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1 indolin-2-ones, which were superseded by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-
2 )indolin-2-ones, which are superseded by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-
4 ctional groups, such as -OH, -NH(2), and the bioisosteric 5-substituted indole moiety in both di and
6 derivatives (i.e., 7 and 8) were designed as bioisosteric analogues based on the phenol prototype 4.
10 he recently discovered hydroxamic acids, all bioisosteric attempts to replace the carboxylic acid of
11 e indole molecular core was replace with the bioisosteric benzofuran or benzothiophene ring systems,
12 urring antibiotic heronapyrrole C carrying a bioisosteric carboxylate in place of the nitro group, wa
13 cially available thiols are divided into 231 bioisosteric clusters, whose compositions agree at least
17 acement of the benzophenone carboxylate with bioisosteric equivalents could lead to potent analogues.
18 e NK3R antagonist chemotype achieved through bioisosteric lead change from the high-throughput screen
19 orus compounds were synthesized as potential bioisosteric mimics of peptide alpha-ketoesters and alph
23 , this study represents the first example of bioisosteric replacement of an acetate group by a spirob
24 c elaboration and exciting opportunities for bioisosteric replacement of hydroxyl with fluorine in na
26 More specifically, the best changes involve bioisosteric replacement of one of the two phenyl rings
27 f these novel antiviral compounds, including bioisosteric replacement of the 4H-thieno[3,2-b]pyrrole
31 such as alpha-alkylation, homologation, and bioisosteric replacement of the aminoguanidine all were
33 oieties connected to the piperazine ring and bioisosteric replacement of the aromatic tetralin moieti
34 imidine-5-carboxylates (16) were designed by bioisosteric replacement of the carbonyl group at positi
35 Series of compounds were generated via the bioisosteric replacement of the carboxylate of 4-ACPCA (
36 eptide conjugation based on the nonclassical bioisosteric replacement of the guanidine group in argin
37 ge urinary incontinence (UUI), we found that bioisosteric replacement of the N-cyanoguanidine moiety
38 computer-assisted design was focused on the bioisosteric replacement of the N1 atom by a CH group in
39 Analogue 23 containing a thiophene ring as a bioisosteric replacement of the phenyl ring Ar(1) displa
42 bioisostere, which could be of importance in bioisosteric replacement strategies for future ligand de
43 IC(50): 0.13-0.37 muM) were designed using a bioisosteric replacement strategy and proved to be effec
44 ize a lead molecule for further development, bioisosteric replacements are generally adopted as one o
45 y are often used with the intention of being bioisosteric replacements for ester and amide functional
46 covered that these compounds can function as bioisosteric replacements for the corresponding WIN 35,0
47 ple substitution, single atom mutations, and bioisosteric replacements for the guanidine and carboxyl
48 effort has focused on the identification of bioisosteric replacements for the usual oxazolidinone A-
49 il the potential of aromatic azaborinines as bioisosteric replacements of naphthalene in drug discove
51 iological evaluation of topologically based, bioisosteric replacements of the quinoxaline moiety in t
52 tuents in the 4, 4', or 5' positions and the bioisosteric substitution of the distal carboxylic acid
53 paper examines the relative effectiveness of bioisosteric sulfamate and sulfamide derivatives for inh
56 h that the tricyclic naphthofuran nucleus is bioisosteric with, and directly superimposable upon, the
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