ライフサイエンスコーパス: biochemical data

1 d controversial because of disagreement with biochemical data.

2 lished structure and are consistent with the biochemical data.

3 ystallography, cryo-electron microscopy, and biochemical data.

4 hematical models that can be trained against biochemical data.

5 for these putative roles comes from in vitro biochemical data.

6 bolism and storage was in agreement with the biochemical data.

7 tion for mRNA bound to eIF4E consistent with biochemical data.

8 d hydroxide as a general base as dictated by biochemical data.

9 he trends were generally correlated with the biochemical data.

10 nts and recently published physiological and biochemical data.

11 el for pol III recruitment that was built on biochemical data.

12 erved in the structure consolidate all known biochemical data.

13 between 1994 and 2015, of whom 699 also had biochemical data.

14 ystal structure that correlate well with our biochemical data.

15 WRC previously identified by mutagenesis and biochemical data.

16 fully reflects the available mutagenesis and biochemical data.

17 ents, as well as a large body of genetic and biochemical data.

18 uction, which we curated against the limited biochemical data.

19 asis of preexisting and novel structural and biochemical data, a catalytic mechanism is proposed.

20 Despite rich structural and biochemical data, a detailed mechanistic explanation of

21 Combining the solution structure and biochemical data, a model of ComAC bound to the ComA rec

22 In the absence of detailed structural and biochemical data about McjB and McjC, these studies allo

23 These biochemical data along with structural modeling suggest

24 Our biochemical data also indicate that the affinity of E2 f

25 Biochemical data and a crystal structure of a ternary co

26 e arrive at a model that supports all of our biochemical data and agrees very well with a cryo-electr

27 In this study, we use extensive biochemical data and algebraic modeling to develop and a

28 the ribozyme that accommodates all available biochemical data and appears competent for catalysis.

29 Thus, biochemical data and cellular studies both suggest a rol

30 Similar baseline biochemical data and comparably high success rates of ro

31 Based on biochemical data and confirmed by molecular modeling, we

32 The structural and biochemical data and experiments with cultured cells sho

33 Interestingly, our biochemical data and homology modeling of the CAT domain

34 Utilizing these new biochemical data and intermolecular distance measurement

35 These, together with biochemical data and modeling by molecular dynamics calc

36 Biochemical data and modeling indicate that pY1473 can f

37 correlate well with published structural and biochemical data and provide mechanistic insights.

38 lows rationalization of existing genetic and biochemical data and provides a framework for targeting

39 Parameter values were estimated using biochemical data and reaction time performance on the ps

40 Structural findings agree with biochemical data and support the hypothesis that both no

41 n unbiased, generic model to integrate prior biochemical data and the constructed brain tumor microen

42 On the basis of a variety of biochemical data and the recently solved NMR structure o

43 used to investigate disparities between the biochemical data and the X-ray structure of the CR2-C3d

44 inetic model that incorporates both existing biochemical data and the, to our knowledge, novel states

45 Biochemical data and three crystal structures provided i

46 ion of available experimental structural and biochemical data, and provides a starting point for more

47 ical with the rapid growth of structural and biochemical data, and the emergence of algorithms that r

48 rmis, for which structural, mechanistic, and biochemical data are available.

49 The biochemical data are consistent with a random sequential

50 away from sites catalyzing proteolysis, and biochemical data are consistent with an allosteric mecha

51 Computer modeling and biochemical data are consistent with the encapsulation o

52 We suggest that the biochemical data are consistent with the osmotic gliopat

53 These biochemical data are consistent with the recently develo

54 Biochemical data are presented supporting a proposed bio

55 pathogenicity of enteric bacteria, available biochemical data are scarce.

56 picture that emerges from the structural and biochemical data are that GLD-3 activates GLD-2 both ind

57 These genetic and biochemical data argue that ccm2l is a necessary compone

58 Using structural and biochemical data as a guide, we characterized the indivi

59 ed to extract patterns from large volumes of biochemical data at molecular-level resolution while 'de

60 On the basis of the biochemical data, binding of NMM to Tel22 does not rely

61 nd validation due to the wealth of available biochemical data, but the method can be applied to any f

62 The structural and biochemical data collectively reveal that S-adenosyl-L-m

63 Together with supporting biochemical data comparing Suv4-20h1 and Suv4-20h2, we d

64 These biochemical data complement earlier biophysical studies

65 Biochemical data confirm that apoParA forms dimers at ph

66 Biochemical data confirm that irisin is a dimer and that

67 Biochemical data confirm that members of this riboswitch

68 Genetic and biochemical data confirmed a predicted binding site in t

69 However, direct biochemical data correlating FAD redox chemistry with Ch

70 Genetic and biochemical data demonstrate a pivotal role for S-nitros

71 Electrophysiological and biochemical data demonstrate that anti-Ro Abs inhibit IK

72 Biochemical data demonstrate that EM5 and FL772 inhibit

73 Biochemical data demonstrate that the enzyme hydrolyzes

74 These results, in combination with biochemical data, demonstrate that residues 23-31 repres

75 Importantly, our biochemical data demonstrated that PRRSV nsp11 exists ma

76 These are the first biochemical data demonstrating a Ku dependence of Artemi

77 hysiological results with CFTR, there are no biochemical data demonstrating intrinsic adenylate kinas

78 We present in vitro biochemical data demonstrating that this enzyme can gene

79 Deletion analysis of SPT5 supports our biochemical data, demonstrating the importance of the KO

80 ted enzyme mevalonate kinase, structural and biochemical data derived on ScMDD and SaMDD, allows us t

81 In contrast, and consistent with our biochemical data, EHD2 defines a different domain at the

82 The expression and biochemical data establish an arogenate pathway for Phe

83 Structural and biochemical data establish how a combination of active a

84 Furthermore, the extent of biochemical data fails to demonstrate a significant leve

85 ases exist that contain either structural or biochemical data, few integrate these two data sources i

86 for >3000 sequences, in vivo phenotypic and biochemical data for >5750 LacI/GalR mutational variants

87 - to 2.6-A-resolution crystal structures and biochemical data for 12 poliovirus polymerase mutants th

88 Here we report the first structure and biochemical data for a monofunctional PRODH.

89 ular systems: (i) to integrate heterogeneous biochemical data for data mining, (ii) to combine top-do

90 The genetic and biochemical data for ime-2 and vib-1 indicate that IME-2

91 N oligomers that support and extend existing biochemical data for IN.LEDGF complexes and lend new ins

92 Biochemical data for mammalian myosin V suggest that a h

93 Recent structural and biochemical data for several multidrug transporters now

94 We present biochemical data for the formation of two distinct oligo

95 structural data and the paucity of in vitro biochemical data for this kinase family leave a void in

96 udy, we collected clinical, histological and biochemical data from 68 patients carrying the homozygou

97 Q and use it as a framework for interpreting biochemical data from both wild-type and variant protein

98 in is sufficient for DNA unwinding activity, biochemical data from several related enzymes suggest th

99 Biochemical data from the mTau mice demonstrated that mo

100 Biochemical data further demonstrate a reduced catalytic

101 Our genetic and biochemical data further indicate that Rap/Fzr regulates

102 The combination of structural and biochemical data has allowed us to assign key residues a

103 Solution structures and biochemical data have provided a wealth of mechanistic i

104 Biochemical data have shown that the amino-terminal 79 r

105 containing Gbeta subunits and complementary biochemical data highlight specific sites within Gbetas

106 atoms in purified Yap8, and our genetic and biochemical data identify the cysteine residues that for

107 nted here, in conjunction with the available biochemical data, illustrates a flexibility of the GCPII

108 Previous structural and biochemical data implicate the DNase I binding loop (D-l

109 ytosolic flagellin, consistent with previous biochemical data implicating NAIP6 in flagellin detectio

110 rphological findings, as well as genetic and biochemical data in 14 fused in sarcoma proteinopathy ca

111 Analysis of the biochemical data in the context of the co-crystal struct

112 omic and genetic, biological, functional and biochemical data in yeast and humans establishes GOLPH3

113 Thus, our genetic, in vivo, and biochemical data indicate a role for Coy1 in regulating

114 The structure together with biochemical data indicate that A-domain Tail arrhythmia

115 Our biochemical data indicate that acidic patches on the con

116 Our crystal and biochemical data indicate that most CDC73 missense mutat

117 Kinetic and biochemical data indicate that one of these phosphoforms

118 Biochemical data indicate that SlmA dimer-of-dimers can

119 this enzyme with other type I FPPSs, but the biochemical data indicate that TgFPPS has unique charact

120 Biochemical data indicate that the closely related yeast

121 Biochemical data indicate that the EGFR complex is seque

122 Genetic and biochemical data indicate that the matrix (MA) domain of

123 Crystal structures and other biochemical data indicate that the N-terminal cap (NCap)

124 Structural and biochemical data indicate the conserved A9 and A10 bases

125 Structure analysis and biochemical data indicate, that AgeI is a monomer in the

126 The structures, together with biochemical data, indicate that NtrC4 binds to DNA in a

127 r modeling of HIV-1 integrase, together with biochemical data, indicate that the conserved residue Q1

128 Biochemical data indicated that a majority of MLK4 mutat

129 Biochemical data indicated that ETR1RD is involved in ph

130 Biochemical data indicated that this mutation impairs la

131 These structures, in conjunction with biochemical data, indicated that AA3 mediates substrate

132 ng pockets in the hub and present supporting biochemical data indicating sugar moiety binding is impo

133 Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor,

134 al model is in good agreement with published biochemical data indicating that procapsid expansion exp

135 We provide structural and biochemical data indicating that the autoinhibitory inte

136 erichia coli cell by gathering the available biochemical data into a ribosome kinetics description.

137 Stepping towards this goal of incorporating biochemical data into ASD diagnosis, this paper analyzes

138 nt limited structural data, the inclusion of biochemical data is critical for achieving the accuracy

139 An important question in the analysis of biochemical data is that of identifying subsets of molec

140 cted, and on the basis of our data and other biochemical data, lithium binds to site II, coupled to a

141 uence analysis, ligand-bound structures, and biochemical data, MTH1020 is confirmed as an archaeal IM

142 low-resolution structural, biophysical, and biochemical data obtained by many teams over decades.

143 rature-based prior knowledge network against biochemical data obtained from primary human hepatocytes

144 Structural and biochemical data of archaellum subunits are missing.

145 ations for existing electrophysiological and biochemical data, offering an explicit mechanism for vol

146 idues in the APE1 active site and to explain biochemical data on APE1-catalyzed 3' repair activities.

147 imization given the wealth of structural and biochemical data on HIV-1 reverse transcriptase (RT) and

148 These structural findings along with biochemical data on NikR support a hypothesis that order

149 Biochemical data on RF3 mutants show that a surface regi

150 f the holoenzyme is consistent with previous biochemical data on RNP assembly and provides a simple s

151 Structural and biochemical data on the bacterial transcription-repair c

152 een the minimal hammerhead structure and the biochemical data on the cleavage properties of chemicall

153 The implications of the structural and biochemical data on the role of the ankyrin repeats in d

154 Biophysical and biochemical data on WRC mutants confirm that Rac1 binds

155 By synthesizing genomic, structural and biochemical data, our framework represents a new approac

156 first step in lysine biosynthesis, and early biochemical data placed it in the cytoplasm or mitochond

157 workflow allowed us to collect thousands of biochemical data points revealing the binding preference

158 Our biochemical data predict that increasing phospholipid EP

159 Taken together, the structural and biochemical data presented here have implications for th

160 The structural and biochemical data presented here provide insights into th

161 The structural, biophysical, and biochemical data presented here provide the framework ne

162 OXs, LTC(4) synthase, and FLAP combined with biochemical data provide a framework for understanding h

163 Our structural and biochemical data provide a mechanistic basis to explain

164 The model and biochemical data provide a rationale for Atg7 dimerizati

165 These biochemical data provide direct evidence for TREX1 resid

166 Structural and biochemical data provide evidence that CYP46A1 activity

167 The combined structural and biochemical data provide insight into dNTP promiscuity a

168 These functional and biochemical data provide novel insights into the mechani

169 Biochemical data provide support for a model of the targ

170 ndings, discussed in relation to genetic and biochemical data, provide a critical foundation for futu

171 microfluidics that, in combination with bulk biochemical data, provides direct visual evidence for ou

172 his novel structure, in combination with new biochemical data, provides important insights into the m

173 The structural and biochemical data reported here expand our knowledge on t

174 The structure and biochemical data reveal a dimeric arrangement of Dok7 PH

175 This structure and supporting biochemical data reveal a mechanism for accurate anneali

176 Current structural and biochemical data reveal a wide range of different helica

177 Biochemical data reveal that both factors accelerate the

178 Biochemical data reveal that conserved aspartate residue

179 Our combined genetic and biochemical data reveal that D53 acts as a repressor of

180 n this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA succ

181 Together, our genetic and biochemical data reveal that it is possible to modulate

182 Structural and biochemical data reveal the molecular basis of polyspeci

183 Our structural and biochemical data reveal the molecular basis underying on

184 Crystal structures and biochemical data revealed a diverse protein superfamily

185 Here, we present structural and biochemical data revealing the organization of Hsp104 fr

186 The structure, in combination with biochemical data, reveals molecular mechanisms for coord

187 re, which is consistent with our kinetic and biochemical data, reveals the molecular interactions tha

188 Guided by biochemical data, rigid body modeling of subunits into t

189 xtracting important information from complex biochemical data sets.

190 Structural, genetic and biochemical data show how the channel opens across the m

191 Recent structural and biochemical data show how the channel opens during trans

192 Interestingly, biochemical data show that all YfgL variants, including

193 Indeed, biochemical data show that CcpA-(HPr-Ser46-P) binds the

194 Biochemical data show that Cdc13N weakly binds long, sin

195 Genetic and biochemical data show that dEGFR is tightly regulated by

196 Biochemical data show that hOAS3.DI is essential for act

197 Combined cryo-electron microscopy and biochemical data show that the monomeric rhesus TRIM5alp

198 Biochemical data show that the mutations associated with

199 Our genetic and biochemical data show that the two ER-resident proteins

200 type III-A Csm complex targets DNA, whereas biochemical data show that the type III-B Cmr complex cl

201 Genetic and biochemical data show that this CR3 motif affects both e

202 In both enzymes, crystallographic and biochemical data show their respective C-terminal transm

203 These structures, accompanied by biochemical data, show that the translocation pathway is

204 Biochemical data showed that Rad26 uses its C-terminal d

205 In addition, we provide biochemical data showing that although CIPK23 is intrins

206 We present structural and biochemical data showing that CARs are peripheral membra

207 :YFP structures by Wortmannin, together with biochemical data showing that GRV2 co-fractionates with

208 t the crystal structure of S14 to 2.65 A and biochemical data showing that S14 can form heterodimers

209 Biochemical data shows that several of the cancer-associ

210 Here, we report biochemical data, small-angle X-ray scattering results,

211 together, these structural, biophysical and biochemical data suggest a model where transition from t

212 The combination of genetic and biochemical data suggest a modified 'bacterial switch' h

213 The structures and existing biochemical data suggest a nucleic acid conformation-ind

214 These structural and biochemical data suggest a previously undescribed mechan

215 The genetic and biochemical data suggest a similar substrate role for he

216 Biochemical data suggest large parts of NS5A are unfolde

217 Biochemical data suggest that alpha-catenin adopts an au

218 econdary structural alignments combined with biochemical data suggest that amino acid residue R609 se

219 The structural and biochemical data suggest that ATP binding is functionall

220 Most important, our biochemical data suggest that cocaine induces CD4(+) T-c

221 Importantly, the structural and biochemical data suggest that domain alternation and rem

222 Our genetic and biochemical data suggest that dRASSF8 acts in concert wi

223 Recent biochemical data suggest that human prostate cancer cell

224 Our structural and biochemical data suggest that refolding of the TL is vit

225 M proteins have been shown to dimerize, and biochemical data suggest that RSV M also dimerizes.

226 These biochemical data suggest that the dipeptide insertion el

227 Biochemical data suggest that the Hoc protein has two fu

228 Biochemical data suggest that the magnesium ions provide

229 The structural and biochemical data suggest that the protein undergoes conf

230 Finally, in vitro biochemical data suggest that the stem-loop sequence is

231 Furthermore, convincing biochemical data suggest that these structures are disti

232 Combined structural and biochemical data suggest that this DNA-activated SlmA ol

233 Biochemical data suggest that this genetic interaction i

234 Biochemical data suggest that unlike the enzymes in the

235 Emerging structural and in vitro biochemical data suggest that XRCC4 and XLF together gen

236 are known to bind ubiquitin, but genetic and biochemical data suggest the existence of at least one o

237 The current results, together with earlier biochemical data, suggest that the proton pumping in com

238 In addition, we report biochemical data suggesting that Hoc can bind to Escheri

239 nucleotide binding domain supporting earlier biochemical data suggesting that the inactive form exist

240 The combination of analytical and biochemical data suggests that the higher 18:2n-6 conten

241 Genetic and biochemical data support a model in which direct binding

242 Genetic and biochemical data support a model in which the pupylation

243 The structures, along with biochemical data, support a model where the recognition

244 in combination with previous structural and biochemical data, support an asymmetric inchworm mechani

245 posed pK(a) shift mechanism accounts for the biochemical data supporting the essential role for the B

246 rms a helical conformation, no structural or biochemical data supporting this hypothesis have been pu

247 The biochemical data taken in conjunction with the biologica

248 the allotetraploids are consistent with the biochemical data that AaCHE showed preferential binding

249 Here, I present genetic and biochemical data that confirm the requirement of MurJ fo

250 This study provides biochemical data that show that SAX-7 associates with DY

251 Notably, we present sequence and biochemical data that suggest that deamidation has been

252 Here we present structural and biochemical data that suggest that two conserved tyrosin

253 ve conceptualized based on morphological and biochemical data that this degeneration is better classi

254 Here we present new biochemical data that underscore the validity of our pre

255 pose, based on phylogenetic, structural, and biochemical data, that the GUAAY pentaloop-receptor inte

256 In agreement with the biochemical data, the crystal structure of Pfk-2 obtaine

257 In accordance with previous biochemical data, the majority of the heterotypic H3K27M

258 By incorporating independently available biochemical data, the model can reproduce a large number

259 In combination with biochemical data, the structure suggests that the antibo

260 Together with biochemical data, the structure supports a mechanistic m

261 Together with the biochemical data, the structures define the molecular de

262 Together with biochemical data, the structures point to a step size fo

263 In accord with the biochemical data, these growth defects were exacerbated

264 Together with our biochemical data, these physiological results indicate t

265 Combined with current biochemical data, these structures offer insight into th

266 l genomes, with refined protein families and biochemical data to assign fully consistent functional a

267 Here, we combine genomic, proteomic, and biochemical data to demonstrate that many common nonsens

268 Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem

269 We used in vivo biochemical data to infer that a conformational intermed

270 d discuss these structures in the context of biochemical data to outline our present understanding of

271 The structural and biochemical data together offer insights into PDGF-PDGFR

272 Our structural and biochemical data together with phylogenetic analyses of

273 panding body of microbial, physiological and biochemical data, together with new technologies for man

274 However, biochemical data using which we may wish to characterize

275 This is consistent with biochemical data, using full-length MDM2, showing that t

276 Consistent with biochemical data, vibrational sum frequency spectroscopy

277 By using the available structural and biochemical data we highlight the evolutionary specializ

278 ologous Type II/IV secretion ATPases and our biochemical data, we believe that EpsE is active as an o

279 On the basis of biochemical data, we herein discussed structure-affinity

280 Informed by mammalian crystallographic and biochemical data, we introduced amino acid substitutions

281 spectrometry with cryo-EM, computational and biochemical data, we investigate the oligomeric formatio

282 Incorporating genetic, immunologic, and biochemical data, we present a multistep pathogenesis mo

283 Based upon genetic, cell biological, and biochemical data, we propose that Opy1 functions as a co

284 Based on this structure and accompanying biochemical data, we propose that p300/CBP uses an unusu

285 On the basis of structural and biochemical data, we propose that pi-pi' is a dynamic in

286 gand-bound crystal structures and supporting biochemical data, we show that this protein, which we re

287 vely the resulting findings on the available biochemical data, we successfully revise the concept of

288 Histologic and biochemical data were collected from 315 kidney transpla

289 lected within 30 days of blood sampling, and biochemical data were collected within 7 days of blood s

290 Demographic, haemodynamic and biochemical data were drawn from participants in the Ang

291 Clinical and biochemical data were obtained at baseline and at 4-week

292 of diabetes, and demographic, clinical, and biochemical data were retrieved from standardized databa

293 Clinical and biochemical data were reviewed.

294 Clinical and biochemical data were systematically recorded perioperat

295 tures, thermodynamic binding parameters, and biochemical data were used to design statin inhibitors w

296 d a platform for interpreting this wealth of biochemical data, while at the same time presenting a fu

297 Electron micrographs and biochemical data with a PFKL/PFKP chimera indicate that

298 r docking simulations supported the observed biochemical data with respect to NQO1 inhibition.

299 Here, we complement the cellular and biochemical data with structural characterization of the

300 On the basis of biochemical data Ydj1p has been proposed to cure [URE3]