ライフサイエンスコーパス: bioactivity

1 Processed or baked foods retained ATI bioactivity.

2 novel bottromycin derivatives with enhanced bioactivity.

3 hance endothelial-derived EV vascularization bioactivity.

4 development, and Gtf activity akin to BF-CM bioactivity.

5 r structure with an unusual biosynthesis and bioactivity.

6 luence of a fourth disulfide bond on insulin bioactivity.

7 eavage at Lys(158) or regulation of chemerin bioactivity.

8 inding, nor did their addition affect hIL-12 bioactivity.

9 overexpression enhances synaptamide-induced bioactivity.

10 gely conserved element, are critical to this bioactivity.

11 -specific Pseudomonad metabolite with unique bioactivity.

12 SH5-07 and SH4-54, respectively) with robust bioactivity.

13 d into cottage cheese to achieve an extended bioactivity.

14 A curated database of rodent uterotrophic bioactivity.

15 ditional factors are required to achieve its bioactivity.

16 nature or synthetic products with potential bioactivity.

17 ticoids can entirely explain the observed GR bioactivity.

18 ellular force transmission and growth factor bioactivity.

19 ion patterns that are crucial for polyketide bioactivity.

20 ibodies of defined composition with retained bioactivity.

21 novel mechanism for amplification of exosome bioactivity.

22 netic properties, which prevents the loss of bioactivity.

23 iety of natural products bearing interesting bioactivity.

24 verses tethered signals) can influence their bioactivity.

25 Ab immobilization, ultimately preserving its bioactivity.

26 eight pectin with high efficiency and higher bioactivity.

27 important feature for DNA intercalation and bioactivity.

28 large class of natural products with diverse bioactivity.

29 the griseusin tetrahydro-spiropyran ring on bioactivity.

30 ecule drugs and RNA ligands without reported bioactivity.

31 us allowing for modular control over peptide bioactivity.

32 n; in turn, insulin favors osteocalcin (OCN) bioactivity.

33 ragment (SlitC) with an unknown receptor and bioactivity.

34 el mass loss and released peptides retaining bioactivity.

35 eads to non-specific modification or loss of bioactivity.

36 affinities directly correlated with observed bioactivity.

37 nd to confer essentially native affinity and bioactivity.

38 nces and lengths, some of them with relevant bioactivity.

39 ening drug compounds libraries for potential bioactivity.

40 date vital structural residues necessary for bioactivity.

41 ology, including cargo sorting, release, and bioactivity.

42 s and many have been shown to have endocrine bioactivity.

43 logical conditions EE2 can desorb and retain bioactivity.

44 ncer preventative Brassica vegetable related bioactivity.

45 ng target-chemical detections to explain the bioactivity.

46 chanism(s) by which heparin influences IL-12 bioactivity.

47 tation in rat hippocampus by 80%, suggesting bioactivity.

48 ptor (ER) and androgen receptor (AR) pathway bioactivity.

49 r alternative uses of end-products with high bioactivity.

50 wo novel MaR1 further metabolites that carry bioactivities.

51 ariable protein mixtures with a multitude of bioactivities.

52 llamide and waikialoid, which possess potent bioactivities.

53 eneration of peptides, soluble phenolics and bioactivities.

54 defined patterns of acetylation and specific bioactivities.

55 ated metabolites, displaying higher or lower bioactivities.

56 dant activities and, consequently, different bioactivities.

57 nerating protein hydrolysates with desirable bioactivities.

58 availability of flavanols, influencing their bioactivities.

59 class harboring untapped chemodiversity and bioactivities.

60 ity of peptides obtained, all with potential bioactivity (28 peptides in the native hydrolysate, 39 i

61 candidate ligands that "explain" patterns of bioactivity across diverse complex mixtures.

62 s can imply conservation or even creation of bioactivity across multiple biological end points and th

63 ease site, we show how the protein gains its bioactivity after proteolysis and is as active as the is

64 The hydrolysates retained bioactivity after simulated gastrointestinal hydrolysis

65 tification of new molecules with therapeutic bioactivity against ACR acute neurotoxicity is urgently

66 s of the reported natural products that have bioactivity against drug-resistant pathogens in order to

67 In addition, a significant antibiofilm bioactivity against Streptococcus mutans, a causative ag

68 affold provides promising improvement of its bioactivity against vancomycin-resistant enterococci (Va

69 For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC ac

70 to explore diverse chemical space; guided by bioactivity alone, the products of just nine of the reac

71 Phytochemical and bioactivity analyses of pistachio hulls revealed the pre

72 pene family possesses an impressive range of bioactivities and high synthetic challenge due to their

73 t three concentrations (1, 2 and 3mM) on the bioactivity and antioxidant capacity of coriander, dill,

74 ut enigmatic since nitrate per se has little bioactivity and cannot be converted to NO by mammalian c

75 ermined the occurrence and attenuation of GR bioactivity and closed the balance by determining those

76 The observed bioactivity and composition of ecdysteroids will contrib

77 al product tree", which can be annotated for bioactivity and intuitively navigated with currently ava

78 A concomitant improvement in the antagonist bioactivity and ligand lipophilic efficiency (LLE) param

79 CD14 (sCD14), a marker of lipopolysaccharide bioactivity and microbial translocation.

80 ntestinal resistance, Caco-2 cell adhesion), bioactivity and microstructure were analysed.

81 Bioactivity and nutritional quality of legumes is affect

82 ferrin synergism in the regulation of Ti(IV) bioactivity and offers insight into the future design of

83 s adopting specific conformations to improve bioactivity and pharmacokinetic profiles of the correspo

84 ein-based polymers offer enhanced endogenous bioactivity and potential for seamless integration with

85 oma cells, GARP expression increased TGFbeta bioactivity and promoted malignant transformation in imm

86 ulting TRAIL-Trimer not only retains similar bioactivity and receptor binding kinetics as native TRAI

87 hormones, focusing on examples of conserved bioactivity and related implications for fate assessment

88 lso be useful for initial examination of the bioactivity and reproducibility of nanomaterials employe

89 Evaluation of the bioactivity and safety of BPS and other BPA analogs is n

90 in Lac density resulted in similar or lower bioactivity and sensor capacity.

91 se of organic solvents impacting on both the bioactivity and the kinetics of drug release.

92 of Agaricus bisporus were studied for their bioactivity and viability as functional ingredients in a

93 al uses of plants were proposed as proxy for bioactivity, and phylogenetic patterns in medicinal plan

94 chemicals, provide a measure of relative ER bioactivity, and rapidly identify chemicals with potenti

95 ith heat or pepsin completely abolished this bioactivity, and selective ultrafiltration of the CM rev

96 encapsulation efficiency, well protection of bioactivity, and steadily long shelf time.

97 y from broad and targeted inhibition of VEGF bioactivity, and the role of VEGF in neuroprotection in

98 ecific IgG is capable of neutralizing GM-CSF bioactivity; and 5) Rasgrp1-deficient mice also lacking

99 sicochemical (pH, proteolysis, fatty acids), bioactivity (antioxidant effect and angiotensin I-conver

100 The bioactivity (antioxidant, anti-swarming) and phenolics c

101 Further analyses of their bioactivities are warranted.

102 ter-soluble AZD/PVP, which exhibited similar bioactivity as cediranib, was developed to enhance the r

103 uch as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors

104 n unique chemical structures and 225 million bioactivity assay results, covering more than 9000 uniqu

105 les, which is consistent with the results of bioactivity assay.

106 The bioactivity assays showed that isolated malonylated flav

107 calculated from a suite of ToxCast in vitro bioactivity assays using in vitro-to-in vivo extrapolati

108 emperature using metabolomics approaches and bioactivity assays.

109 Multifunctional ligands with agonist bioactivities at mu/delta opioid receptors (MOR/DOR) and

110 r in vivo models to better address potential bioactivity at intestinal and target organs level.

111 r potential hazard from parent-product joint bioactivity at locations and times when reversion is a d

112 ta opioid receptors (MOR/DOR) and antagonist bioactivity at the neurokinin-1 receptor (NK1R) have bee

113 erns such as GF spatiotemporal presentation, bioactivity, bioavailability, and localization are addre

114 Due to multiple modes of action, high bioactivity, biorecalcitrance, and direct environment ap

115 giogenesis is inhibited upon reduction of NO bioactivity both in vitro and in vivo Moreover, genetic

116 der this model, the delivery of SNO-based NO bioactivity by Hb redefines the respiratory cycle as a t

117 r the remote spatial and temporal control of bioactivity by light.

118 low micromolar affinity and increase hIL-12 bioactivity by more than 6-fold.

119 randomized, open-label safety, efficacy, and bioactivity clinical trial conducted at 5 clinical cente

120 phylogenetic patterns of presumed underlying bioactivity compared to standardised methods of medicina

121 l thiotetroamide C analogue with potentiated bioactivity compared to the parent molecule.

122 b (T-cell recruitment) demonstrated superior bioactivity compared with trastuzumab.

123 We propose ambient water bioactivity concentrations (AWBCs) generated from high t

124 afy vegetables and beetroot, can increase NO bioactivity, conferring beneficial effects on cardiovasc

125 hods on an extensive data set of proprietary bioactivity data combined with open data.

126 ta; drug metabolism and disposition data and bioactivity data from patents.

127 dicinal chemistry literature, new sources of bioactivity data have also been added to the database.

128 The availability of structures and linked bioactivity data in databases is powerfully enabling for

129 ChEMBL is an open large-scale bioactivity database, previously described in the 2012 a

130 edom of aggregates measured by SEC-HPLC) and bioactivity (defined by TF-1 cell proliferation) of the

131 in structure resulted in different levels of bioactivity, demonstrating the presence of regulation on

132 However, their bioactivity depends on their release and intestinal upta

133 tic libraries, and all had manifold ascribed bioactivities, designating them as invalid metabolic pan

134 nged exposure, with a constant oxyntomodulin bioactivity detectable in serum for at least 5 days as c

135 Projection into occurrence-bioactivity-effort space produces the hyperbolic black h

136 ource, underlining the precise modulation of bioactivity enabled by this bioorthogonally-activated pr

137 eral cycles of hydrolysate fractionation and bioactivity evaluation until the isolation of the pure b

138 to quality control, germplasm screening, and bioactivity evaluation.

139 s further improved by employing experimental bioactivity fingerprints of a small kinase subset.

140 elivery systems evaluated and maintained its bioactivity following a sterilizing dose of gamma irradi

141 identify chemicals with potential endocrine bioactivities for additional screening and testing.

142 PgP/pDNA polyplexes maintain bioactivity for transfection after lyophilization/recons

143 Prioritized bioactivities from the EAR analysis were linked to discr

144 rate-limiting step in generating soluble EGF bioactivity from activated platelets.

145 a computational model that can discriminate bioactivity from assay-specific interference and cytotox

146 tant catechols with fluorescent property and bioactivity from the corresponding phenols.

147 hibitors in the Apocynaceae family and their bioactivity, functional promiscuity that could be exploi

148 ard protocols for chemical fractionation and bioactivity-guided chemical analysis were used to identi

149 olecular networking, as well as conventional bioactivity-guided fractionation and isolation.

150 ield produces a protein that was purified by bioactivity-guided fractionation based on ammonium sulfa

151 Furthermore, bioactivity-guided fractionation revealed a direct link

152 Bioactivity-guided isolation of 3-(octahydro-9-isopropyl

153 al homeostasis and an inhibition of catalase bioactivity have been reported.

154 Our results are consistent with a "bioactivity hypothesis" for explaining variations in car

155 d cell-surface charges, (ii) cells' internal bioactivity, (iii) cell-wall's electronegativity or dipo

156 of this approach in pregnancy to enhance NO bioactivity, improve uteroplacental vascular function an

157 mide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.

158 We assess their in vivo bioactivity in a well-established mouse model of psorias

159 ng these, compound 40 showed the most potent bioactivity in HSCs expansion (ED50 = 5.21 nM).

160 elates to molecular interaction dynamics and bioactivity in living cells.

161 Endogenous NO bioactivity in mammals is largely mediated by S-nitrosot

162 We found evidence for an autophagy-inducing bioactivity in serum from cancer patients and that this

163 Bioactivity in the microenvironment is attributable to p

164 Preliminary indications of bioactivity include decreased scar size, increased viabl

165 PEP, it was possible to suggest a variety of bioactivities, including dipeptidyl peptidase-IV (DPP-IV

166 To facilitate translation of its bioactivity into protein function for drug development,

167 and microvascular integrity, and impaired NO bioactivity is associated with fatal outcomes in malaria

168 Thus, betaCys93-derived SNO bioactivity is essential for tissue oxygenation by RBCs

169 GDF11 bioactivity is instead lost because of deficiencies in i

170 A major route for the transfer of NO bioactivity is S-nitrosylation, the addition of an NO mo

171 cause the evidence regarding each fraction's bioactivity is scarce, we administered high-fat (HF) die

172 f illicit drugs and prolonged freezing on SE bioactivity is unknown.

173 Small molecule bioactivities mapped to protein domains add important pr

174 EDP bioactivities may provide novel insights into the potent

175 ng endothelial-derived MP shedding and their bioactivity may be a promising therapeutic strategy to l

176 ncy to the growth factor, as demonstrated by bioactivity measurements.

177 However, it is not known how NO bioactivity might impact autophagy in obesity.

178 MBL database curates and stores standardized bioactivity, molecule, target and drug data extracted fr

179 d since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het)arenes.

180 The bioactivities of GCSF-Fc and PEG-GCSF were similar to na

181 he BMP4 prodomain contribute to the relative bioactivities of homodimers versus heterodimers in vivo.

182 the supply of essential amino acids and the bioactivities of milk proteins are dependent on their di

183 The chemical identity and bioactivities of phenolic components of the Australian n

184 Anti-inflammatory bioactivities of products prepared from Brewer's and Bak

185 ic acid (OA) is known to bind and change the bioactivities of proteins, such as alpha-lactalbumin and

186 tion of phenolic contents and their in vitro bioactivities of six diverse cultivars of foxtail and li

187 Bioactivities of these products were compared in terms o

188 Here we explore the basis of the distinct bioactivities of VEGF-D using a neutralizing antibody, p

189 odel scores range from 0 (no activity) to 1 (bioactivity of 17beta-estradiol).

190 assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.

191 r the targeted DNA but can also maintain the bioactivity of as-separated protein and DNA solutions.

192 To evaluate the safety and bioactivity of autologous CD34+ cell (CLBS10) intracoron

193 ted that a short heat-treatment improves the bioactivity of beta-carotene but longer treatments made

194 he morphology, encapsulation efficiency, and bioactivity of bFGF-NP were studied.

195 ccount for contaminants characterized by (1) bioactivity of both the parent and transformation produc

196 Other reports on the bioactivity of casein-derived peptides have shown that t

197 data as a health-based screen for endocrine bioactivity of chemicals in water.

198 the present study, chemical composition and bioactivity of Cichorium spinosum leaves were examined a

199 Phenolic composition and bioactivity of cloudberry was modified by bioprocessing,

200 In this work, the bioactivity of commercial natural beta-carotenes, one so

201 ons to preserve the quality and increase the bioactivity of dairy preparations designed for elderly p

202 ent) mechanism underlying the pro-autophagic bioactivity of decorin via PEG3 and TFEB.

203 The structures, stereochemistry, and bioactivity of ELVs were determined using synthetic mate

204 anol conditioning as a method to enhance the bioactivity of endothelial EVs via regulation of EV-asso

205 ning to assess the potential health risks or bioactivity of ENMs.

206 putational methods to evaluate the endocrine bioactivity of environmental chemicals.

207 study was to examine the bioavailability and bioactivity of ethinyl estradiol (EE2) sorbed onto SWCNT

208 gh levels of peptides, soluble phenolics and bioactivity of fermented lentil at pH 8.5 and 11.6h.

209 s sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorabi

210 ous studies have identified the presence and bioactivity of glucocorticoid receptor (GR) active subst

211 e (97-3500m) on the starch digestibility and bioactivity of hulless barley cultivars grown in India.

212 omeningeal cells, we were led to explore the bioactivity of IGF1 in medulloblastoma by elevated CSF l

213 Finally, we found that the bioactivity of IL-33 on the Vgamma9 T cell was indirectl

214 we provide an account of the composition and bioactivity of individual OPCs and more generally highli

215 cing factors (RIFs) to recapitulate the full bioactivity of live Algoriphagus.

216 which have been shown to be essential to the bioactivity of LOS-IV.

217 sozyme through bioaffinity interactions, the bioactivity of lysozyme will be used here for sensing pu

218 olism of phenolic acids, knowledge about the bioactivity of metabolites is extremely important.

219 ment (after atomization) on crosslinking and bioactivity of microspheres was tested.

220 and nano-fabrication, but also preserve the bioactivity of molecular motors.

221 The scientific evidence on the bioactivity of oligosaccharides from lactulose has encou

222 cations in improving the bioavailability and bioactivity of other polysaccharide-based natural compou

223 employed to enhance the bioavailability and bioactivity of parent sequences.

224 confirmed its p18-targeting specificity and bioactivity of promoting HSCs expansion, and then perfor

225 Our analog studies revealed that the bioactivity of promysalin is sensitive to changes within

226 on the colour, phytochemical composition and bioactivity of roselle wine was investigated over 12mont

227 In this review, we describe the bioactivity of selected small molecules that have been u

228 free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion

229 finding highlights the possibility that the bioactivity of such CECs may be effectively preserved th

230 hormone-binding globulin, which reduces the bioactivity of testosterone and estradiol.

231 The bioactivity of the BSG-PI hydrolysates was retained afte

232 however, the pro-domains do not inhibit the bioactivity of the growth factor, and the BMP9.pro-domai

233 The bioactivity of the identified compounds was investigated

234 The cytochrome P450 (CYP)-specific bioactivity of the liver microsomal film on the catalyti

235 ncy of the method developed and evaluate the bioactivity of the non-invasively introduced channelrhod

236 orientation of the scTNF trimers impacts the bioactivity of the oligomerized scTNF ligands.

237 In the light of the promising bioactivity of the tetraarsenic marine metabolite arseni

238 ithin the gastrointestinal tract (GIT) or to bioactivity of their absorbed metabolites.

239 openings of imidazoles, likely affecting the bioactivity of these BTPs.

240 The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoen

241 TX-induced cancer immunosurveillance and the bioactivity of these microbes.

242 Ion depletion studies have shown that the bioactivity of these nanoparticles is time-limited becau

243 ns contents, and so, confirm the fascinating bioactivity of this fruit.

244 Bioactivity of thyme has been described, but mostly rela

245 ing have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to con

246 erations affect the chemical composition and bioactivity of UC.

247 estosterone was unaffected while sex steroid bioactivity on male and female reproductive organs was a

248 otal and free sex steroid concentrations and bioactivity on target organs in mice expressing a human

249 r facile reactions while maintaining protein bioactivity or desired release.

250 e receptor I (functionally blocking TNFalpha bioactivity) or knockdown of TNFRI using antisense oligo

251 s and substrates, HT resulted in the highest bioactivities (ORAC, DPPH scavenging and ACE-inhibitory

252 aking homologous ligand search with flexible bioactivity parameters.

253 sent study compares the NO-generating and NO bioactivity-preserving capability of LtHb with that of h

254 A preliminary investigation on the bioactivity profile and toxic potential of this residue

255 ocyclic polyketides known to have an unusual bioactivity profile influenced by compound glycosylation

256 azole core that is likely key to its unusual bioactivity profile.

257 These GDSs provided a toolbox to measure bioactivity profiles in agglutination assays with sugar-

258 ect-directed analysis can be recommended for bioactivity profiling of food to obtain profound effect-

259 Bioactivity quotients (BQs) are calculated as iR/OED to

260 DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indic

261 he opportunity for improved formulations and bioactivity remains.

262 These patterns indicate that certain NCR bioactivities require cysteines whereas others do not.

263 In vitro testing confirmed peptide drug bioactivity requires sustained delivery.

264 The bioactivity responses were correlated directly to the re

265 High-throughput bioactivity screening did not reveal increased toxicity

266 f permeability-biased libraries suitable for bioactivity screens.

267 ation of biopharmaceuticals may affect their bioactivity, serum half-life, and (bio)chemical stabilit

268 to unknown macromolecular target expands the bioactivity space for this natural product and corrobora

269 A high phenolic content and bioactivity still remain in pomaces which support its us

270 proposed a mapping heuristic for a subset of bioactivities stored in ChEMBL with the Pfam-A domain mo

271 Preliminary bioactivity studies moreover indicated weak cytotoxicity

272 Here, using a bioactivity test based on embryonic cells (C3H10T1/2) tr

273 E3FP is a better predictor of similarity in bioactivity than is ECFP.

274 ariants (such as Emmer or Einkorn) had lower bioactivity than modern (hexaploid) wheat.

275 chito-oligosaccharides (paCOS) have diverse bioactivities that turn them into promising compounds es

276 ol (HT) is a phenolic compound of recognized bioactivity that has been described in wines but little

277 ptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug disc

278 s from vascular dysfunction by promoting NO* bioactivity through ERRalpha induced expression of eNOS.

279 rtion of anti-PCV2 monoclonal antibody (MAb) bioactivity, thus improving the effectiveness of specifi

280 to both interpolate and extrapolate compound bioactivities to new cell lines and tissues and, althoug

281 PPDMs is a resource that maps small molecule bioactivities to protein domains from the Pfam-A collect

282 generate nitric oxide (NO) or to preserve NO bioactivity to compensate for decreased levels of NO in

283 LA showed a higher immobilization degree and bioactivity to the anti-APOA2 antibody (Ab) due to its l

284 asurement of free drug, and (v) neutralizing bioactivity using bioassay.

285 estingly, results of kinetic analysis of LPS bioactivity, using modified limulus amebocyte lysate ass

286 nce of gastrointestinal digestion on peptide bioactivity was also assayed.

287 Bioactivity was assessed by gamma-H2AX ex vivo assay.

288 rGDF11 bioactivity was confirmed in vitro.

289 ution temperature (LCST) and its release and bioactivity was measured.

290 Importantly, the autophagy-inducing bioactivity was reduced by interference with IL-6 trans-

291 Slight changes were observed in proteolysis, bioactivity, water mobility, texture profile, and fatty

292 hromatography and three distinct measures of bioactivity, we show that the predominant forms of Abeta

293 scriptors of engineered nanoparticles (ENPs) bioactivity which may be useful in safer-by-design strat

294 nd duration of semen storage on SE cargo and bioactivity will advance our understanding of SE composi

295 using quartz crystal microbalance; and motor bioactivity with ATPase assay, on a set of model surface

296 ntinuous monitoring of biologics' purity and bioactivity with high sensitivity, resolution and speed.

297 Furthermore, peptides retain bioactivity with residual MMP substrates present after h

298 the Janus-GDs was demonstrated to determine bioactivity, with the highest level revealed for a Janus

299 iven their ability to transduce nitric oxide bioactivity within the microcirculation.

300 C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct sig