ライフサイエンスコーパス: bioactive

1 r potencies in human blood from females, and bioactive 5-LO/FLAP complexes were formed in female, but

2 Our results suggest that OA is a promising bioactive agent for bone tissue regeneration, and inhibi

3 practical synthetic route to these important bioactive agents.

4 , daphlongamine H, isodaphlongamine H, and a bioactive alkaloid, annotinolide A, which shows antiaggr

5 The formation of bioactive amines and their changes in cocoa beans during

6 Neuroendocrine tumours (NETs) can secrete bioactive amines into the bloodstream, causing carcinoid

7 e report the therapeutic effect of an orally bioactive and brain permeable delta-secretase inhibitor

8 ion, and were applied to the modification of bioactive and structurally complex molecules.

9 rs, including unidentified immunostimulatory bioactives and immunosuppressive components; the bioavai

10 Designed-bioactive anthropogenic contaminants (biocides, pharmace

11 Nonetheless, the new generation of bioactive anticaries resins with therapeutic and biofilm

12 Bioactive antioxidant peptides are more and more attract

13 gical applications regarding these FGN-based bioactive architectures.

14 ul chemical reporters, onto a broad range of bioactive azaheterocycles, offering new opportunities in

15 ecular modeling allows the prediction of the bioactive binding pose for this series of GluN2C-selecti

16 Our studies indicate that combinatorial bioactive botanicals from GTPs and BSp are highly effect

17 otential combinatorial effects of epigenetic bioactive botanicals including epigallocatechin-3-gallat

18 thod was applied to synthesize the core of a bioactive carbazole derivative in a concise manner.

19 53-MDM2/MDMX inhibitors and conjugation with bioactive carriers.

20 th aliphatic linkers that enable coupling to bioactive carriers.

21 g/g dry matter) and contained low amounts of bioactive ceramides in a ratio to sphingomyelin of 1:5mo

22 AWBCs are calculated for 110 ER and 212 AR bioactive chemicals using high throughput ToxCast data f

23 rating a framework for identifying endocrine bioactive chemicals.

24 g mediated by DELLA1 decreases the amount of bioactive CKs in roots and negatively impacts the Cytoki

25 in response to 1,309 FDA-approved drugs and bioactives (CMap).

26 be used for the development of well-defined bioactive coatings, biosensors and biomimetic model syst

27 on quali-quantitative profile of the single bioactive colorants.

28 ble fibre content, which is interesting as a bioactive component from a nutritional viewpoint.

29 ein (5,6,7-trihydroxyflavone), a predominant bioactive component isolated from the root of Scutellari

30 Lycopene is a bioactive component mainly found in tomato.

31 a) platensis is a blue-green alga, rich with bioactive components and nutrients.

32 ard the sequestration of their smaller, more bioactive components are important drivers of Abeta toxi

33 or retard the sequestration of smaller, more bioactive components are important drivers of Abeta toxi

34 de effects, increased the content of certain bioactive components but did not raise the erythrocyte a

35 activity for the biochemical enhancement of bioactive components of Kodo millet.

36 betic control, however, less is known of its bioactive components that produce such benefits.

37 barley should be considered a good source of bioactive components, especially because of the broad sp

38 epresent a supply of high-value nutrient and bioactive components, especially in the ripe stage.

39 nvestigated if CS disaccharides may act as a bioactive compound and modulate gut microbial compositio

40 etter understand how natural barriers govern bioactive compound bioaccessibility, an experimental app

41 h several anthocyanin-rich food colorants on bioactive compound content (phenolics, isoprenoids), ant

42 tions can alter quality attributes including bioactive compound content.

43 deprotection, either to directly conjugate a bioactive compound or to introduce a suitable spacer bet

44 uitable spacer between the cRGD unit and the bioactive compound.

45 eding efforts to increase production of this bioactive compound.

46 ffect ultrasound treatment on color, and the bioactive compounds (ascorbic acid, total phenols, carot

47 different time-temperature ratios, studying bioactive compounds (caffeine and individual catechins),

48 nd demonstrate its use as a shock sensor for bioactive compounds (e.g. formaldehyde) in water.

49 separation/purification of a large range of bioactive compounds (including small organic extractable

50 , titratable acidity, total soluble solids), bioactive compounds (phenolic compounds, anthocyanin, DP

51 Six new bioactive compounds [n-propyl-9,12,15-octadecatrienoate

52 Bioaccessibility of bioactive compounds and AAC were higher in pulps of both

53 ction, respiration rate, quality parameters, bioactive compounds and antioxidant activity during plum

54 ing conditions for optimal extraction of the bioactive compounds and antioxidant capacity, while real

55 Bioactive compounds and antioxidant potential of 10 wild

56 wever, detailed analyses of health promoting bioactive compounds and antioxidants are lacking, especi

57 ding blocks that are commonly encountered in bioactive compounds and approved therapeutic agents.

58 we applied IDUP to libraries of DNA-encoded bioactive compounds and DNA-tagged human kinases to iden

59 is of prime importance in the development of bioactive compounds and for applications in supramolecul

60 Alphonse Lavallee, are particularly rich in bioactive compounds and have a great potential for human

61 pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily av

62 tives for their potential use as vehicles of bioactive compounds as food additives or pharmaceuticals

63 Plant-derived bioactive compounds attract considerable interest as pot

64 Natural product screening for new bioactive compounds can greatly benefit from low reagent

65 315W/9min, leads to a better preservation of bioactive compounds content (0.631+/-0.0042mg/g of betac

66 pare fruit morphology, physico-chemistry and bioactive compounds content of the edible pulp of six Ma

67 e to differences in chemical composition and bioactive compounds content.

68 aimed to investigate and to characterize the bioactive compounds formed under different electro-activ

69 ein, wogonin, and their glycosides are major bioactive compounds found in the medicinal plant Scutell

70 pes of polyphenols, micronutrients and other bioactive compounds found in vinegars that contribute to

71 ion method was optimised for the recovery of bioactive compounds from Crocus sativus L. stigmas with

72 g media for the extraction and separation of bioactive compounds from the most diverse origins.

73 d to degranulate, they release a plethora of bioactive compounds from their secretory granules, inclu

74 All the bioactive compounds identified in broccoli juice was wel

75 This study evaluated the stability of bioactive compounds in butia pulp upon pasteurization, d

76 to simultaneously quantify several prominent bioactive compounds in canola oil vis.

77 Bioactive compounds in fruits of four Saskatoon berry ge

78 Secoiridoids are the major bioactive compounds in S. mussotii.

79 ntermediates in organic synthesis as well as bioactive compounds in their own right.

80 h nutraceutical value due to the presence of bioactive compounds including vitamin C, polyphenols, fl

81 Citrus possess a large number of bioactive compounds mainly studied in ripe fruits.

82 Our study suggests that these small bioactive compounds merit further study for their potent

83 -blanched, sharing the nutritional value and bioactive compounds of commercial broccoli heads.

84 For bioactive compounds of the selected fruits, buriti conta

85 ment on anthocyanin concentrations and other bioactive compounds of two blood orange ('Moro' and 'Tar

86 The sensory acceptance and the content of bioactive compounds of whole-sorghum and whole-wheat bre

87 Mushroom extracts contain bioactive compounds potentially useful to functionalize

88 The aim of this work was to identify the bioactive compounds present in an extract of avocado pee

89 oped for a fast analysis of a fingerprint of bioactive compounds present in cocoa beans depending on

90 that kinetic and thermodynamic profiling of bioactive compounds should be incorporated and utilized

91 including proteins and minerals, as well as bioactive compounds such as glucosinolates and phenolics

92 entially be a good feedstock for recovery of bioactive compounds such as pectin, lipids, flavonoids,

93 ng materials are available, the use of small bioactive compounds that can potently stimulate and expe

94 d good sensory acceptance and is a source of bioactive compounds that can promote benefits to human h

95 for 30min showed significant enhancement in bioactive compounds under study.

96 Encapsulation of lipophilic bioactive compounds using plant-derived proteins as deli

97 ive coating for maintaining plum quality and bioactive compounds was AA+RO.

98 Fourty-eight bioactive compounds were identified in Saskatoon berry g

99 unicagranatum) peels contain high amounts of bioactive compounds which inhibit migration of Salmonell

100 nameko are excellent sources of extractable bioactive compounds with much to explore.

101 especially the peel extract, are a source of bioactive compounds with promising antioxidant and anti-

102 The chemical composition, bioactive compounds, antioxidant activity and volatiles

103 lues as well as health benefits due to their bioactive compounds, especially beta-glucans.

104 lity of apple and apple pomace as sources of bioactive compounds, highlighting the UA extraction, and

105 enefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol.

106 ta displayed significantly higher content of bioactive compounds, such as phenolic compounds and diet

107 amination of the accumulated levels of three bioactive compounds, sweroside, swertiamarin, and gentio

108 genic and pro-odontogenic effects of 4 small bioactive compounds- phenamil (Phen), purmorphamine (Pur

109 d pharmaceutical products, or as a source of bioactive compounds.

110 ectrometry was used in order to identify the bioactive compounds.

111 Strawberry is a major natural source of bioactive compounds.

112 , and examples of mitochondrial targeting of bioactive compounds.

113 be of invaluable assistance in designing new bioactive compounds.

114 s of nonribosomal natural products and other bioactive compounds.

115 hould be performed to produce flours rich in bioactive compounds.

116 tial exploitation of PJ and PS as sources of bioactive compounds.

117 , and they contain significant quantities of bioactive compounds.

118 plies enzymatic assembly lines to synthesize bioactive compounds.

119 ould also be used as a source of potentially bioactive compounds.

120 unctional ingredients and as rich sources of bioactive compounds.

121 Mushrooms are important sources of natural bioactive compounds.

122 ecause, presumably, they secrete a wealth of bioactive compounds.

123 expiration date, for a possible recovery of bioactive compounds.

124 ons can be used to successfully design novel bioactive compounds.

125 nd to valorise these varieties as sources of bioactive compounds.

126 potential of millets as a source of valuable bioactive compounds.

127 are acknowledged as an unrivalled source of bioactive compounds.

128 a pharmacophore model and used the putative bioactive conformation of a xanthine inhibitor for scaff

129 and entropically favorable restriction to a bioactive conformation, (2) mitigate toxicity, (3) obtai

130 s with the core structure resembling a known bioactive conformation.

131 he pearled fractions differ depending on the bioactive considered.

132 However, it also promoted leaching of bioactive constituents, such as ascorbic acid and carote

133 s, shogaols and other non-volatiles as chief bioactive constituents.

134 ism of interaction between food proteins and bioactives constitutes the preliminary step to design fo

135 All-trans-retinoic acid (RA), a bioactive derivative of vitamin A, exhibits diverse effe

136 Interstrand cross-links are exceptionally bioactive DNA lesions.

137 M1, and production of simple nitriles as the bioactive end product.

138 so prepared by adding 2% of non-encapsulated bioactive extract.

139 In conclusion, the contents of various bioactive FA were higher in milk fat of cows grazing a C

140 We conclude that O. formigenes-derived bioactive factors stimulate oxalate transport in intesti

141 ind, requiring the chemical incorporation of bioactive factors to either mimic extracellular matrix o

142 Appropriate synthetic techniques to ligate bioactive factors, such as peptides and proteins, onto h

143 n of biocompatible materials, stem cells and bioactive factors.

144 n supplements in the diet as nutritional and bioactive foods.

145 tion of JA-responsive gene expression by the bioactive form JA-isoleucine have been well-studied, kno

146 CAN proteolysis results in the generation of bioactive fragments with novel functions (VCAN-derived m

147 -2-ones were designed to mimic the suggested bioactive gamma-turn conformation of the Bip-Lys-Tyr tri

148 OR 1 (GPS1), that senses nanomolar levels of bioactive GAs.

149 The application of bioactive gibberellin (GA) restored the runnering phenot

150 (BAG) or fluoride-containing phosphate-rich bioactive glass (BAG-F).

151 nclusion, fluoride-containing phosphate-rich bioactive glass incorporated as micrometer-sized filler

152 possessing groups that can be modified with bioactive groups postpolymerization and postprinting.

153 for lutein and beta-carotene, however these bioactives have low bioavailability.

154 Rosemary essential oil (REO) contains bioactives having antioxidant and antimicrobial properti

155 work highlights the relevance of T2 as a key bioactive hormone, and reveals some of the different fun

156 ith microbial stimuli to induce secretion of bioactive IL-12 by DCs.

157 eleased pro-IL-1beta was cleavable to mature bioactive IL-1beta in the extracellular space by the pro

158 educe the Mycobacterium tuberculosis-induced bioactive IL-1beta production.

159 ient to induce the processing and release of bioactive IL-1beta.

160 The metabolic distribution of bioactives in pomegranate peel, inner membrane, and edib

161 reochemistry-function studies of a series of bioactive indolines.

162 the potential of avocado peel as a source of bioactive ingredients for its use in the food, cosmetic

163 enable its multifunctional capabilities as a bioactive interface.

164 ue honeysuckle can be an excellent source of bioactive iridoids.

165 ndocannabinoid in the mammalian brain is the bioactive lipid 2-arachidonoylglycerol (2-AG).

166 Ceramide, a bioactive lipid and signaling molecule associated with c

167 tant cellular processes, and we suggest this bioactive lipid can serve as a link between the environm

168 Autotaxin produces the bioactive lipid lysophosphatidic acid (LPA) and is a dru

169 In this study we report that the bioactive lipid lysophosphatidic acid (LPA) regulates he

170 Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived

171 This study investigated the role of bioactive lipid metabolites in alcohol-induced liver dam

172 Sphingosine kinase 1 (SPHK1) generates the bioactive lipid sphingosine 1-phosphate (S1P) and has es

173 Prostaglandin (PG) E2 is a bioactive lipid that plays protective roles in the lung,

174 hesis that an endothelial barrier-protective bioactive lipid, sphingosine-1-phosphate (S1P), could am

175 ated with hepatic accumulation of ceramides, bioactive lipids implicated in alcoholic liver disease p

176 Bioactive lipids of the milk fat globule membrane become

177 marily targets lipid biosynthesis or effects bioactive lipids that activate specific signalling pathw

178 Eicosanoids are a group of bioactive lipids that are shown to be important mediator

179 olvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate

180 The bioactive LN-511-E8 fragment carrying only C-terminal do

181 saccharides (EPS) as a source of potentially bioactive lower Mw derivatives.

182 uctures of natural bone and provide adequate bioactive material-tissue interactions.

183 Early generation of bioactive matrix fragments activates proinflammatory sig

184 tor in cardiovascular disease, and implicate bioactive matrix fragments as underappreciated agents po

185 sive components; the bioavailability of some bioactives may depend on unidentified factors.

186 In all patients, we identified more than 30 bioactive mediators and pathway markers in peripheral bl

187 ly exposed to monomethyl fumarate (MMF), the bioactive metabolite of DMF, which can stabilize NRF2 an

188 Although bacterial bioactive metabolites have been one of the most prolific

189 unctions like an endocrine organ, generating bioactive metabolites, that can impact host physiology.

190 the bacterium is valuable reservoir of novel bioactive metabolites.

191 effects, in part through their conversion to bioactive metabolites.

192 eptidomic approaches to the investigation of bioactive milk peptides, including bioinformatics, chemo

193 therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, an

194 y evaluation until the isolation of the pure bioactive molecule and its identification.

195 Withaferin A (WA) is a bioactive molecule derived from Withania somnifera and t

196 Honokiol (HNK), a bioactive molecule from Magnolia grandiflora increased L

197 helical folding, allowing facile display of bioactive molecules at high density.

198 s have widely explored its use in developing bioactive molecules because of the possibility to (1) in

199 on SSU gene sequences prior to screening for bioactive molecules can miss potentially interesting nov

200 ronmental conditions such as the presence of bioactive molecules from breast milk dictate gut microbi

201 l endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to

202 ort for controlled release and protection of bioactive molecules in food matrices in different food p

203 introduce by hybridization distinct types of bioactive molecules or bioreceptors, on a reversible man

204 As bioactive molecules present a static binding mode, we de

205 of neuroendocrine cells are a rich source of bioactive molecules such as peptides, hormones, and neur

206 myo-Inositol phosphates (IPs) are important bioactive molecules that have multiple activities within

207 Variability in the contents of bioactive molecules was observed within and between the

208 ive utility of this method in the context of bioactive molecules, we synthesized COR-005, a somatosta

209 especially when it comes to the synthesis of bioactive molecules.

210 nal genome mining for the discovery of novel bioactive molecules.

211 ancient times, and is an important source of bioactive natural compounds and drug derivatives.

212 tudies of the biosynthesis of this important bioactive natural product.

213 oducts could be further transformed into the bioactive natural products and human microflora metaboli

214 lic amines are ubiquitous core structures of bioactive natural products and pharmaceutical drugs.

215 ynthesize and yet are present in a number of bioactive natural products and synthetic pharmaceuticals

216 eterocycles are present in a wide variety of bioactive natural products as well as synthetic molecule

217 Polyketides are a large family of bioactive natural products synthesized by polyketide syn

218 pecies are frequently investigated for their bioactive natural products, and the ecological role of t

219 al diamines are a common structural motif in bioactive natural products, therapeutic agents, and mole

220 rated carbonyls given their preponderance in bioactive natural products.

221 al entry to key structural motifs present in bioactive natural products.

222 nstitute a core structure of a wide array of bioactive natural products.

223 uired to protect the surrounding tissue from bioactive neutrophil molecules and subsequent pathologic

224 s will facilitate the development of CS as a bioactive nutraceutical.

225 food products, representing rich sources of bioactive nutrients.

226 Bioactives of Centella asiatica showed comparatively hig

227 ular weight oligomers are significantly more bioactive on synapses and microglia than the HMW species

228 The influence of two bioactive oxidized phospholipids on model bilayer proper

229 In this work, six new bioactive oxylipins -phytoprostanes - were detected in g

230 Moreover, bioactive peptide 25 (Ki = 9 nM) achieved oral bioavaila

231 n in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability i

232 e development of the PepSAVI-MS pipeline for bioactive peptide discovery.

233 assembly of the C-36 peptide, a circulating bioactive peptide from the alpha1-antitrypsin serine pro

234 novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted in

235 a concise yet extensive survey of key short bioactive peptide sequences for a range of applications

236 d in the biosynthesis of the broad family of bioactive peptides called ribosomally synthesized and po

237 searched the literature for all instances of bioactive peptides derived from milk proteins from any m

238 is showed the production of multi-functional bioactive peptides due to the hydrolysis of whey protein

239 kaline solution can be a potential source of bioactive peptides for addition to foods.

240 A large number of bioactive peptides isolated from natural sources are kno

241 affect protein digestibility and release of bioactive peptides.

242 at STP hydrolysates are potential sources of bioactive peptides.

243 nd strategies followed for the generation of bioactive peptides.

244 can serve as a bioorthogonal modification of bioactive peptides.

245 Dietary intake of bioactive phytochemicals including the cruciferous veget

246 nd cocoa are known to be valuable sources of bioactive phytochemicals, mainly the polyphenols.

247 Grape canes represent a promising source of bioactive phytochemicals.

248 Pomegranate is a source of bioactive phytochemicals.

249 reatment are necessary for maintaining these bioactive phytochemicals.

250 Triterpenoids are widespread bioactive plant defence compounds with potential use as

251 ogy programmes for sustainable production of bioactive plant triterpenoids.

252 e interactions between mitoxantrone and some bioactive polyphenols.

253 ins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standa

254 improvement in the chemical composition and bioactive potential of stevia leaves.

255 thelial nitric-oxide synthase (eNOS) and its bioactive product, nitric oxide (NO), mediate many endot

256 ultaneously identify potentially interesting bioactive products from NRPSs and PKSs, thereby augmenti

257 application in the synthesis of natural and bioactive products.

258 ids (OBCFA) are of interest, since they have bioactive properties and could be regarded biomarkers of

259 ess, chemical composition and functional and bioactive properties that are important to the agricultu

260 n of high quality end-product with increased bioactive properties without compromising total yield.

261 recent years and due to its organoleptic and bioactive properties, its exports have significantly inc

262 omolecules with various physico-chemical and bioactive properties.

263 nutritional value, chemical composition and bioactive properties.

264 der to select elite genotypes with increased bioactive properties.

265 se constituents in the foods, lowering their bioactive properties.

266 id and minor components with antioxidant and bioactive properties.

267 ntial for lower gastrointestinal delivery of bioactive protein material.

268 Venoms contain variable mixtures of bioactive proteins.

269 between concentration and yield of the main bioactive PUFA, with the lowest formation of ethyl carba

270 To identify the bioactive region(s) of Ov-GRN-1, four truncated N-termin

271 nt studies on developing a new generation of bioactive resins with anticaries properties.

272 Several striking trends emerged for bioactive RNA ligands, including: 1) Compliance to medic

273 limide analogues, novelized with high-valued bioactive scaffolds was synthesized by means of click-ch

274 y explored the use organophosphonic acids as bioactive secondary metabolites.

275 particle synthesis, direct incorporation of bioactive sequences displayed from the particle corona,

276 ogonal DNA handles to regulate two different bioactive signals, with the ability to independently up-

277 and facilitates the coordinated discovery of bioactive small molecules and their molecular targets.

278 These often bioactive small molecules originate from nutrition- and

279 ssion profiles from cells treated with other bioactive small molecules.

280 mstances can dissociate into smaller, highly bioactive species.

281 osine 1-phosphate (S1P) is a multifunctional bioactive sphingolipid involved in the development of ma

282 nase 1 (SphK1), the enzyme that converts the bioactive sphingolipid metabolite sphingosine to sphingo

283 The bioactive sphingosine-1-phosphatephosphate (S1P) is pres

284 ding critical light onto the biosynthesis of bioactive stilbenoids.

285 The extracellular matrix (ECM) is a dynamic, bioactive structure critical to organ development, struc

286 The identification of a bioactive substance from probiotic bacteria could circum

287 o, terere and tea mate), all of them rich in bioactive substances.

288 rgeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent pro

289 igh antioxidant activity and high content of bioactives such as rutin and 2-O-beta-d-glucopyranosyl-l

290 vestigated the mode of action of a principal bioactive T. arjuna compound, arjunolic acid (AA), in am

291 Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIAs), including t

292 duces a number of pharmaceutically valuable, bioactive terpenoid indole alkaloids (TIAs).

293 Elevated levels of bioactive TGF-beta1 are associated with asymmetric fate

294 light studies that have identified molecular bioactives that influence human health, and we suggest s

295 ately 8-70 kDa), and these were now far more bioactive: they impaired hippocampal LTP, decreased neur

296 yronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity

297 nce, the results suggested that targeting of bioactives to the brain by ascorbic acid grafted PLGA-b-

298 ondary modifications for the biosynthesis of bioactive triterpenoids.

299 230000 small molecules designed to identify bioactive wall teichoic acid (WTA) inhibitors, we identi

300 optimize productivity by 50-fold to produce bioactive yields that allow spent S. cerevisiae growth m