ライフサイエンスコーパス: biological significance

1 RNAP) and RNAs] and critically analyze their biological significance.

2 n termination for RNAPII and demonstrate its biological significance.

3 to repair in vivo, which may indicate their biological significance.

4 erization reactions, and are thus of immense biological significance.

5 ylation is essential to accurately interpret biological significance.

6 is locus is a prerequisite to understand its biological significance.

7 contain nonsynonymous mutations of potential biological significance.

8 ally identify protein conformers with likely biological significance.

9 converted to B-norbenzomorphan analogues of biological significance.

10 of the canonical pocket that may indicate a biological significance.

11 nd often does represent natural variation of biological significance.

12 together by junctional molecules of unknown biological significance.

13 ubgroups and characterise their clinical and biological significance.

14 inable myocyte-generating progenitor cell of biological significance.

15 nd efficient stabilization of Tel22 may bear biological significance.

16 d H. pylori 16 S rRNA partial sequences have biological significance.

17 ommon for variants with unknown clinical and biological significance.

18 gnificant predictive information, as well as biological significance.

19 e classifier were further examined for their biological significance.

20 ed that these biochemical differences have a biological significance.

21 distances, such as the curvature, may carry biological significance.

22 These variations might have potential biological significance.

23 Both genes have essential, differing biological significance.

24 anking genes based on statistical as well as biological significance.

25 to extract co-expressed modules having high biological significance.

26 ese numbers, limiting understanding of their biological significance.

27 ntly ubiquitinated substrates with different biological significance.

28 r mitochondrial function, underscoring their biological significance.

29 dictions for the newly found genes with high biological significance.

30 much attention due to their large number and biological significance.

31 nts often have small effects without obvious biological significance.

32 PRR5 rs3213550 was also selected based on biological significance.

33 dose-dependent response against enzymes with biological significance (alpha-glucosidase, acetylcholin

34 Underscoring their biological significance, altered Gsk-3 activity has been

35 or plant breeding, as well as understand its biological significance, analytical approaches have been

36 nd other oligosaccharide-binding proteins of biological significance and also that they have potentia

37 Their widespread biological significance and consequent medical potential

38 lice variants, VLDLRI and VLDLRII, but their biological significance and distinction are unknown.

39 A discussion follows on their possible biological significance and effect on mosquito vector co

40 olyphenols is important for evaluating their biological significance and efficacy as functional food

41 a somehow fragmented picture of the possible biological significance and evolution of SL trans-splici

42 In this study, we investigated the biological significance and molecular mechanism of this

43 anged tooth morphology in humans, its direct biological significance and potential adaptive role rema

44 The biological significance and potential clinical applicati

45 However, the biological significance and potential effects of the mic

46 The biological significance and prognostic capacity of this

47 The biological significance and surgical management of MTMC

48 novel and far-reaching discoveries that link biological significance and the bacterial epigenome.

49 These data illustrate the biological significance and therapeutic potential of the

50 Recent data are beginning to reveal the biological significance and universal presence of Sp1 ph

51 -order chromatin in mammalian cells, but its biological significances and molecular mechanisms remain

52 cations constitute a major field of emerging biological significance as mounting evidence demonstrate

53 e euphyllophytes, and their evolutionary and biological significance as well as their transposition m

54 Instead, it could be due either to different biological significances/attractiveness criteria across

55 mTOR folate sensing may have broad biological significance because of the critical role of

56 which include its discovery, structure, and biological significance both in benign and malignant con

57 Despite wide biological significance, delineating filopodia function

58 downstream of BRAF(V600E) has functional and biological significance, driving proliferation, invasion

59 tiation, suggesting a paracrine or autocrine biological significance for the adipocyte-derived 27HC.

60 This work provides insight into the biological significance for the complex array of hydroly

61 se to multiple tumor types, indicating broad biological significance for this CFP/chemokine interacti

62 umbers of preformed nucleocapsids, but their biological significance has been debated, and they have

63 irst crystal structure of a UvrB dimer whose biological significance has been verified using both che

64 he most conserved region of the protein, its biological significance has not been elucidated.

65 ural proteins of the epidermis; however, its biological significance has remained elusive.

66 In spite of their biological significance, however, methods to discover UB

67 Besides their yet to be clarified biological significance, i-motif nanowires may qualify a

68 nthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (2:1

69 th multiple cancer-related proteins, but its biological significance in cancer development remains un

70 ospho-regulation of Ajuba in mitosis and its biological significance in cancer.

71 evel between Hedgehog signaling and AKT with biological significance in DLBCL.

72 nzofuran, indoline, and chroman skeletons of biological significance in good to excellent yields; the

73 tivation in cholangiocarcinoma, although its biological significance in initiating and promoting tumo

74 discuss theories of imprinting evolution and biological significance in light of recent findings.

75 umor initiation and heterogeneity, but their biological significance in melanoma has been controversi

76 (DNICs) are organometallic-like compounds of biological significance in that they appear in vivo as p

77 with schizophrenia risk, establishing their biological significance is a priority.

78 volves large contortions of the nucleus, but biological significance is largely unclear.

79 tIP forms dimers in mammalian cells, but the biological significance is not clear.

80 ndant in several mammalian cell types, their biological significance is sparsely characterized.

81 Although the biological significance is unclear, the results suggest

82 Their global biological significance is unproven and remains controve

83 Despite its biological significance, knowledge of Pol beta activitie

84 Here, we identified and characterized the biological significance of a novel tyrosine kinase that

85 ates an effective approach to appreciate the biological significance of a small effect.

86 hrough the cell cycle; (3) insights into the biological significance of A-DNA as evidenced by an inte

87 To elucidate the biological significance of aberrant AID expression, we s

88 These results support the biological significance of actin catch bonds, as they co

89 The results highlight the biological significance of alternative Bdnf transcripts

90 ibody to see widespread use in analyzing the biological significance of arginine phosphorylation.

91 ity in the ventral striatum to represent the biological significance of associative information in th

92 is overexpressed in many human cancers, the biological significance of ATDC overexpression remains o

93 ere, asking what has been revealed about the biological significance of BES multiplicity and ESAG fun

94 The biological significance of BR-mediated changes in hypoco

95 a1 in endothelial cells, the biochemical and biological significance of c-Cbl, however, in angiogenes

96 The biological significance of C5a receptor [(C5aR)2/C5L2],

97 nologies have highlighted the prevalence and biological significance of cellular heterogeneity.

98 The biological significance of conserved replication timing

99 epithelium, thus opening the possibility of biological significance of counteracting demethylases.

100 The biological significance of COUP-TFII in prostate carcino

101 t study, we examined the possibility and the biological significance of cross-immunoreactivity betwee

102 carbohydrate active enzyme families and the biological significance of cryptic metabolic pathways, s

103 However, the pathogenesis and biological significance of CSLCs in PC has not been well

104 with a particular focus on understanding the biological significance of CTCs, and summarizes emerging

105 s variant of bZIP16 provided support for the biological significance of Cys(330) in redox regulation

106 time-course experiments and to highlight the biological significance of data with regard to the Gene

107 This study also underscores the biological significance of deubiquitinase activity in MS

108 this study, we investigated the clinical and biological significance of Dll4 in ovarian cancer.

109 Currently, the biological significance of Dmp1-cyclin D1 interplay in b

110 temporal features, we know little about the biological significance of each temporal component.

111 s study sought to determine the clinical and biological significance of elevated cardiac troponin T (

112 essing these phenomena, but interpreting the biological significance of epistasis and pleiotropy is o

113 , including PIN5, we define a long-neglected biological significance of ER-based auxin regulation.

114 We review the current understanding and biological significance of ERAD-mediated regulation of l

115 Here we will discuss the evolution and biological significance of eukaryotic DNA methylation, t

116 However, the biological significance of excess endolysosomal Cu accum

117 Biological significance of Fc glycans has been extensive

118 asured, resulting in confusion regarding the biological significance of flow-induced ciliary mechanot

119 The biological significance of frameshifting efficiency and

120 n in microbial and vertebrate organisms, the biological significance of GC content diversity in plant

121 Here, to assess the biological significance of genetic diversity acquired th

122 In this review, we discuss the biological significance of genome-wide binding of transc

123 The biological significance of genomic features is often con

124 be sequenced to further understanding of the biological significance of genomic heterogeneity in comp

125 Seq2pathway associates the biological significance of genomic loci with their targe

126 However, the biological significance of HCV-induced autophagy has not

127 Unraveling the biogenesis and biological significance of heterogenetic RNA expression

128 ever as a model system for understanding the biological significance of human genetic variation and f

129 ods for analysis, underlying mechanisms, and biological significance of hypertranscription.

130 To understand the biological significance of IkappaBalpha-mediated feedbac

131 In this study, we investigated the biological significance of IL-32 in an in vitro model of

132 Here, we examined the molecular and biological significance of IL8 in stress-induced tumor g

133 cuss the major progress in understanding the biological significance of Itch-promoted protein ubiquit

134 However, the biological significance of Jab1 activity in response to

135 However, the biological significance of JAB1 activity in these cellul

136 of the cell cycle, but the mechanism and the biological significance of kinetochore clustering are un

137 Our data shed new light on the biological significance of LN lymphangiogenesis during p

138 These findings highlight the biological significance of lysine fatty acylation and si

139 rginine are well-established, the extent and biological significance of lysine phosphorylation has re

140 resource for future studies of function and biological significance of m5C in mRNA in mammals.

141 ensively in vitro, little is known about the biological significance of membrane fusion activity in p

142 This study aims to clarify the clinical and biological significance of metastasis-associated long no

143 The biological significance of minimal absent words has been

144 This study was performed to assess the biological significance of miR-210 in preeclampsia and s

145 Further we elucidated the biological significance of miR-23b in bladder cancer.

146 The biological significance of miRNAs present in the extrace

147 The present data are the first to show the biological significance of mitochondrial Mb as a potenti

148 However, the biological significance of mycobactins in the growth of

149 nsferase 1 (PMAT1), to better understand the biological significance of NAE 12:0-induced gene express

150 Full understanding of the biological significance of negative feedback processes r

151 The biological significance of NETs is just beginning to be

152 This article discusses the biological significance of network motifs, the motivatio

153 ranscripts, the physiological regulation and biological significance of NMD are not well characterize

154 in vascular tissue called into question the biological significance of NO formation by purified ALDH

155 Although the biological significance of noncoding RNA editing remains

156 e as an excellent tool for investigating the biological significance of NOTCH-mediated JAK3 turnover.

157 The present study examined the biological significance of notes of the male advertiseme

158 P during different stress conditions and the biological significance of omission of enhanced ATF4 fun

159 icrobiome Project, a close evaluation of the biological significance of our findings confirms existin

160 use embryonic fibroblasts, demonstrating the biological significance of our findings.

161 uce oxalic acid levels and to understand the biological significance of OXDC in crop plants have met

162 c antibodies has limited the analysis of the biological significance of p63.

163 interact with host factors for function, the biological significance of pathogenic noncoding RNAs in

164 The biological significance of PB2-S1 to the replication and

165 tively, these studies further underscore the biological significance of Perforin-2 and elucidate crit

166 The method generates the magnitude and the biological significance of personal deregulated pathways

167 The biological significance of PI3K was investigated in vert

168 data are unique in providing evidence of the biological significance of protein O-mannosylation in my

169 s that will advance our understanding of the biological significance of RBPs in plant developmental a

170 To elucidate the biological significance of receptor cleavage by u-PA, we

171 Finally, the biological significance of repression differences was de

172 -NQO resistance, possibly explaining why the biological significance of Rev1's catalytic activity has

173 However, the biological significance of Rev1's unusual conserved DNA

174 B cell development but also underscores the biological significance of reversible epigenetic histone

175 Despite the biological significance of RNase L, the RNAs cleaved by

176 Furthermore, to determine the biological significance of RNPC1-enhanced HuR expression

177 The biological significance of Runx2 repression of this miR

178 In particular, we explore the biological significance of shadow prices in a constraint

179 lines, and Epstein-Barr virus; however, the biological significance of sisRNAs remains poorly unders

180 The biological significance of SSEA-4/FKBP4 interaction was

181 eported in Saccharomyces cerevisiae, but the biological significance of such interactions remains unk

182 An accepted theory explaining the biological significance of such non-uniform codon select

183 However, the biological significance of such regulators in M. avium s

184 To understand the biological significance of such sequence heterogeneity,

185 Although the biological significance of such vesicles was initially d

186 Taken together, our observations explain the biological significance of TET oligomerization and sugge

187 To determine the biological significance of Tf1 integration, we took adva

188 engineered mice are being used to define the biological significance of the "receptor function" of th

189 hroughout all growth phases in S. aureus The biological significance of the 100S ribosome is poorly u

190 The putative biological significance of the centrifugal antennal-lobe

191 Our understanding of the biological significance of the complex architecture of t

192 ngthened proteins were also used to test the biological significance of the crystal structure.

193 Although the biological significance of the DNA-O-glycosidase reactio

194 ermine the individual proteolytic events and biological significance of the ectodomain shedding in th

195 However, the biological significance of the FYF amino acid motif in t

196 However, the biological significance of the H19 noncoding transcript

197 In this study, we have established the biological significance of the HIV-1 RT-IN interaction d

198 objective of this study was to elucidate the biological significance of the HptB-PA3346 interaction a

199 The biological significance of the IL-21/IL-21R system in hu

200 rovides the starting point for revealing the biological significance of the interaction of IL-10 with

201 cond attempt to understand the structure and biological significance of the nucleocapsid.

202 To determine the biological significance of the p53-Rbm38 loop, we showed

203 We validate the biological significance of the pol-II promoter activity

204 gorithms in terms of prediction accuracy and biological significance of the predictions.

205 in response to stress, thus questioning the biological significance of the presence of this MAPK int

206 f galectin-3 in neutrophil migration and the biological significance of the rapid migration of neutro

207 We directly examined the biological significance of the reduced infectivity assoc

208 Biological significance of the resistance-increasing act

209 pread of the mutant virus, strengthening the biological significance of the RFC complex as a host res

210 To determine the biological significance of the RT-IN interaction during

211 now provide the basis for understanding the biological significance of the stereochemical dependence

212 These studies support the biological significance of the triangular trimer assembl

213 However, the expression and biological significance of the VEGFC/VEGF receptor (VEGF

214 mas are highly heterogeneous tumors, but the biological significance of their different subpopulation

215 The biological significance of these amino acid changes can

216 n and amyotrophic lateral sclerosis, but the biological significance of these CTFs and how they are g

217 The biological significance of these differences and whether

218 To examine the biological significance of these findings in the context

219 The biological significance of these findings was confirmed

220 equencing will provide the tools to test the biological significance of these gene regulatory network

221 we found additional evidence to support the biological significance of these gene-gene associations,

222 We validate the biological significance of these genes by assessing thei

223 The biological significance of these genes is evaluated usin

224 Despite the well-established biological significance of these glycans, questions rega

225 However, the biological significance of these hidden polypeptides is

226 and PA directly target RIG-I, but the exact biological significance of these interactions in the rep

227 To understand the biological significance of these interactions, a pif1pif

228 f this study was to investigate the possible biological significance of these metabolic pathways.

229 nd allows for direct investigations into the biological significance of these newly described interac

230 The biological significance of these observations was evalua

231 the involvement of microRNAs in cancer, the biological significance of these phenotypic and genotypi

232 A complete understanding of the potential biological significance of these products remains to be

233 her genomic studies are needed to assess the biological significance of these results.

234 To evaluate the biological significance of these sites, we tested for as

235 However, the biological significance of these transcriptional repress

236 This absolute conservation is evidence for biological significance of these unique biochemical prop

237 ing can be replicated and should explore the biological significance of these variations with respect

238 However, the biological significance of this association in live cell

239 The biological significance of this asymmetrical response in

240 The biological significance of this correlation was corrobor

241 To explore the biological significance of this editing function, we cre

242 sis on contact with host cells; however, the biological significance of this event during intestinal

243 plication demonstrate for the first time the biological significance of this family of DNA lesions.

244 at most, low levels of the "151 mutant," the biological significance of this feature of NA in, for ex

245 To ascertain the biological significance of this hypothesis, we focused o

246 In this study, we examined the biological significance of this interaction during infec

247 However, the biological significance of this interaction was not stud

248 known to affect chromatin dynamics, but the biological significance of this interplay is still not c

249 Multiple VEGF-A isoforms exist, but the biological significance of this is unclear.

250 ed into N- and C-terminal fragments, but the biological significance of this is unknown.

251 e circadian clock, but the mechanism and the biological significance of this link have only begun to

252 The biological significance of this mechanism is indicated b

253 However, the ecological or biological significance of this metabolite diversity is

254 new and improved gene models and assess the biological significance of this method in Oryza sativa.

255 However, the biological significance of this modification is unknown,

256 To further elucidate the biological significance of this modification, we charact

257 The biological significance of this negative feedback contro

258 The biological significance of this observation was seen in

259 However, the biological significance of this organization has been di

260 xia-inducible factor 1 (FIH-1); however, the biological significance of this phenomenon is unclear.

261 In this study, we examine the biological significance of this phenomenon on the trogoc

262 The biological significance of this phenomenon was establish

263 The biological significance of this PKCtheta/alphaPIX/Rac 1

264 C) risk that is heightened in women, but the biological significance of this polymorphism has never b

265 HDAC6 as specific deacetylases, showing the biological significance of this post-translational modif

266 ut the targeting preferences, mechanism, and biological significance of this process remain unclear.

267 To elucidate the biological significance of this proteolytic modification

268 However, the biological significance of this rapid signaling pathway

269 We examined the biological significance of this regulation by performing

270 cally disrupt dimerization, highlighting the biological significance of this regulatory mechanism.

271 However, the biological significance of this response was unclear.

272 n downstream CaM targets, thus expanding the biological significance of this small regulator of CaM s

273 n accompanied by progress in elucidating the biological significance of this transcription factor in

274 The biological significance of this tRNA nuclear import is n

275 The biological significance of this type of complementation

276 ith a noise trimming approach to predict the biological significance of Tn5 mutations.

277 We tested the biological significance of two amino acid mutations in t

278 ee-dimensional (3D) model to investigate the biological significance of unrepaired DNA lesions in dif

279 omogeneous protein crowders, reinforcing the biological significance of weak, nonspecific interaction

280 associated with reduced platelet counts, the biological significance of which has remained elusive.

281 -modified PEs formed during stress and their biological significance remain to be fully characterized

282 re of genes regulated by macroH2As and their biological significance remain unclear.

283 the same protein family, its functional and biological significance remains to be addressed.

284 d for other amyloidogenic proteins but their biological significance remains to be established.

285 te in heterogeneous environments whose exact biological significance remains to be unveiled.

286 ted in response to inflammatory signals, its biological significance remains unclear.

287 Among the macromolecular patterns of biological significance, right-handed alpha-helices are

288 Despite their biological significance, surprisingly little is known of

289 BIOLOGICAL SIGNIFICANCE: Theobroma grandiflorum and Theo

290 ce projected, it can be difficult to ascribe biological significance to the observed features.

291 localized to conserved molecular regions of biological significance to the virus were enriched for H

292 Our study assigns biological significance to TR variations in the human ge

293 with five RNA loop-loop complexes of unique biological significance using explicit-solvent molecular

294 germline, and de novo variants of potential biological significance using publicly available data se

295 North American populations, we studied their biological significance using transgenic mice.

296 To address the biological significance, we generated phospho-deficient

297 To shed light on the potential biological significance, we here adopt a systems approac

298 atistical pipeline to assess statistical and biological significance while managing the multiple test

299 Applied to this protein of biological significance with large inhomogeneous broaden

300 act strongly with several immune proteins of biological significance, with these interactions resulti