ライフサイエンスコーパス: biological macromolecule

1 e of interest (ranging from small ligands to biological macromolecules).

2 NA is arguably the most functionally diverse biological macromolecule.

3 -assembly behaviors of inorganic species and biological macromolecules.

4 for examining the structure and function of biological macromolecules.

5 eveloped as a powerful technique for sensing biological macromolecules.

6 assessment of electrostatic interactions in biological macromolecules.

7 on of molecular materials with DNA and other biological macromolecules.

8 and dynamics is essential to the function of biological macromolecules.

9 tial functions widely used in simulations of biological macromolecules.

10 to be located in smaller crystals of larger biological macromolecules.

11 uired in multidimensional NMR experiments of biological macromolecules.

12 or to become covalently attached to targeted biological macromolecules.

13 ns of low-frequency deformational motions of biological macromolecules.

14 mitted the application of the PRE to various biological macromolecules.

15 for three-dimensional (3D) structure data of biological macromolecules.

16 e-dimensional structures of many filamentous biological macromolecules.

17 coding synthetic small molecules rather than biological macromolecules.

18 used to probe the conformational dynamics of biological macromolecules.

19 ion structural and thermodynamic modeling of biological macromolecules.

20 trinsic and extrinsic magnetic properties of biological macromolecules.

21 120,000 three-dimensional (3D) structures of biological macromolecules.

22 source of information on the 3D structure of biological macromolecules.

23 ues for evaluation of physical properties of biological macromolecules.

24 e and identification of chemical exchange in biological macromolecules.

25 water in the system is interacting with the biological macromolecules.

26 a powerful tool for studying the folding of biological macromolecules.

27 isite complex structures and/or functions of biological macromolecules.

28 ngle worldwide archive of structural data of biological macromolecules.

29 ngle worldwide archive of structural data of biological macromolecules.

30 ive structural and functional information of biological macromolecules.

31 ntrifuge and its application to the study of biological macromolecules.

32 ngle worldwide archive of structural data of biological macromolecules.

33 epository of files containing coordinates of biological macromolecules.

34 ities for the structural characterization of biological macromolecules.

35 ms of life, as they regulate the function of biological macromolecules.

36 ental resource of the tertiary structures of biological macromolecules.

37 NO), a free radical that can damage numerous biological macromolecules.

38 y influence the architecture and activity of biological macromolecules.

39 , biophysical, and biochemical properties of biological macromolecules.

40 ding can alter the structure and function of biological macromolecules.

41 atic for the purpose of fingerprinting large biological macromolecules.

42 allographic characteristics closely resemble biological macromolecules.

43 ve investigation of the dynamics of GNSs and biological macromolecules.

44 n molecular recognition and self-assembly of biological macromolecules.

45 namic, translational friction coefficient of biological macromolecules.

46 gnetic Resonance (NMR) spectroscopic data of biological macromolecules.

47 es in both the mechanism and architecture of biological macromolecules.

48 d other newcomers to computer simulations of biological macromolecules.

49 ajor properties of soft materials, including biological macromolecules.

50 dely used to study conformational changes of biological macromolecules.

51 nd is essential for molecular recognition by biological macromolecules.

52 o model nano-size objects together with real biological macromolecules.

53 king replacement of phosphorus by arsenic in biological macromolecules.

54 uld substitute arsenic for phosphorus in its biological macromolecules.

55 ated our interpretation of ligand binding in biological macromolecules.

56 cterization of the structure and dynamics of biological macromolecules.

57 its ability to act as a molecular sensor of biological macromolecules.

58 catalyse the conformational rearrangement of biological macromolecules.

59 ise from the nanoassembly of these important biological macromolecules.

60 harmful to living systems, causing damage to biological macromolecules.

61 ligands directly influence the functions of biological macromolecules.

62 between structure, dynamics, and function in biological macromolecules.

63 ibrium between folded and unfolded states of biological macromolecules.

64 of complex molecular systems, in particular biological macromolecules.

65 ing increased use in exploring properties of biological macromolecules, alone and in association.

66 l resonances and determine the structures of biological macromolecules and (iv) a database of one- an

67 l changes as occur during the functioning of biological macromolecules and assemblies can be elucidat

68 rarchical structure (tertiary/quaternary) of biological macromolecules and assemblies.

69 s for the study of structure and dynamics of biological macromolecules and complexes.

70 Hydration water is the natural matrix of biological macromolecules and is essential for their act

71 CSB PDB) provides access to 3D structures of biological macromolecules and is one of the leading reso

72 can inflict oxidative damage on all types of biological macromolecules and lead to cell death.

73 analysis of a variety of materials including biological macromolecules and polymers.

74 alizes the advantages of naturally occurring biological macromolecules and their building-block natur

75 Our results demonstrate that the dynamics of biological macromolecules and their hydration water depe

76 logy developed here is broadly applicable to biological macromolecules and will provide useful inform

77 ffectively and rapidly pattern living cells, biological macromolecules, and biomaterials.

78 icity of the interactions within and between biological macromolecules, and hence accurate modeling o

79 biological antibody analogues that recognize biological macromolecules, and hold great promise for me

80 impact of supercooling for future studies of biological macromolecules, and shows that our approach e

81 Many proteins or other biological macromolecules are localized to more than one

82 Biological macromolecules are often studied in mixed sol

83 Therefore, using biological macromolecules as a model system, we have stu

84 till largely ignoring the flexible nature of biological macromolecules as the number of degrees of fr

85 The method is suitable for biological macromolecules, as relaxation not resulting f

86 iction of the structures and interactions of biological macromolecules at the atomic level and the de

87 image nonperiodic nanostructures, including biological macromolecules, at diffraction intensity-limi

88 n types of commercial SWCNTs, representative biological macromolecules (bovine serum albumin and meth

89 Determining the structure of biological macromolecules by X-ray crystallography invol

90 Biological macromolecules can be encapsulated into prefo

91 ny cases, the properties and applications of biological macromolecules can be further expanded by att

92 Crystallization of biological macromolecules can represent a significant ob

93 Collagen is a biological macromolecule capable of second harmonic gene

94 ations such as understanding the dynamics of biological macromolecules, cell-cell interactions and th

95 e tool for the manipulation of cells, single biological macromolecules, colloidal microparticles and

96 own, cannot lead to unique 3-D structures of biological macromolecules comparable to all-atom models

97 ich isolates the core from interactions with biological macromolecules, controls diffusion of oxygen

98 thermodynamic hypothesis', the sequence of a biological macromolecule defines its folded, active (or

99 Crystals of many important biological macromolecules diffract to limited resolution

100 ent of the cell and affect the corresponding biological macromolecules either via direct binding or a

101 Biological macromolecules, especially proteins, provide

102 is a major limitation in crystallography of biological macromolecules, even for cryocooled samples,

103 In biological macromolecules, fluorophores often exhibit mu

104 ctive medium to test the mechanisms by which biological macromolecules fold into complex three-dimens

105 terplay between the topology and activity of biological macromolecules from a mechanochemical perspec

106 R(1 rho) measurements for heteronuclei in biological macromolecules generally require decoupling o

107 Single-molecule imaging of biological macromolecules has dramatically impacted our

108 though cryo-electron microscopy (cryo-EM) of biological macromolecules has made important advances in

109 he functionality and structural diversity of biological macromolecules has motivated efforts to explo

110 le of characterizing binding interactions of biological macromolecules have become commercially avail

111 majority of three-dimensional structures of biological macromolecules have been determined by X-ray

112 Biological macromolecules have evolved to fold and opera

113 molecules that mimic the activity of native biological macromolecules have therapeutic potential, ut

114 Allosteric regulation of biological macromolecules, however, is affected by both

115 rometry (IM-MS) allows structural studies on biological macromolecules in a solvent-free environment.

116 Where possible, the roles of key biological macromolecules in controlling production of t

117 dynamics simulations capture the behavior of biological macromolecules in full atomic detail, but the

118 dy dynamic phenomena such as slow folding of biological macromolecules in greater detail.

119 The interaction between water and biological macromolecules in living organisms is of fund

120 analyze the size, shape, and interactions of biological macromolecules in solution.

121 e applied to the structural determination of biological macromolecules in solution.

122 weaker than those of the strongest bands of biological macromolecules in the same spectral regions.

123 zing different aspects of interactions among biological macromolecules in their native environments.

124 structure and dynamics of proteins and other biological macromolecules in various environments is amo

125 artemisinins form adducts with a variety of biological macromolecules, including haem, translational

126 y is applicable to detection of a variety of biological macromolecules, including proteins and proteo

127 haracterize the conformation and dynamics of biological macromolecules inside living cells.

128 a wavelength of 1042 nm was used to vaporize biological macromolecules intact from the condensed phas

129 or femtosecond laser vaporization to deliver biological macromolecules into the gas phase for mass an

130 or determining high-resolution structures of biological macromolecules invites the questions, how muc

131 Activities of many biological macromolecules involve large conformational t

132 Molecular recognition by biological macromolecules involves many elementary steps

133 The automated functional annotation of biological macromolecules is a problem of computational

134 mputers to simulate the functions of complex biological macromolecules is essential to achieve a micr

135 cadmium(II), mercury(II), and lead(II) with biological macromolecules is metal ion exchange dynamics

136 e xi0 of filamentous networks assembled from biological macromolecules is one of the most important p

137 ence that water structure in the vicinity of biological macromolecules is unusual and that the proxim

138 Cellulose, the most abundant biological macromolecule, is an extracellular, linear po

139 dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of h

140 changes on a nanometer scale, within single biological macromolecules, may be possible with single p

141 Allostery is the process by which biological macromolecules (mostly proteins) transmit the

142 All structured biological macromolecules must overcome the thermodynami

143 arge N) systems, up to molecules as large as biological macromolecules (N > 1000 atoms).

144 Structural information about biological macromolecules near the atomic scale provides

145 cant attention recently for the synthesis of biological macromolecules of defined homogeneous composi

146 dimensional structures of proteins and other biological macromolecules often aids understanding of ho

147 The adsorption or covalent attachment of biological macromolecules onto polymer materials to impr

148 ters entering the long range interactions of biological macromolecules, providing accurate data for t

149 ominant source of structural information for biological macromolecules, providing fundamental insight

150 The ability to activate biological macromolecules remotely, at specific location

151 The most common recognition motifs involve biological macromolecules such as antibodies and aptamer

152 ctions play an import role in the folding of biological macromolecules such as DNA and proteins.

153 hereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and prote

154 atform that can be used for the detection of biological macromolecules such as mismatch repair protei

155 ty of pH-coupled conformational phenomena in biological macromolecules such as protein folding or mis

156 l rings for the minimal motif for binding to biological macromolecules such as RNA and proteins.

157 When the target is a biological macromolecule, such as a protein, the process

158 The exploitation of biological macromolecules, such as nucleic acids, for th

159 RNA is a versatile biological macromolecule that is crucial in mobilizing a

160 all classes of biologically active drugs or biological macromolecules that affect cellular attachmen

161 signaling systems often rely on complexes of biological macromolecules that can undergo several funct

162 est a route to improved energy functions for biological macromolecules that combines the generality o

163 nvestigating rapid conformational changes in biological macromolecules that have previously been inac

164 40-150-nm extracellular vesicles, transport biological macromolecules that mediate intercellular com

165 hniques allow high-resolution experiments on biological macromolecules that were mere pipe dreams onl

166 cts the polymeric primary structure of these biological macromolecules, their intrinsic flexibility,

167 ts, ranging from inorganic nanostructures to biological macromolecules.Three-dimensional ptychographi

168 is a powerful tool for the investigation of biological macromolecules under a wide range of solution

169 The structural features and dynamics of biological macromolecules underlie the molecular biology

170 Biological macromolecules use binding forces to access u

171 ears the primary source of information about biological macromolecules was the Protein Data Bank, whi

172 olar couplings (RDCs), commonly measured for biological macromolecules weakly aligned by liquid-cryst

173 ool in structural and mechanistic studies of biological macromolecules where large conformational cha

174 ies for the binding of a small molecule to a biological macromolecule, which has immense implications

175 of facile structure determination of complex biological macromolecules, which cannot be coaxed to for

176 In particular, samples of biological macromolecules, which usually contain salts t

177 ts aim to expand our structural knowledge of biological macromolecules while lowering the average cos

178 examine and characterize the interaction of biological macromolecules with a binding surface.

179 rophilic amino acids, and (c) DNA fragments, biological macromolecules with double-stranded polymeric

180 used to study the evolution of robustness in biological macromolecules, with similar results.

181 Crystal structure analyses for biological macromolecules without known structural relat

182 decrease the proton T(1) relaxation time of biological macromolecules without the significant line-b

183 groups, such as amines and carboxylates, on biological macromolecules without using ultraviolet irra

184 A fundamental appreciation for how biological macromolecules work requires knowledge of str

185 latter reflects possible oxidative stress to biological macromolecules, yielding supporting data to t