ライフサイエンスコーパス: biological

1 ts proved to be classifiable by their likely biological action as erythrocytic (also associated with

2 ed larger lumen areas and evidence of higher biological activity (smooth muscle cell loss and fibrin

3 The biological activity of methylone and its metabolites was

4 fold features, such as enumerated compounds, biological activity, and liabilities, over 17 years.

5 define the engineering principles impacting biological activity, detail a synthesis process yielding

6 roviding halogenated molecules with improved biological activity, or intermediates for synthetic deri

7 atural products and often impart significant biological activity.

8 nges of the proteins and subsequent abnormal biological activity.

9 which are most likely responsible for their biological activity.

10 family and contributes significantly to its biological activity.

11 The combination of probiotics, vitamins, and biological agents with AIT is highlighting current advan

12 Our results suggest that both biological aging and reduced regenerative capacity contr

13 In this Review, we consider the biological and analytical techniques that could facilita

14 d based on CO2 capture literature as well as biological and atmospheric chemistry studies.

15 The method can be extensively applied in biological and biomedical research.

16 etection and visualization of NPs in complex biological and environmental matrices.

17 s to recruit a diverse cohort, and collected biological and environmental samples and extensive data

18 science of culture that is grounded in both biological and evolutionary theory, but also treats cult

19 Here, we evaluated the biological and functional role of p21-activated kinase 4

20 Mechanical properties of a cell reflect its biological and pathological conditions and there have be

21 determination of ultra-trace RIF amounts in biological and pharmaceutical samples with satisfactory

22 enzymes thus contribute significantly to the biological and pharmacological diversity of small molecu

23 nsequently, newborn behaviors may serve both biological and social-cognitive purposes during developm

24 Many biological and synthetic systems exploit self-assembly t

25 been used to provide insight into a range of biological and synthetic systems.

26 We also analyze the impact of several biological and technical factors on the quality of footp

27 The quest to comprehend genetic, biological, and symptomatic heterogeneity underlying Alz

28 limited, we combined molecular modeling with biological assays to ascertain how modifications of phos

29 easured by waist-to-hip ratio, have distinct biological backgrounds.

30 Although we are far from understanding the biological basis of aging, research suggests that target

31 The biological basis of these sex differences is poorly unde

32 a risk factor for dementia, but the precise biological basis remains unknown, hampering the search f

33 issions is an entirely distinct concept from biological C sequestration projects to enhance C storage

34 suggest an increase in the efficiency of the biological carbon pump that could have accounted for as

35 We report here new electrical laws in a biological cell, which follow from a nonlinear electro-d

36 their unfolded polypeptide subunits, without biological chaperones.

37 The biological characteristics of these viruses, especially

38 phase synthesis (6-7 d) and its spectral and biological characterization as a live-cell imaging probe

39 for E. gracilis, serving as an indicator of biological clock status, photosynthetic and respiratory

40 ental to health, deeper knowledge of how our biological clocks change with age may create valuable op

41 noncovalent interactions to incorporate the biological cofactor heme-B for catalysis.

42 Yet, how biological communities respond to concurrent stressors a

43 n an abnormal immune response targets normal biological components.

44 tionally related genes change over different biological conditions.

45 vestock operations contain both chemical and biological constituents that represent a potential human

46 roteins and metabolites were placed in their biological context (spatial distribution within cells, c

47 y alter the efficiency of self-assembly in a biological context.

48 ong the first steps toward understanding the biological contributions to the etiology of this psychia

49 e tissue regeneration through structural and biological cues.

50 inform conservation and policy efforts where biological data are not available.

51 Finally, we curated biological data from the literature to show that neural

52 matics algorithm will optimize the extracted biological data using in vitro-in vivo correlations.

53 The lowest amounts of total DNA used for the biological data where SNVs and indels could be detected

54 These techniques allow for biological differentiation between visual communication

55 embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncolog

56 s and will ultimately serve as an engine for biological discovery and increase our insight into cance

57 By means of an example of a biological dissipative self-assembled material, the uniq

58 versity loss is central to the Convention on Biological Diversity and United Nations Sustainable Deve

59 owth contribute substantially to the loss of biological diversity.

60 ther steps of data analytics and modeling of biological dynamics.

61 elicitation of these cells in vivo and their biological effect in cell to cell communication during t

62 To study the biological effects of low GSH levels, we disrupted its s

63 hematopoiesis and focus particularly on the biological effects of Runx1 in the generation of hematop

64 volutionary relationship with other cellular biological entities that share the common function of pe

65 to explain their behavior in solution and in biological environment.

66 ver, interfacing to nanomaterials in complex biological environments is challenging and can result in

67 Here, we describe a combined biological/enzymatic synthesis that is capable of effici

68 This study establishes the occurrence of biological epistasis in humans and provides mechanistic

69 and to a higher degree, the pathway model of biological ET partly capture the predicted rate enhancem

70 ips (SAR) through the design, synthesis, and biological evaluation of a systematic series of analogue

71 understanding the molecular basis of diverse biological events and important in drug development.

72 evolvability that may have implications for biological evolution.

73 is the source of genetic variation and fuels biological evolution.

74 ain brain starvation signals, and identify a biological factor required for appetite evoked by alcoho

75 The biological factors necessary for ethanol-induced overeat

76 Exact biological factors promoting lymphatic involvement remai

77 nces (Pearson Coefficient) in terms of their biological features compared to the manually processed c

78 Considering these biological features of Spirodela and its basal position

79 However, their utility in biological fluids can be compromised through denaturatio

80 is sustained by heme-hemopexin complexes in biological fluids that resist oxidative damage during he

81 rces and internal growth parameters regulate biological forms and could be revealed via geometric tra

82 ized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5'

83 human genome, but direct evidence for their biological function is scarce.

84 nth anniversary of the identification of the biological function of CRISPR-Cas as adaptive immune sys

85 To determine the biological function of FDXR, we generated a Fdxr-deficie

86 e editing technologies for understanding the biological function of genes, and the pathological signi

87 dy aimed to elucidate potential clinical and biological function of IL-6R mRNA expression in ovarian

88 g of benenodin-1 may also be relevant to the biological function of these molecules.

89 ins and cells is important for understanding biological function.

90 ellular networks for signal transduction and biological function.

91 essed genes revealed distinct differences in biological functions and pathways before and after onset

92 also discuss challenges faced in identifying biological functions for this large and complex class of

93 Many biological functions of ABA in mammals are mediated by i

94 l-oxo species, are the basis for the various biological functions of O2-utilizing metalloproteins.

95 Biological functions of RNA molecules are dependent upon

96 One of the major biological functions of the retinal pigmented epithelium

97 a decade, the DNA-binding activities and the biological functions of these proteins have been largely

98 To differentiate the biological functions of Uba1 and Uba6, we applied an ort

99 Rewriting the genetic code could lead to new biological functions such as expanding protein chemistri

100 In general, the biological functions supported by these diverse polypept

101 has complicated the attribution of distinct biological functions to specific FZD and Wnt subtype int

102 These loci highlight novel biological functions, including response to oxidative st

103 RNA enables us to understand and control its biological functions.

104 coconjugates are widely involved in numerous biological functions.

105 ues cover alternatives that may suit various biological goals, experimental designs, and laboratories

106 ), the latter while employed at a commercial biological house.

107 biomedical field including chemical sensing, biological imaging, drug delivery, and photothermal ther

108 eased concentration of FL leads to decreased biological impact.

109 ct with multiple proteins, can have profound biological impacts on cells.

110 enzymes, informing our understanding of the biological importance of A-to-I editing.

111 By doing so, it suggests the biological importance of optogenetic follow-up of less-p

112 to and destabilizes microtubules using cell biological, in vitro, and structural approaches.

113 ression, comprehensive quality controls, and biological information retrieval in large volumes of gen

114 g methylation across RE may lose significant biological information.

115 kably precise medium for copying and storing biological information.

116 the adoption of mating disruption and use of biological insecticides.

117 ts a high bar for both statistical power and biological interpretability.

118 t of the resistance that PAs provide against biological invasions and climate change on a continental

119 Globally, biological invasions can have strong impacts on biodiver

120 Understanding biological invasions is crucial for their control and pr

121 Biological investigation of 2-5 on human cancer cell lin

122 grate a data-driven network model with prior biological knowledge (i.e., protein-protein interactions

123 non-linear projection and incorporate prior biological knowledge (such as pathway information) to le

124 wide expression data that makes use of prior biological knowledge on gene-regulatory interactions in

125 SPACE method is more consistent with current biological knowledge than the SPACE method.

126 Together, these findings highlight a biological link between inner ear dysfunction and behavi

127 ymptoms, etiological models suggest that the biological male phenotype carries a higher intrinsic ris

128 Semen quality has been suggested to be a biological marker of long-term morbidity and mortality;

129 ws great potential for providing much-needed biological markers for diagnosing, tracking, and predict

130 ion and structure of minerals and associated biological materials is critical in geomicrobiology and

131 Spider silks are the toughest known biological materials, yet are lightweight and virtually

132 sensitive detection of chemokines in various biological matrices and its interaction with a natural r

133 presence of common interfering factors from biological matrixes.

134 exists without a nursing mechanism, and the biological meaning of such connectivity remains obscure.

135 ynamics of variables (e.g., physiological or biological measures) with the probabilities of end point

136 s, this study reveals a potential underlying biological mechanism of a novel risk gene for major mood

137 al heart disease (CHD), while the underlying biological mechanism remains unclear.

138 oints toward DNAm as a potentially important biological mechanism through which developmental environ

139 cadian rhythms in body temperature suggest a biological mechanism through which transits of one of th

140 The underlying biological mechanism was shown to be interference with t

141 , thereby linking statistical association to biological mechanism.

142 However, the biological mechanisms are still not fully understood.

143 Cell-biological mechanisms mediating delamination are, howeve

144 ructural underpinnings provide insights into biological mechanisms of polysaccharide degradation.

145 Previously proposed biological mechanisms, such as alterations in parasympat

146 sets can be context-specific revealing novel biological mechanisms.

147 ncentrations of target virus even in complex biological media.

148 turally occurring domains, such as rafts, in biological membranes.

149 For the first time Rutin (RU) as a biological molecule with inherent properties was used as

150 Riboflavin was used as a biological molecule with inherent properties, for the fi

151 llostery is a common means for regulation in biological molecules suggests that it is a relatively ea

152 drive the self-assembly and cohesion of many biological molecules, including the adhesion proteins of

153 dge (i.e., protein-protein interactions) for biological network inference.

154 sity of connectivity favors cooperation in a biological network.

155 es for the classification of data from other biological networking problems.

156 underlying the evolution of the diversity of biological networks across plants and animals and (ii) c

157 in gene expression impact the robustness of biological networks and cause alternate behaviors when t

158 ty, although the densely connected nature of biological networks suggests that full coverage may not

159 sed to predict how the resulting geometry of biological networks then governs their allometric scalin

160 or predicting haploinsufficiency incorporate biological networks, e.g. protein-protein interaction ne

161 advances our ability to analyze and compare biological networks, inferred from experimental data, in

162 Despite the enormous complexity in biological networks, it is possible to identify network

163 e identified through comparative analysis of biological networks.

164 lds may soon create a correspondence between biological neural circuits and optimization in structure

165 ing the contributors (i.e. pathogens) to the biological or medical status of microbial samples.

166 ee-dimensional (3D) optical imaging of whole biological organs with microscopic resolution has remain

167 ity across color lexicons, and the potential biological origin of infant color categories.

168 Circadian rhythms are biological oscillations that schedule daily changes in p

169 crucially regulates their cancer-associated biological outputs.

170 ne expression changes induced by defeat, and biological pathway analysis revealed a dominant pattern

171 ench experiments, our findings highlight new biological pathways for blood pressure regulation enrich

172 We sought to identify biological pathways in ARDS that differentiate survivors

173 These results implicate biological pathways through which clozapine may act to c

174 In this Review, we highlight synergistic biological pathways through which co-occurring risks rel

175 ke has been found to be associated with many biological pathways, the genetic mechanism of ischemic s

176 as protein-protein interactions and curated biological pathways.

177 ia GWAS loci and in schizophrenia-associated biological pathways.

178 From a biological perspective, our work helps shed light on how

179 been shown to be involved in a wide range of biological phenomena such as protein half-life regulatio

180 rs from HPAI epizootics, and identifying the biological potential of these species as an epidemiologi

181 l have the largest impact on the accuracy of biological predictions under climate change.

182 of innovative materials, molecular machines, biological probes, and even commercial medicines.

183 approaches compare when applied to the same biological problem, and what differences in behaviour ar

184 ver or following injury represents a central biological problem.

185 Wound healing is a biological process directed towards restoration of tissu

186 the LOF phenotype must take into account the biological process that is targeted by each method.

187 ciceptors revealed oxidative stress as a key biological process.

188 in-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance

189 ino acids is very promising for the study of biological processes and for the diagnosis and treatment

190 ordered proteins (IDPs) have roles in myriad biological processes and numerous human diseases.

191 er have been associated with a number of key biological processes and therefore are proposed to be po

192 been implicated in the regulation of diverse biological processes by phosphorylation-dependent protei

193 s (miRNAs) have been known to affect various biological processes by repressing expression of specifi

194 of specific alleles of genes responsible for biological processes common to angiosperms during the br

195 fficient, and convenient tool to dissect the biological processes controlled by a GPCR-independent me

196 The potential to understand fundamental biological processes from gene expression data has grown

197 erstanding of the role of PARPs in different biological processes has grown considerably of late.

198 (3D) molecular imaging enables the study of biological processes in both living and nonviable system

199 method to obtain information about different biological processes in cell biology studies.

200 endogenous timekeeper critical for multiple biological processes in many organisms.

201 oteins (SSBs) during fundamentally important biological processes including DNA repair and replicatio

202 These targets regulated diverse biological processes including nutrient sensing and the

203 life, as they are a crucial requirement for biological processes including reproduction, somatic gro

204 olecular recognition, controls virtually all biological processes including the interactions between

205 ll not only further our understanding of the biological processes of this plant model but also of oth

206 ized alkenes underpins a plethora of complex biological processes ranging from natural product biosyn

207 echanistic and functional aspects of several biological processes such as autophagy, inflammation, pr

208 The biological processes used by A. baumannii to cause disea

209 biology approach for characterizing complex biological processes using a unique multidimensional fra

210 ncRNA co-expression networks, unraveling key biological processes where lincRNAs might be involved du

211 These results highlight key genes, biological processes, and cell types that can be targete

212 iated mechanisms in cancer disease and other biological processes, and discovery of new therapeutics.

213 embranes is of profound significance in many biological processes, from the development of multicellu

214 practiced as a means of characterizing most biological processes, I propose that the progression and

215 ne kinases (RTK) are major regulators of key biological processes, including cell growth, survival, a

216 Although dynamics underlie many biological processes, our ability to robustly and accura

217 tegrated model outputs incorporate important biological processes, such as competition, physiological

218 ndomembranes, and mediate a diverse range of biological processes.

219 naptic plasticity, and a vast range of other biological processes.

220 diverse and complex roles in a wide array of biological processes.

221 pth, or how plasma-derived RONS intervene in biological processes.

222 hat regulates gene expression and downstream biological processes.

223 on of actin cytoskeleton dynamics in diverse biological processes.

224 modifications play critical roles in diverse biological processes.

225 MAPK (p38alpha) plays a pivotal role in many biological processes.

226 he discovery of chemical probes for studying biological processes.

227 lglucosamine (GlcNAc) and regulates numerous biological processes.

228 at, nutrient resupply for sustaining oceanic biological production, and the melt rate of ice shelves.

229 of protein, extractability of phenolics, and biological properties of isolated proteins and protein c

230 nans and phenolic compounds having important biological properties.

231 classified problems of asthma patients into biological, psychological and adherence factors, and inv

232 no one method is appropriate to address all biological questions, as each variant differs markedly i

233 isen that report a 'good enough' solution to biological questions.

234 Biological quorum sensing refers to the ability of cells

235 ting certain parameters, albeit within their biological range, the mathematical model reproduced the

236 GNIFICANCE STATEMENT This study examines the biological rather than socio-environmental reasons why h

237 d greater prominence alongside complementary biological reagents for target validation in drug discov

238 h the lack of stability and high cost of the biological recognition element (enzyme).

239 understand gene-gene co-expression based on biological regulation but not SCNA, we describe a method

240 cusing on the case study, we show the higher biological relevance of the biomarkers selected by our a

241 nteractions (>500,000) and better functional biological relevance than comparable resources.

242 ensive care medical conditions (hemodynamic, biological, renal, and liver insults) than donors withou

243 This platform can be broadly applied to biological research, across the spectrum of molecular bi

244 tissue-like in vitro models for mechanistic biological research, disease modelling, therapeutic targ

245 ncorporated into the everyday methodology of biological researchers.

246 ments, has improved our understanding of the biological responses during droughts and contributes to

247 in bacteria has never been reported, and no biological role for such a modification has ever been pr

248 Therefore, the biological role of CCRL2 in immunity is still unclear.

249 rtant and robust tools for investigating the biological roles of vitamin B12 .

250 d by different genes that play non-redundant biological roles.

251 ntify cell subpopulations in a heterogeneous biological sample, infer cell identities of each subpopu

252 ualization of heterogeneous ion transport of biological samples for the first time.

253 chemical and topographic imaging of complex biological samples is demonstrated using living Bacillus

254 rge-molecule proteins at the intact level in biological samples without digestion.

255 tive inactivation of virus contaminations in biological samples.

256 ification of a wide range of gangliosides in biological samples.

257 uire information synthesized across multiple biological scales, from the patient to the molecular sca

258 age analysis program extensively used in the biological sciences and beyond.

259 on diseases and the lack of rapid, sensitive biological screening systems.

260 identify originator attributes, specifically biological sex, from a single analyte.

261 robustly and accurately profile time-varying biological signals and regulatory programs remains limit

262 resource for future studies of function and biological significance of m5C in mRNA in mammals.

263 hange is required for accurate assessment of biological sources of NADPH's high energy electrons.

264 From the biological standpoint, multiple studies have correlated

265 response to the microenvironment induced by biological stimuli.

266 visualization and quantification of complex biological structures.

267 Findings from clinical and biological studies are often not reproducible when teste

268 A recent series of genetic and cell biological studies have shed light on the question-the s

269 Genetic and cell biological studies over almost 2 decades have revealed s

270 e functions to facilitate biclustering-based biological studies, including the qualitative representa

271 Though we emphasize biological studies, we also discuss the application of c

272 s platforms have garnered significant use in biological studies.

273 ng about their extent and causes for any one biological system.

274 A variety of biological systems affect apical end points used in regu

275 similarities with chiral supramolecular and biological systems also emerged.

276 gene prioritization, comparative analysis of biological systems and prediction of new interactions.

277 was discovered as a third gasotransmitter in biological systems and recent years have seen a growing

278 d refinement to the model to reflect diverse biological systems and tissue types will further improve

279 Biological systems are increasingly being studied by hig

280 te how gene co-expression analysis of intact biological systems can provide insights into the transcr

281 (EPR) is being applied to ever more complex biological systems comprising multiple subunits.

282 or modular and hierarchical networks such as biological systems in general and cancer in particular.

283 Production of public goods in biological systems is often a collaborative effort that

284 e full potential of mapping intact lipids in biological systems with better than 10 mum lateral resol

285 be complicated, particularly in more complex biological systems, such as photosystems.

286 Inspired by biological systems, we report a supramolecular polymer-c

287 ells is fundamental to understanding complex biological systems.

288 tative analysis of lysine residues in native biological systems.

289 leavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems.

290 thods can facilitate deep optical imaging in biological tissue by reducing light scattering and this

291 ge of the high native optical contrast among biological tissues and can treat microvessels without ca

292 al domain, of probing bulk media, to imaging biological tissues and single cells at the micro scale,

293 se combinations are, however, commonplace in biological tissues, and are therefore needed for applica

294 predicting the scattering properties of many biological tissues.

295 Because there are currently no biological treatments for hearing loss, we sought to adv

296 Further understanding of the biological tropism with cells and proteins and the newer

297 ical nature of the tunneling medium at short biological tunneling distances.

298 their molecular and cellular targets offer a biological underpinning for development of clinical reha

299 The inclusion of sex as a biological variable in research is absolutely essential

300 le and not generalizable due to cohort bias, biological variation and limited sample size.