ライフサイエンスコーパス: biochemically

1 capacitance) and hormone secretion (measured biochemically).

2 uction in the levels of soluble amyloid-beta biochemically.

3 issect both Mia40 activities genetically and biochemically.

4 nism for FACT reorganization that we confirm biochemically.

5 binding to Hsc70 as substrate, as determined biochemically.

6 wn protein-DNA interactions structurally and biochemically.

7 AG domain, and this finding is substantiated biochemically.

8 as synthesized, characterized, and evaluated biochemically.

9 d EgtE functionality remained to be verified biochemically.

10 FaEXP2 were characterized phenotypically and biochemically.

11 rboxypeptidase activity, which was confirmed biochemically.

12 e carrier, has been thoroughly characterized biochemically.

13 SLC25A36, have been thoroughly characterized biochemically.

14 CERK1 and CERK1-4 proteins were analyzed biochemically.

15 ne, which we have purified and characterized biochemically.

16 nendothelial cells, an association confirmed biochemically.

17 d efforts to delineate fermentation pathways biochemically.

18 ich we extensively validated genetically and biochemically.

19 t is important for the formation of open and biochemically accessible chromatin fiber that is conduci

20 ace of ancient Mars, potentially providing a biochemically accessible source of nitrogen.

21 lty, we synthesized solenopsin analogs which biochemically act as ceramides, but cannot be metabolize

22 hment of the protocols for the production of biochemically active CHIKV nsP2 and optimization of the

23 are a prolific source of tightly regulated, biochemically active non-coding elements, such as transc

24 :1 (Delta3trans) uniquely labels a small but biochemically active plastid phosphatidylglycerol pool i

25 ing the question of whether nonconserved but biochemically active regions are truly functional.

26 However, the biochemically active regions cover a much larger fractio

27 Here, we were able to biochemically analyze autophagic intermediate membranes

28 e cultivars, and their encoded proteins were biochemically analyzed.

29 We characterized sumoylation of FOXP2 biochemically and analyzed the region-specific function

30 M1, CCM2, and CCM3, interact genetically and biochemically and are mutated in cerebral cavernous malf

31 tein synthesis, and made mice resistant both biochemically and behaviorally to the antidepressant eff

32 We analyzed the effects biochemically and behaviorally, using the forced swim, t

33 to expand on these previous observations, we biochemically and biophysically characterized the intera

34 VIII collagen - are present in BMs, creating biochemically and biophysically distinct structures that

35 mmonly used concentrations and characterized biochemically and biophysically.

36 Autophagy was monitored biochemically and cell death was measured using multiple

37 of HDAC proteins are becoming apparent both biochemically and clinically, how this class of proteins

38 We verified the PACSIN1-KCC2 interaction biochemically and demonstrated that shRNA knockdown of P

39 0693 potently inhibited PrkA kinase activity biochemically and exhibited significant selectivity for

40 tein metabolism, it is of upmost interest to biochemically and functionally characterize the in vivo

41 identify two pools of gamma-tubulin that are biochemically and functionally distinct and differential

42 We find that dynein can be in biochemically and functionally distinct pools: either tr

43 n 43 (TDP-43) Drosophila ortholog (TBPH) can biochemically and functionally overlap the properties of

44 Herein, we biochemically and functionally probe PRC2's recognition

45 te that in P. patens the canonical Galpha is biochemically and functionally replaced by an XLG protei

46 This polarized epithelium is composed of biochemically and functionally separate apical and basol

47 ious TTSPs have been characterized in detail biochemically and functionally, the basic properties of

48 he crystal structure and characterized, both biochemically and functionally, the macrodomain protein

49 IR3DS1 bound to HLA-F, a result we confirmed biochemically and functionally.

50 ysbindin, and subunits of the BLOC-1 complex biochemically and genetically interact, modulating Droso

51 dered a transcriptional activator, interacts biochemically and genetically with the nucleosome remode

52 31A) in full-length RECQ1 were characterized biochemically and genetically.

53 planation for many of the complexes detected biochemically and illustrates the ability of Vps75 to in

54 These conjugates were characterized biochemically and immunologically.

55 nism of Ub E2 activity, which we demonstrate biochemically and in cell-based assays.

56 UF5(Vv) processing of Ras, which occurs both biochemically and in mammalian cell culture, inactivates

57 amined the mutation of the human IGHV3-23*01 biochemically and in the endogenous heavy chain locus of

58 enesis model in which cells were cultured in biochemically and mechanically defined matrices to exami

59 to the brain involves cell migration through biochemically and physically complex microenvironments a

60 ressure were either histologically scored or biochemically and physically quantified in all animals.

61 ase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influe

62 Although BamB has been biochemically and structurally characterized, its mechan

63 oned, over-expressed in Escherichia coli and biochemically and structurally characterized.

64 and signal transduction, few have been both biochemically and structurally characterized.

65 Here we study biochemically and structurally one of the Naegleria Tet-

66 These were characterized biochemically and structurally, and the one partially sh

67 domain, confirming the designed interaction biochemically and structurally, and then transplanting t

68 c1(WD40) deleted was generated and evaluated biochemically and structurally.

69 ediated by cofactors Psy2 and Ddc2, is shown biochemically and through FRET in subnuclear repair foci

70 lower prevalences were more likely to differ biochemically and to be part of an electrophoretic mixtu

71 t CD41-fragments by neutrophils, as assessed biochemically and visualized by microscopy, with no infl

72 he absolute brightness of Arch, as confirmed biochemically and with live-cell imaging (in Escherichia

73 al findings were validated morphometrically, biochemically, and by immunofluorescence microscopy (IFM

74 nd kindlin-3 in human platelets, as assessed biochemically, and by immunofluorescence microscopy and

75 ellar transport complexes, which we validate biochemically, and by probing structurally predicted, di

76 We show that Tmods and Lmods do not compete biochemically, and display similar but distinct localiza

77 Thus, PKCiota and SOX2 are genetically, biochemically, and functionally linked in LSCC, and toge

78 es an excellent opportunity to structurally, biochemically, and genetically dissect the mechanism of

79 efine AAV-AAVR interactions, genetically and biochemically, and show that different AAV serotypes hav

80 We characterized occludin biochemically as a novel NADH oxidase that controls the

81 Rhodopsin phosphorylation has been measured biochemically at C-terminal serine residues, suggesting

82 Currently, these interactions are defined biochemically, but a method is needed to evaluate them q

83 tified by Masson trichrome blue staining and biochemically by hydroxyproline content, in wild-type bu

84 uced at these positions were first evaluated biochemically by monitoring nsp14 exoribonuclease activi

85 aim of the current study was to generate and biochemically characterize analogues of this peptide wit

86 Here, we further biochemically characterize the AAV-AAVR interaction and

87 Here we biochemically characterize the substrate preferences of

88 To biochemically characterize this interaction and identify

89 In this study we biochemically characterize Tpr.

90 Here, we biochemically characterized 13 yeast phosphatases from t

91 Although PstP has been biochemically characterized and multiple in vitro substr

92 action, because only a few members have been biochemically characterized and no three-dimensional str

93 The assay is biochemically characterized and optimized for high-throu

94 RcaB, RcaD, and RcaE were overexpressed and biochemically characterized as riboflavin kinase, ribofl

95 ight that mutant enzymes should be carefully biochemically characterized before making in vivo infere

96 h syndrome, a fatal childhood cardiomyopathy biochemically characterized by reduced cardiolipin mass

97 To this end, we recombinantly produced and biochemically characterized CML36 from Arabidopsis thali

98 pecialized motifs on proteins that have been biochemically characterized decades ago.

99 alysis to confirm the over-expression of the biochemically characterized enzymes during growth of the

100 ot belong to the F3'5'H clade, but resembles biochemically characterized F3'Hs (flavonoid 3' hydroxyl

101 and the plant barley (Hordeum vulgare) were biochemically characterized in vitro.

102 Here, we functionally and biochemically characterized Kirrel2, an immunoglobulin s

103 ansferases RP789 and RP027-028 are the first biochemically characterized methyltransferases to cataly

104 Hence, OxsB represents the first biochemically characterized non-methylating Cbl-dependen

105 In the current study, we have identified and biochemically characterized novel ulvan lyases from thre

106 tigate this possibility, we structurally and biochemically characterized recombinant PhiCpeT.

107 In the present study, we have biochemically characterized SerB2 enzyme and developed m

108 Recently, we structurally and biochemically characterized the enzyme human L-asparagin

109 We also biochemically characterized the enzyme with respect to p

110 Here, we biochemically characterized the interactions between Ubp

111 We also biochemically characterized the molecular events associa

112 ent arrangements of the mutated modules, and biochemically characterized their interactions with GroE

113 ions that induce protein misfolding and have biochemically characterized this site of phosphorylation

114 We identified and biochemically characterized three leucoanthocyanidin red

115 TRK1 mutations in the cognitive phenotype we biochemically characterized three TrkA mutations identif

116 Selected circRNAs were biochemically characterized, and we found that the major

117 study, Cape gooseberry PPO was isolated and biochemically characterized.

118 til now, few of these transporters have been biochemically characterized.

119 y, the 11S globulin (Hs11S) was purified and biochemically characterized.

120 identified, and the recombinant enzymes were biochemically characterized.

121 ditional lethal mutants were genetically and biochemically characterized.

122 Biochemically, chelerythrine induced the activation of c

123 Here we biochemically compared the previously documented microtu

124 Of note is a candidate drug that did not biochemically compete with the ATP substrate for the con

125 e analytically harmful interference from the biochemically complex sample matrix of blood serum.

126 We biochemically confirmed BLOC-1 presence in Drosophila ne

127 Relapse during the first 7 days was biochemically confirmed by the presence of the nicotine

128 The main efficacy endpoint was biochemically confirmed continuous abstinence for weeks

129 C-NRT produced no significant differences in biochemically confirmed rates of smoking abstinence at 2

130 allenging and only a small fraction has been biochemically confirmed.

131 Outcomes were biochemically confirmed.

132 d topology of Mfn1 and Mfn2 was demonstrated biochemically, confirming that the C-terminal, redox-sen

133 y influencing systemic lipid homeostasis and biochemically contributing many metabolites.

134 to occur in mechanically active media can be biochemically controlled to robustly drive morphogenetic

135 VX-809 biochemically corrected approximately 10% of both of the

136 ne kinase inhibitory potential in silico and biochemically; cyanidin-3-O-glucoside had one of the hig

137 ely uridylates these miRNAs in vitro, and we biochemically define a bipartite sequence motif that is

138 We genetically and biochemically define a minimal subcomplex comprising jus

139 We biochemically define the CHR consensus as TTYRAA and det

140 ), contains a compaction region that has the biochemically defined activity of bridging adjacent nucl

141 well documented, but without assays that use biochemically defined components and measure single-pore

142 titatively explored for the first time using biochemically defined kinetic assays examining rates of

143 BT-263, ABT-737, GX15-070, HA14.1, TW-37) in biochemically defined large unilamellar vesicle model sy

144 Our structures are fully consistent with all biochemically defined ligand-contacting residues, and th

145 STRIP1 is a core component of the biochemically defined mammalian striatin-interacting pho

146 ls, based on rescue expression with a set of biochemically defined mutants.

147 wild-type GFP fragments represent the first biochemically defined natural defective ribosomal produc

148 trates, providing additional support for the biochemically defined network.

149 but pore properties are poorly known because biochemically defined single-pore assays are lacking.

150 mone receptor (TR)-driven transcription in a biochemically defined system in a Mediator-dependent man

151 steps of DNA damage checkpoint response in a biochemically defined system.

152 This study genetically and biochemically delineates the functions of the enzymes re

153 Here, we biochemically demonstrate that the HA antigenic site B o

154 ad PhoX and PhoD implies the potential for a biochemically dependant interplay between oceanic zinc,

155 tional bifurcation analysis, performed for a biochemically-detailed and biologically-relevant model t

156 Here, we characterize A46 biochemically, determine by microscale thermophoresis bi

157 osylation (CDG) are known, but many patients biochemically diagnosed with CDG do not have mutations i

158 th phase with a reduced replication rate and biochemically different from extracellular bacteria prov

159 r cell cycle, initiation is divided into two biochemically discrete steps: the Mcm2-7 helicase is fir

160 hermore, structural analyses have identified biochemically discrete subunit modules that assemble alo

161 We biochemically dissected these two classes of NPFs to det

162 In support, we reveal the existence of two biochemically distinct DAXX-containing complexes: the AT

163 in which individual faces are established as biochemically distinct domains by endomembrane trafficki

164 Yet, within the biochemically distinct environments of cellular organell

165 ence-dependent pathway that is spatially and biochemically distinct from bulk recycling.

166 itopes recognized by these antibodies define biochemically distinct glycoforms of RPTPzeta/phosphacan

167 itch that controls the relative abundance of biochemically distinct types of collagen cross-links in

168 ty-based probe-labelled enzymes isolated was biochemically distinct, with different enzyme kinetic pr

169 ack of cis, medial, trans cisternae that are biochemically distinct.

170 t with the ancestral hosts in ways which are biochemically distinct.

171 pplying similar approaches to clinically and biochemically diverse neurometabolic disease cohorts.

172 Spores are usually regarded as biochemically dormant, but our findings demonstrate that

173 These observations suggest that biochemically equivalent organic matter has accumulated

174 in non-template DNA, corroborating with all biochemically established properties of R-loops.

175 /+), Nnt(+/-), and Nnt(-/-) mouse liver were biochemically evaluated and challenged with exogenous pe

176 used most often by mutations in K-Ras, which biochemically favours the stabilization of active RAF si

177 uestion, we construct in silico all possible biochemically feasible alternatives to the trunk pathway

178 es have been reported to inhibit HIV RNase H biochemically, few show significant antiviral activity a

179 The serine proteases in saliva differ biochemically from trypsin and chymotrypsin, and the cat

180 fferences in cell viability were observed in biochemically GPI-AP-deficient cells and were further in

181 We find that biochemically identical annexins (annexin V) display dif

182 s work on respiratory chlorate reduction has biochemically identified the terminal reductase ClrABC a

183 um-motive force and proton-motive force, and biochemically identify protein regions and residues that

184 ime-resolved serial crystallography to study biochemically important interactions between biomacromol

185 /MS was used to identify these neuropeptides biochemically in Cataglyphis fortis.

186 The enzyme has been previously characterized biochemically in fungi, but no structural information is

187 roteins have been implicated genetically and biochemically in the assembly of eukaryotic ribosomes.

188 ropagating in a variety of wild yeast differ biochemically, in their intracellular distributions, and

189 Mutants are biochemically inconspicuous, while their clustering into

190 The six human clinical isolates were biochemically indistinguishable from each other and show

191 LCA mutants of CCTbeta, T400P and R516H, are biochemically instable and the affinity for the adjacent

192 Dysbindin/BLOC-1 and ATP7A genetically and biochemically interact.

193 Strip genetically and biochemically interacts with both Glued (the regulator o

194 Finally, human KIAA0556 biochemically interacts with ciliary proteins and p60/p8

195 CBX8 biochemically interacts with TRIM33, and its recruitment

196 s containing a beta3 linked GlcNAc known, we biochemically interrogated this human enzyme.

197 o co-expressed recombinant TioN and TioT and biochemically investigated three potential pathways invo

198 Ligand chemotaxis has been biochemically investigated using mammalian and model sys

199 ology in which any cell subpopulation can be biochemically investigated.

200 We used cdN-conjugated beads to biochemically isolate host receptors for bacterial cdNs,

201 Cellular compartments that cannot be biochemically isolated are challenging to characterize.

202 itatory synaptic input onto neurons, and are biochemically isolated from the parent dendritic shaft b

203 ar mechanism underlying this observation, we biochemically isolated reporter-tagged Mbp mRNA granules

204 To address this question, we biochemically isolated skeletal muscle proteins that ass

205 Biochemically, KatB was an efficient, robust catalase th

206 portant human PHD isoform, is proposed to be biochemically/kinetically suited as a hypoxia sensor due

207 riptional activity via the quantification of biochemically labeled nascent RNA molecules derived from

208 eat kinase 2 (LRRK2) gene is genetically and biochemically linked to several diseases that involve in

209 hough pathogenic LCs have been characterized biochemically, little is known about the biology of amyl

210 Biochemically, Lmods differ from Tmods, acting as powerf

211 Biochemically, marked accumulation of CYP7B1 substrates

212 on model postulates that transient cisternae biochemically mature to ensure anterograde transport.

213 via vesicles and another one where cisternae biochemically mature to ensure anterograde transport.

214 data for 100 patients were assessed against biochemically measured TPMT enzyme activity, clinical re

215 l-Th biochemically modulates various anti-neoplastic agents b

216 However, higher plant mitochondria differ biochemically, morphologically, and dynamically from tho

217 Biochemically, Mte1 stimulates Mph1-mediated DNA replica

218 Biochemically mutant mice showed impaired electron trans

219 ucturally characterized 101 Mass2Motifs with biochemically or chemically relevant substructures.

220 sis of 227 DUF156 protein members, including biochemically or structurally characterized CsoR/RcnR re

221 Although biochemically patterned hydrogels are capable of recapit

222 To biochemically probe the function of metal ion interactio

223 Livers from each animal were biochemically profiled using UHPLC-QTof-MS in ESI+ mode

224 oys, aged 5-10 years, (mean 8.14 years) with biochemically proved X-ALD, underwent plain MR imaging w

225 We used this system to biochemically purify factors responsible for inhibiting

226 To correlate biochemically quantifiable defects resulting from point

227 We biochemically reconstituted a 12-component signaling pat

228 We biochemically reconstituted NPC core protomers and eluci

229 ay for [2Fe-2S] cluster biosynthesis that we biochemically reconstituted using purified mitosomal ISC

230 Biochemically, RECQ5 alleviates the inhibitory effect of

231 Imaging of biochemically recurrent prostate cancer has been establi

232 n men (mean age +/- SD, 74.3 +/- 5.9 y) with biochemically recurrent prostate cancer underwent both (

233 (18)F-fluciclovine images from subjects with biochemically recurrent prostate cancer with acceptable

234 utions in this small cohort of patients with biochemically recurrent prostate cancer.

235 T tracers in a small cohort of patients with biochemically recurrent prostate cancer.

236 on the intended management of patients with biochemically recurrent prostate cancer.

237 fluxes of methane emanating from ecosystems biochemically reducing organic carbon.

238 bit bona fide Rab-GGT activity, and they are biochemically redundant in vitro.

239 ific sex pheromone, consisting of a blend of biochemically related components, to which males are att

240 tematically infer covariation patterns among biochemically related metabolites, as well as unknown on

241 tion data from a given experiment to extract biochemically relevant features in an unsupervised manne

242 cluding membrane structure and function, and biochemically relevant for their exquisite enzymatic cyc

243 tational tools that enable extraction of key biochemically relevant information.

244 Our approach extracts biochemically relevant molecular substructures ("Mass2Mo

245 viously, we presented MS2LDA, which extracts biochemically relevant molecular substructures ("Mass2Mo

246 constants of binding were estimated for four biochemically relevant molecular systems by a method tha

247 We introduce a new biochemically responsive Mn-based MRI contrast agent tha

248 em provides a new paradigm for the design of biochemically responsive MRI contrast agents.

249 mation fuelled by MYC, the chaperome becomes biochemically 'rewired' to form a network of stable, sur

250 tructural disequilibrium unbalances ribosome biochemically: rotated ribosomes favor binding of the eE

251 Biochemically, Rrh(-/-) mice had approximately 2-fold hi

252 le biological functions through independent, biochemically separable activities of its individual str

253 However, independent of CPT, biochemically similar chimeric enzymes produced striking

254 ns of ligands in a fluctuating background of biochemically similar ligands binding to the same recept

255 However, nanoparticle-formulated drugs are biochemically sophisticated, which causes their translat

256 dings suggest a previously unappreciated and biochemically specific method of clinically fine-tuning

257 the same sites and physically interact as a biochemically stable complex.

258 nserved C-terminal portion of the peptide is biochemically stable in human serum, and most serum-stab

259 led many to assume that these parasites are biochemically static and uninteresting.

260 adin 1 (rGG1) was purified and characterized biochemically, structurally, and immunologically by usin

261 viable mutant, suggesting that although BTZ biochemically targets DprE1, killing also occurs through

262 purified human mRNA-capping enzymes, we show biochemically that efficient inhibition by IFIT1 is depe

263 We demonstrate biochemically that irreversible DSBs are generated by su

264 We then show biochemically that MOAG-2/LIR-3 can also catalyze the ag

265 We determined biochemically that PGAM5 is required for the stabilizati

266 We demonstrated biochemically that PotriKCS1 elongates monounsaturated f

267 Biochemically, the Kcnq2 deficiency secondarily results

268 Biochemically, the L8A mutation alone slightly weakens t

269 hough MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis

270 Biochemically, there is a deficit in cholesterol and an

271 unicate with each other, both physically and biochemically, thereby facilitating the functions of thi

272 and missense p.Pro272Leu mutations are shown biochemically to be loss of function.

273 nly bacterial MMP to have been characterized biochemically to date.

274 s a V-1 homolog that we show is very similar biochemically to mouse V-1.

275 heoretical and experimental models for these biochemically ubiquitous classes of reaction.

276 known; nonetheless, the mutant's survival in biochemically uncharacterized environments (such as the

277 tance to mycobacterial disease, has remained biochemically uncharacterized.

278 iallelic mutations in LYRM7 in patients with biochemically unclassified leukoencephalopathy.

279 We biochemically validate the binding of one of these novel

280 Biochemically validated 7-day tobacco abstinence at 6 mo

281 These binding sites were biochemically validated by EMSA-FRET analysis and valida

282 determined by parent or child reports and/or biochemically validated measures including cotinine, car

283 sult of our exhaustive virtual screening, we biochemically validated novel potent and selective inhib

284 We biochemically validated the screen by demonstrating that

285 Computational predictions, which were biochemically validated, show an extensive overlap of re

286 The primary endpoint was biochemically verified 7 day point prevalence abstinence

287 We also assessed biochemically verified 7-day abstinence at 3, 6, and 18

288 nence rates for weeks 12 through 64 based on biochemically verified abstinence and weeks 12 through 7

289 o a maximum of U.S. $1,650, were offered for biochemically verified abstinence at 1, 2, and 3 weeks,

290 g at very low unit costs; however, long-term biochemically verified evidence is scarce and such inter

291 Variables considered to assess efficacy were biochemically verified smoking cessation, mean cigarette

292 tances of cross-pathway regulation, which we biochemically verified.

293 ich fungi acquire, utilize, and control this biochemically versatile trace element.

294 the first time, differentiates SAG and RBX1 biochemically via their respective binding to different

295 Biochemically, we detect an interaction between MADD-4 a

296 Additionally, we show that CLPB interacts biochemically with ATP2A2, known to be involved in apopt

297 on approaches revealed that SERK1 interacted biochemically with EMS1.

298 en that they were established and delineated biochemically with only a few model organisms.

299 w months, he began to improve clinically and biochemically, with complete resolution by one year post

300 high-risk localized prostate cancer relapse biochemically within 5 years.