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1 tically, but many nNOS inhibitors are poorly bioavailable.
2 S inhibitors mimic l-arginine and are poorly bioavailable.
3 tors, which have the benefit of being orally bioavailable.
4 ustaining tumorigenesis and whether they are bioavailable.
5 the micelles and, therefore, were also more bioavailable.
6 ed in the eastern equatorial Pacific(30)) is bioavailable.
7 ACE inhibitory peptides that are potentially bioavailable.
8 The Caco-2 cell assay indicated that Fe is bioavailable.
9 potency, microsomal stability, and is orally bioavailable.
10 cterization of a series of selective, orally bioavailable 1-(chroman-4-yl)urea TRPV1 antagonists is d
11 arged species will sorb to soils and be less bioavailable; (2) many biocides are short-lived or degra
14 A positive correlation was observed between bioavailable 25-hydroxyvitamin D and LL-37 (Spearman rho
17 and safely improves 25-hydroxyvitamin D and bioavailable 25-hydroxyvitamin D levels in patients with
18 nts, blacks and whites had similar levels of bioavailable 25-hydroxyvitamin D overall (2.9+/-0.1 ng p
19 (30-82%), and 69% (55-106%) (p < 0.001); 2) bioavailable 25-hydroxyvitamin D, 4% (-8% to 7%), 45% (4
24 of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse
26 e apelin receptor, the development of small, bioavailable agonists and antagonists of the apelin rece
30 iation kinetics, which make the QS molecules bioavailable and at the same time secure within the extr
31 approach for the development of both orally bioavailable and bioactive cyclic N-methylated hexapepti
33 imidin-5(6H)-one was identified as an orally bioavailable and brain penetrating PDE1B enzyme inhibito
34 idines and phenylpyrimidines that are orally bioavailable and brain-penetrant without disruption of P
35 ne class of nNOS inhibitors, although orally bioavailable and brain-penetrant, suffer from unfavorabl
36 emonstrate that these antagonists are orally bioavailable and cause pronounced beta1-mediated reducti
37 imization effort identified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 r
38 the P retained in the engineered biochar was bioavailable and could be released equally at multiple s
41 ow phenolic compounds in cranberry juice are bioavailable and exert antioxidant actions in healthy ol
42 his multifunctional drug candidate is orally bioavailable and exhibits good antipsychotic efficacy in
43 lusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the
44 in their work was demonstrated to be orally bioavailable and fully protective in a MS disease animal
45 pound 8; the compound was found to be orally bioavailable and highly effective, leading to a reductio
46 utochthonous and allochthonous DOM is highly bioavailable and is transformed by resident microbial co
47 al ingredient and, in biscuits, it is highly bioavailable and lowers postprandial oxidised-LDL levels
51 6827443), is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective PAM with mi
53 rtant step in our efforts to develop stable, bioavailable, and selective inhibitors for the PADs.
54 e used a novel, potent, and selective orally bioavailable antagonist, LY2940094, to test the hypothes
55 a), a novel, selective, nonclassical, orally bioavailable antifolate with potent and specific inhibit
56 de that (1) pepstatin is a potent but poorly bioavailable antimalarial; (2) PfPARE is a functional es
59 the highly crystalline mineral magnetite are bioavailable as electron sinks and electron sources unde
63 show that the structurally novel and orally bioavailable BET inhibitor RVX2135 inhibits proliferatio
66 pharmaceutical production to favor the more bioavailable but metastable Form I with limits of detect
67 leased to the environment will not be highly bioavailable but will likely persist in soil for extende
68 al calcium content, had nearly twice as much bioavailable calcium than other GLVs, because of low fib
70 has identified significant concentrations of bioavailable carbon and iron in Greenland Ice Sheet (GrI
71 acid (N-acetylneuraminic acid [Neu5Ac]) is a bioavailable carbon and nitrogen source that is abundant
74 cant and preferentially degradable source of bioavailable carbon in Arctic freshwaters, which is like
75 vation has revealed the selective and orally bioavailable CCR1 antagonist BMS-817399 (29), which ente
77 NE-145) were identified as selective, orally bioavailable ChK1 inhibitors offering excellent in vitro
80 ntermediate filaments to maintain a pool of "bioavailable" complexes for polarized assembly during mi
81 reveal the presence of weak (and potentially bioavailable) complexes; but such measurements (particul
83 ce therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation a
84 I=0.92), while potentially bioaccessible and bioavailable compounds acted synergistically (CI=0.43 an
85 ow applicable underlying mechanisms are with bioavailable concentrations and biological half-life.
86 suggests that they are exposed to equimolar bioavailable concentrations of these elements in our stu
88 exposure models, including test conditions, bioavailable concentrations, mode of action, MNM product
90 and relative abundance of the dissolved and bioavailable constituents of biodiesel and petrodiesel i
92 aminopropyl carbazole, named P7C3, is orally bioavailable, crosses the blood-brain barrier, and is no
93 t of Cu in pore water rather than estimating bioavailable Cu from the various solid-phase ligands, wh
96 s been acknowledged as a potential source of bioavailable dissolved organic matter (DOM) to downstrea
99 g rift sediments alter deep-ocean budgets of bioavailable DOM, creating organic-rich habitats for ben
100 dimerization inhibitors that includes orally bioavailable drug candidates has been recently developed
101 ecylphosphocholine (HPC)] is the only orally bioavailable drug for the disease visceral leishmaniasis
103 scovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including
105 d lead resulting in AT-IAP, a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 and a st
106 ng and selection methods aimed at increasing bioavailable element content and improving crop growth.
111 oxidizable and residual fractions while the bioavailable (exchangeable) fraction accounted for up to
112 we present a novel application for measuring bioavailable exposure with silicone wristbands as person
115 onditions we identified auranofin, an orally bioavailable FDA-approved antirheumatic drug, as having
116 timately increases the amount of potentially bioavailable Fe delivered to oceans, while conditions in
117 rking of Fe in dust aerosol can increase the bioavailable Fe inputs to the ocean, yet the processes a
118 he facility were enriched in Ra and had high bioavailable Fe(III) concentrations relative to upstream
122 the feeding regime, which could make MWCNTs bioavailable for organisms at higher trophic levels.
125 nt mode of converting hydrothermal iron into bioavailable forms that can be dispersed throughout the
127 the GI phase suffices for assessment of the bioavailable fraction as a result of the fast immobiliza
128 ignature of wines is strongly related to the bioavailable fraction of the soil rather than to its bul
129 he use of Sr isotope composition in the soil bioavailable fraction, as assessed by 1mol/L NH4NO3, to
131 vy metal biosensor for the quantification of bioavailable free heavy metals in the cytoplasm of the m
134 camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able
135 (PPS) is a glycan derivative that is orally bioavailable, has few toxic side effects, and is current
137 ly produced MeHg is important to identifying bioavailable Hg in natural systems and the interpretatio
138 drological fluxes of methylmercury (MeHg), a bioavailable Hg species of ecological and health concern
142 evidence that enteric-coated (EC) calcium is bioavailable in pregnant women and to explore the dose-r
144 gen fixation and suggest that molybdenum was bioavailable in the mid-Archaean ocean long before the G
146 s studied except for Fe, between the content bioavailable in the soil and the accumulated in both lea
147 r quantitatively, they are considerably less bioavailable in vegetarian diets, which suggests the nee
148 and the iron in the white flour fraction was bioavailable in vitro, suggesting that food products mad
149 a show that FeSO4 and nanoFe(3+) are equally bioavailable in WT mice, and at wk 8 the mean +/- SEM he
150 istry optimization resulted in 83, an orally bioavailable inhibitor molecule with remarkable selectiv
152 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity
156 report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with
158 of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to
163 I-838 is a clinically well-tolerated, orally bioavailable, investigational prodrug that delivers to t
164 This can deliver substantial amounts of bioavailable iron and contribute to the fertilization of
167 ing of staple crops to accumulate additional bioavailable iron in edible parts, thus improving the ir
168 b-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia.
169 drug administration, and improved intake of bioavailable iron, coupled with health and nutritional e
172 ght to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against
175 eversible inhibition by ibrutinib, an orally bioavailable kinase inhibitor that has shown outstanding
176 pecific biokinetic slope factors, we related bioavailable lead from these sources to children's blood
177 lved via medicinal chemistry to yield orally bioavailable leads with potent anti-T. cruzi activity in
178 ted solely by a pharmacologically inert, but bioavailable, ligand (clozapine-N-oxide; CNO), while bei
181 mall molecule is a potent, selective, orally bioavailable, mechanism-based irreversible inactivator o
182 ies and yield a new potent and highly orally bioavailable Mer inhibitor, 11, capable of inhibiting Me
184 treatment, despite the lack of difference in bioavailable metal fractions, metal oxidation state, and
188 Y2934747), a novel, potent, and systemically bioavailable mGlu2/3 receptor agonist which exhibits bot
194 l describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG
196 ntileukemic effects of merestinib, an orally bioavailable multikinase inhibitor with suppressive effe
197 minated by a highly reactive and potentially bioavailable nanoparticulate suspended sediment fraction
198 en human-like Neu5Gc-deficient mice were fed bioavailable Neu5Gc and challenged with anti-Neu5Gc anti
199 icient mice immunized against Neu5Gc and fed bioavailable Neu5Gc developed a much higher incidence of
200 e invention of MLN9708 (ixazomib), an orally bioavailable next-generation proteasome inhibitor with i
201 e discovery of potent, selective, and orally bioavailable NHE3 inhibitors with 13d as best compound,
202 hemeridae) was reduced in sites with greater bioavailable Ni, but accounting for Fe oxide-bound Ni gr
205 ial sodium channel activation, reductions in bioavailable nitric oxide, increased vascular remodeling
208 fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; ho
210 e fashion, and although oil does not provide bioavailable nitrogen, phosphorus or iron, there are eno
211 Biological N2 fixation is a major input of bioavailable nitrogen, which represents the most frequen
213 mpound 2 represents a first-in-class, orally bioavailable, novel compound that offers potential for t
214 tory mucins represent a potentially abundant bioavailable nutrient source, although we have recently
215 90 Tonnes.yr(-1), the recycling of primarily bioavailable nutrients by fish plays an important role r
217 e sediments harbored large concentrations of bioavailable organic carbon that fueled anaerobic microb
218 We show that acidification can increase bioavailable P deposition over large areas of the globe,
219 osphorus when it becomes scarce, contributes bioavailable P for primary production, and supports the
222 a significant, long-term source of in-stream bioavailable P that contributes to a legacy of wildfire
223 ss mobility in the environment and with less bioavailable P to algae in comparison to the soluble cou
226 the identification of potent, selective, and bioavailable PAD inhibitors that can be used to elucidat
228 tributary inputs contained higher levels of bioavailable particulate P (NAIP) - these effects were a
231 cles can dramatically increase the amount of bioavailable phosphorus (P) deposited on the surface oce
233 ation for food crops can lead to presence of bioavailable phthalic acid esters (PAEs) in soils, which
236 scovery of two potent, selective, and orally bioavailable PI3Kdelta inhibitors, 1 (AM-8508) and 2 (AM
237 scovery of two potent, selective, and orally bioavailable PI3Kdelta inhibitors, 6a (AM-0687) and 7 (A
241 ration, and selectively protecting otherwise bioavailable, reduced organic compounds such as lipids a
243 idence of so far unreported depletion of the bioavailable Se pool, a plausible driving mechanism of d
244 ibe GDC-0810, a novel, non-steroidal, orally bioavailable selective ER downregulator (SERD), which wa
246 The discovery and development of orally bioavailable SERDs provide the opportunity to evaluate t
247 zation of a series of small-molecule, orally bioavailable SERDs which are potent antagonists and degr
248 ing support for the determination of free or bioavailable sex steroid concentrations in medicine, and
250 onsumer products is predicted to be low, and bioavailable silver is expected to be in ionic rather th
251 roup previously developed a series of orally bioavailable small molecule activators of PP2A, termed S
252 characterization of GDC-0994 (22), an orally bioavailable small molecule inhibitor selective for ERK
253 port the development of highly selective and bioavailable small molecule IRAK4 inhibitors, ND-2158 an
254 was realized with the approval of the orally bioavailable small molecule PI3Kdelta inhibitor idelalis
256 the development of highly potent and orally bioavailable small-molecule inhibitors of the menin-MLL
257 diaryl ureas are described as potent, orally bioavailable small-molecule P2Y1 antagonists with improv
258 igated by examining the effects of an orally bioavailable, small molecule p75NTR ligand, LM11A-31, on
265 s mainly present as selenomethionine, a good bioavailable source of selenium, which accounted for 73%
268 Here, we describe a water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, that tri
272 discovery of 45h as a potent, selective, and bioavailable TGR5 agonist to test in preclinical metabol
273 lk and aqueous forms were significantly more bioavailable than (68)ZnO NPs (p < 0.05), but after corr
274 obalamin is several orders of magnitude less bioavailable than cobalamin to several B12-dependent mic
275 metal sulfide phases were considerably less bioavailable than metal contaminants introduced to sedim
282 nents therefore should be considered readily bioavailable to aerobic, siderophore-producing microorga
283 d show that physically separated FLU becomes bioavailable to bacteria after transport by mycelia.
284 and can provide useful predictions of metal bioavailable to benthic organisms in dynamic sediment en
285 Overall, sediment-bound Cs is sufficiently bioavailable to deposit-feeding polychaetes, and macrofa
292 lts showed that Hg(II) was considerably more bioavailable under nonequilibrium conditions than when D
295 otics decreases miR-204, increases Sirt1 and bioavailable vascular nitric oxide, and improves endothe
299 ed water fortified with a low dose of highly bioavailable zinc is an effective intervention in childr
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