ライフサイエンスコーパス: bioactivation

1 s renal phosphate reabsorption and vitamin D bioactivation.

2 ue hypoxia, hemoglobin allostery and nitrite bioactivation.

3 impact via its ability to inhibit carcinogen bioactivation.

4 ol as well as acivicin, an inhibitor of GSNO bioactivation.

5 on as a nitrite reductase, abolishes nitrite bioactivation.

6 ugh enhanced polycyclic aromatic hydrocarbon bioactivation.

7 not related to greater extents of carcinogen bioactivation.

8 racellular ATP without interfering with APAP bioactivation.

9 indicating that the drug interfered with GTN bioactivation.

10 ed chemotherapy by selectively promoting its bioactivation.

11 peutic AM without the need for P450-mediated bioactivation.

12 pired by the mechanisms underlying cisplatin bioactivation.

13 ne methide mechanism involving metal or haem bioactivation.

14 derivatives can act as substrates for CYP1A1 bioactivation.

15 uman liver 3A enzymes in AFB1 metabolism and bioactivation, a combination of approaches including seq

16 The combined data suggest that the extent of bioactivation across P450 enzymes does not correlate wit

17 In vitro studies indicated that the NA bioactivation activities in OM and lung of the CYP2A13/2

18 potential contributing roles of AOR-mediated bioactivation and adduct stability to the cytotoxicity o

19 rug-related risk factors include metabolism, bioactivation and covalent binding, and the inhibition o

20 ehydrogenase (XO/XDH) also contribute to the bioactivation and cytotoxicity of RH1 in human tumor cel

21 The balance between bioactivation and degradation of 1,25-dihydroxyvitamin D

22 small family of selenoenzymes catalyzing the bioactivation and disposal of thyroid hormone.

23 vitro, was used to explore the potential for bioactivation and enzyme inactivation of additional P450

24 P) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug developm

25 dence for the essential role of ALDH2 in GTN bioactivation and may have implications to other fields

26 in vivo function of CYP2A13 and CYP2F1 in NA bioactivation and NA-induced respiratory tract toxicity

27 Rates of microsomal NA bioactivation and the effects of an anti-CYP2A antibody

28 e hepatocyte clock dramatically reduces APAP bioactivation and toxicity in vivo and in vitro because

29 ell cycle progression, apoptosis, carcinogen bioactivation, and DNA repair.

30 e thiol (S-nitrosothiol, SNO) that subserves bioactivation, and in transfer of the NO moiety from S-n

31 rated that isoquine does not undergo in vivo bioactivation, as evidenced by the complete lack of glut

32 ian cells may not be due solely to decreased bioactivation, as has been hypothesized previously, but

33 Bioactivation assays using LNCaP cytosols showed that en

34 sted except CYP2E1 was capable of raloxifene bioactivation, based on glutathione adduct formation.

35 nic anhydrase) results in diminished nitrite bioactivation, but the role of carbonic anhydrase is abr

36 ne diethyl ester, bypasses the need for GSNO bioactivation by gamma-glutamyl transpeptidase to increa

37 oxide synthase at the remote site or nitrite bioactivation by myoglobin within the target organ abrog

38 and immunotoxic effects, as a consequence of bioactivation by P-450 cytochromes to dihydrodiol epoxid

39 tathione S-transferase (GST) conjugation and bioactivation by renal cysteine beta-lyase (CCBL1).

40 properties of redox status and intracellular bioactivation can be leveraged by rational combinatorial

41 tracellular role of this enzyme in mitomycin bioactivation, Chinese hamster ovary cell transfectants

42 However, their biotransformation capability (bioactivation/detoxification processes) is rarely report

43 mechanism of CPR-CP-mediated organic nitrate bioactivation, EPR, chemiluminescence NO analyzer, NO el

44 he oxazaphosphorine ring to avoid cytochrome bioactivation favoring the release of the active entity

45 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they conv

46 eventive strategies is whether procarcinogen bioactivation in an extrahepatic target tissue (e.g., th

47 nhibited CYP1A1-mediated benzo(a)pyrene diol bioactivation in both oral SCC cells and intact oral muc

48 tance in endogenous metabolism and herbicide bioactivation in crops and weeds discussed.

49 erstand the mechanisms of heterocyclic amine bioactivation in humans, the most mass abundant heterocy

50 the principal enzymatic determinants of RH1 bioactivation in MDA468 tumor cells and that b5R, P450R,

51 ifen-metabolizing enzymes suggests tamoxifen bioactivation in the endometrial vasculature in vivo.

52 oavailability, consistent with decreased NNK bioactivation in the lung.

53 modified hydroxamate moieties are subject to bioactivation in vitro.

54 ormation is necessary and sufficient for GTN bioactivation in VSMC.

55 n the wide range of cellular targets, but if bioactivation is insufficient in vivo, it may also help

56 culating and tissue storage form of NO whose bioactivation is mediated by the enzymatic action of xan

57 etween the groups, suggesting that increased bioactivation is not the mechanism for this amplified to

58 The final step in the proposed bioactivation is the formation of a platinum-cysteine S-

59 itumor prodrugs that require cytochrome P450 bioactivation leading to 4-hydroxy derivatives.

60 Combination oncolysis and prodrug bioactivation leads to significant prolongation of survi

61 sis coupled with an in vitro assay to assess bioactivation led to replacement of the fluoroquinazolin

62 cytotoxicity (IC(50) value and biomarker of bioactivation levels, respectively: 10beta-(p-fluorophen

63 suggested that thiol-dependent nonenzymatic bioactivation may be responsible for the superior antitu

64 gue dihydro-2-pyridone 1 maintains a similar bioactivation mechanism concluding with covalent labelin

65 upport for a cytochrome P450 (P450)-mediated bioactivation mechanism involving the initial formation

66 otherapeutic prodrugs that undergoes hepatic bioactivation mediated predominantly by cytochrome P450

67 Consistent with hypoxia-dependent nitrite bioactivation, nitrite was reduced to NO, S-nitrosothiol

68 f FpD, with greater cell kill occurring when bioactivation occurs in the proximity of its target, nuc

69 Bioactivation occurs through the sequential actions of c

70 Denitration and bioactivation of 1-2 microM GTN, assayed as 1,2-glycerol

71 he cytochrome P450 responsible for metabolic bioactivation of 3-MI.

72 In contrast, HSV1yCD-mediated bioactivation of another prodrug, ganciclovir, impairs v

73 in, suggesting that heparin did not diminish bioactivation of APAP.

74 esults reveal a mechanism by which metabolic bioactivation of B[a]P may mediate RyR dysfunction of pa

75 wever, it has not yet been described for the bioactivation of BaP-7,8-diol.

76 table to individual differences in enzymatic bioactivation of benzo(a)pyrene.

77 ated to estimate relative rates of genotoxic bioactivation of benzo[a]pyrene (BP) for several differe

78 showed 3-fold higher activity for genotoxic bioactivation of BP than myoglobin.

79 ine can provide useful information about the bioactivation of chemical carcinogens and can be used to

80 hypothesis that mitAspAT plays a role in the bioactivation of cisplatin.

81 (CYP1As) are involved in detoxification and bioactivation of common environmental pollutants.

82 Bioactivation of curcumin occurred readily in vitro, whi

83 erivatives has been synthesized to study the bioactivation of cytotoxic fatty acids by the mitochondr

84 -CoA hydratase is an important enzyme in the bioactivation of DCTFTH-CoA, in a pathway which does not

85 ich has implications for chemoprotection and bioactivation of DNA-damaging antitumor agents.

86 1) is implicated in both chemoprevention and bioactivation of DNA-damaging antitumor agents.

87 generated endogenously, or via the metabolic bioactivation of drugs and other environmental chemicals

88 posed as an early unifying event linking the bioactivation of drugs to hepatotoxicity and as a more d

89 a very important role in the metabolism and bioactivation of drugs, carcinogens, and other xenobioti

90 derivative of the proposed intermediate from bioactivation of FK317 that is responsible for DNA cross

91 ons that are still unresolved, mitochondrial bioactivation of GTN in blood vessels is still lacking e

92 n the present study, we investigated whether bioactivation of GTN is affected by the subcellular loca

93 The data indicate that vascular bioactivation of GTN is catalyzed by cytosolic ALDH2.

94 Bioactivation of halothane occurred similarly in all thr

95 many procarcinogens, serve as a mechanism of bioactivation of HONH-AalphaC.

96 on is dependent on thrombospondin-1-mediated bioactivation of latent TGF-beta.

97 ve a more important role than CYP 3A4 in the bioactivation of low AFB(1) concentrations associated wi

98 of cytochrome P450s that may be involved in bioactivation of malathion.

99 Metabolic bioactivation of many different chemicals results in the

100 ired post-translational modification for the bioactivation of many neuropeptides, entails sequential

101 icrosomal P450 enzymes, is essential for the bioactivation of many procarcinogens.

102 ue among members of this superfamily because bioactivation of MIS via proteolytic processing is hypot

103 an cells results in efficient processing and bioactivation of MIS.

104 suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.

105 ylpyridine (MPP+) which is formed during the bioactivation of MPTP by monoamine oxidase B.

106 is enzyme is also of great importance in the bioactivation of mutagens, including the N-hydroxylation

107 The bioactivation of nitrate involves its active accumulatio

108 he vasodilator properties and mechanisms for bioactivation of nitrite in the human forearm.

109 dehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN

110 els, which requires O2-regulated binding and bioactivation of NO by Hb and transfer of NO equivalents

111 ategies to mitigate cytochrome P450-mediated bioactivation of novel 2,7-disubstituted pyrrolo[2,1-f][

112 nstrate that the rate-limiting enzyme in the bioactivation of peptide messengers is differentially re

113 The bioactivation of polycyclic aromatic hydrocarbons (PAHs)

114 Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs)

115 human skin will probably result in enhanced bioactivation of polycyclic aromatic hydrocarbons and ot

116 The bioactivation of procarcinogens by cytochrome P450 2W1 m

117 D(P)H:quinone oxidoreductase 1 (NQO1) in the bioactivation of quinone prodrugs has been shown through

118 mes have shown that SULT1A2 can catalyze the bioactivation of several procarcinogens, indicating a po

119 le in the processes of detoxification and/or bioactivation of specific pharmaceuticals and xenobiotic

120 Bioactivation of styrene to its metabolite styrene oxide

121 When bioactivation of substrates in the films gives reactive

122 oxia (1% O(2)) increases gene expression and bioactivation of TGF-beta2 and induces its downstream ef

123 cating that an autocrine mechanism driven by bioactivation of TGF-beta2 leads to its gene expression

124 e dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN

125 e dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN

126 and to the associated regional shift in the bioactivation of the APAP challenge dose from centrilobu

127 gamma binding potency was observed following bioactivation of the dust using rat hepatic S9 fractions

128 vitro biotransformation which will result in bioactivation of the lipophilic compounds into THD hydro

129 :cytochrome b5 reductase in the differential bioactivation of the mitomycins and indicate that the su

130 enerated by the mitomycins, we proposed that bioactivation of the mitomycins in the nucleus close to

131 osylceramide synthase (GCS), responsible for bioactivation of the proapoptotic mediator ceramide to a

132 the rat CYP2B1 transgene responsible for the bioactivation of the prodrugs, cyclophosphamide and ifos

133 It was expected that the bioactivation of these prodrugs would initiate a cascade

134 oforms of NOS [inducible NOS (NOSII)] in the bioactivation of this DNA-damaging antitumor agent.

135 II iodothyronine 5'-deiodinase catalyzes the bioactivation of thyroid hormone in the brain.

136 e or more of the enzymes responsible for the bioactivation of TPZ is/are thought to be at or near the

137 Bioactivation of vitamin D consists of two sequential hy

138 al processes, including: 1) deactivation and bioactivation of xenobiotics, 2) inactivation of hormone

139 d in the cytidine transport, metabolism, and bioactivation pathway contribute to this variation in re

140 orm 5,6-EET-EA represents an endocannabinoid bioactivation pathway in the context of immune cell func

141 e, robust, and a powerful tool for assessing bioactivation potential.

142 ction products, including oxidants, and this bioactivation process is essential for vasodilation.

143 njugates constitutes an integral part of the bioactivation processes for clopidogrel.

144 In the case of ifosfamide (IFO), the bioactivation produces two toxic metabolites: acrolein,

145 Systematic exploration of their bioactivation profile revealed that glucose-based prodru

146 a number of metabolic liabilities including bioactivation, PXR activation, as well as CYP3A4 inducti

147 specifically tested 3 proposed mechanisms of bioactivation: reduction to nitric oxide by xanthine oxi

148 This shift in APAP bioactivation results in less-intense covalent binding t

149 ystem led to modulation of reactivity toward bioactivation, studied by HPLC-MS/MS analysis of reactio

150 y player in the control of second-line drugs bioactivation such as ethionamide and has been shown to

151 that NQO2 may be particularly relevant as a bioactivation system for RH1 in NQO1-deficient tumors su

152 expression and place toxicant and carcinogen bioactivation systems in overdrive?

153 Through sequential enzymatic bioactivation, the Tyr-Lys dipeptide is released in a su

154 iency of vitamin D, genetic disorders of its bioactivation to 1,25-dihydroxyvitamin D [1,25(OH)2D], o

155 Clozapine undergoes bioactivation to a chemically reactive nitrenium ion, wh

156 yclic amine found in cooked meats, undergoes bioactivation to a nitrenium ion, which alkylates guanin

157 AalphaC undergoes bioactivation to form electrophilic N-oxidized metabolit

158 Lysosomal accumulation and bioactivation to generate reactive quinoneimine metaboli

159 and other heterocyclic arylamines and their bioactivation to mutagens.

160 s observed to correlate with thiol-dependent bioactivation to produce NO(2)(-), but not with depletio

161 , in certain instances, sulfation results in bioactivation to reactive electrophilic or therapeutical

162 )H:quinone oxidoreductase 1 (NQO1) metabolic bioactivation, triggering a massive induction of reactiv

163 We conclude that the paradigm of metabolic bioactivation uncovered here should be considered for th

164 ently a proherbicide that requires metabolic bioactivation via cleavage of the benzyl-ether side chai

165 family that have been implicated in hormone bioactivation via proteolytic processing after dibasic a