ライフサイエンスコーパス: bioavailability

1 hat is absorbed and reaches the bloodstream (bioavailability).

2 al properties may influence the extent of Zn bioavailability.

3 -carotene, however these bioactives have low bioavailability.

4 its half-life, tissue distribution, and oral bioavailability.

5 t with the largest difference in comparative bioavailability.

6 al of DRIFTS for estimating soil heavy metal bioavailability.

7 inistration, quick onset of action, and high bioavailability.

8 tion of Hg(II)-DOM thiol complexes with high bioavailability.

9 ogeneity of P influences P accessibility and bioavailability.

10 dissolution rate is vital to guarantee oral bioavailability.

11 , suggesting microplastics could increase Zn bioavailability.

12 y have a critical role in controlling nickel bioavailability.

13 inal digestion was used for determination of bioavailability.

14 dilatory function and baseline nitric oxide bioavailability.

15 ts a significant challenge given its limited bioavailability.

16 self-administered with rapid onset and high bioavailability.

17 also reduced by oral vancomycin that has 0% bioavailability.

18 etabolism of resveratrol strongly limits its bioavailability.

19 d to identify parameters that influence oral bioavailability.

20 ial nitric oxide generation and preserve its bioavailability.

21 and lipids and therefore can influence oral bioavailability.

22 le DGAT1 inhibitor 1 led to 9 with good oral bioavailability.

23 rties of aqueous GAA solutions, but also its bioavailability.

24 acteria of organic pollutants that have poor bioavailability.

25 d oxidative stress and enhanced nitric oxide bioavailability.

26 as developed to determine inhibitor cellular bioavailability.

27 although the biscuit matrix could affect HT bioavailability.

28 monstrate potent antiviral activity but poor bioavailability.

29 sed to enhance their stability, delivery and bioavailability.

30 cts metal cation toxicity, accumulation, and bioavailability.

31 P2(Delta/+) mice, as was aortic nitric oxide bioavailability.

32 gainst degradation and also in improving its bioavailability.

33 e dose administration showing favorable oral bioavailability.

34 OS inhibitors mimic l-arginine and have poor bioavailability.

35 to other elemental cycles that can limit its bioavailability.

36 athological state influenced flavanol plasma bioavailability.

37 and endowed with better solubility and oral bioavailability.

38 inal bacterial profile to enhance isoflavone bioavailability.

39 difying insulin-like growth factor-I (IGF-I) bioavailability.

40 dietary strategies to reduce in vivo mercury bioavailability.

41 exhibit a modest increase in pharmacokinetic bioavailability.

42 d for its anti-inflammatory effects, has low bioavailability.

43 otential have high bioaccessibility but poor bioavailability.

44 ould be considered in the context of mercury bioavailability.

45 (94.7 +/- 6.2%) and normalised nitric oxide bioavailability (115.6 +/- 22.3%) in the fetal heart, an

46 n (167 +/- 13.7%) and decreased nitric oxide bioavailability (54.7 +/- 6.1%) in the fetal heart, and

47 such as pain, adverse side effects and poor bioavailability, a new approach is needed for DHE delive

48 d on interindividual variations in flavanone bioavailability.A 7-d cessation of endurance training en

49 atural particles was inversely related to Zn bioavailability; a finding that would not have been poss

50 mins B6, K1, and D3) as enhancers of calcium bioavailability according to recommended dietary allowan

51 ough Lipinski's rule of five filter for oral bioavailability, ADMET risk filter for drug like feature

52 iological barriers that result in low ocular bioavailability after topical application.

53 stically significant (p<0.05) improvement in bioavailability, after transdermal administration of nan

54 lso interact with peptides and improve their bioavailability, although the mechanism is unclear.

55 riched milk powders had the greatest calcium bioavailability among the groups, but bioavailability of

56 to deliver nanodrugs with an increase in the bioavailability and a decrease in toxicities.

57 cidofovir, brincidofovir, has improved oral bioavailability and achieves higher intracellular concen

58 ung adults, the present work showed that the bioavailability and assimilation of meat amino acids in

59 har presents potential implications for HOCs bioavailability and bioaccessibility in sediments, while

60 e objective of this study was to examine the bioavailability and bioactivity of ethinyl estradiol (EE

61 l have broader applications in improving the bioavailability and bioactivity of other polysaccharide-

62 ides has been widely employed to enhance the bioavailability and bioactivity of parent sequences.

63 nisms that may explain discrepancies between bioavailability and bioefficacy.

64 aFe2 O3 nanofluids are conducted to estimate bioavailability and biofeasibility.

65 33 has good stability and oral bioavailability and can cross the blood-brain barrier.

66 Intravascular hemolysis can impair NO bioavailability and cause oxidative stress, altering red

67 Increased bioavailability and cell permeability of Ru-thio-chrysin

68 l has some issues including solubility, oral bioavailability and cost of preparation.

69 We compared the bioavailability and dose response of potassium from nonf

70 is increasing interest in understanding the bioavailability and effects of ENMs released into soil s

71 coming ENM (i.e., sulfidized or pristine) on bioavailability and fate is limited.

72 richomonas is capable of regulating galectin bioavailability and function to the benefit of its paras

73 The improved bioavailability and functionality warrants further devel

74 2 in cancer treatment is hindered by its low bioavailability and hypoxia-induced resistance.

75 i mobility, thereby increasing micronutrient bioavailability and inhibiting contaminant sequestration

76 whey protein or citrus pectin influences the bioavailability and intestinal accessibility of anthocya

77 d our hypothesis of target-specific enhanced bioavailability and limited unwanted toxicity, thus lead

78 nones in micronized GP of SM had higher oral bioavailability and lower individual variances, thus we

79 derstand important determinants of flavonoid bioavailability and metabolism and to advance the knowle

80 f biochar on HOC biodegradation coupled with bioavailability and microbial ecology are rarely documen

81 the present investigation was to improve ATV bioavailability and overcome complications attendant wit

82 ll colony advantage, providing enhanced iron bioavailability and perhaps affecting the structure of t

83 cells, and exhibited consistently high oral bioavailability and pharmacokinetic parameters across pr

84 t of red cabbage fermentation on anthocyanin bioavailability and plasma antioxidant capacity in human

85 ugrel is associated with more favorable drug bioavailability and platelet inhibitory effects compared

86 However, owing to low bioavailability and poor skin permeability, transdermal

87 tives, have serious limitations, such as low bioavailability and severe side effects.

88 limited by genetic variance, metabolism, and bioavailability and should be used in addition to rather

89 rior in vitro activity to 2 were studied for bioavailability and shown to cause regression of a TR, e

90 testinal (GI) absorption of prions (i.e. the bioavailability and subsequent biodistribution) is mostl

91 y protein encapsulation modulated short-term bioavailability and that citrus pectin encapsulation inc

92 armacological potential of TCMPs, their oral bioavailability and their resistance to industrial proce

93 l (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy.

94 RVXB reduced oxidative stress, improved NO bioavailability, and ameliorated endothelial dysfunction

95 The stability, bioavailability, and bioactivity of these compounds can

96 on and flavonoid source are likely to affect bioavailability, and emerging data suggest a critical ro

97 the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the

98 rculation half-life, an 8.6-fold increase in bioavailability, and reduced renal accumulation.

99 has medication-like duration of action, oral bioavailability, and target engagement.

100 Projections of U transport and bioavailability, and thus its threat to human and ecosys

101 ceptor degrader (SERD), exhibiting good oral bioavailability, antitumor efficacy, and SERD activity i

102 ies thought to influence oral absorption and bioavailability are analyzed, including molecular weight

103 Values for dietary iron bioavailability are required for setting dietary referen

104 luding endothelial NO synthase (eNOS) and NO bioavailability, are unknown.

105 nce point to impaired nitric oxide (NO)-cGMP bioavailability as playing a central role in each of the

106 ects a loss in venular nitric oxide and PGI2 bioavailability, associated with the chronic elevation i

107 etermination of their blood levels to ensure bioavailability at an appropriate dose level.

108 PT) has been widely used to characterize the bioavailability (BA) of compounds applied on the skin.

109 IVC bypasses bioavailability barriers of oral ingestion, provides pha

110 xtures but might be predicted by mechanistic bioavailability-based toxicity models.

111 crease of 23.7% (15.8%-32.5%) in piperaquine bioavailability between each piperaquine dose occasion.

112 cal parameters needed to explain and predict bioavailability, biodynamics, and baseline toxicity are

113 of the NP to be around 200nm to improve its bioavailability, but also can effectively protect the ly

114 nolones have equivalent oral and intravenous bioavailability, but hospitalized patients with communit

115 y the sEPD significantly improved zidovudine bioavailability by 100% as compared to oral gavage deli

116 this manuscript, we attempted to improve its bioavailability by encapsulation in mixed phosphatidylch

117 Magnesium may reduce carotenoid bioavailability by forming insoluble complexes with bile

118 ia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion.

119 Values for dietary iron bioavailability can be derived for any target concentrat

120 he context of potentially increased selenium bioavailability caused by microbial activity in aquatic

121 on and bioavailability, polyphenol potential bioavailability could be an effective selection criterio

122 Iron (Fe) bioavailability depends upon its solubility and oxidatio

123 The in vitro study of bioavailability establishes a low percentage of stomach

124 this study, PK parameters and absolute oral bioavailability expressed as percentage (F%) of celecoxi

125 YP11B1 (IC50 = 2 muM) and showed a high oral bioavailability (F = 50%) and sufficient plasma concentr

126 ree method for quantifying the intracellular bioavailability (Fic) of drug molecules predicts drug ac

127 s temperature dependence, as this controlled bioavailability for benthos (the main source of cVMS for

128 ction in serum samples, suggesting low or no bioavailability for DBDPE in cats.

129 he role of DOM sulfurization in enhancing Hg bioavailability for microbial methylation was evaluated

130 is cofactor, which likely ensures its timely bioavailability for proper cellular function.

131 The relative iron bioavailability from FeFum+NaFeEDTA compared with FeSO4

132 Zinc bioavailability from the natural particles was inferred

133 Calcium bioavailability from two types of enriched (calcium citr

134 solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migratio

135 use of dietary components to reduce mercury bioavailability has been previously proposed.

136 Its bioavailability has varied dramatically over the history

137 associated with decreased IHVR, enhanced NO bioavailability, HSC deactivation, and reduced intrahepa

138 had a significant positive correlation with bioavailability in a model that included allometric scal

139 STO-609, its toxicity, pharmacokinetics and bioavailability in a variety of mouse tissues.

140 entella asiatica showed comparatively higher bioavailability in all phases with respect to its origin

141 g iron and organic matter transformation and bioavailability in aquatic systems.

142 We reported previously that alpha-tocopherol bioavailability in healthy adults is higher than in thos

143 andomized, double-blind study to evaluate HT bioavailability in HT-enriched biscuits (HT-B) versus no

144 but anthocyanins are associated with limited bioavailability in humans.

145 The role of Hg speciation on Hg bioavailability in marine systems has not been teased ap

146 e in vitro ADME profile as well as good oral bioavailability in mice, rats, and dogs.

147 Falpha and/or RANKL, thereby adjusting their bioavailability in order to regulate osteoclastogenesis.

148 mutagenic potential as well as very low oral bioavailability in rats (F = 2%) and was therefore modif

149 droxides, carbonates) played a role in metal bioavailability in single metal exposure but not in mixt

150 to assess how metal oxides play a role in Ni bioavailability in surficial sediments exposed to efflue

151 Some of these strategies also reduce Hg bioavailability in swordfish (glutathione, cysteine, hom

152 5+), are the most relevant to V mobility and bioavailability in the environment, and accounted for on

153 f bacterial cells on metal cycling and metal bioavailability in the environment.

154 %) was very low, possibly related to its low bioavailability in the gastrointestinal tract, steric co

155 s anti-neoplastic agents by increasing their bioavailability in tumour cells.

156 lecular size of pectin severely prevents its bioavailability in vivo.

157 d support prior evidence of cadmium's higher bioavailability in women and its long tissue half-life.

158 new interactive tool to predict dietary iron bioavailability.Iron intake and serum ferritin, a quanti

159 Endothelial dysfunction/NO bioavailability is associated with worse plasma leakage,

160 erences in temperature-dependent contaminant bioavailability is investigated in detail.

161 In addition, coal bioavailability is no longer a limiting factor.

162 Ni bioavailability, its role in the flavour of food and its

163 and systemic hemodynamic, nitric oxide (NO) bioavailability, LF, HSC activation, and microthrombosis

164 rom diet, and an assumption of 100% relative bioavailability likely overestimates exposure to cPAHs u

165 ver, high instability and extremely low oral bioavailability limit its further clinical development.

166 alized following zero-order kinetics, due to bioavailability limitations.

167 studied lipophilic ingredients, but low oral bioavailability limits their clinical application.

168 The high stability and bioavailability, low normal-tissue uptake of [(64)Cu]Cu-

169 ntrinsic solubility and low to moderate oral bioavailability made this series unsuitable for further

170 eatic cancer suggested that TRES with higher bioavailability may be a potential agent for pancreatic

171 In conclusion, purified REP with efficient bioavailability may be safe and useful for dietary suppl

172 Reduced bioavailability may contribute to "aspirin resistance" i

173 Antibiotic resistance and substrate bioavailability may therefore represent critical new det

174 goal of this study was to determine if oral bioavailability mediates nonresponsiveness.

175 vironmental Protection Agency (EPA) in vitro bioavailability methodology was applied to archived BHSS

176 water chemistry parameters that influence Cu bioavailability, namely dissolved organic carbon (DOC),

177 hey were minimally absorbed in the BC with a bioavailability of 0.13% and 0.49% respectively.

178 in rats confirmed a good safety profile and bioavailability of 16d.

179 oactive peptide 25 (Ki = 9 nM) achieved oral bioavailability of 18% in rats, which was commensurate w

180 We estimated the oral PAH bioavailability of 19 historically contaminated soils fe

181 57 had a superior oral exposure and desired bioavailability of 45% after oral administration in rats

182 d to subcutaneous injection, with a relative bioavailability of 97%.

183 evaluate the in vivo effects of heat on the bioavailability of a drug delivered from a TDS.

184 the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nit

185 nanomaterials' (CNMs) potential to alter the bioavailability of adsorbed contaminants, information ch

186 ch as unsaturated soils, and thus affect the bioavailability of Ag.

187 the importance of the large intestine on the bioavailability of anthocyanins from bilberries in human

188 Comparison of the bioavailability of anthocyanins in healthy subjects vers

189 Low bioavailability of anthocyanins in plasma and urine was

190 an atrial appendages, can regulate the local bioavailability of antihypertrophic and profibrotic grow

191 We propose that TSP-1 could regulate bioavailability of BMPs, either produced locally or reac

192 thione, quercetin, albumin and tannic reduce bioavailability of both mercury species.

193 The bioavailability of carotenoid from oral dosage formulati

194 l exercise has been reported to increase the bioavailability of citrus flavanones.We investigated the

195 relationship between adsorption behavior and bioavailability of CNM-adsorbed contaminants is still li

196 This study shows that the variability in bioavailability of CNM-adsorbed PAHs is largely driven b

197 Furthermore, the reduction in bioavailability of CNM-adsorbed PAHs was negatively corr

198 lation and bioaugmentation is limited to the bioavailability of coal-derived compounds and is conside

199 ineral-water interfaces exert control on the bioavailability of contaminant arsenic species in natura

200 tressors induce brain activation, increasing bioavailability of cortisol and catecholamine.

201 de a strong basis for establishing that oral bioavailability of cPAHs from soil is less than from die

202 s metabolic complexity in the production and bioavailability of different vitamin forms, coupled with

203 tionally considered to be important for oral bioavailability of drug-like small molecules, although f

204 de an enhanced oral absorption and increased bioavailability of EGCG.

205 nd statistically significant increase in the bioavailability of erlotinib during esomeprazole treatme

206 The bioavailability of existing pools of natural precursor m

207 al condition could affect the metabolism and bioavailability of flavanols, influencing their bioactiv

208 iminately compared to MWCNTs, the subsequent bioavailability of GN-adsorbed PAHs was more sensitive t

209 The bioavailability of heavy metals in soil is controlled by

210 We show that ionic strength controls the bioavailability of Hg species, regardless of their charg

211 achment to surfaces, predation, and improved bioavailability of hydrophobic substrates.

212 es to improve the solubility, stability, and bioavailability of inorganic nanoparticles.

213 age of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors.

214 ron uptake in Caco-2 cells and the predicted bioavailability of iron from these breads with added iro

215 centrations of Fe(II) thereby increasing the bioavailability of iron in calcium-containing waters.

216 demonstrate that ceruloplasmin decreases the bioavailability of iron in urine by a transferrin-depend

217 There is evidence that the bioavailability of ivacaftor in the body may be influenc

218 However, the bioavailability of Lf is limited as it is susceptible to

219 GN was effective at reducing bioavailability of linear PAHs by approximately 70%, but

220 models to determine the bioaccessibility and bioavailability of lipophilic compounds.

221 gen (P < 0.001), evidencing lower peripheral bioavailability of meat amino acids with RM than with FC

222 alcium bioavailability among the groups, but bioavailability of nano-sized calcium carbonate-enriched

223 dimentary organic matter and demonstrate how bioavailability of natural organic substrates may affect

224 The unexpected anaerobic bioavailability of negatively charged halocomplexes may

225 adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.

226 training enhanced, rather than reduced, the bioavailability of OJ flavanones.

227 ity of citrus flavanones.We investigated the bioavailability of orange juice (OJ) (poly)phenols in en

228 e differences and whether they extend to the bioavailability of other dietary (poly)phenols remain to

229 PPAR-gamma signaling also limits the luminal bioavailability of oxygen by driving the energy metaboli

230 an important factor in determining the plant bioavailability of P in soils.

231 The potential bioaccessibility and bioavailability of phenolics, caffeine and antioxidant a

232 Also, the gastric and intestinal bioavailability of phenols is poorly known.

233 The bioavailability of polycyclic aromatic hydrocarbons (PAH

234 lls by competitively blocking the downstream bioavailability of PpIX.

235 Simulated bioavailability of reaction products (alpha-ZOL/ZEA-AITC

236 c Escherichia and Salmonella by reducing the bioavailability of respiratory electron acceptors to Ent

237 , sprouting and cooking on the stability and bioavailability of saponins in pulses is an important ar

238 biofilm components has implications for the bioavailability of selenium in the environment.

239 The determination of the cellular bioavailability of small-molecule inhibitors is a critic

240 S is a promising technique for assessing the bioavailability of soil heavy metals and related ecologi

241 ite to goethite, which thereby decreases the bioavailability of solid-phase Fe(III).

242 rties affecting the dissolution kinetics and bioavailability of soluble metal-based nanomaterials in

243 ctives and immunosuppressive components; the bioavailability of some bioactives may depend on unident

244 proven that micronization could improve the bioavailability of some drugs, so we've conducted this r

245 e key principles that contribute to the oral bioavailability of successful bRo5 compounds and improve

246 granular powder (GP) of SM could improve the bioavailability of tanshinones compared with traditional

247 combined with repeated injury, increased the bioavailability of TGFbeta, which promoted extracellular

248 ene (GN) in conjunction with determining the bioavailability of the adsorbed PAHs to Pimphales promel

249 without soil, to address differences in the bioavailability of the compounds.

250 w ProTide strategy was shown to enhance oral bioavailability of the corresponding monoester phosphora

251 PTEN in regulating the surface delivery and bioavailability of the deltaR, explain the low efficacy

252 l-world exposure scenarios must consider the bioavailability of the extracted PACs compared to those

253 y improving both pharmacokinetic profile and bioavailability of the HP-beta-CD agent.

254 ed to examine the protocol, and the cellular bioavailability of the inhibitors in cancer cells was de

255 lene was reduced by approximately 80%, while bioavailability of the larger PAHs was reduced by less t

256 d phytate content to determine the potential bioavailability of the micronutrients.

257 and also determines the bioaccessibility and bioavailability of the reaction products isolated and id

258 tes NPY-mediated signaling by increasing the bioavailability of the truncated form of NPY.

259 , thereby affecting the fate, transport, and bioavailability of these metals in both natural and engi

260 indirectly impede ER action by reducing the bioavailability of translational molecules needed for tu

261 CNTs were sensitive to molecular size, where bioavailability of two-ringed naphthalene was reduced by

262 These results indicate that changes in the bioavailability of VEGF-A sourced from ATII cells, namel

263 The bioavailability of was evaluated using the mysid America

264 Bioavailability of yerba mate phenolic compounds was ass

265 of a novel tracing technique to quantify the bioavailability of zinc (Zn) associated with natural par

266 cervate into sebum and, consequently, higher bioavailability on the skin surface.

267 ved mixture interactions could be related to bioavailability or by competition interactions, either f

268 x does not ensure their ready absorption and bioavailability, polyphenol potential bioavailability co

269 ed oxidant stress-based loss of nitric oxide bioavailability (post-capillary) and increased alpha1 -

270 ated the lead dissolution, thus changing the bioavailability processes (bioaccessibility) of particle

271 entions aimed at enhancing nitric oxide (NO) bioavailability remain a key area of interest in obstetr

272 macokinetic properties with 63% and 61% oral bioavailability, respectively, in rat.

273 ce the environmental relevance, particularly bioavailability, rises with decreasing particle size, th

274 oxidative stress and increased nitric oxide bioavailability; Sildenafil does not protect against fet

275 equivalence is evaluated through comparative bioavailability studies.

276 e established methodology is appropriate for bioavailability studies.

277 hat MeS pathological state modified flavanol bioavailability, supporting the hypothesis that flavanol

278 ly account for the parameters influencing Cu bioavailability than current hardness-based criteria.

279 Isoflavone aglycones show higher bioavailability than their glycosidic counterparts and t

280 lower BP was attributable to an increased NO bioavailability that dynamically dilated resistance vess

281 nsumption relative to a meal influences iron bioavailability.The aim of the study was to investigate

282 Mercury (Hg) bioavailability to bacteria in marine systems is the fir

283 I) oxide (CuO) nanoparticles (NPs) and their bioavailability to Gulf killifish (Fundulus grandis) emb

284 lexes of Hg(II) with DOM thiols have similar bioavailability to Hg(II) complexes with low-molecular-w

285 to U species (UO2(CO3)2(-2)) best predicts U bioavailability to L. stagnalis, challenging the free-io

286 Their bioavailability to mediate signaling in distributed tiss

287 o-primary outcomes in both studies were iron bioavailability (total and fractional iron absorption),

288 How zinc bioavailability triggers activation of SczA is unknown.

289 isease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxic

290 key problem is their short half-life and low bioavailability under in vivo conditions.

291 This, coupled with enhanced NO bioavailability, underpins differences in NO signaling i

292 ative to glucose (1mM) absorption, obtaining bioavailability values (5.1%) comparable to HPLC analysi

293 Bioavailability was assessed by the quantitative analysi

294 rogate marker of endothelial function and NO bioavailability, was evaluated using peripheral artery t

295 On the basis of potency and bioavailability, we selected a small molecule, SR-18292,

296 in the spectra influencing soil heavy metal bioavailability were identified and used in prediction m

297 i-restenotic natural drug but subject to low bioavailability when systemically administered.

298 B inhibitors, but these inhibitors lack oral bioavailability, which limits their potential for drug d

299 suppressed NP biodegradation by reducing NP bioavailability, while at high NP concentrations, modera

300 Pharmacokinetics in mice showed >90% oral bioavailability with sustained therapeutic serum levels