1 ne of most challenging of all substrates for
biochemical study.
2 eractions, which we validated by genetic and
biochemical studies.
3 siological studies of the endplate, and from
biochemical studies.
4 gnal relay through the allosteric network by
biochemical studies.
5 is of streptide was addressed by genetic and
biochemical studies.
6 nous telomerase and is thus a good model for
biochemical studies.
7 ray scattering, electron microscopy (EM) and
biochemical studies.
8 both mutant proteins and carried out further
biochemical studies.
9 reconstituted into phospholipid bilayers for
biochemical studies.
10 ction, we integrated structural modeling and
biochemical studies.
11 ts about the insertion mechanism provided by
biochemical studies.
12 viral fusion protein E1 in conjunction with
biochemical studies.
13 domains, was characterized by structural and
biochemical studies.
14 eotides, laying the foundation for future SP
biochemical studies.
15 he BamA assisted model, based on genetic and
biochemical studies.
16 2+) ions as probes for ESR spectroscopic and
biochemical studies.
17 tion in neurons emerging from functional and
biochemical studies.
18 venient soluble NUDT9H models for structural/
biochemical studies.
19 family, a character yet to be highlighted in
biochemical studies.
20 n studies, 5 for pharmacogenetics and 21 for
biochemical studies.
21 tructure to 2.15 A and performed genetic and
biochemical studies.
22 al role in Th17 differentiation suggested by
biochemical studies.
23 Despite considerable structural and
biochemical studies,
a molecular-level theory of process
24 Our
biochemical studies also extend the potential involvemen
25 Serological and
biochemical studies also supported a diagnosis of subcli
26 rai channels as elucidated by functional and
biochemical studies,
analyze the dOrai crystal structure
27 icial bioreactors are desirable for in vitro
biochemical studies and as protocells.
28 Biochemical studies and cryo-electron microscopy identif
29 The structure provides a template for future
biochemical studies and modelling of ICP27 homologs from
30 Here we combined complex genetic analyses,
biochemical studies and pharmacological interference to
31 -NPG to provide specificity, as indicated by
biochemical studies and shown directly by X-ray crystall
32 Biochemical studies and X-ray crystallography revealed t
33 logy used will have broad application across
biochemical study and drug discovery and development.
34 tion of transcription obtained from in vitro
biochemical studies,
and the cellular, phenomenological
35 spare tire concept is proposed based on this
biochemical study,
and this concept opens up a potential
36 Molecular, genetic, and
biochemical studies are demonstrating an increasingly im
37 for producing such polysaccharides, in vitro
biochemical studies are needed to determine, for example
38 ute conditions in which most biophysical and
biochemical studies are performed.
39 Results from our
biochemical studies are underscored by genome-wide analy
40 maging, pathological, molecular genetic, and
biochemical studies,
as well as studies of animal transm
41 Structural and
biochemical studies by Ferrao et al. (2014) in this issu
42 mulation experiment reported here and recent
biochemical studies by others support this hypothesis.
43 Biochemical studies challenged this model because the pu
44 Here we report detailed
biochemical studies clearly demonstrating that, in purif
45 Biochemical studies confirm the structural observations
46 Final
biochemical studies confirmed dose-dependent, competitiv
47 Microscopic and
biochemical studies confirmed the localization of tagged
48 Biochemical studies corroborate key features of the stru
49 In
biochemical studies,
CS disrupted TCR multimers, apparen
50 Together, our genetic and
biochemical studies define the molecular nature of the D
51 Previous structural and
biochemical studies defined critical roles for several o
52 Although genetic and
biochemical studies demonstrate that AGO2 phosphorylatio
53 Biochemical studies demonstrate that the CK2 component o
54 Genetic and
biochemical studies demonstrate that the tube is essenti
55 Our molecular and
biochemical studies demonstrate that Zic2 preferentially
56 ined, combined with normal mode analysis and
biochemical studies,
demonstrate that the plasticity of
57 Biochemical studies demonstrated that 17e could induce a
58 g promotes epicardium formation in vivo, and
biochemical studies demonstrated that CDC42 is involved
59 Biochemical studies demonstrated that ChlR1 efficiently
60 Biochemical studies demonstrated that HDAC1 was present
61 ot yet been identified, crystallographic and
biochemical studies demonstrated that LRH-1 could bind r
62 Biochemical studies demonstrated that NKG2D(TR) was boun
63 Further
biochemical studies demonstrated that oxidative stress i
64 Live-cell microscopy and
biochemical studies demonstrated that p130Cas knockdown
65 Further
biochemical studies demonstrated that the shelterin prot
66 Biochemical studies demonstrated that zinc strongly inhi
67 Biochemical studies demonstrated this class to exert its
68 se genetic data are strongly corroborated by
biochemical studies demonstrating physical interactions
69 ecause of their very high sequence identity,
biochemical studies done on H-Ras have been considered r
70 M6C) is inactive as a KDM, we demonstrate by
biochemical studies,
employing MS and NMR, that UTY(KDM6
71 Further
biochemical studies establish that coordination of Ni(II
72 Predictive modeling and
biochemical studies establish why mutations in a positiv
73 These investigations, together with
biochemical studies,
established the nanostructure-activ
74 A previous
biochemical study has shown that budding yeast Hop2-Mnd1
75 Structural analysis, in conjunction with
biochemical studies,
has uncovered the molecular basis f
76 Most
biochemical studies have been performed either with the
77 While a variety of structural and
biochemical studies have been reported that elucidate di
78 Overall, our structural and
biochemical studies have defined the molecular basis for
79 Biochemical studies have demonstrated that as little as
80 Recent
biochemical studies have demonstrated that EsxA is a mem
81 Previous
biochemical studies have demonstrated that in the presen
82 Structural and
biochemical studies have demonstrated that p73, p63 and
83 ve revealed the location of these sites, and
biochemical studies have explored the kinetics of ACs, b
84 Although recent structural and
biochemical studies have identified conserved sites of p
85 Although traditional genetic and
biochemical studies have identified major players of tra
86 Previous
biochemical studies have identified PriC residues that m
87 Genetic and
biochemical studies have implicated impaired lysosomal a
88 the formation of highly cross-linked PG, but
biochemical studies have not reached a consensus on its
89 Genetic and
biochemical studies have previously implicated exonuclea
90 Several computational and
biochemical studies have proposed an acetate-escape hypo
91 Although extensive
biochemical studies have provided insight into the NO ac
92 Although multiple physiologic and
biochemical studies have reported defects in mitochondri
93 ical (Golgi-Kopsch, electron microscopy) and
biochemical studies have revealed an increased occurrenc
94 Recent NMR and
biochemical studies have revealed that binding of the pr
95 Yeast two-hybrid and
biochemical studies have revealed that the more distantl
96 Although structural and
biochemical studies have shed some light on their functi
97 Biochemical studies have shown that "autonomous" CaMKII
98 Bulk
biochemical studies have shown that Bloom helicase (BLM)
99 Biochemical studies have shown that GI NoVs exhibit geno
100 Genome mining and
biochemical studies have shown that oomycetes, which bel
101 Structural and
biochemical studies have shown that RelE cuts with some
102 Structural and
biochemical studies have shown that these enzymes sharpl
103 Structural and
biochemical studies have shown that when TBP binds DNA,
104 Genetic and
biochemical studies have suggested that GON4L is a trans
105 Cellular and
biochemical studies identified distinct molecular defect
106 Structural and
biochemical studies identified key residues that are cru
107 acts downstream of SnRK2.2/2.3 kinases, and
biochemical studies identified phosphorylation sites in
108 Transcriptomic, proteomic, and
biochemical studies identified the chaperone BiP/GRP78/H
109 Structural and
biochemical studies identify a conserved region on TREX-
110 Genetic and
biochemical studies implicate alpha-synuclein and leucin
111 Accumulating evidence from genetic and
biochemical studies implicates dysfunction of the autoph
112 as well as earlier electron microscopic and
biochemical studies implicating a replication origin at
113 Biochemical studies in colonic epithelial cell lines rev
114 Mutagenesis and
biochemical studies in HEK293T cells revealed that alpha
115 Biochemical studies in primary cells established that th
116 We performed immunologic, genetic, and
biochemical studies in the 2 siblings, their family memb
117 We performed immunologic, genetic, and
biochemical studies in the patients, family members, and
118 Molecular and
biochemical studies in these mice indicate that FR ameli
119 Genetic and
biochemical studies in vertebrate and invertebrate model
120 Biochemical studies in vitro and functional complementat
121 Using genetic and
biochemical studies in vitro and in human MM xenograft m
122 As inferred from
biochemical studies,
in the Poliota/Polkappa pathway, Po
123 l domains combine to create a basic pore and
biochemical studies indicate residues in this region par
124 Biochemical studies indicate that Hook proteins interact
125 Our
biochemical studies indicate that in the Poliota/Polthet
126 Biochemical studies indicate that PDE4s are anchored to
127 Our
biochemical studies indicate that PRORP2 requires Mg(2+)
128 Biochemical studies indicate that R742A as well as D113R
129 Biochemical studies indicate that the noncognate compete
130 Our
biochemical studies indicate that this interaction is re
131 Our
biochemical studies indicate that YTHDC2 is an RNA-induc
132 In vitro
biochemical studies indicated that cortactin binds PI(3,
133 Moreover, structural comparison and
biochemical studies indicated that Tyr 97 and His 138 ar
134 line but difficult to reconcile with former
biochemical studies indicating that PAG is constitutivel
135 Biochemical studies informed by these structures demonst
136 The aim of this clinico-
biochemical study is to estimate and compare the levels
137 access homogeneously modified chromatin for
biochemical studies,
is well suited to the sensibilities
138 relevance of this enzyme as a model in early
biochemical studies,
its structure had not yet been solv
139 surements as well as sufficient material for
biochemical studies like protein purifications, enzyme a
140 From a series of
biochemical studies,
live imaging, and analyses of mutan
141 were not enough genetic, pharmacogenetic and
biochemical studies of ADHD in adults and that more inve
142 Here, we report the first comparative
biochemical studies of all the A3H variants using highly
143 Cellular and
biochemical studies of alphaE- and alphaN-catenins show
144 cribe negative-stain electron microscopy and
biochemical studies of alphaXbeta2 and alphaMbeta2 in co
145 omposition and structure through genetic and
biochemical studies of angiosperms, as well as underlyin
146 lomeric DNA is susceptible to oxidation, few
biochemical studies of base excision repair in telomeric
147 Biochemical studies of DDX1 and its interactions with Re
148 c approach, including chemical, physical and
biochemical studies of EBN, is a reliable and scientific
149 Biochemical studies of exopolysaccharide synthesis are h
150 Biochemical studies of GEN1 revealed that it cleaves syn
151 , gene expression and enhancer analysis, and
biochemical studies of gene regulation.
152 Biochemical studies of H3 and H4 tails binding to seven
153 This review covers topics from the classic
biochemical studies of human biospecimens to the use of
154 ics and cell-biology studies with those from
biochemical studies of MMR proteins and reconstituted MM
155 As
biochemical studies of most proteins depend on their iso
156 Biochemical studies of mutant UBA5 proteins and studies
157 Although many structural and
biochemical studies of NRPSs exist, few studies have foc
158 can precursors, including Lipid II, enabling
biochemical studies of proteins involved in cell wall as
159 Here, we utilized signaling assays and
biochemical studies of purified recombinant ligand and r
160 tein, Y3, from the mushroom Coprinus comatus
Biochemical studies of recombinant Y3 from a yeast expre
161 tomic sequencing, proteomics, phenotype, and
biochemical studies of relatively unexplored basal fungi
162 Although recent structures and
biochemical studies of RNA bound exosomes from S. cerevi
163 S. cerevisae V-ATPase that explains numerous
biochemical studies of that enzyme.
164 RNA-sequencing and
biochemical studies of the DeltamybA strain suggested th
165 performed transcriptomic, histological, and
biochemical studies of the early events during the infec
166 Structural and
biochemical studies of the monomeric archaeal XPD homolo
167 played markedly decreased phototransduction,
biochemical studies of the mutant rhodopsin revealed onl
168 n silico modeling, mutagenesis, and in vitro
biochemical studies of the P. falciparum SUMO E1 and E2
169 Crystallographic and
biochemical studies of the PMTs in this pathway provide
170 Here, detailed
biochemical studies of the RxLR effector AVR3a from the
171 Biochemical studies of the terminase proteins have been
172 ted MMR reaction now makes possible detailed
biochemical studies of the wealth of mutations identifie
173 Early
biochemical studies of viral replication suggested that
174 The
biochemical study of Nodal and its signaling pathway has
175 s process, we have carried out a genetic and
biochemical study of proteins proposed to function in ir
176 Recent
biochemical studies on bovine papillomavirus 1 (BPV1) E1
177 aspects of resistance in VISA and summarize
biochemical studies on cell wall synthesis in a VRSA str
178 results highlight the importance of detailed
biochemical studies on GLUT protein expression levels in
179 Subsequent
biochemical studies on identified partner proteins showe
180 Despite
biochemical studies on individual gene products, the com
181 Microbiological and
biochemical studies on the class D beta-lactamases OXA-1
182 ll allow for further detailed structural and
biochemical studies on the interaction of PAR with its m
183 Biochemical studies on the kinesins confirmed KIFC1, KIF
184 Crystallographic and
biochemical studies on the Pseudomonas syringae ethylene
185 Prior
biochemical studies on the Sen1 homolog from Schizosacch
186 However, in vitro
biochemical studies on the thermal stability of Rho show
187 Structural and
biochemical studies on this enzyme elucidate the mechani
188 dered to be requisite A-EJ factors, based on
biochemical studies or extrachromosomal substrate end-jo
189 Together with the results of complementary
biochemical studies,
our smFRET studies demonstrate that
190 Biochemical studies over the past 10 years have allowed
191 Genetic and
biochemical studies,
primarily in Salmonella enterica, h
192 Biochemical studies proved the importance of the C-termi
193 EF-G) bound to the ribosome, as well as many
biochemical studies,
provide evidence that the direct in
194 vely, the structure along with corroborating
biochemical studies provided insights into the novel mod
195 A
biochemical study provided evidence that Cav1.233L chann
196 While genetic and
biochemical studies remain the major approaches in chara
197 Many of these
biochemical studies require access to a structurally wel
198 Our structural and
biochemical studies reveal an unusually tight interactio
199 Our structural and
biochemical studies reveal catalytically essential resid
200 Biochemical studies reveal that ATOH8, GATA4, and FOG2 a
201 Furthermore,
biochemical studies reveal that L. pneumophila uses two
202 Confocal microscopy and
biochemical studies reveal that neutrophil surface PDI i
203 Our structural and
biochemical studies reveal that SAV1 and MST2 heterodime
204 Biochemical studies reveal that the domain is a glucosyl
205 impedes proper recruitment of Orc6 into ORC;
biochemical studies reveal that this region of Orc6 asso
206 Our recent molecular and
biochemical studies revealed that impaired mitochondrial
207 Biochemical studies revealed that MltG is an inner membr
208 Recent
biochemical studies revealed that NisB glutamylates Ser/
209 Biochemical studies revealed that platelet DREAM positiv
210 Biochemical studies revealed that R129E-E2 and R150E-E2
211 Biochemical studies revealed that scFvG9 impairs the mat
212 Biochemical studies revealed that the enhanced anoikis r
213 Structural and
biochemical studies revealed that the helix domain is re
214 Genetic and
biochemical studies revealed that the incompatibility is
215 BIRC3 as a negative regulator of NF-kappaB,
biochemical studies revealed the presence of constitutiv
216 tural modeling, coupled with mutagenesis and
biochemical studies,
revealed dual binding sites for fed
217 chromatin presents a formidable obstacle to
biochemical studies seeking to understand the role of co
218 Here,
biochemical studies show a direct TFIID-E-protein intera
219 In vitro
biochemical studies show that G-CSF programs MPO-EL expr
220 Biochemical studies show that Lyn(+/-) B cells have defe
221 Biochemical studies show that most analogues consistentl
222 Biochemical studies show that Nrf2 is concentrated into
223 ns the pH dependence of this transition, and
biochemical studies show that pH regulates calcium influ
224 Crystallographic and
biochemical studies show that quinolone binding involves
225 Biochemical studies show that SLX-MUS is a HJ resolvase
226 Moreover,
biochemical studies show that TAF7L associates with TRF2
227 Biochemical studies show that the calcium dependence of
228 Biochemical studies show that the hinge stimulates topo
229 Our genetic and
biochemical studies show that UBCH7 (UBC-18) and the RBR
230 Consistent with these observations,
biochemical studies showed a reduction in the accumulati
231 Finally, immunocytochemical and
biochemical studies showed preferential enrichment of th
232 Second,
biochemical studies showed that aldolase indeed catalyze
233 Our
biochemical studies showed that auranofin inhibits the b
234 Biochemical studies showed that DCM-associated RAF1 muta
235 Biochemical studies showed that NCU08746 requires copper
236 Recent
biochemical studies showed that one pool of cholesterol
237 Previous
biochemical studies showed that optimal AUF1 binding req
238 Biochemical studies showed that Plk1 phosphorylates PTEN
239 Biochemical studies showed that sIL-27Ralpha is released
240 Biochemical studies showed that TDE0214 binds c-di-GMP i
241 Biochemical studies showed that the affinities of ACm1A
242 Biochemical studies showed that the C-6 benzyl and biary
243 Combined genetic and
biochemical studies showed that the cytoplasmic tail of
244 Our previous
biochemical studies showed that the TREX1 dominant autoi
245 Biochemical studies showed that, similar to previous NS-
246 Biochemical studies showed the two subtypes with an N-1
247 We report
biochemical studies showing that the hallucinogen lyserg
248 cation of Orai, a plethora of functional and
biochemical studies sought to compare Orai homologs, det
249 Our genetic and
biochemical studies strongly support a novel phytochrome
250 However, recent
biochemical studies suggest alternative molecular models
251 Further
biochemical studies suggest that EcEndoV is able to bind
252 Biochemical studies suggest that excitatory neurons are
253 Genetic, cell biological, and
biochemical studies suggest that reducing amyloid-beta (
254 Biochemical studies suggest that Spc110 facilitates high
255 Further
biochemical studies suggested that EGFR signaling stimul
256 Biochemical studies suggested that spontaneous migration
257 Previous
biochemical studies suggested that the recognition site
258 Our genetic and
biochemical studies support a model whereby Top1p recrui
259 on coordinate, combined with mutagenesis and
biochemical studies support a single Mg(2+)-ion mechanis
260 Our
biochemical studies support a uniquely nuanced pathway o
261 Biochemical studies support that promotion of spine form
262 It was shown by several
biochemical studies that activation and regulation depen
263 Here, we report through crystallographic and
biochemical studies that K-80003 binds to and stabilizes
264 Recent structural and
biochemical studies that provide insight into the mechan
265 In this study, we conducted structural and
biochemical studies that revealed that HdeB indeed works
266 dels of Cas9 function and the structural and
biochemical studies that support it.
267 Here, we report an in vitro
biochemical study that shows that Sco1 is a metallochape
268 Finally, for
biochemical studies,
the designed sequences can suggest
269 the light of previous genetic, cellular and
biochemical studies,
the most parsimonious conclusion fr
270 In combination with
biochemical studies,
the structural basis of self-protec
271 In
biochemical studies,
the V124W mutant recapitulated the
272 t two crystal structures of Sda1, as well as
biochemical studies to address key structural features a
273 Using
biochemical studies to characterize the wild-type (WT) a
274 rystal structure of GS-5745.MMP9 complex and
biochemical studies to elucidate the mechanism of inhibi
275 We combined genetic, physiological, and
biochemical studies to explore coevolution between the A
276 membrane anchor has allowed for physical and
biochemical studies to identify the role of substrate in
277 Biochemical studies using muscle extracts from transgeni
278 Our previous
biochemical studies using synaptoneurosomes demonstrate
279 Our
biochemical studies,
using recombinant Delta22 (a versio
280 Using mutational, genetic and
biochemical studies we demonstrate that cellular concent
281 Through genome mining and
biochemical studies,
we identified yet another subset of
282 isms in a milieu amenable for structural and
biochemical studies,
we identified, cloned, and partiall
283 Based on structural and
biochemical studies,
we now provide insight into an unpr
284 In
biochemical studies,
we show that CB1R and 5-HT2AR form
285 Through an E3 ligase screen and
biochemical studies,
we unexpectedly identified that RNF
286 f these, 15 genetic, 2 pharmacogenetic and 6
biochemical studies were included in the meta-analyses.
287 Biochemical studies were performed to determine the func
288 me from Methanococcus vannielii, a series of
biochemical studies were pursued to test the basic hypot
289 ibroblasts (MEFs) are convenient sources for
biochemical studies when cell number in mouse embryos is
290 This included not only
biochemical studies which revealed the expected presence
291 lly heme-loaded MamP from AMB-1 for in vitro
biochemical studies,
which show that its Fe(III)-Fe(II)
292 In combining our
biochemical studies with crystal structures of bacterial
293 roposed to anchor Tim44 to the membrane, but
biochemical studies with MB-10 show that this region is
294 Biochemical studies with myofilaments showed that RLC ph
295 Mutant phenotypic analyses and
biochemical studies with purified proteins revealed that
296 h alternative forks may be utilized, and new
biochemical studies with purified proteins that are aime
297 Biochemical studies with recombinant human DHODH led us
298 Biophysical, mutational, and
biochemical studies with the hyperthermostable two-domai
299 phate, this study sets the stage for further
biochemical studies with this material.
300 oaches has complemented previous genetic and
biochemical studies,
yielding new information about how