ライフサイエンスコーパス: biological activity

1 family and contributes significantly to its biological activity.

2 which are most likely responsible for their biological activity.

3 equires processing for signal biogenesis and biological activity.

4 volved showing increased target affinity and biological activity.

5 lds, which are well-known for their enriched biological activity.

6 nd create a harsh environment, which reduces biological activity.

7 hampered the detailed investigation of their biological activity.

8 ahydropyran (THP) ring that is essential for biological activity.

9 olved oxygen concentrations may have limited biological activity.

10 ntration of 14% had the highest potential of biological activity.

11 ounds of lyophilization while retaining high biological activity.

12 ic pathway, the metabolites of which display biological activity.

13 cells, the recombinant pINSL3 possessed full biological activity.

14 ompounds are of interest for their potential biological activity.

15 l and synthetic compounds, often with potent biological activity.

16 is paramount, enabling one to understand its biological activity.

17 e domain sequence, which potentially confers biological activity.

18 membrane and be arrayed in nanoclusters for biological activity.

19 uced by jet drops can be modulated by marine biological activity.

20 ducts containing N-N bonds exhibit important biological activity.

21 family of natural products known to exhibit biological activity.

22 nt environments in the absence of any direct biological activity.

23 ilm regeneration in vitro that preserved its biological activity.

24 ery rates of novel chemistry with functional biological activity.

25 lore the influences of backbone structure on biological activity.

26 pensable for IL-12 secretion, stability, and biological activity.

27 hemical structure, molecular properties, and biological activity.

28 ched in selected polyphenols while retaining biological activity.

29 ride (LPS), and how this binding affects its biological activity.

30 l at the 2-position of the imidazole ring on biological activity.

31 anges in stereochemistry dramatically impact biological activity.

32 iphenyl dimer, which both display noteworthy biological activity.

33 nificant improvements in their stability and biological activity.

34 the GH binding domain (W104A) would increase biological activity.

35 at provide the catalytic engine to drive the biological activity.

36 sting that a polysaccharide was required for biological activity.

37 xosomes have been shown to possess intrinsic biological activity.

38 of the structural conformation versus their biological activity.

39 egion of p17 is irrelevant for the protein's biological activity.

40 potential for deliberately controlling this biological activity.

41 racts of B. setosa fruits and their in vitro biological activity.

42 atural products and often impart significant biological activity.

43 mino forms likely accounts for their loss in biological activity.

44 nges of the proteins and subsequent abnormal biological activity.

45 ms, and TOrC removal was further enhanced by biological activity.

46 ions within any of these severely compromise biological activity.

47 of truncated natural products optimised for biological activity.

48 positions were synthesized and evaluated for biological activity.

49 ation of drugs and generally abolishes their biological activity.

50 cules that modulate selectively hUII and URP biological activities.

51 including H(+) ions that profoundly modulate biological activities.

52 constrained conformations that confer their biological activities.

53 c triterpenic compounds, which exert several biological activities.

54 but possess a variety of potent and valuable biological activities.

55 related natural products and elicit powerful biological activities.

56 which may explain some differences in their biological activities.

57 phospholipid products with a broad range of biological activities.

58 pice in food preparations in addition to its biological activities.

59 release of proteins without impairing their biological activities.

60 terns that are responsible for their various biological activities.

61 aration of natural compounds, and their main biological activities.

62 l products and drug candidates with relevant biological activities.

63 ation of their phytochemical composition and biological activities.

64 products that display diverse structures and biological activities.

65 amino acid derivatives, with a wide range of biological activities.

66 uctures that possess a number of interesting biological activities.

67 strained natural products that have diverse biological activities.

68 nd complex topologies and possess a range of biological activities.

69 eine (SAMC) have been shown to have multiple biological activities.

70 and contributing to the wealth of other MIF biological activities.

71 at are extensively studied for their diverse biological activities.

72 y oxidized structures as well as significant biological activities.

73 their diverse chemical structures and potent biological activities.

74 nteractions, physicochemical properties, and biological activities.

75 ic terpenoid natural products have important biological activities.

76 iers of nitric oxide (NO) and have important biological activities.

77 allow spatiotemporal control of a variety of biological activities.

78 rmeability, however, can strongly impair its biological activities.

79 beta,beta-diarylalanines exhibit significant biological activities.

80 conformations of viruses, relevant to their biological activities.

81 r the immune system to tune a broad range of biological activities.

82 rkedly enhance target binding and functional biological activity (100-fold), and likely represents a

83 levels after different treatments and their biological activities after production of the recombinan

84 Boehringer Ingelheim screening deck to show biological activity after having tested as inactive prev

85 The conjugates showed potent biological activities against all tested bacteria includ

86 pound, has been investigated in light of its biological activities against plant pathogens.

87 However, the proportion of lncRNAs with biological activities among the thousands expressed in m

88 tural products known for their wide range of biological activities and complex chemical structures.

89 isoprenoids), antioxidant capacity, in vitro biological activities and consumer acceptance.

90 asses of natural products, emphasizing their biological activities and functions as they have been de

91 n seaweeds have been studied regarding their biological activities and health benefit effects.

92 According to the distinct levels of biological activities and regulatory effects on target g

93 isplayed hEGF ligands on BLNs possess higher biological activities and targeting capabilities.

94 Polyphenols display various biological activities and tea polyphenols in particular

95 es from diverse natural sources with various biological activities and unique structures.

96 Probes were designed to retain biological activity and alkylate the molecular target(s)

97 differences regarding metabolic composition, biological activity and antioxidant capacity.

98 s of the synthesis of JDs and JGDs and their biological activity and applications after assembly in a

99 ered as a source of phytoestrogens with high biological activity and as a dietary supplement reducing

100 ronment in vivo and plays a decisive role in biological activity and associated toxicity.

101 family peptides contain key determinants for biological activity and binding specificity, although th

102 In the present study, we determined the biological activity and chemical constituents of peanuts

103 d a range of almost 4 orders of magnitude in biological activity and illustrate the continued potenti

104 Its recombinant form has biological activity and is suitable for use in skin test

105 ion to assess whether such formulations have biological activity and potential utility for ocular use

106 The shortened spacer length reduces biological activity and stability in solution towards de

107 oxyresveratrol (a type of stilbene with high biological activity) and modified cyclodextrins (CDs) wa

108 al (phenolics content, antioxidant activity, biological activity) and nutritional potential (starch a

109 lassification, association of scaffolds with biological activities, and activity prediction.

110 ing pathway is associated with many cellular biological activities, and is also a critical player in

111 for its worldwide consumption and important biological activities, and these effects are related to

112 24 min to 117 days depending on temperature, biological activity, and aqueous media composition.

113 fold features, such as enumerated compounds, biological activity, and liabilities, over 17 years.

114 We report on the synthesis, biological activity, and mechanism of action of a group

115 Since biological activities are a major contributor to accumul

116 ationships between compounds, scaffolds, and biological activities are beginning to be globally explo

117 he BMP9.pro-domain complexes have equivalent biological activities as the BMP9 mature ligand dimers.

118 to the beginning of 2016, including reported biological activities as well as the isolation of new me

119 roduction by various microorganisms point to biological activity as a significant source of ROS in th

120 ylated pyrrolizidines exhibiting outstanding biological activity as glycosidases inhibitors.

121 Several instances of biological activity assays of remodeled natural product

122 esperidin which has been observed to possess biological activities associated with a healthy life.

123 even deletion of the residue does not affect biological activities at the KOR.

124 IVA with a two-residue linker maintained the biological activity at the human alpha9alpha10 nAChR and

125 We hypothesized that NLRP1 has additional biological activities besides IL-1beta maturation and in

126 Multivalent binding proteins can gain biological activities beyond what is inherent in the ind

127 members require N-terminal cleavage for full biological activity but the mechanisms of IL-36Ra activa

128 features of the carboxylic acid critical for biological activity, but appropriately modifying the phy

129 led millions of compounds to be assessed for biological activity, but challenges remain in the priori

130 typic screening is used to identify drugs or biological activities by directly assessing effects in i

131 cular system, where they regulate a range of biological activities by linking cellular metabolism wit

132 Reevaluation of the biological activity calls into question the initial exub

133 lin-36 has been linked to two major types of biological activities: cardiovascular (stimulation of ca

134 ies to the solid surface that avoids loss of biological activity caused by covalent attachment; (2) w

135 the structures of SERMs and their incidental biological activity (cholesterol accumulation), we hypot

136 Biological activity data of chemical substances tested i

137 define the engineering principles impacting biological activity, detail a synthesis process yielding

138 ATIs were extracted and their biological activities determined in TLR4-responsive mous

139 ions between inhibition of the enzymatic and biological activities, discovery of MIF inhibitors has f

140 Proteins tend to lose their biological activity due to their fragile structural conf

141 jugates (Glc-Pts) were synthesized and their biological activities evaluated.

142 To investigate its biological activity, fluorophores such as Oregon Green h

143 and may regulate the T-cell antigen receptor biological activities for this cell-surface receptor sys

144 ' polymerase activity of TLPs as a bona fide biological activity for the first time since its unexpec

145 nanostructured mineral coating maintains its biological activity for weeks during release, while it m

146 immunohistochemistry show clear evidence of biological activity from the delivered CPT in the posttr

147 tides (RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodyn

148 t the position of d-Phe1-Pro2 eradicates the biological activity (GS mimetic 16).

149 designated d-allo-ShK, for which significant biological activity had been observed in a similar recep

150 s recapitulating nature's niche to influence biological activities has been a prolific area of invest

151 emical features of ionic liquids, their high biological activity has been attracting significant atte

152 A majority of PERK's biological activities have been attributed to its functi

153 Their structural diversity and biological activities have generated further interest in

154 results of undetectable mispairing and high biological activity have indicated that this method has

155 uitous timing systems that induce rhythms of biological activities in synchrony with night and day.

156 l shed light on the studies of salt-affected biological activities in the intertidal zone.

157 osition of these fractions, as well as their biological activities in vitro.

158 nges in the gut microbiota are linked to its biological activity in individuals with signs of MetS.

159 dimerization interface is crucial for their biological activity in splicing regulation, and suggest

160 an oxidized biomass and provide evidence for biological activity in submarine-hydrothermal environmen

161 tween sediment texture, biogeochemistry, and biological activity in the Columbia River HZ, the grain

162 l polyketides that have displayed remarkable biological activity in vitro against a variety of cancer

163 ed by in silico refinement and screening for biological activity in vitro, we identified 21 hit compo

164 y occurring polyphenolic molecules with many biological activities, including antioxidant effects.

165 IFNs) are a family of cytokines with diverse biological activities, including antiviral, antiprolifer

166 plex molecular architectures and an array of biological activities, including potent antimicrobial ac

167 nionophores) have potential for new modes of biological activity, including therapeutic applications.

168 des identified from the literature as having biological activity, including those with antihypertensi

169 ation), we hypothesized that this incidental biological activity induced by SERMs could be a plausibl

170 tein and its repetition can transform a weak biological activity into a potent one through cooperativ

171 Biological activity is a major factor in Earth's chemica

172 This pattern of biological activity is distinct from other related prodi

173 nterconvert in solution, we investigated how biological activity is influenced by axial chirality and

174 information on chemical substances and their biological activities, launched in 2004 as a component o

175 globule membrane (MFGM) has many associated biological activities, many of which are linked with spe

176 acellular targets, their internalization and biological activity may be limited by inefficient membra

177 f natural l-ShK toxin, and that the apparent biological activity may have arisen from inadvertent con

178 r myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function

179 ion has a pivotal role in a diverse range of biological activities, modulating the structure and func

180 heir wide range of often clinically relevant biological activities, nonaromatic polyketide natural pr

181 tion of putative metabolites and support the biological activity observed.

182 ort for the first time a rapid synthesis and biological activities of an LM glycan backbone, alpha(1-

183 differentiating between the two dichotomous biological activities of ANG, this strategy could provid

184 st translational modifications (PTMs) on the biological activities of antibodies, even when the PTM l

185 ay underlie observed differences between the biological activities of CNbeta1 and canonical CNbeta2.

186 Here, to better understand the biological activities of DAAM, we studied the role of DA

187 secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the sec

188 of these domains in multiple biochemical and biological activities of H1.

189 This Review is dedicated to biological activities of ionic liquids, with a special e

190 uld represent a mechanism for modulating the biological activities of NAEs in plants.

191 N therapy, AcCS were shown to potentiate the biological activities of natural IFNs by approximately 1

192 metric isomerization can expand the scope of biological activities of natural products.

193 r functionalities have a major impact on the biological activities of natural products.

194 t, to annotate rapidly and inexpensively the biological activities of newly synthesized compounds.

195 Chen studies the formation and biological activities of noncoding RNAs.

196 The endocytosis pathways and biological activities of PEGylated BP nanosheets in canc

197 characteristics, functional properties, and biological activities of polysaccharides extracted from

198 tion on the chemical composition and diverse biological activities of staghorn sumac.

199 nd provide important clues for understanding biological activities of synthetic anion transporters an

200 The biological activities of the compounds were evaluated bo

201 Remarkably, we find that the biological activities of the largely synthetic Abeta agg

202 Revealed biological activities of the protein expression changes

203 Biological activities of these iodinated and brominated

204 the design, synthesis, and assessment of the biological activity of a library of perhydrophenanthrene

205 We report the stereoselective synthesis and biological activity of a novel series of tranylcypromine

206 al modifications that preserve the exquisite biological activity of acid 1 and offer the opportunity

207 t promise for maintaining or reinforcing the biological activity of active compounds, while they simu

208 In order to enhance the biological activity of alpha-mangostin, we formulated ma

209 mechanisms that allow plants to regulate the biological activity of an array of secondary metabolites

210 The biological activity of anthocyanins is influenced by the

211 The biological activity of B7-H4 has been associated with de

212 the observation that anatomical-therapeutic biological activity of certain types typically precludes

213 To understand the biological activity of clinically effective Sublingual i

214 Biological activity of degraded soils was obviously decr

215 ious drug-disease indications by linking the biological activity of drugs and diseases at multiple ti

216 that precipitation, degradation and loss of biological activity of drugs occurred upon mixing soluti

217 erimentally investigate the localization and biological activity of each tetrameric assembly.

218 es, structure, purity, Dectin-1 binding, and biological activity of five different laminarin preparat

219 ct of d-glucose substitution position on the biological activity of glucose-platinum conjugates (Glc-

220 hogonal modifications which reconstitute the biological activity of GS.

221 several countries, none, on the presence and biological activity of high risk (HR) HPV in BC has been

222 The biological activity of IL-1 is tightly regulated by the

223 critical for assembly-induced secretion and biological activity of IL-12 versus misfolding and degra

224 ate a new role for heparin in modulating the biological activity of IL-12.

225 ant to consider this when characterizing the biological activity of inter-alpha-inhibitor.

226 The accumulated data on the biological activity of ionic liquids, including their an

227 merization is functionally important for the biological activity of IreB.

228 doplasmic reticulum (ER) ensures the correct biological activity of its distinct domains.

229 Mimicking this transient biological activity of kinases is challenging due to the

230 olecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not

231 The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpe

232 itro gastrointestinal digestion enhanced the biological activity of meat.

233 The biological activity of methylone and its metabolites was

234 e, shape and surface chemistry influence the biological activity of nanoparticles.

235 us our attention on the ecological roles and biological activity of natural products, versus products

236 synthesis, structural characterization, and biological activity of new hydroxamic acid-based inhibit

237 Finally, we demonstrate the biological activity of oligoTEA macrocycles designed to

238 ya pulp and the first reports of an in vitro biological activity of papaya pectins that were modified

239 lity of this labelling technique to modulate biological activity of RNA.

240 In contrast, the biological activity of SDF1-ELP in vivo was significantl

241 The biological activity of SDF1-ELP, as measured by intracel

242 herapy, we used this method to determine the biological activity of solution and tablet Timothy grass

243 allow the virus to specifically dictate the biological activity of STAT1 during infection.

244 ocessing on the biochemical features and the biological activity of TCMPs, we developed a method for

245 In an attempt to fine-tune the biological activity of Teixobactin, we examined the effe

246 (GPCRs), there is limited knowledge linking biological activity of the GLP-1R with the molecular str

247 Our results suggest the biological activity of the leukocyte membrane can be ret

248 on and process does not adversely affect the biological activity of the peptide.

249 oduced often having a profound effect on the biological activity of the resulting natural products.

250 The biological activity of the SNPs on miRNA regulation was

251 ide synthesis of mambalgin-1 and confirm the biological activity of the synthetic toxin both in vitro

252 this strategy to modulate the stability and biological activity of therapeutic proteins containing d

253 aller wheal size than Oralair((R)) , and the biological activity of these clinically effective TIM ta

254 e instead of adenosine was described, but no biological activity of this compound was revealed.

255 ructure offers opportunities to modulate the biological activity of tumor necrosis factor alpha throu

256 drocinnamates has been shown to increase the biological activity of various drug candidates.

257 Our findings indicate that the biological activity of VE-cadherin in regulating endothe

258 confocal microscopy studies suggest that the biological activity of vesicles is not impaired.

259 The fusion proteins have similar in vitro biological activities on the cognate receptors as the co

260 resulting in an overall magnification of the biological activity on a highly expressing alphavbeta3 h

261 roviding halogenated molecules with improved biological activity, or intermediates for synthetic deri

262 e of both oAd and DCs while preserving their biological activity over a considerable time period, lea

263 three sites over 150 years reveals increased biological activity over the past ca. 50 years, in respo

264 Although the elegant architectures and biological activity profiles of these natural products h

265 tural products displaying a diverse array of biological activities ranging from neurotrophic to anti-

266 Mechanistically, this biological activity relies on the regulation of the stem

267 of such derivatives in circulation and their biological activities remain poorly understood.

268 rous chronic inflammatory diseases, in which biological activity remains unclear.

269 The high productivity, together with several biological activities reported for sclerotiorin highligh

270 r 104 RNA-targeted ligands with demonstrated biological activity (RNA-targeted BIoactive ligaNd Datab

271 lycans significantly modulate the stability, biological activity, serum half-life, safety, and immuno

272 an be dual-natured, we hypothesized that its biological activity should be tightly regulated to limit

273 ed larger lumen areas and evidence of higher biological activity (smooth muscle cell loss and fibrin

274 hemicals and even to specialty products with biological activity such as pharmaceuticals.

275 an organic drug synthesis with a cell-based biological activity testing system, require a solvent ex

276 Usually divalent molecules show enhanced biological activities than their corresponding monomers.

277 due to sampling over waters with much lower biological activity than in previous studies.

278 containing two unknown species with a better biological activity than the pure compound.

279 perform impossible tricks and be engaged in biological activities that are inaccessible to well fold

280 arides (HMOs) have important nutritional and biological activities that guide the development of the

281 ted microbes have a critical role in various biological activities that modulate the behavior of neig

282 syntheses by illuminating trends relating to biological activity that would be difficult to predict i

283 Here, we report on the biological activity, the structural basis, and therapeut

284 parate chemokines, OPRAH exhibited increased biological activity, thus providing evidence that physic

285 through physical-biochemistry properties and biological activities to confirm expected quality of the

286 The biological activity was characterized using different ap

287 As no biological activity was prescribed to hybrubin A except

288 y amino acid analysis in PP5ar06007, and its biological activity was shown to be comparable to natura

289 -Lys-Xxx-Tyr-Gly] were synthesized and their biological activity was tested.

290 GnRHa biological activity was validated by secretion of gonado

291 For in vivo biological activities we used a procedure based on Caeno

292 inct structural conformations with different biological activities, we asked whether Abeta can assume

293 To understand its apparent biological activity, we set out to chemically synthesize

294 by HPLC-DAD-MS/MS in mature fruits and their biological activities were assessed by in vitro and in v

295 Known biological activities were mapped to series from ChEMBL,

296 thermal denaturation, aggregation state, and biological activity when formulated for long-time storag

297 s of peptides that can be used to obtain new biological activities while avoiding or limiting bacteri

298 on sample heterogeneity than the presence of biological activity, with 0.63, 21.7, 2.6, and 6.3 nmol/

299 ill be useful for habitat selection or other biological activities within a reef.

300 Fungal polyketides have significant biological activities, yet the biosynthesis by highly re