

193 e, qualitatively and quantitatively, the DNA binding specificities of closely related TFs and, thus,

194 study, a predictive understanding of the DNA-binding specificities of either natural or engineered ZF

195 Whereas the peptide-binding specificities of HLA-A and -B molecules have bee

196 specificity of CNV and to compare it to the binding specificities of noroviruses from other genogrou

197 The distinctive binding specificities of PGHS subunits permit different

198 n as another feature that fine-tunes the DNA binding specificities of some transcription factor famil

199 DNA shape information when analysing the DNA binding specificities of TFs, we developed a new tool, t

200 algorithm (TF2DNA) is developed to identify binding specificities of TFs.

201 tide-binding assay and use it to analyze the binding specificities of the endoplasmic reticulum Hsp70

202 approach, with features that reflect the DNA-binding specificities of the putative co-factors.

203 show that bispecific antibodies contain the binding specificities of the two parental antibodies and

204 se findings are consistent with the measured binding specificities of these proteins for ganglioside

205 pid composition to quantify the phospholipid binding specificities of these seven clotting proteins.

206 DNA binding specificities of transcription factors (TFs) are

207 Characterizing the binding specificities of transcription factors (TFs) is

208 otifs are quite accurate descriptions of DNA binding specificities of transcription factors (TFs), pr

209 Purpose To determine the binding specificity of (18)F-16alpha-17beta-fluoroestrad

210 The DNA binding specificity of a transcription factor (TF) is ty

211 alendronate confirmed the microcalcification binding specificity of alendronate derivatives.

212 a general strategy to determine the peptide-binding specificity of any MHC class I molecule.

213 Effector Design (SIFTED), to predict the DNA-binding specificity of any TALE.

214 model that could accurately estimate the DNA-binding specificity of any ZFP based on its amino acid s

215 ng could explain the ppGpp regulation of the binding specificity of BipA.

216 The binding specificity of BRP1 with Q-satRNA was confirmed

217 The binding specificity of canine noroviruses is therefore v

218 Binding specificity of Cas9-guide RNA complexes to DNA i

219 s study sought to determine the carbohydrate binding specificity of CNV and to compare it to the bind

220 tic oligosaccharides were used to assess the binding specificity of CNV virus-like particles (VLPs) a

221 intrafamily protein interactions affect DNA binding specificity of floral MADS domain proteins.

222 e molecular determinants responsible for the binding specificity of Gleevec remain poorly understood.

223 us thermodynamic contributions affecting the binding specificity of Gleevec to the kinases.

224 titatively characterized the glycan receptor-binding specificity of HAs from representative strains o

225 an sulfate (HS) 3-O-sulfation determines the binding specificity of HS/heparin for antithrombin III a

226 s recently been used to deeply probe the DNA binding specificity of hundreds of eukaryotic transcript

227 ound that homo-trimerization defines the DNA binding specificity of Myrf N-terminal fragments.

228 e of termination pathway, we altered the CTD-binding specificity of Nrd1 by domain swapping.

229 Early works suggested binding specificity of PRC2 to certain long non-coding R

230 Rapid evolution of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM

231 e first strategy to exhaustively explore the binding specificity of protein domain-peptide interactio

232 nstrate that the CTR domain confers receptor-binding specificity of RELN.

233 rotein histochemistry showed that the tissue binding specificity of S1 proteins of turkey, quail, and

234 -chain variable fragment (scFv) retained the binding specificity of the 3H3 IgG and, when expressed i

235 ults outline the molecular mechanism driving binding specificity of the BRPF1 bromodomain for discret

236 ts they regulate is not fully known, and the binding specificity of the CPEB2 subfamily is a matter o

237 , particularly of sites corresponding to the binding specificity of the overexpressed SH2 domain.

238 Our result shows that the binding specificity of the PHD-finger domain of VIN3 pla

239 An alteration in the binding specificity of the PHD-finger domain of VIN3 res

240 data, (iii) inadequate consideration of the binding specificity of the target mRNAs and (iv) reducti

241 Of these processes, the binding specificity of the TCR is a key component.

242 It has been recently proposed that the binding specificity of the yeast mitochondrial ADP/ATP c

243 Analysis of the binding specificity of their bromodomains suggests that

244 We analyzed the binding specificity of three MSI family RRM domains usin

245 Uncovering the mechanisms that affect the binding specificity of transcription factors (TFs) is cr

246 n cis-regulatory elements or by altering the binding specificity of transcription factors (TFs).

247 networks are reconfigured by changes in the binding specificity of transcription factors and their c

248 Finally, we show that the DNA-binding specificity of ZFP809 is evolutionarily conserve

249 We predict DNA-binding specificities on a per-finger basis and merge pr

250 CD4, b12, and VRC01 share binding specificities on the outer domain of gp120.

251 To evaluate the impact of RT-aptamer binding specificity on replication, we engineered provir

252 binding affinity on one hand, but increases binding specificity on the other hand, and the decreasin

253 ne to accommodate new function(s), fine-tune binding specificities or change/create novel protein int

254 he increasing number of TFs for which either binding specificities or genome-wide occupancy data are

255 d Cha2 internal region results in changes in binding specificity or binding affinity and may be assoc

256 eering proteins for thermodynamic stability, binding specificity, or enzymatic activity in a 'single

257 ed; however, questions still arise regarding binding specificity outside the core GGA recognition seq

258 oped an algorithm, SelexGLM, that quantifies binding specificity over a large (31-bp) binding site by

259 chine learning revealed that the accuracy of binding specificity predictions improves by adding shape

260 However, the rules determining the PIC binding specificity remain poorly understood.

261 e 3Q fibril structure, but the origin of the binding specificity remained obscure.

262 complex induced transient Ab responses with binding specificity similar to the CD4bs-directed bNAbs.

263 In vivo binding specificity studies (n = 26 tumors) showed that

264 ated TFs and, thus, uncover differential DNA binding specificities that are not apparent from nucleot

265 e-binding proteins display a range of glycan-binding specificities that ensure the capture of glucose

266 f these proteins have markedly different DNA binding specificities that ensure the selective recruitm

267 ption factors with new DNA-binding or ligand-binding specificities that respond appropriately to indu

268 The results show some surprising changes in binding specificity that do not appear to affect the abi

269 how the partnering of RBPs evokes changes in binding specificity that underlie regulatory network dyn

270 Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofa

271 n to providing new insights into viral Bcl-2 binding specificity, this study will inform future work

272 We show that human CENP-N confers binding specificity through interactions with the L1 loo

273 ining AMPARs, regardless of receptor subunit binding specificity, through increased internalization a

274 lready characterized, increasing coverage of binding specificities to 292 C. elegans TFs ( approximat

275 and a control case to assess the 18F-AV-1451 binding specificity to Alzheimer's and non-Alzheimer's t

276 conformational space, causing this dual DNA-binding specificity to be selectively enhanced in the GR

277 Like Stau1, PKR displayed binding specificity to domain IIId of HCV-IRES.

278 role of residues Tyr45 and Asp72 in shaping binding specificity to HLA-A*11:01.

279 rticoid receptor (GR), which has similar DNA-binding specificity to the androgen receptor (AR).

280 HTB1M displayed high binding specificity toward SOD1 mutants, inhibited their

281 pose novel regression-based models of TF-DNA binding specificity, trained using high resolution in vi

282 ed here is the development of an altered DNA-binding specificity variant of Rap1 (Rap1(AS)).

283 tudies to have an electrostatic influence on binding specificity, VASP-E identified electrostatically

284 samples had antibodies with multiple epitope binding specificities, viz.

285 Binding specificity was assayed in CD-1 and sEH knock-ou

286 Binding specificity was confirmed by blocking studies us

287 DFG-out conformation, it was suggested that binding specificity was controlled by a "conformational

288 Binding specificity was demonstrated using a non-binding

289 on live rat insulinoma INS-1E cells, and the binding specificity was validated by a CRISPR/Cas9 media

290 ls have been used successfully to predict TF binding specificities, we found that including DNA shape

291 ional flexibility in the dsRBD regulates the binding specificity, we determined the backbone dynamics

292 To investigate EBNA3 binding specificity, we identified sequences and transcr

293 t determined the receptors' response element-binding specificity were far from the proteins' DNA-bind

294 ture: a variable Fab domain mediates antigen-binding specificity, whereas the constant Fc domain enga

295 G12V directly affects binding specificity while leaving the energy landscape l

296 ng RNAs reveals that each display degenerate binding specificity, while still displaying different de

297 s from apoE4 with respect to different lipid-binding specificities, why lipid increases the binding o

298 The combination of high binding specificity with cytotoxicity has resulted in CP

299 an MHC class Ib molecule that shares peptide-binding specificity with Qa-1 but differs in function.

300 this system that allows rapid modulation of binding specificity within a high affinity background.