ライフサイエンスコーパス: biochemical approach

1 used a combined bioinformatics, genetic and biochemical approach.

2 ing a combined immunoelectron microscopy and biochemical approach.

3 thway and demonstrate the usefulness of this biochemical approach.

4 ice, in combination with pharmacological and biochemical approaches.

5 oited therapeutically using both genetic and biochemical approaches.

6 in situ proximity ligation assay (PLA), and biochemical approaches.

7 .14.99) was studied using genetic, cell, and biochemical approaches.

8 ogenesis using a variety of cell biology and biochemical approaches.

9 of the human PLC using both biophysical and biochemical approaches.

10 functions using a combination of genetic and biochemical approaches.

11 s for these differences using structural and biochemical approaches.

12 lectron microscopic immunohistochemistry and biochemical approaches.

13 ct analysis of specific genes by genetic and biochemical approaches.

14 ument, and envelope layers using traditional biochemical approaches.

15 hese pathways with complementary genetic and biochemical approaches.

16 EJ by a combination of molecular genetic and biochemical approaches.

17 n of physiological, structural, genomic, and biochemical approaches.

18 ing activity by using different cellular and biochemical approaches.

19 been possible with traditional fixed-cell or biochemical approaches.

20 rized in petunia through reverse genetic and biochemical approaches.

21 important biosynthetic enzymes by classical biochemical approaches.

22 as long been pursued by reverse genetics and biochemical approaches.

23 -43(A315T) mice using a battery of tests and biochemical approaches.

24 st a library of CTLA-4 mutants and by direct biochemical approaches.

25 function has primarily been studied through biochemical approaches.

26 gth ABC transporter ABCC1/MRP1 using several biochemical approaches.

27 thylphenidate (MPD) are using behavioral and biochemical approaches.

28 NB/DYRK1A using a combination of genetic and biochemical approaches.

29 basis using a combination of microarray and biochemical approaches.

30 break repair by a combination of genetic and biochemical approaches.

31 initiation of DNA replication by genetic and biochemical approaches.

32 have been conducted exclusively by in vitro biochemical approaches.

33 F-1-H3/H4 architecture using biophysical and biochemical approaches.

34 potheses that can be tested using genetic or biochemical approaches.

35 s were examined using cell physiological and biochemical approaches.

36 ice was investigated using pharmacologic and biochemical approaches.

37 a combination of genetic, physiological, and biochemical approaches.

38 was further reinforced through cellular and biochemical approaches.

39 cardiomyopathy (DCM) mutants were studied by biochemical approaches.

40 models and combining genetics, genomics, and biochemical approaches.

41 ing morphological, electrophysiological, and biochemical approaches.

42 asses are still being discovered by targeted biochemical approaches.

43 n combination with other cell biological and biochemical approaches, a robust and streamlined strateg

44 Here, using molecular genetics and biochemical approaches, a series of hypotheses was teste

45 Despite numerous attempts, largely involving biochemical approaches, a specific interaction between P

46 stal structures provide stunning snap shots, biochemical approaches addressing the dynamics have prov

47 A combination of bioinformatic and biochemical approaches allowed identification of phage p

48 sociation with Golgi enzymes, as detected by biochemical approaches and 3D Structured Illumination Mi

49 eir impact on the transport cycle of SERT by biochemical approaches and by electrophysiological recor

50 Here, we use a variety of biochemical approaches and compare histone-based substra

51 Using biochemical approaches and electron microscopy, we show

52 Combining biochemical approaches and in vitro bioassays, we found

53 Here we show using super-resolution imaging, biochemical approaches and in vivo models that the trans

54 Using biochemical approaches and reverse transcriptase-polymer

55 Using a combination of biochemical approaches and various mutant Fis proteins,

56 the hrpS promoter region, using genetic and biochemical approaches, and show how it integrates vario

57 Through biochemical approaches as well as Atomic Force Microscop

58 We used biochemical approaches as well as fluorescence resonance

59 Using biochemical approaches, as well as confocal microscopy,

60 Using unbiased proteomic and targeted biochemical approaches, as well as two independent metho

61 Using a combination of genetic and biochemical approaches, both in vivo and in vitro, we id

62 In some cases, biophysical and biochemical approaches can provide important complementa

63 fer studies were complemented with a classic biochemical approach: coimmunoprecipitation.

64 Using several biochemical approaches combined with functional analysis

65 Using biochemical approaches combined with time-lapse microsco

66 AP complex as well as additional genetic and biochemical approaches confirmed that DksA binds to the

67 mass spectroscopic, molecular modeling, and biochemical approaches confirms that electrophile-protei

68 etwork at the CR and its function, we used a biochemical approach coupled to proteomics to identify a

69 Serendipitously, using a biochemical approach coupled with mass spectrometry, we

70 Genetic and biochemical approaches coupled with functional assays in

71 ble.Significance: Combined computational and biochemical approaches demonstrate that the BAP1-ASXL2 i

72 In this study, several biochemical approaches demonstrated that activated Galph

73 Despite biochemical approaches describing the physiological acti

74 By using electrophysiological and biochemical approaches, diverse mechanisms that dynamica

75 Several biochemical approaches exist to profile DNA methylation,

76 Expression profiling and biochemical approaches exposed the canonical E2F3a activ

77 explain the discrepancies reported in prior biochemical approaches focused on quantitating the traff

78 e the role of PI/TRP interactions, we used a biochemical approach, focusing on TRPC6.

79 Using a recently developed biochemical approach for detecting m(6)A, the researcher

80 Here, we review the use of different biochemical approaches for biological synthesis of circu

81 tegy that outperforms existing cell-based or biochemical approaches for identifying CRISPR-Cas9 genom

82 Herein we discuss five biochemical approaches for isolating and characterizing

83 tially useful tool for combining genetic and biochemical approaches for the study of chloroplast prot

84 Here, we purified EVs using straightforward biochemical approaches from multiple cancer cell lines a

85 A series of biochemical approaches further established that SycP spe

86 ith pharmacological, immunocytochemical, and biochemical approaches further suggest that, in the adul

87 Biochemical approaches have allowed the identification o

88 ntifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent, but

89 Genetic or biochemical approaches have been used to generate these

90 Biochemical approaches have been used to pair pathway pr

91 Genetic and biochemical approaches have clarified several aspects of

92 Although classical genetic and biochemical approaches have identified hundreds of prote

93 ves LysM domain receptor-like kinases, while biochemical approaches have identified LECTIN NUCLEOTIDE

94 Traditional biochemical approaches have only identified the possible

95 ains unclear, crystal structure analyses and biochemical approaches have revealed critical features o

96 Past studies using biochemical approaches have revealed minor kinetic diffe

97 Using an unbiased biochemical approach, however, we have identified a nove

98 In this study, a biochemical approach identified the SH2 domain-containin

99 is in FLVCR1-defient animals via genetic and biochemical approaches improved the anemia, implying tha

100 We utilized flow cytometry and biochemical approaches in combination with lifted whole

101 AT-6 and established the utility of rigorous biochemical approaches in dissecting the virulence of M.

102 Here we present a novel biochemical approach, in vivo click selective 2'-hydroxy

103 s-expansions was explored with three genetic-biochemical approaches including first, the utilization

104 Using a combination of genetic and biochemical approaches including gene knockouts, signal

105 Using several biochemical approaches, including a novel site-specific

106 istributions by a variety of biophysical and biochemical approaches, including in-tandem atomic force

107 Here, we undertook biochemical approaches, including MS and posttranslation

108 In our procedures, we used a combination of biochemical approaches, including quantitative PCR and W

109 Using a panel of biochemical approaches, including size exclusion chromat

110 Furthermore, immunohistochemical and biochemical approaches indicate binding of lumican to be

111 Genetic and biochemical approaches indicate that, upon UV irradiatio

112 P, which was previously identified through a biochemical approach is a bona fide receptor for HBV and

113 Using a biochemical approach, it is here established that ubiqui

114 Biochemical approaches led to the identification of cycl

115 Complementary functional and biochemical approaches led to the unexpected finding tha

116 Here, we use biochemical approaches (mammalian two-hybrid, pull-down,

117 new modality that, together with traditional biochemical approaches, may eventually allow augmentatio

118 sicle proteins has been estimated using bulk biochemical approaches, no information exists on the int

119 The biochemical approach of Kutik et al. uncovered an unexpe

120 Here we undertake the biochemical approach of substituted cysteine accessibili

121 Using biochemical approaches, only a limited number of factors

122 changes, suppression of MuRF1 by genetic or biochemical approaches prevented muscle fiber atrophy, w

123 Here, we combine biochemical approaches, quantitative imaging and mathema

124 Molecular genetics and biochemical approaches reveal that the processing of the

125 Biochemical approaches reveal the impact of specific sub

126 A combined genetic and biochemical approach revealed that human DNMT2 did not m

127 Biochemical approaches revealed a cell wall fraction con

128 However, neither immunolocalization nor biochemical approaches revealed significant accumulation

129 Genetic and biochemical approaches revealed that the initial two tra

130 Biochemical approaches show that both SH-SY5Y and SK-N-A

131 Photoactivation and biochemical approaches show that lysosomally targeted in

132 They also demonstrate that widely used biochemical approaches such as detergent-resistant membr

133 tein-protein interactions, while traditional biochemical approaches such as sub-cellular fractionatio

134 A combined genetic, cellular, and biochemical approach supports that some of the tested ba

135 ctation, we found by electron microscopy and biochemical approaches that endogenous Bcl-x(L) also loc

136 crophages are usually studied by genetic and biochemical approaches that require costly breeding and

137 We demonstrate using both genetic and biochemical approaches that the observed structural cons

138 ution offered by the traditional genetic and biochemical approaches that were used to create it.

139 using a combination of mass spectrometry and biochemical approaches, that native TRPP2 is glycosylate

140 we endeavored to dissect, using genetic and biochemical approaches, the domains of this protein that

141 on of bioinformatic, genetic, structural and biochemical approaches, the universal protein family Yrd

142 Here, we use a combined computational and biochemical approach to assign folds for approximately 9

143 We have also developed a biochemical approach to define candidate transcripts tha

144 We used a combined proteomic and functional biochemical approach to determine the overall impact of

145 Chemical genetics is a biochemical approach to develop small peptide-mimetic li

146 We took a biochemical approach to directly isolate and characteriz

147 Here, we use a combined structural and biochemical approach to explore the role of Sec71-Sec72

148 We have currently undertaken a biochemical approach to further characterize Complex I a

149 This in vitro system also provides a biochemical approach to further study the function of ac

150 Here, we use a biochemical approach to identify Dynamin-associated prot

151 his issue of Neuron, Jeworutzki et al. use a biochemical approach to identify GlialCAM, a protein wit

152 In a biochemical approach to identify non-histone substrates

153 Here, we have used a biochemical approach to identify Rumpelstiltskin, a Dros

154 of a combined genetic, genomic and in vitro biochemical approach to identify the evolutionary mechan

155 Here, we used an unbiased biochemical approach to identify this enzyme.

156 To establish new links, we are taking a biochemical approach to identify transcription factors t

157 We have taken a biochemical approach to investigate DNA end processing i

158 In this work, we used a molecular biochemical approach to investigate how the efficiency o

159 Here, we present a biochemical approach to investigate the internal subunit

160 We also used a biochemical approach to perturb Wnt signaling and found

161 Our results demonstrate an effective biochemical approach to systematically identify miRNA ta

162 used a combination of genetic, cellular, and biochemical approaches to address the role of lipid modi

163 sa and utilized a combination of genetic and biochemical approaches to characterize the activity and

164 ution to the dnaN159 phenotypes, we utilized biochemical approaches to characterize the purified muta

165 e have utilized a combination of genetic and biochemical approaches to characterize the role(s) playe

166 Here, we used genetic and biochemical approaches to clarify the contribution of th

167 ation of directed evolution and chemical and biochemical approaches to demonstrate that tellurite inh

168 study, we employed electrophysiological and biochemical approaches to demonstrate that Trp(136), loc

169 , electrophysiological, cell biological, and biochemical approaches to describe a novel mechanism in

170 We used genomics and biochemical approaches to determine if lambda-exo digest

171 echanism of translation control, we employed biochemical approaches to determine the regulatory featu

172 Here, we combine genomic and biochemical approaches to dissect a role of ZFP-1, the C

173 Comparative genomics complements genetic and biochemical approaches to dissect metabolism, continues

174 Therefore, we used biochemical approaches to elucidate how proteins contain

175 We have used biophysical and biochemical approaches to establish the second order rat

176 In this study, we used biochemical approaches to examine the distribution of am

177 In this study we have combined genetic and biochemical approaches to examine the molecular mechanis

178 In this study, we used genetic and biochemical approaches to examine the PHD1-PHD2 region o

179 CRISPR/Cas9-based genetic manipulations and biochemical approaches to examine the role of YB-1 in ti

180 Here, we use a combination of genetic and biochemical approaches to examine these sites individual

181 We used crystallographic and biochemical approaches to gain insight into activating m

182 h9Delta cells were shown by both genetic and biochemical approaches to have abnormally high levels of

183 We combined molecular and biochemical approaches to identify a functional variant

184 In this issue, Malhotra and colleagues use biochemical approaches to identify a new class of secret

185 hobic nature complicates the use of standard biochemical approaches to identify interacting proteins.

186 We have used cell biological and protein biochemical approaches to identify novel coat proteins i

187 We have used genetic and biochemical approaches to identify residues critical for

188 We used biochemical approaches to identify seven constituents of

189 The development of molecular and biochemical approaches to identify start sites of DNA re

190 This study implemented biochemical approaches to infer changes in ACD6 complexe

191 talytic cycle, we used multiple independent, biochemical approaches to interrogate the catalytic cycl

192 zebrafish in concert with bioinformatics and biochemical approaches to investigate CISH function.

193 Here we combine clinical specimens with biochemical approaches to investigate secretory immunogl

194 Here we used various biochemical approaches to investigate Set-beta isoforms

195 We used primary patient cells and biochemical approaches to investigate the effects of pat

196 modeling, induced fit docking, genetic, and biochemical approaches to investigate the molecular basi

197 We have used functional and biochemical approaches to investigate the stoichiometry

198 ta are complementing traditional genetic and biochemical approaches to more fully address the complex

199 We used cytological and biochemical approaches to show that Baf200 plays an impo

200 We have combined genetic and biochemical approaches to show, that endogenous WT1 bind

201 We combined transcriptomic and biochemical approaches to study rhizobial and plant sulf

202 e many advantages of Caenorhabditis elegans, biochemical approaches to study tissue-specific gene exp

203 We have used biochemical approaches to test structural models for how

204 e the need to apply multiple biophysical and biochemical approaches to the elucidation of the physica

205 stmortem studies, discuss the application of biochemical approaches to this substrate, and present ex

206 conjunction of structural, biophysical, and biochemical approaches to this system has brought our un

207 conjunction of structural, biophysical, and biochemical approaches to this system reveals molecular

208 he channel, in particular the structural and biochemical approaches to understanding channel gating.

209 review progress in the use of structural and biochemical approaches to understanding how each FANC pr

210 er the years, a common theme emerges: simple biochemical approaches to understanding molecular messen

211 Both computational and biochemical approaches underscore the relevance of exoni

212 econcile these two findings, we have taken a biochemical approach using yeast extracts and asked whet

213 e yeast two-hybrid assay as well as in vitro biochemical approaches using purified recombinant protei

214 A biochemical approach was developed to analyze portal fun

215 To address this issue, a biochemical approach was taken using recombinant Alg2 an

216 Here, a biochemical approach was used to identify host factors i

217 A combination of cellular imaging and biochemical approaches was used to refine the cellular l

218 Through structural biology and biochemical approaches we demonstrate that these copper-

219 ation of bioinformatic, cell biological, and biochemical approaches we have (a) cloned and expressed

220 Using biochemical approaches we identify a nucleosome interact

221 Using genetic and biochemical approaches we identify Ankyrin2 as a key pre

222 Combining genomic and biochemical approaches we show that CTCF and cohesin co-

223 Using bioinformatics and biochemical approaches we show that interaction of PTBP1

224 Using live imaging and biochemical approaches we show that TTC26/DYF13 is an IF

225 Using a biochemical approach, we aimed to assess the hepatic bio

226 Finally, using a biochemical approach, we demonstrate that incorporation

227 Using an unbiased biochemical approach, we discovered that the transcripti

228 ecific antibody and a combined morphological/biochemical approach, we establish that Id1 is a nuclear

229 Using a biochemical approach, we establish that the Ia.2 epitope

230 Using a biochemical approach, we found that MYOC localizes intra

231 Using a biochemical approach, we found that the K63-specific DUB

232 First, using a biochemical approach, we found that the total isoasparty

233 Using a comprehensive genetic and biochemical approach, we have delineated the physiologic

234 Using an unbiased in vitro biochemical approach, we have identified ICBP90, a trans

235 Using a biochemical approach, we have studied the role of the nu

236 Using a biochemical approach, we identified lipoproteins LprG an

237 Using a combined genetic and biochemical approach, we identified PA1343 as the PA gen

238 Using a biochemical approach, we now report that dimerization of

239 Using an activity-based biochemical approach, we recently uncovered the JmjC dom

240 Using a biochemical approach, we show that all four C1ql protein

241 Using a biochemical approach, we show that the A673T substitutio

242 Using fluorescence, EPR, and biochemical approaches, we also find intriguing evidence

243 Using various biochemical approaches, we clearly demonstrate that both

244 On the basis of microscopic and biochemical approaches, we conclude that death results f

245 ing a citrate-insensitive AtALMT9 mutant and biochemical approaches, we could demonstrate that AtALMT

246 Using convergent genetic and biochemical approaches, we demonstrate LRP130 complexes

247 Using both genetic and biochemical approaches, we demonstrate that Arp10p is th

248 Using a combination of imaging and biochemical approaches, we demonstrate that inside cells

249 Using combined genetic, molecular, and biochemical approaches, we demonstrate that MepS is rapi

250 Using complementary cellular and biochemical approaches, we demonstrate that RGS14 forms

251 microscopy (cryo-EM) structure analysis and biochemical approaches, we demonstrate that there is a c

252 Using molecular and biochemical approaches, we demonstrated that the C-termi

253 Here, through genetic and biochemical approaches, we describe a previously unident

254 Using bioinformatic and biochemical approaches, we determined that ORF57 contain

255 oscopy and molecular modelling combined with biochemical approaches, we determined the I-layer struct

256 Using biophysical and biochemical approaches, we discovered that CB(2) recepto

257 combination of pharmacological, genetic, and biochemical approaches, we examined the possible relatio

258 Using genetic and biochemical approaches, we find that MEF2 is phosphoryla

259 Using biophysical and biochemical approaches, we found that CXCR4 can form an

260 e in longitudinal axon guidance, and through biochemical approaches, we found that Dscam1 and Robo1 f

261 of recombinant human Hsp70 and quantitative biochemical approaches, we found that high-affinity RNA

262 Using single-molecule and bulk biochemical approaches, we found that Tn5 transposase as

263 Using a number of biochemical approaches, we found these interactions to b

264 By using several biochemical approaches, we have analyzed the influence o

265 Using bioinformatic and biochemical approaches, we have identified a new Schizos

266 Using bioinformatics, genetics, and biochemical approaches, we have identified three residue

267 By integrating computational and biochemical approaches, we identified TARBP2, a double-s

268 Using reverse-genetic and biochemical approaches, we identified that the AN8677 ge

269 h a variety of pharmacological, genetic, and biochemical approaches, we identified the DNA damage res

270 Using in silico and biochemical approaches, we identified two heme binding s

271 g metabolic genetics, mass spectrometry, and biochemical approaches, we identify new activities in DA

272 Here, using bioinformatic and biochemical approaches, we identify the AMPA receptor Gl

273 Using genetic and biochemical approaches, we investigated interaction of t

274 a combination of bioinformatic, genetic, and biochemical approaches, we investigated the mechanism by

275 Using genetic, cellular, and biochemical approaches, we now demonstrate that the CD45

276 Using imaging and quantitative biochemical approaches, we now report that APP selective

277 Using biophysical and biochemical approaches, we observe that RAM increases th

278 Employing genetic and biochemical approaches, we obtained evidence that the pu

279 By utilizing a variety of computational and biochemical approaches, we present evidence for a class

280 lectrophysiological, immunohistochemical and biochemical approaches, we provide evidence that vagal a

281 ing a combination of genetic, proteomic, and biochemical approaches, we report a divergent RDE-10/RDE

282 Using pharmacological and biochemical approaches, we show that both the convention

283 Using genetic and biochemical approaches, we show that charged residues in

284 Using structural biology and biochemical approaches, we show that GR binds directly t

285 Using proteomic and biochemical approaches, we show that RPGR interacts with

286 Using genetic and biochemical approaches, we show that this increased requ

287 Using genetic and biochemical approaches, we show that TLX modulates retin

288 Combining metabolomics, plant genetics and biochemical approaches, we show that transgenic BAR inde

289 Using molecular and biochemical approaches, we show the presence of several

290 lectron microscopy and other biophysical and biochemical approaches, we unveil the underlying mechani

291 Molecular and biochemical approaches were employed to evaluate the mec

292 Arabidopsis organelles, reverse genetic and biochemical approaches were employed.

293 Bioinformatic, genetic, and biochemical approaches were used to document and analyze

294 In this study, biochemical approaches were used to identify the consequ

295 ns and others from tissue recombinations and biochemical approaches, which have revealed the molecula

296 teractions combining traditional genetic and biochemical approaches with 'omics' based approaches in

297 Flux measurement and proteomic, genetic, and biochemical approaches with a metabolomics bent are all

298 Coupling traditional genetic and biochemical approaches with advanced technologies, such

299 In this report, we combined biochemical approaches with in vivo mRNA reporter assays

300 scale precision, here we combine traditional biochemical approaches with superresolution microscopy m