ライフサイエンスコーパス: binucleate

1 U, or both often had enlarged nuclei or were binucleated.

2 se cells fail to undergo cytokinesis and are binucleated.

3 yokinesis, develop aneuploidy, and are often binucleated.

4 ternberg" (RS) cells, are characteristically binucleated.

5 Most VMs were binucleated (87% versus 12% mononucleated) and larger th

6 s to Rab6-KIFL results in the cells becoming binucleate after one cell cycle, and time-lapse microsco

7 se-dead mutant causes an increased number of binucleate and multinucleate cells, suggesting that the

8 Furthermore, we observed a large number of binucleated and apoptotic cells-signs of failed cytokine

9 The presence of binucleated and multinucleated cells, reminiscent of lar

10 degrees C, defective scd1-1 guard cells are binucleate, and the formation of their ventral cell wall

11 Rat and sheep cardiac myocytes become binucleate as they complete the 'terminal differentiatio

12 Induced cardiomyocytes became binucleate, assembled sarcomeres and had cardiomyocyte-l

13 ay 21; 5% (rodent) to 25% (human) cells were binucleated by day 21.

14 red with high frequency in cells that became binucleated by furrow regression, but not in cells that

15 NRG1 induces mononucleated, but not binucleated, cardiomyocytes to divide.

16 s elongation and inhibited trophoblast giant binucleate cell differentiation as observed on day 16.

17 f the mitotic checkpoint in one spindle of a binucleate cell failed to arrest cytokinesis induced by

18 oscopy revealed that loss of Tek2 results in binucleate cell formation by aberrant fusion of daughter

19 es cytokinesis arrest in cancer cells, where binucleate cell formation occurs after mitosis takes pla

20 nd CaM also promotes cytokinesis failure and binucleate cell formation.

21 firmed AP-2alpha variants in ovine chorionic binucleate cell nuclear extracts, one of which migrates

22 I protection analysis using ovine chorionic binucleate cell nuclear protein, identified 19 footprint

23 of His2Av/H2A.z also suppressed the Myb-null binucleate cell phenotype, suggesting a novel role for t

24 We estimate that the binucleate cell-expressed PAG originated 52 +/- 6 millio

25 In normal cultures, highly spread pigmented binucleate cells (type 3) bound and rapidly ingested mul

26 14-3-3sigma impairs mitotic exit to generate binucleate cells and provides a potential explanation of

27 Time-lapse videomicroscopy demonstrated that binucleate cells are delayed in the first growth phase o

28 asin to block cleavage, we confirm that most binucleate cells arrest in G1.

29 Therefore, we used Myb-null binucleate cells as a quantitative phenotypic readout of

30 lactin gene family, is produced by chorionic binucleate cells at the maternal-fetal interface, and is

31 stage of cytokinesis but fused back to form binucleate cells because of the absence of the midbody m

32 stimulated an increase in footprint area of binucleate cells but Ang II did not.

33 forced expression of activated mDia2 yields binucleate cells due to failed cytokinesis, and 4) the c

34 mline cell morphology, we determined whether binucleate cells form by defective cytokinesis or by fus

35 Surprisingly, up to 50% of the resulting binucleate cells generated colonies.

36 have a "tetraploidy checkpoint" that arrests binucleate cells in G1, thereby preventing their propaga

37 cappuccino, and chickadee mutants contained binucleate cells in which ring canal remnants stained wi

38 the endometrial LE and GE, as well as in the binucleate cells of the conceptus.

39 nceptuses, enJSRV RNAs were also detected in binucleate cells of the trophectoderm.

40 The progeny of binucleate cells progressively dropped out of the cell c

41 ersification of PAG expressed in trophoblast binucleate cells seems to have been associated with the

42 concentrations of cytochalasin, we find that binucleate cells undergo DNA synthesis and later proceed

43 n of abscission does not appear to result in binucleate cells, but in apoptosis.

44 ealed specific expression in the trophoblast binucleate cells, consistent with a role in the formatio

45 te stage of cytokinesis and the formation of binucleate cells, mirroring the defects resulting from a

46 lted in cytokinesis failure and formation of binucleate cells, or by chemical inhibition of Aurora ki

47 cts in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5

48 In most of these binucleate cells, the damaged nucleus arrested prior to

49 We now show that binucleate cells, the hallmark phenotype of cytokinesis

50 Furthermore, using binucleate cells, we show that exit from mitosis occurs

51 ctivation of the oPL gene in ovine chorionic binucleate cells.

52 mbers that are expressed only in trophoblast binucleate cells.

53 Ns in the ;garland' and to their fusion into binucleate cells.

54 se-1 at the midbody, and the accumulation of binucleate cells.

55 demonstrated by an increase in the number of binucleate cells.

56 ate cells arose through aberrant division of binucleated cells and displayed abnormal metaphase plate

57 ion of T37V mutant of Cdc6 (Cdc6-TV) induces binucleated cells and incompletely separated nuclei.

58 Finally, we describe a phenomenon by which binucleated cells are resolved via cytokinesis into two

59 Time-lapse microscopy revealed that binucleated cells arise by incomplete abscission of prog

60 term imaging experiments indicated that most binucleated cells arose through a bipolar mitosis follow

61 We observed that spontaneously arising binucleated cells exhibited chromosome mis-segregation r

62 ed to the coculture system were recovered as binucleated cells expressing an epithelial surface epito

63 o increase the prevalence of micronuclei and binucleated cells in parallel with aberrant mitotic chec

64 to a mitotic defect, resulting in unstable, binucleated cells in vitro and in vivo.

65 for mitosis, or arrested in cytokinesis, and binucleated cells in which nuclear division had occurred

66 Binucleated cells proliferate slowly.

67 Binucleated cells were also detectable in primary murine

68 are arrested in the cell cycle as septated, binucleated cells with highly condensed chromatin, fragm

69 before arresting as elongated, predominantly binucleated cells with incompletely segregated chromosom

70 ugh RNA interference leads to an increase in binucleated cells, implicating its reduced expression in

71 pression is accompanied by the appearance of binucleated cells, indicating the process of cell divisi

72 was sufficient to elicit donut formation and binucleated cells, whereas blocking proteasomal degradat

73 esulted in a large increase in the number of binucleated cells.

74 s cytokinesis, resulting in the formation of binucleated cells.

75 as often incomplete after mitosis, producing binucleated cells.

76 her rate of cytokinesis failure resulting in binucleated cells.

77 lure of cytokinesis, and increased number of binucleated cells.

78 e of cytokinesis leading to the formation of binucleated cells.

79 fibroblasts cultured from Spg20-/- mice, and binucleated chondrocytes were prominent in epiphyseal gr

80 The macronucleus of the binucleate ciliate Tetrahymena thermophila contains frag

81 Intensity ratios of binucleated CPCs with bromodeoxyuridine of >/=70:30 betw

82 roblem and cytokinesis defects, resulting in binucleate daughter cells.

83 lasia as evidenced by an increased number of binucleated epithelial cells and a marked elevation in c

84 Giardia lamblia is an anaerobic binucleate flagellated protozoan known to lack de novo s

85 In RPE1 cells, 90% of colonies obtained from binucleate founders had a karyotype that matched the par

86 Kirre (Duf) and Sns are co-expressed within binucleate garland cell nephrocytes (GCNs) that contribu

87 cells grew approximately 5 times faster than binucleate germlings.

88 ll in classical Hodgkin lymphoma (HL) is the binucleated giant Reed-Sternberg cell.

89 s not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cyt

90 of miRNAs resulted in a 3-fold reduction in binucleate hepatocytes, indicating that miRNAs regulate

91 sm or is confined to the nucleus, we created binucleate heterokaryon yeast cells in which one nucleus

92 disease, with ~0.4% of Purkinje cells being binucleate heterokaryons.

93 rkinje neurons resulting in the formation of binucleated heterokaryons.

94 ogerin/LADelta50-expressing normal cells are binucleated, implicating progerin/LADelta50 as causing s

95 ared in small mononucleated (SMMs) and large binucleated (LBMs) myocytes.

96 Co(2+)(H(2)O)](+), contains an unsymmetrical binucleating ligand (oxapyme) which provides five- and s

97 Complexes incorporating the binucleating ligand N[omicron-(NHCH2P(i)Pr2)C6H4]3 with

98 A new binucleating ligand scaffold is introduced that supports

99 PR(2+) are initially self-assembled from the binucleating ligand, 3,6-bis(5-methyl-2-pyridine)-1,2,4,

100 MN frequency in maternal binucleated lymphocytes was found to increase with BTHM

101 may increase the frequency of MN in maternal binucleated lymphocytes.

102 plasmic bridges, and nuclear buds) per 1,000 binucleated lymphocytes.

103 A binucleating macrocycle was prepared which specifically

104 urred in association with podocytes becoming binucleate (mitotic podocyte catastrophe) and subsequent

105 rrested with multiple buds, several SPBs and binucleate mother cells.

106 idine (BrdU) uptake) separately in mono- vs. binucleate myocytes.

107 myocytes; (3) PE is a hypertrophic agent in binucleate myocytes; and (4) the ERK cascade is required

108 id not significantly alter the proportion of binucleated myocytes or cell cycle activity in either ve

109 roximately 70% (P < 0.05); the proportion of binucleated myocytes was also lower in UPE fetuses at th

110 Binucleated myocytes were 12% and 25% larger in WT than

111 onal state (as measured by the proportion of binucleated myocytes) and cell cycle activity (as measur

112 of membrane structures and the formation of binucleate nurse cells.

113 that nucleolin-colocalizing cells were often binucleated or apoptotic, suggesting that the presence o

114 Second, LMW-E-overexpressing cells are binucleated or multinucleated with amplified centrosomes

115 failure leads to incomplete abscission and a binucleate outcome.

116 The binucleate pathogen Giardia intestinalis is a highly div

117 Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and highe

118 ranyl cation and a rare-earth trication in a binucleating polypyrrole Schiff-base macrocycle (Pacman)

119 termine if similar increase in the number of binucleated Purkinje neurons, occurs in children that re

120 del for cellular and molecular biology, is a binucleated single-celled organism with a germline micro

121 were normal but the rest had arrested at the binucleate stage of development, were small, pear-shaped

122 Microspores at late uninucleate/early binucleate stages were isolated from flower buds of toba

123 Cells became binucleated, suggesting a failure of cytokinesis, and mi

124 Binucleate tetraploid cells that formed after incubation

125 range of different nuclear morphologies from binucleated to multimicronucleated.

126 Initially binucleate, trimeras underwent coordinated nuclear divis

127 ccumulate specifically in pollen at the late binucleate/trinucleate stage of development rather than

128 change their expression oppositely in mouse binucleate ventricular cardiomyocytes during development

129 MOX4 is identical to UPC2, encoding a binucleate zinc cluster protein controlling expression o