ライフサイエンスコーパス: biologic

1 vel therapeutics (183 pharmaceuticals and 39 biologics).

2 conduct a continuous size-based analysis of biologics.

3 capabilities compared to small molecules and biologics.

4 strategy is compatible with a wide array of biologics.

5 rsification studies with small molecules and biologics.

6 , and no previous use of immunomodulators or biologics.

7 ically modified bacteria for the delivery of biologics.

8 vention trials with specific agents, such as biologics.

9 r new strategies to generate next-generation biologics.

10 etween IBD patients treated with and without biologics.

11 per 1,000 person-years were as follows: non-biologic, 14.2 (11.5-17.4); etanercept, 15.3 (11.6-20.1)

12 Continuous production of biologics, a growing trend in the biopharmaceutical indu

13 ant metabolism when attempting to define the biologic action of small molecules.

14 ein chemistry in the 1950s revealed that the biologic activities of proteins, such as hemoglobin and

15 the KL1 domain is sufficient for the tested biologic activities.

16 migenes CM reflects the in vivo retention of biologic activity and the therapeutic potential of these

17 Evidence of biologic activity consistent with CD27 stimulation-chemo

18 We aimed to characterize the biologic activity of ATIs in various foods and their eff

19 ding JNK and WNT/beta-catenin, inhibited the biologic activity of domain 4.

20 Here, we explore recent biologic advances that are redefining the spectrum of ca

21 CI, 0.46-4.32) vs patients not exposed to a biologic agent (SIR, 2.17; 95% CI, 0.59-5.56), even when

22 more rational approach to picking a specific biologic agent for a specific patient.

23 assigned (1:1) to receive a non-TNF-targeted biologic agent or an anti-TNF that differed from their p

24 As a live biologic agent, OV has the ability to target and selecti

25 s with malignancy had also been exposed to a biologic agent.

26 thotrexate was used by 270 patients (69.2%), biologic agents (primarily etanercept) by 106 (27.2%), a

27 I discuss biologic agents already approved for the management of a

28 Biologic agents are important therapeutic options for tr

29 However, despite the number of biologic agents available, the treatment of advanced-sta

30 The utility of biologic agents for the management of allergic diseases

31 s have important implications for the use of biologic agents targeting such pathways to modulate auto

32 Novel biologic agents that target specific and critical pathop

33 2; and adalimumab, 1), but methotrexate and biologic agents were taken for a mean duration that was

34 stases become refractory to chemotherapy and biologic agents, at which point the median overall survi

35 Exposure to chemotherapeutic or biologic agents, prior liver therapies, biochemical para

36 s the role of TDM for more recently approved biologic agents, such as vedolizumab or ustekinumab.

37 , such as the requirement for treatment with biologic agents.

38 f additional treatment, including injectable biologic agents.

39 heir rarity among sarcomas, as well as their biologic and clinical heterogeneity, is that management

40 by several orders of magnitude, depending on biologic and environmental factors.

41 omposition of the gut microbiome, as well as biologic and genetic influences.

42 other, including combination therapy with a biologic and immunomodulator compared to biologic monoth

43 have been reported to play diverse roles in biologic and pathologic processes, including myogenesis.

44 repair patients and offers an alternative to biologic and permanent synthetic meshes in these complex

45 come measures were implant and FPD failures, biologic and prosthetic complications, and marginal bone

46 e Ets-1/NRAS regulatory network and may have biologic and therapeutic implications.

47 Cell biologic and transcriptome analyses implicate dysregulat

48 integrative approaches, to address specific biologic and/or clinical questions.

49 y stage of the development and production of biologics and bio-therapeutic formulations.

50 nfliximab (IFX) with patients not exposed to biologics and calculated standardized incidence ratios (

51 ntial alternative method for the delivery of biologics and engineering MSCs.

52 Two trends related to drugs/biologics and generic drugs/biosimilars underlie this ov

53 at age 60 years or older with a lower use of biologics and immunomodulators but higher absolute risk

54 adult-onset IBD, elderly patients used fewer biologics and immunomodulators but more systemic cortico

55 rugs offer future alternatives to the use of biologics and less costly long-term disease management.

56 The development of effective biologics and small-molecule kinase inhibitors in the pa

57 tempt to give a bird's-eye view of the major biologics and to highlight insights and implications der

58 libraries as a robust method to discover new biologics and uncover membrane-to-nucleus signaling path

59 The relative contribution of social, biologic, and clinical risk factors to RSV mortality in

60 tigated, and its association with microbial, biologic, and periodontal disease clinical parameters is

61 the total drug payments to ophthalmologists, biologic anti-VEGF agents ranibizumab and aflibercept ac

62 regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden.

63 Drugs and biologics approved by the FDA that mention TPPs are asso

64 esearch and is being used to produce several biologics approved for use in human or veterinary medici

65 Several biologics are currently available that target proinflamm

66 Biologics are made of protein components, and thus can b

67 Although most of these biologics are tested and approved for one or a few indic

68 pharmaceutical products, or brand drugs and biologics, are at levels that some assessments consider

69 critical for the manufacture of high-quality biologics as it enables continuous, real-time and on-lin

70 data suggest that pregnancy is a formidable biologic barrier for women and contributes uniquely to s

71 re, we review the underlying biochemical and biologic basis for a variety of PET tracers and how they

72 placental function have been suggested as a biologic basis for these findings.

73 suggests that cfDNA may better reflect tumor biologic behavior or aggressiveness rather than tumor bu

74 e antiangiogenic response with the anti-VEGF biologic bevacizumab.

75 We report the initial physical and biologic characterization of this novel ligand.

76 vely, and 3,421 participants were in the non-biologic cohort.

77 ss multiple time points or between different biologic compartments (e.g., blood and tissue samples) i

78 Nine biologic complications occurred in the NDI group and twe

79 and soft tissue level changes, technical and biologic complications, and implant failure rate associa

80 in soft tissue level changes, technical and biologic complications, or implant failure rate.

81 These ADAs can lead to a decrease in biologic concentration, which is associated with lower t

82 how their production is regulated, and what biologic consequences ensue.

83 mation from dense protein assemblies under a biologic context.

84 nt of allergic and respiratory disorders and biologics currently in development or recently abandoned

85 vier than the modern atmosphere, requiring a biologic cycle with nitrogen fixation, nitrification and

86 quantitative PCR and collected clinical and biologic data by reviewing the patients' medical records

87 at initial diagnosis and relapse, indicating biologic divergence.

88 more tumor necrosis factor inhibitors, other biologic DMARDs, or both, we randomly assigned the patie

89 safety and the maximum tolerated and optimal biologic doses of varlilumab.

90 eliver chemical drugs without excipients and biologics drugs in the presence of sugar excipients into

91 orona, and the ability to easily encapsulate biologics during particle preparation using a mild solve

92 re seen in the comparisons between the newer biologics (e.g. vedolizumab) and the anti-tumor necrosis

93 e developed injection technique can elicit a biologic effect in vivo.

94 MBq of (225)Ac-PSMA-617 assuming a relative biologic effectiveness of 5 revealed mean doses of 2.3 S

95 to leverage progress made in identifying the biologic effects of schizophrenia alleles to identify no

96 of our knowledge murine models to study the biologic effects of various activity levels have not bee

97 evels close to lethal and was accompanied by biologic effects that reduced long-term survival.

98 SUV differences are likely due to legitimate biologic effects.

99 a pleiotropic cytokine with a wide range of biologic effects.

100 , may still not fully characterize the total biologic effects.

101 orded high radiochemical purity suitable for biologic evaluation (radiochemical purity > 95%, decay-c

102 This biologic evaluation suggests that (18)F-JNJ64349311 is a

103 In the United States, the Center for Biologics Evaluation and Research of the US Food and Dru

104 and gauging the tempo of changes in climate, biologic evolution, and magmatic processes throughout Ea

105 These findings suggest that diverse biologic exposures, including allergens and endotoxin, i

106 ERK signaling pathway, BRAF-V600E shapes key biologic features of HCL, including its specific express

107 ert SMIC due to their distinct phenotype and biologic features.

108 roduced by epithelial cells and are found in biologic fluids including blood and urine.

109 ns suggest that use of EBI3 as a therapeutic biologic for autoimmune diseases will likely require co-

110 ADCs) are among the most promising empowered biologics for cancer treatment.

111 decade has seen the approval of several new biologics for the treatment of severe asthma-targeting s

112 m for rapid and switchable production of two biologics from a single yeast strain as specified by the

113 for genomic alterations to understand their biologic function and to translate that knowledge into c

114 riptomic and genetic toolkit reveals in vivo biologic function for the Drosophila m(6)A pathway.

115 Furthermore, we reveal a new biologic function of TRAF2 that contributes to epithelia

116 for GPR27 complicates the examination of its biologic function.

117 emory T cells, indicating these lncRNAs have biologic function.

118 tood how these activities and the consequent biologic functions of EYA are regulated.

119 Biologic functions that were overrepresented by common v

120 C3a exerts multiple biologic functions through activation of its cognate C3a

121 rms, ERalpha and ERbeta, which have distinct biologic functions.

122 ators of gene expression involved in diverse biologic functions.

123 present a new alternative to these cadaveric biologic grafts.

124 ncentrated platelets that provides a pool of biologic growth-promoting factors and cytokines, which h

125 ood clearance was biexponential, with a mean biologic half-life of 0.3 h (58%) for the rapid alpha ph

126 y clearance was monoexponential, with a mean biologic half-life of 1.95 h, whereas blood clearance wa

127 The median biologic half-life T1/2beta was 111 h (range, 78-193 h).

128 of sickle crises and with correction of the biologic hallmarks of the disease.

129 e microstructure, allows the development of 'biologic hard drives' that can characterize perinatal te

130 Recent efficacy studies of asthma biologics have included highly enriched patient populati

131 re indices, precise tracer distribution, and biologic heterogeneity needs to be clarified.

132 in specific subgroups, which underlines the biologic heterogeneity of this cohort selected according

133 iver tumors in mice with growth patterns and biologic, histologic, and genetic features similar to hu

134 The field of biologic immune modulators is currently mushrooming at a

135 The successes and failures of biologics in clinical trials have facilitated our abilit

136 tistically significantly more frequent among biologics (incidence rate ratio [IRR] = 1.93; 95% CI, 1.

137 LSIRs were compared with biologic inflammatory parameters and baseline FDG posito

138 ns and are associated with a more pronounced biologic inflammatory syndrome.

139 suggests that the 2TC-1K model reveals more biologic information about the regional density of TSPO

140 of the image formation process coupled with biologic insights on tissue distributions into account b

141 However, the application of new biologic insights to therapeutic development indicates t

142 in the British Association of Dermatologists Biologic Interventions Register were included.

143 om the British Association of Dermatologists Biologic Interventions Register.

144 y modified bacteria as delivery vehicles for biologics is of considerable interest scientifically and

145 otein-based pharmacokinetic approaches using biologics like vaccines, monoclonal antibodies, and enzy

146 ce, which has been identified as a potential biologic link in the development of obesity-associated c

147 X as the only biologic vs those unexposed to biologics (malignancy: 1.12/1000 patient-years; HLH: 0.5

148 rapy and tested microbiologic, clinical, and biologic markers as prognostic indicators for clinical s

149 these to fluorodeoxyglucose (FDG) uptake and biologic markers of inflammation.

150 ons, such as long-acting bronchodilators and biologics, may be required in moderate and severe asthma

151 The biologic measurement of the skin pigment of a child's ar

152 atient reported outcome measures (n=31), and biologic measures and reports (n=28).

153 pic, and epigenetic analysis to identify the biologic mechanism by which a common, non-coding variant

154 When a biologic mechanism of interest is anticipated to operate

155 n ancestral populations; yet, the underlying biologic mechanisms remain uncertain.

156 To understand the biologic mechanisms underlying these associations, studi

157 further analyses to elucidate the underlying biologic mechanisms.

158 Tissue engineering aims to utilise biologic mediators to facilitate tissue regeneration.

159 Biologic medications are increasingly given to treatment

160 However, the use of cadaveric biologic mesh has been expensive and plagued by complica

161 Despite widespread application of cadaveric biologic mesh, little data exist on the superiority of t

162 ased benefit compared with porcine cadaveric biologic mesh.

163 CVH repair with synthetic or biologic meshes has reported chronic biomaterial infecti

164 The unique combination of biologic molecules in ST266 provides an innovative appro

165 Combining biologic monoclonal antibodies with chemotherapeutic cyt

166 h a biologic and immunomodulator compared to biologic monotherapy.

167 ively propagated downstream, would introduce biologic noise compromising cognate ligand detection.

168 GPCR signaling from endosomes functions as a biologic noise filter to enhance reliability of cognate

169 t safety events of novel pharmaceuticals and biologics occur when new safety risks are identified aft

170 ferent immunosuppressive regimens, including biologics, on HBV reactivation (HBVr) among patients wit

171 ease treated with immunosuppressive therapy (biologic or nonbiologic) were randomized to receive 4 do

172 sts were higher in IBD patients treated with biologics (OR = 3.98, CI: 3.72-4.27, p < 0.001) when com

173 Various clinical, biologic, or physiologic markers of asthma have been use

174 sions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube

175 lar targets that link exposure with specific biologic outcomes.

176 rmed a systematic assessment of clinical and biologic parameters, histopathology, circulating DSA, an

177 RPR expression and clinical, pathologic, and biologic parameters.

178 GR transcriptional activity toward specific biologic pathways by changing GR binding and transcripti

179 Among the biologic pathways identified by the associations of schi

180 Our results provide new insights into the biologic pathways influenced by adiposity, and may enabl

181 Biologic pathways mediated by myeloid differentiation pr

182 These findings may point to new biologic pathways on which to expand diagnostic and ther

183 Furthermore, biologic plausibility supports the notion that a subset

184 With the passage of the Biologics Price Competition and Innovation Act of 2009,

185 iron-deficient RTRs and that the underlying biologic process driving production and cleavage of iFGF

186 C) as a PAT tool for monitoring a continuous biologics process and forced degradation studies.

187 sively measure the dynamics of various tumor biologic processes in vivo.

188 These genes are related to biologic processes involved in the control of cell survi

189 renowned ecologist who had been studying the biologic processes of ecosystem disturbance and recovery

190 These signatures included two related biologic processes related to activation by TREM-1 (trig

191 While diverse biologic processes were associated with siRNAs reducing

192 itro expression of genes involved in several biologic processes, including inflammation and immune re

193 The circadian clock plays a role in many biologic processes, yet very little is known about its r

194 cant regions of open marine water and active biologic productivity throughout one of the harshest gla

195 We herein report on the biologic profile of resulting (67/68)Ga-, (111)In-, and

196 detection rates, interval cancer rates, and biologic profiles of MR imaging-detected additional canc

197 also address how the physical, chemical, and biologic properties of a unified imaging agent can be ta

198 the effects of Pg protein extract (PgPE) on biologic properties of CD105-enriched PDL progenitor cel

199 ived metabolites may alter the structure and biologic properties of important proteins in periodontiu

200 participants provided new insights into the biologic properties of indoor exposures, indoor exposure

201 -urea-Lys-HBED-CC was synthesized, and their biologic properties were determined in cell-based assays

202 Biologic prostheses have been increasingly favored despi

203 From 1996 through 2013, the use of biologic prostheses increased substantially for aortic-v

204 itral-valve replacement with a mechanical or biologic prosthesis in California in the period from 199

205 al-valve replacement, either a mechanical or biologic prosthesis is used.

206 s significantly higher among recipients of a biologic prosthesis than among recipients of a mechanica

207 rwent mitral-valve replacement, receipt of a biologic prosthesis was associated with significantly hi

208 rwent aortic-valve replacement, receipt of a biologic prosthesis was associated with significantly hi

209 a mechanical prosthesis, as compared with a biologic prosthesis, persisted until 70 years of age amo

210 age groups, stroke than did recipients of a biologic prosthesis.

211 Biologics, psychiatric therapeutics, and accelerated and

212 idic device for the continuous monitoring of biologics' purity and bioactivity with high sensitivity,

213 le differences between innovator and copycat biologics raise questions regarding product interchangea

214 Furthermore, they provide biologic rationale for therapeutic strategies in AML tar

215 Finally, biologic relevance was tested using in situ hybridizatio

216 issue augmentation procedures may modify the biologic remodeling of periodontal dimensions over time

217 This study assesses the long-term "biologic remodeling" of periodontal dimensions of teeth

218 ional modulation of the immune response with biologics represents one of the most promising and activ

219 This study highlights the dynamic biologic response of multicellular organisms to deguelin

220 damage while ignoring protective, organismal biologic responses.

221 Understanding the biologic role of N(6)-methyladenosine (m(6)A) RNA modifi

222 ous miRNA levels, has revealed the important biologic roles miRNAs have in the major cell lineages th

223 The biologic roles of these proteins remain speculative, alt

224 ods Protocols were approved by the office of biologic safety and institutional animal care and use co

225 lity monitoring of three separate commercial biologic samples within 50 minutes has been demonstrated

226 et and dust intake and on measured levels in biologic samples.

227 s commonly used to identify heterogeneity in biologic samples.

228 icity of the procedure and the safety of the biologic scaffold components, represented sufficient pre

229 t decade after the introduction of cadaveric biologic scaffolds.

230 mply direct contribution of GPR17 in complex biologic settings.

231 However, the biologic significance of FEN1 phosphorylation in respons

232 tion of both Dicer and Bim, to determine the biologic significance of increased Bim expression in Dic

233 Other biologics similarly inhibit TH2 cytokines (thymic stroma

234 Although all had a biologic sister with breast cancer, 16.5% had average or

235 le and demand-based production of functional biologics starting from DNA sequence information.

236 These studies have revealed biologic subgroups characterized by distinct molecular,

237 xposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXI

238 Biologics such as etanercept are the most successful dru

239 likely, and would be a formidable barrier to biologic survival.

240 is by comparison with a cohort receiving non-biologic systemic therapies in a propensity score-weight

241 0.92, 95% CI = 0.60-1.41) compared with non-biologic systemic therapies or methotrexate-only (etaner

242 f-reported non-adherence to conventional and biologic systemic therapies used for psoriasis and evalu

243 nts and clinicians when choosing between non-biologic systemic therapies, etanercept, adalimumab, and

244 late materials elicit different responses in biologic systems, affecting human health.

245 gree of asthma control and implicate a novel biologic target (TREM-1).

246 soriasis and atopic dermatitis, although the biologic target and mechanism of action had been unknown

247 us suggesting plausible novel biomarkers and biologic targets for critical illness.

248 imaging catheters are emerging to assess new biologic targets in vivo and in coronary arteries.

249 ts toward development of small molecules and biologics that could be of therapeutic use.

250 ven models and compared with other anti-VEGF biologics that have been used in ocular anti-angiogenic

251 isease is improved by treatment with current biologics that target disease-specific pathways is uncle

252 umab, an anti-IgE mAb, is the first targeted biologic therapeutic approved for the treatment of moder

253 Proteins are important biologic therapeutics used for the treatment of various

254 nclusion, drug survival rates differed among biologic therapies and decreased over time; second-line

255 We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent d

256 known about the drug survival of second-line biologic therapies for psoriasis in routine clinical pra

257 er cancer chemotherapy, immunosuppressive or biologic therapies for the management of rheumatologic c

258 vent of newer and emerging forms of targeted biologic therapies, it has become important to understan

259 compared with 28% in patients without use of biologic therapies, whereas inpatient costs didn't diffe

260 oncern for patients with psoriasis receiving biologic therapies.

261 Treatment of IBD is more and more based on biologic therapies.

262 0.001) when compared to IBD patients without biologic therapies.

263 tients with psoriasis who had failed a first biologic therapy and switched to a second in a large, mu

264 Discontinuation of the first biologic therapy because of adverse events was associate

265 al decision making when choosing second-line biologic therapy for patients with psoriasis.

266 ancer, but the optimal choice of the initial biologic therapy in previously untreated patients is unk

267 verity Index at switching to the second-line biologic therapy were predictors of overall discontinuat

268 Initiating biologic therapy without trying triple therapy first inc

269 tlines treatment indications and forthcoming biologic therapy, and discusses challenges to performing

270 agents compared with chemotherapy, targeted biologic therapy, and treatment of premenopausal women.

271 s, and focused on the application of TDM for biologic therapy, specifically anti-tumor necrosis facto

272 all the patients also required some form of biologic therapy.

273 </=90 kg or >90 kg) and previous exposure to biologics therapy for psoriasis.

274 ring, and the real-time quality assurance of biologics throughout the biomanufacturing processes.

275 l intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal dama

276 that it is possible to discriminate between biologics to inform clinical practice and decision makin

277 (AF) repair strategy that delivers cells and biologics to IVD injury site is needed to limit the prog

278 re biomarkers that enhance the usefulness of biologics to manage uncontrolled asthma, urticaria, and

279 e stimulants and immune checkpoint inhibitor biologics to produce durable cures in mouse models of gl

280 ab vs bevacizumab to chemotherapy as initial biologic treatment.

281 Multiple biologic treatments are licensed for psoriasis.

282 for randomized controlled trials of licensed biologic treatments for skin psoriasis.

283 /mean tumor-to-brain-ratio [TBRmax/TBRmean], biologic tumor volume [BTV], and time-activity curves wi

284 Better understanding of the biologic underpinnings of asthma control may lead to the

285 n tumors to enhance our understanding of the biologic underpinnings of response and resistance.

286 how best to incorporate rapid changes in our biologic understanding of medulloblastoma into the next

287 he US Food and Drug Administration regulates biologics used for diagnosis and treatment of allergic d

288 assessed the risk of serious infections for biologics used to treat psoriasis by comparison with a c

289 ts provide some evidence of the clinical and biologic validity of these image features.

290 f the NIH that the possible role of sex as a biologic variable be factored into research design, anal

291 hods and techniques for integrating sex as a biologic variable in preclinical research.

292 We evaluated clinical and biologic variables for patients with stage III FHWT with

293 ears) in patients exposed to IFX as the only biologic vs those unexposed to biologics (malignancy: 1.

294 With the renewed interest in anti-TH2 biologics, we propose a rationale for why they are parti

295 the total costs in IBD patients treated with biologics were due to drug costs, compared with 28% in p

296 All included biologics were efficacious compared with placebo or meth

297 Biologics, which target specific cytokines and pathways,

298 The median biologic whole-body retention half-life was 370 h (range

299 ntify direct and indirect evidence comparing biologics with one another, methotrexate, or placebo.

300 tial strategy of etanercept-methotrexate and biologics with similar cost and efficacy is unlikely to