ライフサイエンスコーパス: biochemical

1 Regulation of RECQL4 biochemical activities by RPS3 along with nuclear intera

2 By comparing the biochemical activities of different tau mutations with t

3 Together, these findings suggest that biochemical activities of the cell are spatially organiz

4 ion via changes in gene expression and other biochemical activities to regulate physiological respons

5 In this Review, we summarize the biochemical activities, host cell interaction partners,

6 plex, independent of catalysis, and that its biochemical activity in septum formation can be provided

7 chanisms for rescuing cell division when the biochemical activity of PBP 2B is perturbed evolved prio

8 these peptides as substrates, we confirm the biochemical activity of the protease in propeptide remov

9 inflammation produce complex structural and biochemical alterations to the lung known to impact work

10 Biochemical analyses and immunohistochemical techniques

11 At the end of treatment, morphological and biochemical analyses assessed the effects of these compo

12 in group 1 continued to have weight gain and biochemical analyses comparable to wild-type pigs.

13 Structural, mutational, and biochemical analyses confirmed the enzyme adopts a fold

14 f phylogenetic analyses, gene silencing, and biochemical analyses coupled with structural elucidation

15 Furthermore, biochemical analyses demonstrate that Daam2 associates w

16 Genetic and biochemical analyses demonstrated that SepA-related indu

17 Our biochemical analyses reveal that Baf200 forms at least t

18 Biochemical analyses reveal that, in this context, Drosh

19 Comparative bioinformatics, mutagenesis, and biochemical analyses revealed that the highly conserved

20 Structural and biochemical analyses revealed that UbVs specifically inh

21 urrent study sought to use computational and biochemical analyses to characterize decision-making pro

22 Biochemical analyses using (14)C-PA as a substrate demon

23 eles, live-cell spindle assays, and in vitro biochemical analyses, we show that She1 is required for

24 Here, we describe a thorough molecular and biochemical analysis of a mutant FOS protein we identifi

25 , mouse embryonic stem cells, and Drosophila Biochemical analysis of BRWD2 demonstrated an associatio

26 Biochemical analysis of C-RPS3 revealed that it comprise

27 Biochemical analysis of cortical extracts from behaviora

28 Here, we report a biochemical analysis of the ASK1 kinase domain in conjun

29 d to nonantigenic lipids, followed by direct biochemical analysis of the lipid antigens trapped at th

30 Our structure and biochemical analysis of this enzyme reveals its activati

31 Biochemical analysis of WRN protein purified from TT lym

32 Biochemical analysis revealed that carotenoids are absen

33 In addition, biochemical analysis reveals that RPA serves to stimulat

34 mers together at the base of the trimer, and biochemical analysis suggests that it neutralizes by inh

35 Biochemical analysis suggests that this defect is multil

36 increasingly important role in chemical and biochemical analysis.

37 2-ol (alkynol) moiety was important for both biochemical and antimicrobial activity.

38 Here, we review the underlying biochemical and biologic basis for a variety of PET trac

39 in order to spatially and temporally analyze biochemical and biomechanical drivers of angiogenesis in

40 This method can be widely applied in biochemical and biomedical research and provide insights

41 Biochemical and biophysical methods were used to determi

42 were compared with results from conventional biochemical and cefoxitin disk methods performed at an i

43 However, the long biochemical and cellular prodromal phases of the disease

44 the ADAM10 ectodomain, which, together with biochemical and cellular studies, reveals how access to

45 PCOS women with both biochemical and clinical hyperandrogenism as opposed to

46 assessment of adenine-based inhibitors using biochemical and docking methods.

47 Biochemical and electrophysiological experiments demonst

48 The biochemical and evolutionary mechanisms that underlie th

49 ls a mechanism that integrates intracellular biochemical and extracellular mechanical signals into su

50 Using biochemical and fluorescence imaging analyses, we show t

51 Biochemical and functional analyses reveal that Fxr1 is

52 s knowledge gap, we sought to understand the biochemical and functional properties of the structurall

53 olved in invasion have been identified using biochemical and genetic approaches including specific kn

54 work provides a structural basis to explain biochemical and genetic data on the importance of B-subu

55 Biochemical and genetic evidence implicate soluble oligo

56 In addition, several biochemical and genetic studies have indicated an inhibi

57 Results of biochemical and genetic tests were explored for associat

58 Biochemical and immunohistochemical analyses confirmed t

59 of m1G9 methylation by Trm10, we performed a biochemical and kinetic analysis of Trm10 and variants w

60 Interestingly, biochemical and mass spectrometry analyses also showed t

61 tains tissue separation independently of the biochemical and mechanical features of the local tissue

62 The biochemical and mineral compositions of the curds and th

63 Therefore, we performed a detailed biochemical and molecular study of all KIM-PTP family me

64 ck transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defects caused by protei

65 us suggesting barrier restoration has both a biochemical and physical component, and both are necessa

66 ges its architecture and size in response to biochemical and physical cues.

67 ic phosphate (Pi) levels is critical to most biochemical and physiologic processes.

68 Additional biochemical and physiological adaptations to land, and a

69 algal blooms, but little is known about the biochemical and physiological changes associated with ce

70 This comprehensive review describes the biochemical and structural characterization of the ARD f

71 ome's multistep ATP-dependent mechanism, its biochemical and structural features that ensure efficien

72 Here we use biochemical and structural methods to show that two mole

73 Here, through a biochemical and structural screening paradigm, we have i

74 tein biogenesis continue to be elucidated by biochemical and ultrastructural investigations.

75 mice, we examined the electrophysiological, biochemical, and behavioral effects of 2-AG deficiency b

76 lga from which they inherited developmental, biochemical, and cell biological attributes.

77 Collectively, our structural, biochemical, and cell biological data suggest that multi

78 Recent research at the genetic, biochemical, and chemical levels has unearthed a broad r

79 We report here structural, biochemical, and functional studies on the inhibition of

80 We investigated the physical, biochemical, and immunological components of retinal inj

81 Functional, biochemical, and morphological characterization revealed

82 cation site by a combination of structural, biochemical, and spectroscopic approaches.

83 Using a recently developed biochemical approach for detecting m(6)A, the researcher

84 A combined genetic, cellular, and biochemical approach supports that some of the tested ba

85 We have also developed a biochemical approach to define candidate transcripts tha

86 Here, we present a biochemical approach to investigate the internal subunit

87 Using a comprehensive genetic and biochemical approach, we have delineated the physiologic

88 ains unclear, crystal structure analyses and biochemical approaches have revealed critical features o

89 Using biochemical approaches we identify a nucleosome interact

90 Using genetic and biochemical approaches, we show that charged residues in

91 Combining metabolomics, plant genetics and biochemical approaches, we show that transgenic BAR inde

92 cardiomyopathy (DCM) mutants were studied by biochemical approaches.

93 Biochemical as well as functional experiments revealed t

94 ber-optic probe (for the case of oxygen) and biochemical assays (for glucose and lactate).

95 these genes using a combination of in vitro biochemical assays and heterologous expression in planta

96 ses of APDS mutations using a combination of biochemical assays and hydrogen-deuterium exchange mass

97 ANT-GTPgammaS binding, thermal denaturation, biochemical assays and sequence homology analysis all st

98 Subsequent biochemical assays identified two candidate compounds wi

99 Biochemical assays revealed Abl phosphorylates Mical to

100 Biochemical assays show direct, substrate-independent co

101 Biochemical assays show that both a conserved surface on

102 By combining site-directed mutagenesis, biochemical assays, and spectroscopic analyses, we show

103 tructure of the CPSF160-WDR33 subcomplex and biochemical assays, we define the molecular architecture

104 and attractive for the control of integrated biochemical assays.

105 r (C6706) V. cholerae biotypes in growth and biochemical assays.

106 Biochemical assessment of iron status relies on serum-ba

107 The biochemical basis for this unprecedented mechanism of si

108 For these reasons, and to establish a solid biochemical basis on which to begin to model its actions

109 In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggeste

110 In this article, we describe a particular biochemical-biomechanical network based on the microtubu

111 e-organism C. elegans coupled with versatile biochemical, biophysical, and genetic tools, we provide

112 st we may be drastically underestimating the biochemical capabilities, strategies and diversity of sy

113 The objective of this study was to evaluate biochemical changes associated with cell death and impac

114 mpound 71 (PF-05085727) that effects in vivo biochemical changes commensurate with PDE2A inhibition a

115 Viability was assessed with reference to biochemical changes in the perfusate.

116 t involves a succession of physiological and biochemical changes reflecting the transcriptional modul

117 Selenbp1-knockout mice showed biochemical characteristics similar to those in humans.

118 hrough analysis of their sensory attributes, biochemical characteristics, microbial population and fl

119 s report, we describe the identification and biochemical characterization of a thiolase-ketoreductase

120 As a proof of concept, we performed a biochemical characterization of LipA from Xac306 and ver

121 Biochemical characterization of orthologs along the phyl

122 and serve as a "translation method" for the biochemical characterization of receptor-ligand interact

123 The biochemical characterization of the L. major phosphatase

124 Here we report a detailed biochemical characterization of the MsrQ protein from Es

125 Biochemical characterization of the recombinant purified

126 Comprehensive molecular and biochemical characterization of the resulting lines expr

127 Biochemical characterization of these variants revealed

128 In line with this structural similarity, biochemical characterization of this effector, termed Tn

129 Biochemical circuits made of rationally designed DNA mol

130 The structural and biochemical comparison of these enzymes suggests key det

131 A biochemical complementation assay was developed to show

132 to greatly advance our understanding of this biochemical complexity.

133 ulting in swelling and associated changes in biochemical composition and physiology.

134 the effect of 100 mus electric pulses on the biochemical composition of live cells using a label-free

135 nalyzed its conformations under 10 different biochemical conditions using negative stain single-parti

136 Using proteomics and direct biochemical confirmation, we found that Cdc48 serves as

137 To assess the functional and biochemical consequences of this variant, we generated t

138 aint-based metabolic modelling, physical and biochemical constraints define a polyhedral convex set o

139 ortant regulatory deacylases in a variety of biochemical contexts and may therefore be potential ther

140 surface we propose merging topographical and biochemical cues on the surface of a clinically relevant

141 Biochemical data indicated that this mutation impairs la

142 Biophysical and biochemical data on WRC mutants confirm that Rac1 binds

143 xtracting important information from complex biochemical data sets.

144 Biochemical data show that the mutations associated with

145 Biochemical data shows that several of the cancer-associ

146 Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem

147 spectrometry with cryo-EM, computational and biochemical data, we investigate the oligomeric formatio

148 WRC previously identified by mutagenesis and biochemical data.

149 how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that bo

150 fficient to rescue keratinocyte adhesion and biochemical differentiation in these mice.

151 berrant urea metabolism could be the primary biochemical disruption initiating neuropathogenesis in H

152 his establishes a foundation for genetic and biochemical dissection of the perception and the downstr

153 Here, we utilize biochemical, electrophysiological, and behavioral measur

154 tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network re

155 133 targeted chemicals was determined using biochemical endpoints, exposure activity ratios for biol

156 fying CS-glycopeptides with a combination of biochemical enrichment, enzymatic digestion, and nano-sc

157 lts demonstrate an approach to study dynamic biochemical events in vivo.

158 Many biochemical events occur inside grains during post-harve

159 mination of the Psb28 binding site and other biochemical evidence allow us to propose a mechanism by

160 Genetic and biochemical evidence supporting CATALASE2 as a salicylic

161 controls 24 hours post injection, providing biochemical evidence that inhibition of apoptotic activi

162 provide molecular, genetic, cytological, and biochemical evidence that the Mex67-Mtr2 (TAP-p15) heter

163 crystallography, SAXS and EM, together with biochemical evidences, here we show that the three domai

164 Genetic and biochemical experiments consistently demonstrated that t

165 Genetic and biochemical experiments have found that increased modifi

166 A series of biochemical experiments indicated that these miniprotein

167 In conclusion, we provide a biochemical explanation for the cooperation between p16

168 ct was greater in the group of patients with biochemical failure after definitive surgery or radiatio

169 simultaneous assessment of morphological and biochemical features of coronary vessels in vivo.

170 w nanoscale materials with precisely defined biochemical features, and emerging analytical techniques

171 have novel biosynthetic pathways and unknown biochemical features.

172 A combined metabolomic, biochemical, fluxomic, and metabolic modeling approach w

173 Discovery of these proteins by traditional biochemical fractionation can be plagued with contaminan

174 Co-immunoprecipitation and biochemical fractionation data suggested that p75 TM sti

175 A conserved biochemical function of the CST complex is its primase-P

176 mic, manipulate, and measure biophysical and biochemical function within the plasma membrane of livin

177 Histological, immunohistochemical, biochemical, functional, and behavioral analyses were pe

178 stage-specific expression, and characterized biochemical functions in vitro and in vivo.

179 outside the plastid), 122 proteins awaiting biochemical/genetic characterization, and 228 proteins f

180 Overproduction of catecholamines is the biochemical hallmark of pheochromocytoma (PCC) and parag

181 characterization of CTL function provides a biochemical handle for understanding the relationship be

182 nd complex system, we carried out mutagenic, biochemical, hydrodynamic and structural studies using a

183 However, biochemical hypoglycaemia also was increased in the stud

184 nary exploration resulted in compound 2 with biochemical IC50 = 160 nM.

185 etal density, we conclude that there must be biochemical influences that probably include binding of

186 irst 200 mum of the intima provide important biochemical information that can supplement IVUS data fo

187 adjudicated using all available clinical and biochemical information without knowledge of cMyC.

188 Structural and biochemical insights confirmed the potential of pathway

189 Here, we used biochemical insights into CARD9 variant proteins to crea

190 and Simmune use "reaction rules" to specify biochemical interactions compactly, where each rule spec

191 Here we present a biophysical and biochemical interrogation of the structure of the full l

192 for evaluating intracellular redox states in biochemical investigations.

193 components and therefore can be used in any biochemical laboratory having access to a mass spectrome

194 nguishable from Columbia-0 at phenotypic and biochemical levels, whereas the ndufs8.1 ndufs8.2 double

195 This is supported by biochemical ligand-receptor interaction assay data.

196 Biochemical markers can also help in screening patients

197 and to identify the associated clinical and biochemical markers of AKI.

198 Conventional biochemical measurements are used to ascertain the effec

199 cells is based on a biophysical as well as a biochemical mechanism.

200 The structural and biochemical mechanisms by which EBNA1 allows the long-te

201 ractome of RNA modifications and reveals the biochemical mechanisms underlying m(6)A function in the

202 However, the biochemical mechanisms underlying these double alteratio

203 n also facilitate elucidation of fundamental biochemical mechanisms within these systems.

204 ated complexes, which, in concert with other biochemical/medical considerations, should provide benef

205 Here, we developed a biochemical method (SITE-Seq), using Cas9 programmed wit

206 fide and subsequent SU release from Env with biochemical methods and found that this early activation

207 In this study, in vitro biophysical and biochemical methods were utilized to elucidate the mecha

208 Epigenetics is the study of biochemical modifications carrying information independe

209 Using biochemical, molecular biology, immunostaining and trans

210 Here, we report combined bioinformatic, biochemical, mutational, and X-ray crystallographic stud

211 Structure-guided biochemical, mutational, computational, and binding stud

212 conservation in Ras depends strongly on the biochemical network in which it operates, providing a fr

213 iable and tractable sampling of genome-scale biochemical networks.

214 stration resulted in significant reversal of biochemical, neuropathological, neurophysiological, and

215 Biochemical noise significantly diminishes the fidelity

216 e possibility to combine the high-throughput biochemical or living cell screenings using the droplet

217 e link between our findings and the emerging biochemical or physiological mechanisms involved.

218 of cell death does not share morphological, biochemical, or genetic similarities with classic necros

219 on, definitive treatment, and pathologic and biochemical outcomes after delayed radical prostatectomy

220 h total coliforms, E. coli, enterococci, and biochemical oxygen demand (Kendall's tau = 0.348 to 0.60

221 significant effects on the physiological and biochemical parameters were varied.

222 single bacterial protein drives a multistep biochemical pathway to control ubiquitination and tubula

223 well beyond fatty acid oxidation, regulating biochemical pathways associated with amino acid metaboli

224 ive disorders suggests that disease-affected biochemical pathways can be characterized by the presenc

225 y annotate relevant features and map them to biochemical pathways is hampering the full exploitation

226 lites are indicative of changes in important biochemical pathways such as vitamin metabolism, the cit

227 y key roles in directing metabolic fluxes of biochemical pathways, as well as large, assembly-line ty

228 nism behind these shape fluctuations, we use biochemical perturbations.

229 oint to the criticality of understanding the biochemical phenomena involved with cytoskeleton/membran

230 eficiency and GMDS deletion produce the same biochemical phenotype of GDP-fucose deficiency.

231 tracellular target engagement, compared with biochemical potency measurements alone.

232 an age, 70.4 years; range, 58-82 years) with biochemical primary hyperparathyroidism and inconclusive

233 for a coactivator sequential recruitment and biochemical process in ER-mediated transcription.

234 jury (TBI) involves a combination of complex biochemical processes beginning with the initial insult

235 this article, we have incorporated multiple biochemical processes describing the CCL19-CCL21-CCR7-AC

236 ers and cofactors that help regulate diverse biochemical processes such as transcription and hormone

237 suggest that temperature acclimation of the biochemical processes that underlie plant carbon exchang

238 unctions, thus confirming their roles in the biochemical processes underlying plant growth.

239 hanistic integrations of these peptides into biochemical processes.

240 Biochemical profiling was conducted to confirm a CDG typ

241 rostate cancer, associating alterations with biochemical progression.

242 e HMR, which begins from Lys-58, retains its biochemical properties in phytochrome signaling.

243 ly in RTs that may contribute to distinctive biochemical properties of group II intron RTs, and it pr

244 ndividual lymphocytes, the morphological and biochemical properties of the cells are quantitatively r

245 long-running avenues of research, namely the biochemical properties of the PcG/TrxG system and the ap

246 In light of the cellular location and the biochemical properties of the two characterized beta-man

247 These biochemical properties suggest that CARMILs play a varie

248 oduced by the kidney tubule and has specific biochemical properties that mediate important functions

249 Biochemical reaction networks (BRNs) in a cell frequentl

250 of mineral surfaces in mimicking aspects of biochemical reaction pathways.

251 without detailed knowledge of the underlying biochemical reactions.

252 Using a combination of biochemical reconstitution and mammalian cell culture, w

253 management of prostate cancer patients with biochemical recurrence (BCR).

254 genes were less likely to be associated with biochemical recurrence (P = 0.028).

255 We examined 191 consecutive patients with biochemical recurrence according to standard acquisition

256 and risk of definitive treatment or risk of biochemical recurrence after delayed RP.

257 disease in 25% of patients and for restaging/biochemical recurrence in 75% of patients.

258 linicopathologic prognostic factors (10-year biochemical recurrence-free survival [bRFS], 29%; distan

259 prospectively evaluated 50 PCa patients with biochemical relapse after surgery or external-beam radia

260 ate cancer (PCa) recurrence in patients with biochemical relapse.

261 Here, we report biochemical results that better define the properties of

262 The remaining hematologic and biochemical results were normal.

263 is paralleled in the many physiological and biochemical roles that CAs play in plants.

264 , nanoscale assembly, fluidics, and chemical/biochemical sensing.

265 to translating field effect transistors into biochemical sensor platforms is the requirement of a gat

266 eractions between proteins and a plethora of biochemical signaling events based on the development of

267 avior when in groups, even in the absence of biochemical signaling.

268 atially and temporally precise modulation of biochemical signals within growth cones.

269 in the conversion of mechanical forces into biochemical signals.

270 By tracking biochemical species within the cell, our model enables p

271 t for actin-activated phosphate release, the biochemical step in myosin's ATPase cycle associated wit

272 provide a comprehensive view of the genetic, biochemical structural, and serological bases of serotyp

273 8F, I548F, and M629P) for more comprehensive biochemical, structural, and antigenicity analyses.

274 By using biochemical, structural, and biophysical methods, we pre

275 ies of these compounds were compared through biochemical, structural, and calorimetric studies, showi

276 tabolomics data, methods for elucidating the biochemical structure and function of novel metabolites,

277 Further biochemical studies establish that coordination of Ni(II

278 Previous biochemical studies have demonstrated that in the presen

279 Although recent structures and biochemical studies of RNA bound exosomes from S. cerevi

280 Here, we report through crystallographic and biochemical studies that K-80003 binds to and stabilizes

281 rystal structure of GS-5745.MMP9 complex and biochemical studies to elucidate the mechanism of inhibi

282 roposed to anchor Tim44 to the membrane, but biochemical studies with MB-10 show that this region is

283 Our biochemical studies, using recombinant Delta22 (a versio

284 city of the proteins identified by combining biochemical subcellular fractionation to the protein iso

285 artz crystal microbalance (QCM) for studying biochemical surface reactions.

286 r control of metabolic pathways for improved biochemical synthesis.

287 yzed (EH), and one amino acid formula, using biochemical techniques and specific antibody probes was

288 In this study we used a combination of biochemical techniques and transmission electron microsc

289 olecules and their interactions, but current biochemical techniques detect only a single proximity pa

290 Biochemical techniques probed the mechanism of inhibitio

291 signs and volume status; availability of key biochemical testing; adequate staffing ratios; and avail

292 binant FplA constructs, we have identified a biochemical toolbox that includes lipid substrates for e

293 used a combination of molecular imaging and biochemical tools to study the properties of the BRCA1 i

294 However, recent advances in genetic and biochemical tools, development of high-resolution micros

295 ce for the dissection of many biological and biochemical traits and also provides important insights

296 Recent advances in the mapping of biochemical traits have been reported in Lolium perenne.

297 hemists and modellers to identify models for biochemical transformation pathways, being a prominent e

298 Biochemical ubiquitination reactions identified two site

299 brane oxygenation mechanical ventilation and biochemical variables, inotrope requirements, extracorpo

300 Such biochemical wall heterogeneities precede wall bending.