ライフサイエンスコーパス: biological role

1 tes amboinensis (TaOr8) suggests a different biological role.

2 ecific sequences contribute to this manifold biological role.

3 e the substrate specificity required for its biological role.

4 iphthamide, and importantly, its ill-defined biological role.

5 can modify motor properties to enhance their biological role.

6 expand our knowledge on their metabolism and biological role.

7 ts have generally not been thought to have a biological role.

8 eripheral nerves, suggests a potential wider biological role.

9 stimuli is crucial for the fulfilment of its biological role.

10 at early-evolving ARABIDILLOs had additional biological roles.

11 cations on proteins to determine their exact biological roles.

12 n which motor proteins move to perform their biological roles.

13 series of mutants to examine Abl's many cell biological roles.

14 d structures form in vivo and play essential biological roles.

15 rse oxidative transformations with important biological roles.

16 1 interaction is conserved and has important biological roles.

17 ere short, raising questions regarding their biological roles.

18 teins with undefined molecular functions and biological roles.

19 across vertebrate species suggest important biological roles.

20 the full spectrum of events underlying their biological roles.

21 or inorganic materials and have wide-ranging biological roles.

22 tion assists critical examination of further biological roles.

23 ty differences finely tuned to mediate their biological roles.

24 genetic entities with potentially important biological roles.

25 st in novel DNA base modifications and their biological roles.

26 hingosine and dihydroceramide, with distinct biological roles.

27 ase-1 and not in caspase-3 may reflect their biological roles.

28 glycans is essential in understanding their biological roles.

29 d by different genes that play non-redundant biological roles.

30 ing determined in relation to their putative biological roles.

31 ecules, recent findings point to its broader biological roles.

32 nriched with important genes and likely play biological roles.

33 ential and stationary growth phases play key biological roles.

34 tep in studying their expression pattern and biological roles.

35 opment and tumourigenesis, questioning their biological roles.

36 of general importance in understanding their biological roles.

37 Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7

38 In this study we investigated the biological role and mechanism of miR-198 in colorectal c

39 This and other implications for the biological role and mechanism of TDG sumoylation are dis

40 e context of understanding their fundamental biological role and of potentially using them as disease

41 biology, and isomers usually differ in their biological role and pharmacological effects.

42 ly conserved throughout all organisms, their biological roles and biochemical redundancies remain lar

43 itical importance in deciphering their exact biological roles and effects.

44 These channels fulfil a number of biological roles and have intriguing biophysical propert

45 Carbohydrate-active enzymes have multiple biological roles and industrial applications.

46 Phosphate plays essential biological roles and its plasma level in humans requires

47 ion in substrate recognition despite diverse biological roles and origins.

48 ophages, it is important to understand their biological roles and requirements for efficient targetin

49 of leads for future investigations into the biological roles and significance of DP8 and DP9 in huma

50 Owing to its widespread biological roles and unique chemical properties, H2S is

51 In this study, we aim to investigate the biological roles and use of sarcKATP and mitoKATP in hES

52 These enzymes play a variety of biological roles and, accordingly, display often strikin

53 However, the biological roles and/or clinical applications of such pa

54 The identity of these cascades and their biological roles are known; however, the molecular mecha

55 bundant class of small non-coding RNAs whose biological roles are not well understood.

56 stitute the largest enzyme family, yet their biological roles are obscured by our rudimentary underst

57 any of these molecular fossils is that their biological roles are still poorly understood.

58 emical properties, and it plays an important biological role as a chaperone of phosphodiesterase 6 (P

59 ed to fluctuating light, demonstrating FLV's biological role as a safety valve from excess electrons

60 otein sequence and structure, play important biological roles as macromolecular binding and scaffoldi

61 increases our resolution of the cellular and biological roles associated with this poorly characteriz

62 owing part of the review concentrates on the biological roles attributed to polyreactive Abs and to p

63 nderstanding of this enzyme and its critical biological role but also for the rational design of regu

64 DNA haplotypes in a cell, plays an important biological role, but its features are not well understoo

65 nucleobases are believed to have fundamental biological roles, but their prevalence and functional im

66 chromatin remodeling enzymes play essential biological roles by mobilizing nucleosomal DNA.

67 Protein kinases play essential biological roles by phosphorylating a diverse range of s

68 probe suitable for further understanding the biological role CARM1 plays in cancer and other diseases

69 ovide both distinct, as well as overlapping, biological roles during development.

70 ggesting that these enzymes play distinctive biological roles during parasite infection of mammalian

71 ect to ATI and ATT show major differences in biological roles, expression and selection patterns.

72 This work reveals a novel biological role for a rhomboid protease and highlights n

73 evidence in additional datasets to support a biological role for AMH in complex traits and diseases i

74 h5.2nb lines of N. benthamiana accentuated a biological role for BRP1 in the Q-satRNA infection cycle

75 tuberculosis infection, representing a novel biological role for CFP-10 in the ESAT-6:CFP-10 complex,

76 We have here identified a major biological role for FMRFamide-like neuropeptides in nema

77 The results reveal a biological role for mammalian polzeta in tolerating DNA

78 We confirm an important biological role for MEP50 and PRMT5 in regulating kerati

79 This work presents the expansion of the biological role for PepN in antibiotic maturation and th

80 for its canonical dsDNA ligand, suggesting a biological role for RNA binding by SMAD3.

81 Collectively, these data highlight a biological role for SMRT in mediating DNA damage respons

82 in bacteria has never been reported, and no biological role for such a modification has ever been pr

83 ate and it additionally hints at a plausible biological role for the Grp94/OS-9 complex.

84 matically at pH <7, suggesting a significant biological role for the protonated KP1212 molecules.

85 er developmental stages suggesting a similar biological role for this gene family in this species.

86 Our results uncover a biological role for TRMT1-catalyzed tRNA modification in

87 n articles, reveal conserved biochemical and biological roles for a widely distributed ribosomal oxyg

88 In an effort to explore the diversity of biological roles for DEAD-box proteins, our laboratory r

89 el for dimethylation and suggesting discrete biological roles for mono- and dimethylarginine-modified

90 Several biological roles for Pic have been described, including

91 died extensively, few examples of definitive biological roles for site-specific PARylation have been

92 ver the properties, molecular mechanisms and biological roles for TEI.

93 lar studies, here we demonstrate independent biological roles for the DDR kinases DNA-PKcs, ATM, and

94 stigations aimed at deconvoluting the myriad biological roles for Ub.

95 for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6.

96 y a major challenge is linking IDRs to their biological roles from the molecular to the systems level

97 Over the years its biological role has been extensively studied generating

98 teins in poplar (Populus spp) xylem, but its biological role has remained obscure.

99 expressed in hESC/iPSC-vCMs and its defined biological role in beta-adrenergic signaling, we investi

100 re ranked according to knowledge about their biological role in body weight regulation and classified

101 ic resonance spectra, and plays an important biological role in establishing the ribosomal intersubun

102 nd metabolite accumulation did not support a biological role in flavonoid metabolism but correlated w

103 e and AMP salvage pathways suggests a strong biological role in high-CO2 subsurface carbon cycling.

104 eins has been sufficiently demonstrated, its biological role in higher eukaryotes remains poorly unde

105 factors, with the aims of (i) studying their biological role in human neural progenitors and (ii) inc

106 As SOX9 biological role in mammalian gonads is to determine Sert

107 5 is highly expressed in MCC tumors, but its biological role in MCC remains unknown.

108 is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been el

109 Given its compelling biological role in organizing ameloblasts during ameloge

110 mmunoprecipitation, as was NEDD9's potential biological role in prostate cancer cell growth regulatio

111 cooperative recruitment to chromatin and its biological role in target gene expression.

112 early response transcripts play an important biological role in the acclimation of plants to light st

113 arget-specific translation repression to its biological role in the maternally controlled stages of v

114 Compound 12 may be used to probe LSD1's biological role in these cancers.

115 cNAcylation have assisted in delineating its biological roles in a variety of cellular processes and

116 Fatty alcohols play a variety of biological roles in all kingdoms of life.

117 ave long been proposed to play multiple cell biological roles in cancer.

118 c is an essential micronutrient with diverse biological roles in cell growth, apoptosis and metabolis

119 Some novel smORFs have crucial biological roles in cells and organisms, which motivates

120 hat is likely to be highly relevant to their biological roles in DNA metabolism.

121 nvolved in flagellar glycosylation and their biological roles in emerging hypervirulent C. difficile

122 oproteins and glycolipids that play numerous biological roles in health and disease.

123 e composition of VLVs and demonstrated their biological roles in manipulating host cell responses and

124 a new MT1-MMP substrate that plays important biological roles in melanoma.

125 ate transporters that underpin their diverse biological roles in metabolism and detoxification.

126 elengths, has been suggested to play several biological roles in metazoans.

127 ar or identical to those that play important biological roles in normal tissues of the body.

128 To accommodate two seemingly contradictory biological roles in plant physiology, providing both the

129 tasis, though their subcellular location and biological roles in plants are unclear.

130 their high complexity, glycans play crucial biological roles in protein quality control and recognit

131 arrangement and epigenetic programming, with biological roles in stem-cell function, whole-body regen

132 ycosides produced by bacteria play important biological roles in the evasion and modulation of host i

133 Vertebrate Bicaudal-C (Bicc1) has important biological roles in the formation and homeostasis of mul

134 synthase kinase-3beta (GSK3beta) has diverse biological roles including effects on cellular different

135 LncRNAs are involved in numerous biological roles including imprinting, epigenetic regula

136 rdered regions in proteins possess important biological roles including transcriptional regulation, m

137 Diverse biological roles--including the regulation of viral repl

138 Their most widespread biological role is providing a rigid hydrophobic contact

139 yl, HNO) is a highly reactive compound whose biological role is still a matter of debate.

140 uses increased postnatal growth, its precise biological role is still unknown.

141 While its biological role is unclear, CarD functions by interactin

142 Despite its prominent biological role, little is known about the structure/fun

143 and their reference spectra as well as their biological roles, locations, concentrations and raw data

144 To assess the gene product's biological role more directly, a Staphylococcus aureus s

145 parison with other Th effector cells, as the biological role of a GC Tfh cell is to provide help to i

146 We now delineate the biological role of a novel SENP7 isoform SENP7S in mamma

147 These tools were used to investigate the biological role of AlyA1, the only Z. galactanivorans al

148 In this study, we have characterized the biological role of Arabidopsis thaliana Ethylene Respons

149 G-II), little information is known about the biological role of B in membranes.

150 selective tool compounds to interrogate the biological role of BRD9 in diverse cellular systems.

151 Therefore, the biological role of CCRL2 in immunity is still unclear.

152 to the roots of a host plant, resembling the biological role of cellulose in other bacteria.

153 establish a basis for future studies on the biological role of CL-L1.

154 en up an important new avenue to address the biological role of CPE, an enigmatic membrane constituen

155 additional loci are needed to determine the biological role of CTCF sites associated with enhancers.

156 assays for substrate specificity supported a biological role of CYP750B1 in alpha- and beta-thujone b

157 hich contributes to our understanding of the biological role of cytosine methylation.

158 This result emphasizes the biological role of DEWs which are very poor substrate fo

159 unpairing, which are fundamental to both the biological role of DNA and its technological application

160 oward a potentially distinct mechanistic and biological role of DNA methylation in dictating the comp

161 the identified proteins correlated with the biological role of each organ.

162 e not known, hindering identification of the biological role of endogenous LRRK2.

163 role in various diseases, understanding the biological role of extracellular Trx may provide critica

164 Thus, the biological role of FAN1 remains unclear.

165 EMO activity with broad implications for the biological role of free polyubiquitin.

166 These results reveal an unexpected biological role of IN binding to the viral RNA genome du

167 Although the biological role of KRAS is clearly established in carcin

168 ively, this report provides insight into the biological role of LPMOs and redox proteins in cellulose

169 The biological role of LRBA in immunologic disease is unknow

170 knock-out mouse model, we characterized the biological role of Lzts2 in tumorigenesis.

171 he first time, to our knowledge, the in vivo biological role of m(6)A modification in T-cell-mediated

172 However, the biological role of MatR remains unclear.

173 However, the biological role of miR-15b/16-2 is still controversial.

174 However, the biological role of mutation of PPP2R1A in ovarian and en

175 The biological role of mvT* miR was verified by overexpressi

176 sylated, but the glycosylation sites and the biological role of N-linked glycosylation have not been

177 al model where both the clinical utility and biological role of neutralizing MAbs against B cell or e

178 ange as a proxy to the quantification of the biological role of non-coding SNPs.

179 function of these genes sheds light into the biological role of other members of the superfamily, inc

180 ha1 and -alpha4 have been described, but the biological role of PGC-1alpha2 and -alpha3 remains elusi

181 While the biological role of PIMT1 has been elucidated, the role a

182 present study we addressed the function and biological role of PntAB in oxygenic photosynthetic cyan

183 n for future efforts aimed to understand the biological role of PSM recognition by innate host defens

184 However, the biological role of PSMA has not been explored, and its r

185 l be useful in efficiently interrogating the biological role of RA in larger study populations.

186 this study provides the first insight on the biological role of rhomboid proteases in Archaea, sugges

187 The understanding of the biological role of RNA molecules has changed.

188 The biological role of SCARA5 has been unknown.

189 A better understanding of the biological role of serum chloride is warranted.

190 nalogue development, designed to explore the biological role of substitution at the C(11) position of

191 acterium tuberculosis infection, and yet the biological role of such markers remains unclear.

192 vestigation for over a decade, the scope and biological role of sulfenic/sulfinic acid modifications

193 ciated TRMT1 mutations is unknown, since the biological role of the encoded TRMT1 protein remains to

194 To gain insight into the biological role of the entire operon, we characterized S

195 ween GNC and GNL, nothing is known about the biological role of the four other LLM-domain B-GATAs, GA

196 for new research aimed at investigating the biological role of the gut virome in human physiology, a

197 despite its importance for understanding the biological role of the interaction.

198 for known proteins and hypothesize about the biological role of the localization of some viral ORFan

199 We elucidated a major biological role of the nematode mir-35 family of materna

200 We predict that the essential biological role of the PHD1-PHD2 module of ZFP-1/AF10 is

201 Little is known about the biological role of the phospholipase A2 receptor (PLA2R1

202 The biological role of the transcription factor GLI1 in the

203 ely used both as chemical tools to study the biological role of their targets in living organisms and

204 To determine the biological role of these DGs, null animal models have be

205 rt on recent insights into the mechanism and biological role of these intricate cotransport processes

206 ides a new chemical tool to study the unique biological role of this abundantly expressed molecular c

207 ine receptor for CCL18 will help clarify the biological role of this highly expressed chemokine in hu

208 tify these cells explains the poorly defined biological role of this macrophage subset.

209 The biological role of this phenomenon can only be elucidate

210 Here, we study the biological role of this protein family by systematic ana

211 ibitors can aid in further investigating the biological role of this specific methyltransferase in tr

212 wn photoreceptor families and unveiled a new biological role of this vitamin.

213 irus-free lines enabling studies probing the biological role of trypanosomatid viruses.

214 The most studied biological role of type III interferons (IFNs) has so fa

215 These results expand the biological role of vitamin B12 and provide fundamental i

216 chemical probe suitable to help dissect the biological role of WDR5.

217 However, the biological roles of alternative splicing during developm

218 Despite three decades of investigation, the biological roles of AMPK and its potential as a drug tar

219 Here we analyzed the biological roles of approximately 600 genes - we previou

220 the field for an in vivo model to define the biological roles of B. burgdorferi adhesins in tissue-sp

221 However, to fully understand the biological roles of BIN1 in vivo and to answer critical

222 evious studies on macrophages elucidated the biological roles of caspase-1 in post-translational acti

223 hould be useful in studies investigating the biological roles of CBP and p300 and to validate the CBP

224 engineering will open avenues to explore the biological roles of cell surface mucins.

225 se observations support the idea of distinct biological roles of cutaneous DC types.

226 .521 will be useful toward understanding the biological roles of cyclic GMP-AMP synthase and can serv

227 FGFR heterodimers form, suggesting that the biological roles of FGFR heterodimers may be as signific

228 We examine the regulation and biological roles of genes acting downstream of JH and Me

229 e useful as a tool to further understand the biological roles of GIP.

230 bioorthogonal ligation have enabled study of biological roles of glycans in vivo; however, direct inv

231 microRNA can be used as a proxy to identify biological roles of glycosylation enzymes (glycogenes).

232 r study provides important insights into the biological roles of GPC SSP and implicates it as a good

233 ing new chemical tools for understanding the biological roles of H2 S include developing platforms th

234 New discoveries of the biological roles of hydroxymethylation serve to raise qu

235 is integrated overview into the physical and biological roles of intertwining are highlighted.

236 However, defining the biological roles of intestinal macrophages has been impe

237 Inference of the biological roles of lncRNAs in breast cancer development

238 In particular, the biological roles of long non-coding RNAs (lncRNAs) have

239 The biological roles of low molecular weight penicillin-bind

240 roach provides a novel tool for studying the biological roles of methyllysine readers in epigenetic s

241 Improved understanding of biological roles of miRNAs in the pathogenesis of haemat

242 However, the biological roles of most microdomain-associated proteins

243 will summarize the current knowledge of the biological roles of mRNA caps in eukaryotic cells.

244 ding of not only laminopathies, but also the biological roles of nuclear structure.

245 For over half a century, the biological roles of nucleic acids as catalytic enzymes,

246 phingolipid metabolism could indicate shared biological roles of ORMDLs, influencing airway remodelin

247 The biological roles of oxylipins have been extensively stud

248 lins will play a seminal role in identifying biological roles of phyllobilins.

249 xamination of pathway enzymes and evolution, biological roles of protein modification in the native h

250 and our results may relate to the different biological roles of RecA, Rad51, and Dmc1.

251 Fs) arise in cancers, and the functional and biological roles of relatively few of these have been ch

252 Although the biological roles of ribosome hibernation are not complet

253 The biological roles of RNAPII pause release and the mechani

254 ractive strategy for determining the diverse biological roles of senescent cells and developing speci

255 sis and to increase our understanding of the biological roles of specific enzyme targets.

256 nces are not only providing insight into the biological roles of specific receptor populations, but h

257 Other biological roles of surface acidity may be found, now th

258 Here, we investigated the biosynthesis and biological roles of the 8-O-methylated benzoxazinoids, D

259 regulator of MYC and highlight the distinct biological roles of the different PKA catalytic subunits

260 es crucial questions regarding the potential biological roles of the enhancer transcription process a

261 e variation within this locus is complex and biological roles of the factor H-related proteins, unlik

262 been studied extensively, the fact that the biological roles of the metals often stem from their pla

263 type I interferon (IFN) suppression, but the biological roles of the NP RNase in viral replication an

264 sed phosphorylation reaction and investigate biological roles of the observed directional phosphoryla

265 otein localization and give insight into the biological roles of the so-far uncharacterized Arabidops

266 This manuscript reviews the phylogeny and biological roles of the T6SS in plant-associated bacteri

267 Findings from this study unveil novel biological roles of the UDP-sugar receptor P2Y14 in hCPC

268 However, the biological roles of the vast majority of imprinted plant

269 However, the biological roles of the vast majority of these molecules

270 immunity and cancer, yet elucidation of the biological roles of their glycodomains has been complica

271 understanding of both unique and overlapping biological roles of these critical enzymes.

272 d biosynthesis, review recent studies on the biological roles of these polymers, and highlight remain

273 The biological roles of these proteins are unknown, but they

274 Efforts to understand the origin and biological roles of these Treg populations in regulating

275 One major challenge in separating the biological roles of thiols and H2S is developing tools t

276 ompound will be critical for elucidating the biological roles of this isozyme and may ultimately be u

277 cNAcylation and are helping to elucidate key biological roles of this novel PTM.

278 There is limited information on the biological roles of this RGS-containing family of RhoGEF

279 which allow for better understanding of the biological roles of this widespread post-translational m

280 The implications of these findings for the biological roles of triple-stranded DNA structures are d

281 rtant and robust tools for investigating the biological roles of vitamin B12 .

282 Considering the biological roles of WNT4 and WNT5A involved in adipogene

283 ite a well-defined repression mechanism, few biological roles or gene targets of KRAB-ZFP are known.

284 tr1 and Ctr2 that discriminate between their biological roles, providing mechanistic insights into th

285 se findings suggest that circRNAs might play biological roles relevant to the aging nervous system.

286 translation efficiency, their exact in vivo biological roles remain largely unexplored.

287 heme-binding proteins for which chemical and biological roles remain unclear.

288 r, stilbene epoxidation biosynthesis and its biological roles remain unknown.

289 While its biological role remains unclear, crystal structure analy

290 ins many types of small RNAs (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remai

291 However, the biological role(s) served by these channels, if any, rem

292 hin the body, extending its function to cell biological roles such as mediating cellular receptors an

293 ncreatitis, and carcinogenesis, although the biological role that these isoforms serve in the systemi

294 animal PABPs are well-studied proteins, the biological role, three-dimensional structure and RNA-bin

295 cture-seq allows the RNA structurome and its biological roles to be interrogated on a genome-wide sca

296 to cell-fate programs and assigned putative biological roles to uncharacterized genes.

297 s numerous volatile compounds with undefined biological roles, were detected.

298 tures in nature are ultrafine and ordered in biological roles, which have attracted material scientis

299 HIF-2alpha has both distinct and overlapping biological roles with HIF-1alpha and has not previously

300 l growth and development, DCs have important biological roles with respect to pathogenicity in some f