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1 ne of most challenging of all substrates for biochemical study.
2 eractions, which we validated by genetic and biochemical studies.
3 siological studies of the endplate, and from biochemical studies.
4 gnal relay through the allosteric network by biochemical studies.
5 is of streptide was addressed by genetic and biochemical studies.
6 nous telomerase and is thus a good model for biochemical studies.
7 ray scattering, electron microscopy (EM) and biochemical studies.
8 both mutant proteins and carried out further biochemical studies.
9 reconstituted into phospholipid bilayers for biochemical studies.
10 ction, we integrated structural modeling and biochemical studies.
11 ts about the insertion mechanism provided by biochemical studies.
12  viral fusion protein E1 in conjunction with biochemical studies.
13 domains, was characterized by structural and biochemical studies.
14 eotides, laying the foundation for future SP biochemical studies.
15 he BamA assisted model, based on genetic and biochemical studies.
16 2+) ions as probes for ESR spectroscopic and biochemical studies.
17 tion in neurons emerging from functional and biochemical studies.
18 venient soluble NUDT9H models for structural/biochemical studies.
19 family, a character yet to be highlighted in biochemical studies.
20 n studies, 5 for pharmacogenetics and 21 for biochemical studies.
21 tructure to 2.15 A and performed genetic and biochemical studies.
22 al role in Th17 differentiation suggested by biochemical studies.
23          Despite considerable structural and biochemical studies, a molecular-level theory of process
24                                          Our biochemical studies also extend the potential involvemen
25                              Serological and biochemical studies also supported a diagnosis of subcli
26 rai channels as elucidated by functional and biochemical studies, analyze the dOrai crystal structure
27 icial bioreactors are desirable for in vitro biochemical studies and as protocells.
28                                              Biochemical studies and cryo-electron microscopy identif
29 The structure provides a template for future biochemical studies and modelling of ICP27 homologs from
30   Here we combined complex genetic analyses, biochemical studies and pharmacological interference to
31 -NPG to provide specificity, as indicated by biochemical studies and shown directly by X-ray crystall
32                                              Biochemical studies and X-ray crystallography revealed t
33 logy used will have broad application across biochemical study and drug discovery and development.
34 tion of transcription obtained from in vitro biochemical studies, and the cellular, phenomenological
35 spare tire concept is proposed based on this biochemical study, and this concept opens up a potential
36                      Molecular, genetic, and biochemical studies are demonstrating an increasingly im
37 for producing such polysaccharides, in vitro biochemical studies are needed to determine, for example
38 ute conditions in which most biophysical and biochemical studies are performed.
39                             Results from our biochemical studies are underscored by genome-wide analy
40 maging, pathological, molecular genetic, and biochemical studies, as well as studies of animal transm
41                               Structural and biochemical studies by Ferrao et al. (2014) in this issu
42 mulation experiment reported here and recent biochemical studies by others support this hypothesis.
43                                              Biochemical studies challenged this model because the pu
44                      Here we report detailed biochemical studies clearly demonstrating that, in purif
45                                              Biochemical studies confirm the structural observations
46                                        Final biochemical studies confirmed dose-dependent, competitiv
47                              Microscopic and biochemical studies confirmed the localization of tagged
48                                              Biochemical studies corroborate key features of the stru
49                                           In biochemical studies, CS disrupted TCR multimers, apparen
50                    Together, our genetic and biochemical studies define the molecular nature of the D
51                      Previous structural and biochemical studies defined critical roles for several o
52                         Although genetic and biochemical studies demonstrate that AGO2 phosphorylatio
53                                              Biochemical studies demonstrate that the CK2 component o
54                                  Genetic and biochemical studies demonstrate that the tube is essenti
55                            Our molecular and biochemical studies demonstrate that Zic2 preferentially
56 ined, combined with normal mode analysis and biochemical studies, demonstrate that the plasticity of
57                                              Biochemical studies demonstrated that 17e could induce a
58 g promotes epicardium formation in vivo, and biochemical studies demonstrated that CDC42 is involved
59                                              Biochemical studies demonstrated that ChlR1 efficiently
60                                              Biochemical studies demonstrated that HDAC1 was present
61 ot yet been identified, crystallographic and biochemical studies demonstrated that LRH-1 could bind r
62                                              Biochemical studies demonstrated that NKG2D(TR) was boun
63                                      Further biochemical studies demonstrated that oxidative stress i
64                     Live-cell microscopy and biochemical studies demonstrated that p130Cas knockdown
65                                      Further biochemical studies demonstrated that the shelterin prot
66                                              Biochemical studies demonstrated that zinc strongly inhi
67                                              Biochemical studies demonstrated this class to exert its
68 se genetic data are strongly corroborated by biochemical studies demonstrating physical interactions
69 ecause of their very high sequence identity, biochemical studies done on H-Ras have been considered r
70 M6C) is inactive as a KDM, we demonstrate by biochemical studies, employing MS and NMR, that UTY(KDM6
71                                      Further biochemical studies establish that coordination of Ni(II
72                      Predictive modeling and biochemical studies establish why mutations in a positiv
73          These investigations, together with biochemical studies, established the nanostructure-activ
74                                   A previous biochemical study has shown that budding yeast Hop2-Mnd1
75     Structural analysis, in conjunction with biochemical studies, has uncovered the molecular basis f
76                                         Most biochemical studies have been performed either with the
77            While a variety of structural and biochemical studies have been reported that elucidate di
78                  Overall, our structural and biochemical studies have defined the molecular basis for
79                                              Biochemical studies have demonstrated that as little as
80                                       Recent biochemical studies have demonstrated that EsxA is a mem
81                                     Previous biochemical studies have demonstrated that in the presen
82                               Structural and biochemical studies have demonstrated that p73, p63 and
83 ve revealed the location of these sites, and biochemical studies have explored the kinetics of ACs, b
84               Although recent structural and biochemical studies have identified conserved sites of p
85             Although traditional genetic and biochemical studies have identified major players of tra
86                                     Previous biochemical studies have identified PriC residues that m
87                                  Genetic and biochemical studies have implicated impaired lysosomal a
88 the formation of highly cross-linked PG, but biochemical studies have not reached a consensus on its
89                                  Genetic and biochemical studies have previously implicated exonuclea
90                    Several computational and biochemical studies have proposed an acetate-escape hypo
91                           Although extensive biochemical studies have provided insight into the NO ac
92            Although multiple physiologic and biochemical studies have reported defects in mitochondri
93 ical (Golgi-Kopsch, electron microscopy) and biochemical studies have revealed an increased occurrenc
94                               Recent NMR and biochemical studies have revealed that binding of the pr
95                         Yeast two-hybrid and biochemical studies have revealed that the more distantl
96                      Although structural and biochemical studies have shed some light on their functi
97                                              Biochemical studies have shown that "autonomous" CaMKII
98                                         Bulk biochemical studies have shown that Bloom helicase (BLM)
99                                              Biochemical studies have shown that GI NoVs exhibit geno
100                            Genome mining and biochemical studies have shown that oomycetes, which bel
101                               Structural and biochemical studies have shown that RelE cuts with some
102                               Structural and biochemical studies have shown that these enzymes sharpl
103                               Structural and biochemical studies have shown that when TBP binds DNA,
104                                  Genetic and biochemical studies have suggested that GON4L is a trans
105                                 Cellular and biochemical studies identified distinct molecular defect
106                               Structural and biochemical studies identified key residues that are cru
107  acts downstream of SnRK2.2/2.3 kinases, and biochemical studies identified phosphorylation sites in
108               Transcriptomic, proteomic, and biochemical studies identified the chaperone BiP/GRP78/H
109                               Structural and biochemical studies identify a conserved region on TREX-
110                                  Genetic and biochemical studies implicate alpha-synuclein and leucin
111       Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autoph
112  as well as earlier electron microscopic and biochemical studies implicating a replication origin at
113                                              Biochemical studies in colonic epithelial cell lines rev
114                              Mutagenesis and biochemical studies in HEK293T cells revealed that alpha
115                                              Biochemical studies in primary cells established that th
116       We performed immunologic, genetic, and biochemical studies in the 2 siblings, their family memb
117       We performed immunologic, genetic, and biochemical studies in the patients, family members, and
118                                Molecular and biochemical studies in these mice indicate that FR ameli
119                                  Genetic and biochemical studies in vertebrate and invertebrate model
120                                              Biochemical studies in vitro and functional complementat
121                            Using genetic and biochemical studies in vitro and in human MM xenograft m
122                             As inferred from biochemical studies, in the Poliota/Polkappa pathway, Po
123 l domains combine to create a basic pore and biochemical studies indicate residues in this region par
124                                              Biochemical studies indicate that Hook proteins interact
125                                          Our biochemical studies indicate that in the Poliota/Polthet
126                                              Biochemical studies indicate that PDE4s are anchored to
127                                          Our biochemical studies indicate that PRORP2 requires Mg(2+)
128                                              Biochemical studies indicate that R742A as well as D113R
129                                              Biochemical studies indicate that the noncognate compete
130                                          Our biochemical studies indicate that this interaction is re
131                                          Our biochemical studies indicate that YTHDC2 is an RNA-induc
132                                     In vitro biochemical studies indicated that cortactin binds PI(3,
133          Moreover, structural comparison and biochemical studies indicated that Tyr 97 and His 138 ar
134  line but difficult to reconcile with former biochemical studies indicating that PAG is constitutivel
135                                              Biochemical studies informed by these structures demonst
136                      The aim of this clinico-biochemical study is to estimate and compare the levels
137  access homogeneously modified chromatin for biochemical studies, is well suited to the sensibilities
138 relevance of this enzyme as a model in early biochemical studies, its structure had not yet been solv
139 surements as well as sufficient material for biochemical studies like protein purifications, enzyme a
140                             From a series of biochemical studies, live imaging, and analyses of mutan
141 were not enough genetic, pharmacogenetic and biochemical studies of ADHD in adults and that more inve
142        Here, we report the first comparative biochemical studies of all the A3H variants using highly
143                                 Cellular and biochemical studies of alphaE- and alphaN-catenins show
144 cribe negative-stain electron microscopy and biochemical studies of alphaXbeta2 and alphaMbeta2 in co
145 omposition and structure through genetic and biochemical studies of angiosperms, as well as underlyin
146 lomeric DNA is susceptible to oxidation, few biochemical studies of base excision repair in telomeric
147                                              Biochemical studies of DDX1 and its interactions with Re
148 c approach, including chemical, physical and biochemical studies of EBN, is a reliable and scientific
149                                              Biochemical studies of exopolysaccharide synthesis are h
150                                              Biochemical studies of GEN1 revealed that it cleaves syn
151 , gene expression and enhancer analysis, and biochemical studies of gene regulation.
152                                              Biochemical studies of H3 and H4 tails binding to seven
153   This review covers topics from the classic biochemical studies of human biospecimens to the use of
154 ics and cell-biology studies with those from biochemical studies of MMR proteins and reconstituted MM
155                                           As biochemical studies of most proteins depend on their iso
156                                              Biochemical studies of mutant UBA5 proteins and studies
157                 Although many structural and biochemical studies of NRPSs exist, few studies have foc
158 can precursors, including Lipid II, enabling biochemical studies of proteins involved in cell wall as
159       Here, we utilized signaling assays and biochemical studies of purified recombinant ligand and r
160 tein, Y3, from the mushroom Coprinus comatus Biochemical studies of recombinant Y3 from a yeast expre
161 tomic sequencing, proteomics, phenotype, and biochemical studies of relatively unexplored basal fungi
162               Although recent structures and biochemical studies of RNA bound exosomes from S. cerevi
163 S. cerevisae V-ATPase that explains numerous biochemical studies of that enzyme.
164                           RNA-sequencing and biochemical studies of the DeltamybA strain suggested th
165  performed transcriptomic, histological, and biochemical studies of the early events during the infec
166                               Structural and biochemical studies of the monomeric archaeal XPD homolo
167 played markedly decreased phototransduction, biochemical studies of the mutant rhodopsin revealed onl
168 n silico modeling, mutagenesis, and in vitro biochemical studies of the P. falciparum SUMO E1 and E2
169                         Crystallographic and biochemical studies of the PMTs in this pathway provide
170                               Here, detailed biochemical studies of the RxLR effector AVR3a from the
171                                              Biochemical studies of the terminase proteins have been
172 ted MMR reaction now makes possible detailed biochemical studies of the wealth of mutations identifie
173                                        Early biochemical studies of viral replication suggested that
174                                          The biochemical study of Nodal and its signaling pathway has
175 s process, we have carried out a genetic and biochemical study of proteins proposed to function in ir
176                                       Recent biochemical studies on bovine papillomavirus 1 (BPV1) E1
177  aspects of resistance in VISA and summarize biochemical studies on cell wall synthesis in a VRSA str
178 results highlight the importance of detailed biochemical studies on GLUT protein expression levels in
179                                   Subsequent biochemical studies on identified partner proteins showe
180                                      Despite biochemical studies on individual gene products, the com
181                          Microbiological and biochemical studies on the class D beta-lactamases OXA-1
182 ll allow for further detailed structural and biochemical studies on the interaction of PAR with its m
183                                              Biochemical studies on the kinesins confirmed KIFC1, KIF
184                         Crystallographic and biochemical studies on the Pseudomonas syringae ethylene
185                                        Prior biochemical studies on the Sen1 homolog from Schizosacch
186                            However, in vitro biochemical studies on the thermal stability of Rho show
187                               Structural and biochemical studies on this enzyme elucidate the mechani
188 dered to be requisite A-EJ factors, based on biochemical studies or extrachromosomal substrate end-jo
189   Together with the results of complementary biochemical studies, our smFRET studies demonstrate that
190                                              Biochemical studies over the past 10 years have allowed
191                                  Genetic and biochemical studies, primarily in Salmonella enterica, h
192                                              Biochemical studies proved the importance of the C-termi
193 EF-G) bound to the ribosome, as well as many biochemical studies, provide evidence that the direct in
194 vely, the structure along with corroborating biochemical studies provided insights into the novel mod
195                                            A biochemical study provided evidence that Cav1.233L chann
196                            While genetic and biochemical studies remain the major approaches in chara
197                                Many of these biochemical studies require access to a structurally wel
198                           Our structural and biochemical studies reveal an unusually tight interactio
199                           Our structural and biochemical studies reveal catalytically essential resid
200                                              Biochemical studies reveal that ATOH8, GATA4, and FOG2 a
201                                 Furthermore, biochemical studies reveal that L. pneumophila uses two
202                      Confocal microscopy and biochemical studies reveal that neutrophil surface PDI i
203                           Our structural and biochemical studies reveal that SAV1 and MST2 heterodime
204                                              Biochemical studies reveal that the domain is a glucosyl
205 impedes proper recruitment of Orc6 into ORC; biochemical studies reveal that this region of Orc6 asso
206                     Our recent molecular and biochemical studies revealed that impaired mitochondrial
207                                              Biochemical studies revealed that MltG is an inner membr
208                                       Recent biochemical studies revealed that NisB glutamylates Ser/
209                                              Biochemical studies revealed that platelet DREAM positiv
210                                              Biochemical studies revealed that R129E-E2 and R150E-E2
211                                              Biochemical studies revealed that scFvG9 impairs the mat
212                                              Biochemical studies revealed that the enhanced anoikis r
213                               Structural and biochemical studies revealed that the helix domain is re
214                                  Genetic and biochemical studies revealed that the incompatibility is
215  BIRC3 as a negative regulator of NF-kappaB, biochemical studies revealed the presence of constitutiv
216 tural modeling, coupled with mutagenesis and biochemical studies, revealed dual binding sites for fed
217  chromatin presents a formidable obstacle to biochemical studies seeking to understand the role of co
218                                        Here, biochemical studies show a direct TFIID-E-protein intera
219                                     In vitro biochemical studies show that G-CSF programs MPO-EL expr
220                                              Biochemical studies show that Lyn(+/-) B cells have defe
221                                              Biochemical studies show that most analogues consistentl
222                                              Biochemical studies show that Nrf2 is concentrated into
223 ns the pH dependence of this transition, and biochemical studies show that pH regulates calcium influ
224                         Crystallographic and biochemical studies show that quinolone binding involves
225                                              Biochemical studies show that SLX-MUS is a HJ resolvase
226                                    Moreover, biochemical studies show that TAF7L associates with TRF2
227                                              Biochemical studies show that the calcium dependence of
228                                              Biochemical studies show that the hinge stimulates topo
229                              Our genetic and biochemical studies show that UBCH7 (UBC-18) and the RBR
230          Consistent with these observations, biochemical studies showed a reduction in the accumulati
231              Finally, immunocytochemical and biochemical studies showed preferential enrichment of th
232                                      Second, biochemical studies showed that aldolase indeed catalyze
233                                          Our biochemical studies showed that auranofin inhibits the b
234                                              Biochemical studies showed that DCM-associated RAF1 muta
235                                              Biochemical studies showed that NCU08746 requires copper
236                                       Recent biochemical studies showed that one pool of cholesterol
237                                     Previous biochemical studies showed that optimal AUF1 binding req
238                                              Biochemical studies showed that Plk1 phosphorylates PTEN
239                                              Biochemical studies showed that sIL-27Ralpha is released
240                                              Biochemical studies showed that TDE0214 binds c-di-GMP i
241                                              Biochemical studies showed that the affinities of ACm1A
242                                              Biochemical studies showed that the C-6 benzyl and biary
243                         Combined genetic and biochemical studies showed that the cytoplasmic tail of
244                                 Our previous biochemical studies showed that the TREX1 dominant autoi
245                                              Biochemical studies showed that, similar to previous NS-
246                                              Biochemical studies showed the two subtypes with an N-1
247                                    We report biochemical studies showing that the hallucinogen lyserg
248 cation of Orai, a plethora of functional and biochemical studies sought to compare Orai homologs, det
249                              Our genetic and biochemical studies strongly support a novel phytochrome
250                              However, recent biochemical studies suggest alternative molecular models
251                                      Further biochemical studies suggest that EcEndoV is able to bind
252                                              Biochemical studies suggest that excitatory neurons are
253                Genetic, cell biological, and biochemical studies suggest that reducing amyloid-beta (
254                                              Biochemical studies suggest that Spc110 facilitates high
255                                      Further biochemical studies suggested that EGFR signaling stimul
256                                              Biochemical studies suggested that spontaneous migration
257                                     Previous biochemical studies suggested that the recognition site
258                              Our genetic and biochemical studies support a model whereby Top1p recrui
259 on coordinate, combined with mutagenesis and biochemical studies support a single Mg(2+)-ion mechanis
260                                          Our biochemical studies support a uniquely nuanced pathway o
261                                              Biochemical studies support that promotion of spine form
262                      It was shown by several biochemical studies that activation and regulation depen
263 Here, we report through crystallographic and biochemical studies that K-80003 binds to and stabilizes
264                        Recent structural and biochemical studies that provide insight into the mechan
265   In this study, we conducted structural and biochemical studies that revealed that HdeB indeed works
266 dels of Cas9 function and the structural and biochemical studies that support it.
267                  Here, we report an in vitro biochemical study that shows that Sco1 is a metallochape
268                                 Finally, for biochemical studies, the designed sequences can suggest
269  the light of previous genetic, cellular and biochemical studies, the most parsimonious conclusion fr
270                          In combination with biochemical studies, the structural basis of self-protec
271                                           In biochemical studies, the V124W mutant recapitulated the
272 t two crystal structures of Sda1, as well as biochemical studies to address key structural features a
273                                        Using biochemical studies to characterize the wild-type (WT) a
274 rystal structure of GS-5745.MMP9 complex and biochemical studies to elucidate the mechanism of inhibi
275      We combined genetic, physiological, and biochemical studies to explore coevolution between the A
276 membrane anchor has allowed for physical and biochemical studies to identify the role of substrate in
277                                              Biochemical studies using muscle extracts from transgeni
278                                 Our previous biochemical studies using synaptoneurosomes demonstrate
279                                          Our biochemical studies, using recombinant Delta22 (a versio
280                Using mutational, genetic and biochemical studies we demonstrate that cellular concent
281                    Through genome mining and biochemical studies, we identified yet another subset of
282 isms in a milieu amenable for structural and biochemical studies, we identified, cloned, and partiall
283                      Based on structural and biochemical studies, we now provide insight into an unpr
284                                           In biochemical studies, we show that CB1R and 5-HT2AR form
285              Through an E3 ligase screen and biochemical studies, we unexpectedly identified that RNF
286 f these, 15 genetic, 2 pharmacogenetic and 6 biochemical studies were included in the meta-analyses.
287                                              Biochemical studies were performed to determine the func
288 me from Methanococcus vannielii, a series of biochemical studies were pursued to test the basic hypot
289 ibroblasts (MEFs) are convenient sources for biochemical studies when cell number in mouse embryos is
290                       This included not only biochemical studies which revealed the expected presence
291 lly heme-loaded MamP from AMB-1 for in vitro biochemical studies, which show that its Fe(III)-Fe(II)
292                             In combining our biochemical studies with crystal structures of bacterial
293 roposed to anchor Tim44 to the membrane, but biochemical studies with MB-10 show that this region is
294                                              Biochemical studies with myofilaments showed that RLC ph
295               Mutant phenotypic analyses and biochemical studies with purified proteins revealed that
296 h alternative forks may be utilized, and new biochemical studies with purified proteins that are aime
297                                              Biochemical studies with recombinant human DHODH led us
298                 Biophysical, mutational, and biochemical studies with the hyperthermostable two-domai
299 phate, this study sets the stage for further biochemical studies with this material.
300 oaches has complemented previous genetic and biochemical studies, yielding new information about how

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