ライフサイエンスコーパス: biological action

1 the biophysical properties of GlcCer and its biological action.

2 ibonucleolytic activity is essential for its biological action.

3 riphosphate metabolites is crucial for their biological action.

4 hat of RNase A but nonetheless essential for biological action.

5 able structural modifications without losing biological action.

6 r signaling pathways, despite their distinct biological actions.

7 l (PI) 3-kinase pathways that mediate leptin biological actions.

8 tiple fragments, many of which have distinct biological actions.

9 e, has been shown to cause multiple systemic biological actions.

10 R), to confer diverse and sometimes opposing biological actions.

11 gues to provide a structural basis for their biological actions.

12 er cGMP, which in turn leads to a variety of biological actions.

13 ome marine animals, possess a broad range of biological actions.

14 the peptide and reversibly neutralizing its biological actions.

15 DNA target sequences, events needed for all biological actions.

16 the key phospholipid product mediating these biological actions.

17 ignal the CNS to elicit centrally controlled biological actions.

18 NA sequence CACGTG, yet have quite different biological actions.

19 TPP likely is a major contributor to these biological actions.

20 vered to the surroundings to exert its known biological actions.

21 itical for mediating signal transduction and biological actions.

22 the therapeutic classification through their biological actions.

23 ized, along with descriptions of their known biological actions.

24 lifies IGF-I-linked downstream signaling and biological actions.

25 d possible distinct temporal and potentially biological actions.

26 d R-(+)equol, both of which have significant biological actions.

27 is a ubiquitous cellular signal with diverse biological actions.

28 nd is likely a critical determinant of their biological actions.

29 d determine its subcellular distribution and biological actions.

30 for TSHR antibodies, thus influencing their biological action and clinical effects.

31 a challenging task, which requires that the biological actions and bioavailability of the >200 indiv

32 nt protein, have allowed studies on both its biological actions and clinical utility.

33 s of resveratrol broaden the spectrum of its biological actions and may be relevant to the reported c

34 tain, and there is sparse evidence regarding biological actions and pathways implicated in its effect

35 elated agents that nevertheless have diverse biological actions and therapeutic consequences.

36 This study assessed the biological actions and therapeutic utility of a novel (p

37 The present study assessed the biological actions and therapeutic utility of novel GIP/

38 y of drugs and diseases at multiple tiers of biological action, and is therefore a useful approach to

39 However, their cognate receptors, biological actions, and signaling pathways are poorly st

40 ing Set" of 230 compounds, with well-defined biological actions, and the "Diversity Set" of 2000 chem

41 hts into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the hea

42 cellular functions, yet their mechanisms of biological action are still a matter of debate.

43 Its biological actions are demonstrated in various cell type

44 Their biological actions are dependent on the structure of the

45 sue raises questions about which of leptin's biological actions arise from direct effects of the horm

46 ts proved to be classifiable by their likely biological action as erythrocytic (also associated with

47 , chronically in 2 normal dogs to assess its biological actions as a blood pressure-lowering agent an

48 GH exerts its biological action by stimulating JAK2, a GH receptor (GH

49 ting polypeptide (PACAP) elicits its diverse biological actions by interacting with both PACAP-select

50 id mediator which elicits a diverse array of biological actions by interacting with G protein-coupled

51 clusion, the regulation of PG metabolism and biological actions constitutes a novel pathway of calcit

52 These biological actions depend on adoption of an alpha -helic

53 ings show that BTK has specific pro-tumoural biological actions downstream of surface CD117 activatio

54 chondrial content that vary in their general biological actions, from cell signaling to cell traffick

55 In light of its widespread biological actions, immunohistochemical detection of the

56 Understanding its biological action in mammary development is critical for

57 In contrast to their restricted biological action in vivo, however, most homeodomain fac

58 ssays are necessary to analyse the described biological actions in humans.

59 lels in their physicochemical properties and biological actions in in vitro models.

60 ish neuropeptide, exerts a broad spectrum of biological actions in mammals: responses that influence

61 igations into their production and potential biological actions in vivo.

62 However, there are differences in the biological actions, in binding affinities to E-cadherin

63 e cytokinin family, has shown in humans many biological actions, including antitumoral effects throug

64 The putative mechanism for cannabinoid biological action involves binding to cannabinoid recept

65 depend on better understanding its range of biological actions, its mechanism of action, and the mol

66 e for mediation of a wide range of essential biological actions, most of which are mediated by specif

67 Studies in knock-out mice confirmed the biological action of [dA(2)]GLP-1/GcG via multiple targe

68 ministration of antibodies that mitigate the biological action of anthrax toxin.

69 may play an important role in mediating the biological action of hormone and the receptor protein.

70 thways are linked and how they relate to the biological action of IL-2 is incompletely understood.

71 The biological action of neurotrophins is thus regulated by

72 These observations suggest that the biological action of NF-kappaB in different cell types c

73 Despite growing reports on the biological action of nitric oxide (NO) as a function of

74 Furthermore, the biological action of R-Ras3 in PC12 cells was dependent

75 s in Elapidae snakes also interfere with the biological action of short-chain alpha-neurotoxins.

76 Since these effects may be related to the biological action of the drugs, it was of interest to de

77 Nuclear expression and consequent biological action of the eukaryotic NF-kappa B transcrip

78 The in vitro biological action of the gold complexes and the phosphon

79 d its role in the intracellular behavior and biological action of the hormone, a single chain CG vari

80 traits are required to better determine the biological action of the unclassified variants.

81 randial window were sufficient to elicit the biological action of these peptides (ie, opioid and anti

82 The biological action of this peptide includes inhibition of

83 In this study, we investigated the biological action of three alpha1-adrenoceptor antagonis

84 The biological actions of 1, 25-dihydroxyvitamin D, are medi

85 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)

86 Investigations into the potential biological actions of 15-HETE-G indicate that this lipid

87 ch investigators have clearly documented new biological actions of 1alpha,25(OH)(2)D(3) through the V

88 These insights into the biological actions of 7,3',4'-THIF provide a molecular b

89 anscription factor that mediates many of the biological actions of a large class of environmental com

90 Here we have studied the biological actions of a ligand-receptor fusion of growth

91 -mRNA splicing, important in determining the biological actions of agrin, is not well understood.

92 rotein tyrosine kinases, is critical for the biological actions of alpha/beta interferon (IFN-alpha/b

93 The biological actions of anandamide (arachidonylethanolamid

94 AR manifests the biological actions of androgens and its transcriptional

95 (AR), the nuclear receptor that mediates the biological actions of androgens.

96 ry ANP and cGMP excretion, markers for renal biological actions of ANP, were greatest in mild CHF.

97 An essential component of the biological actions of Arfs is their ability to reversibl

98 This observation explains how the biological actions of B-cell lymphoma 6 can be physiolog

99 In this review, we examined the biological actions of bFGF and FGF-18 in articular and I

100 the molecular basis underlying these diverse biological actions of BHA is thus of great importance.

101 Taken together, the biological actions of Clld7 are consistent with those of

102 of HCs could help to understand some of the biological actions of CO in physiological and pathologic

103 ide expression monitoring to investigate the biological actions of complex extracts.

104 in target tissues, possibly by antagonizing biological actions of diurnally fluctuating circulating

105 These observations suggested that biological actions of E2 are derived from expression of

106 Recent work has revealed the presence and biological actions of eicosanoids in insects and many ot

107 The biological actions of estrogens are mediated via two dis

108 elective pharmacological probes to study the biological actions of estrogens mediated through ERbeta,

109 The biological actions of extracellular nucleotides are exer

110 5 as an important signaling component in the biological actions of G-CSF.

111 ism of GAG biosynthesis, and to decipher the biological actions of GAG chains in model organisms.

112 Because many biological actions of heparin including the antiallergic

113 ption, or protein nitration may modulate the biological actions of IDO expressed in inflammatory tiss

114 the role of STAT2 as it relates to not only biological actions of IFN but also resistance to chemoth

115 us, there is a close concordance between the biological actions of IFN-alpha and the appearance of th

116 establish the role of STAT1 in mediating the biological actions of IFN-alpha in the CNS, transgenic m

117 IGF-I receptor (IGF-IR), which mediates the biological actions of IGF-I and IGF-II, has emerged in r

118 Despite its clinical potential, the biological actions of IL-21 are not yet fully understood

119 Such biological actions of IL-6 are characterised by both the

120 eact with numerous cysteine-active proteins, biological actions of individual signal inducers have em

121 The biological actions of insulin are associated with a rapi

122 Biological actions of insulin are initiated by activatio

123 strates for PKC-zeta that participate in the biological actions of insulin have not been reported.

124 Biological actions of insulin regulate glucose metabolis

125 Insulin receptor substrates (IRS) mediate biological actions of insulin, growth factors, and cytok

126 lose proximity to it is a key target for the biological actions of leptin.

127 he biology of OSM but, rather, reflected the biological actions of LIF.

128 cerning the importance of pleiotropy for the biological actions of miRNAs and provide mechanistic ins

129 s about the importance of pleiotropy for the biological actions of miRNAs.

130 ever-increasing substrates and diversity of biological actions of MMPs, it is likely that continued

131 Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond recipro

132 unknown role for telomerase in mediating the biological actions of neurotrophic factors during brain

133 Many of the biological actions of nitric oxide are mediated by the g

134 fate has generated confusion, separating the biological actions of NO on the basis of its physiologic

135 emoglobin which binds to and inactivates the biological actions of NO, but not by methylene blue (Mel

136 Different biological actions of NPY are assigned to NPY receptor s

137 The biological actions of P4 in target cells are mediated by

138 an influence in vivo signaling responses and biological actions of pharmacological agents used to man

139 Functionally, CID755673 inhibited the known biological actions of PKD1 including phorbol ester-induc

140 Here, to help evaluate the biological actions of PP5, a Cre/loxP-conditional mouse

141 advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the e

142 atase (PPP) are essential to investigate the biological actions of PPPs and to guide drug development

143 aled that PPARgamma is a key mediator of the biological actions of PR in the granulosa cells and acti

144 PR signaling pathways that contribute to the biological actions of progesterone in the normal breast

145 Thus, the biological actions of R-Ras are mediated by multiple eff

146 hts into similarities and differences in the biological actions of related drugs or toxic agents, the

147 The diverse biological actions of retinoic acid (RA) are mediated by

148 The diverse biological actions of retinoic acid (RA) are mediated by

149 The diverse biological actions of retinoic acid (RA) are mediated by

150 interrelationships may have relevance to the biological actions of retinol, including its role in car

151 These diverse biological actions of RSK1 involve regulation of both cy

152 Because several of the biological actions of S1P are assumed to proceed through

153 The biological actions of SNC may also involve the transnitr

154 opmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.

155 ivatives will be valuable in determining the biological actions of specific tocopherols and tocotrien

156 However, the biological actions of SST/CORT are conditioned by the me

157 mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly r

158 naling, it appears to be dispensable for the biological actions of the Axl kinase.

159 Although the biological actions of the cell membrane and serum lipid

160 We review the biological actions of the chemokine superfamily, focusin

161 The biological actions of the hormonal form of vitamin D, 1,

162 The widespread biological actions of the neurotransmitter dopamine (DA)

163 ignaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may

164 r level the diversity and its effects on the biological actions of the toxin, including receptor bind

165 rovides a useful means by which to probe the biological actions of these and other related enzymes.

166 e often keenly invested in understanding the biological actions of these drugs.

167 Indeed, many of the biological actions of these gases can be accounted for b

168 ons of steroid hormones, responsible for the biological actions of these molecules.

169 on with functional studies to illuminate the biological actions of these pathways in humans as well a

170 by which the cGMP-dependent and -independent biological actions of this agent are amplified.

171 e concentrations, and drugs that augment the biological actions of this system, show the potential fo

172 hese results support the conclusion that the biological actions of TrkC activation affect medulloblas

173 ith prolonged in vivo survival and sustained biological action on the target cells, which may account

174 inds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, sur

175 nous and exogenous IGFBP-5 exhibits opposing biological actions on cell survival and underscore the n

176 r that exerts a number of well characterized biological actions on fibroblasts and other cells.

177 the first time that FSH may exert different biological actions on OVCA cells than on HOSE cells, by

178 nd the mechanisms via which DAPK elicits its biological action remain largely unknown.

179 To determine if E-peptide biological actions required the IGF-IR, we took advantag

180 This raises the question: Do alcohol's biological actions result predominantly from direct prot

181 NO is known to exert numerous biological actions resulting in rapid but transient phys

182 of mechanisms by which DHEA and DHEAS exert biological actions, show that they have specific functio

183 suggests that these ligands can have a broad biological action, stimulating the transcriptional activ

184 s are markers of oxidative stress that exert biological actions such as vasoconstriction.

185 ns of nitrogen have a much richer profile of biological actions than hitherto assumed, and several ef

186 Several members utilize a unique mode of biological action that involves the sequestration of lip

187 NO-generating component of NCX-2216 confers biological actions that go beyond those of typical NSAID

188 These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomoto

189 rs unique opportunities to probe its mode of biological action through the preparation of otherwise u

190 NO, which exerts its biological actions through cGMP and heme, has recently b

191 Evaluation of their biological action to inhibit human acetylcholinesterase

192 ion illustrate the challenges of attributing biological actions to specific sulfation patterns, and s

193 aises the possibility that MIF may exert its biological action via an enzymatic reaction.

194 Estrogens exert their biological action via both genomic and non-genomic mecha

195 potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled re

196 2Cp2 (Cp = eta-C5H5)2, to assume its mode of biological action was closely aligned with cisplatin [ci

197 use protein molecules to carry out very fast biological actions, we quantified single-molecule reacti

198 IGF-I-stimulated downstream signaling and biological actions were also significantly impaired in N

199 OPN biological actions were studied in human hepatic stellat

200 l stress response have a range of additional biological actions which are involved in bacterial virul

201 administrated systemically, exert peripheral biological actions which may be mediated by brain pathwa

202 ntal translocation, have distinct endogenous biological actions within each compartment, and are regu

203 cule was implicated as possessing many other biological actions within the cardiovascular system, inc