ライフサイエンスコーパス: biomolecular

1 into senescence, we observed rather similar biomolecular abundances in all four cell strains and bet

2 ecific to biological contexts and individual biomolecular activities, resulting in a total of 112 int

3 a deep understanding of many of its members' biomolecular activities, the current list of pathway mem

4 energy transfer (FRET) to dynamically report biomolecular activities.

5 Quantitative analysis of biomolecular adsorption on a substrate is crucial for un

6 h-throughput, solution-phase alternative for biomolecular affinity characterization.

7 The ability to control the morphologies of biomolecular aggregates is a central objective in the st

8 o various causes like diseases, which is why biomolecular analysis and imaging play an important role

9 hip are miniaturized systems able to perform biomolecular analysis in shorter time and with lower rea

10 pectrometer are of fundamental importance to biomolecular analysis.

11 Dark quenchers are extensively used in many biomolecular analytical applications, such as studies wi

12 ng the benchmark molecule against which many biomolecular analytical techniques are assessed and eval

13 e generic tool for analyzing mixing paths in biomolecular and analytical chemistry.

14 dy advocates the huge potential of combining biomolecular and biogeochemical provenance tracer analys

15 re of potential interest for applications in biomolecular and cellular imaging, but it has been chall

16 n association at the Grotte du Renne through biomolecular and chronological analysis.

17 Here, we combine analysis of biomolecular and isotopic compositions of lipids preserv

18 ive chirality phenomena extensively exist in biomolecular and organic systems via intra- and inter-mo

19 n the period between June 2015 and May 2016, biomolecular and virological tests were performed on 845

20 n have been enabling many recent advances in biomolecular applications of NMR.

21 d (ca. 6,000-5,000 BC), provide the earliest biomolecular archaeological evidence for grape wine and

22 sorption characteristics generated by common biomolecular assays.

23 ents an attractive strategy to create hybrid biomolecular assemblies from peptide- and DNA-based buil

24 A major challenge in the study of biomolecular assemblies is to identify reaction coordina

25 The modeling of large biomolecular assemblies relies on an efficient rendering

26 nanotubes rivals some of the largest tubular biomolecular assemblies, such as GroEL and microtubules.

27 ate-limiting mechanisms underlying multistep biomolecular assembly pathways.

28 r or much slower than bimolecular diffusion, biomolecular association is not stable, but as the recon

29 tive capacity of DNA confers straightforward biomolecular attachment and multistep derivatization cap

30 and nanodiscs enables rapid interrogation of biomolecular binding interactions at model cell membrane

31 ZnO nanostructures leading to enhancement of biomolecular binding on the sensor electrode surface.

32 t to infer the binding strength of a second, biomolecular binding reaction under physiological condit

33 the first instance of real-time detection of biomolecular binding-induced polymer shrinkage in soft m

34 ic process of gNP aggregation responses upon biomolecular binding.

35 indicator for surface modifications, such as biomolecular bindings.

36 We applied biomolecular, biochemical and geochemical analyses to re

37 umption by examining the assembly of various biomolecular building blocks from prebiotically plausibl

38 hways that underlie successful coassembly of biomolecular building blocks in a noninvasive approach w

39 ttractive and repulsive interactions between biomolecular building blocks.

40 atio between the total surface area used for biomolecular capture with respect to the entire sensing

41 Biomolecular cargo encapsulated within the particle core

42 It is hypothesized that the release rate of biomolecular cargo from the vault lumen is related to th

43 ase (INT) has been used as a shuttle to pack biomolecular cargo in the vault lumen.

44 cal and pharmacological research, uncovering biomolecular changes associated with disease and providi

45 the potential usefulness of our approach for biomolecular characterization in biomedical applications

46 zed in terms of excitons moving on a grid of biomolecular chromophores on typical timescales [Formula

47 turally related electrical signatures of the biomolecular circuit, which will ultimately lead us to t

48 ts ( approximately 5 nm) in a densely packed biomolecular cluster remains a challenge.

49 on the origins of the pathway complexity in biomolecular coassembly.

50 re emerging techniques for determining large biomolecular complex and subcellular structures.

51 to mitosis) to regulate function by altering biomolecular complex concentrations.

52 termolecular interaction interfaces in large biomolecular complexes in the solid state.

53 orm from which to investigate other flexible biomolecular complexes through the integration of NMR da

54 ation about structures and dynamics of large biomolecular complexes, including ones that are not acce

55 -atom level of accuracy even for the largest biomolecular complexes.

56 pens new avenues for multiscale processes of biomolecular complexes.

57 obe the mechanics and activity of individual biomolecular complexes.

58 simulations provide predicted affinities for biomolecular complexes.

59 directly applies to even larger photoactive biomolecular complexes.

60 ic excitation energy of the light-harvesting biomolecular complexes.

61 s any biofunctional role in real photoactive biomolecular complexes.

62 single organelles of live cultured cells by biomolecular component analysis using microRaman data.

63 Our findings shed light on the biomolecular composition of hypoxic tumor regions, which

64 a technique that is well suited to study the biomolecular composition of specific tissue regions, suc

65 o bone rely on an intricate interplay of its biomolecular composition, microstructure and micromechan

66 0 mum with a distinct fibre organization and biomolecular composition.

67 We validated our approach by comparing the biomolecular compositions of lysosomes and plasma membra

68 dentify disease-related alterations in their biomolecular compositions.

69 t to contribute to the establishment of many biomolecular condensates, eukaryotic cell structures tha

70 ics is thus not valid; our results show that biomolecular conformational fluctuations are essential t

71 svApp was 12620+/-390M(-1), and the apparent biomolecular constant was 3.94x10(12)M(-1)s(-1), which s

72 we report the development of an ultrastable biomolecular construction kit for the assembly of filame

73 ive proteomics identified differences in the biomolecular content of the BC due to the ball-milling p

74 ethal reaction precipitates Fe(3+)-oxides as biomolecular damage proceeds.

75 o mine, cluster and compare multidimensional biomolecular datasets.

76 These features allow non-experts to explore biomolecular design in silico.

77 hat ISAMBARD will find broad applications in biomolecular design, biotechnology and synthetic biology

78 r nano-gap architecture having potentials on biomolecular detection through monitoring of surface-pot

79 In biomolecular detection, transition-metal dichalcogenides

80 hniques in bioanalysis rely on surface-based biomolecular detection, which requires the confinement o

81 ffer a new paradigm to promote surface-based biomolecular detection.

82 ectrodes to manufacture MoSe2 nanolabels for biomolecular detection.

83 guration rate becomes similar to the rate of biomolecular diffusion, the association is more stable a

84 ires create electronic junctions via spatial biomolecular doping of graphene and manifest themselves

85 The biomolecular doping of nanosheets defined by peptide nan

86 me an invaluable, powerful approach to study biomolecular dynamics and interactions via selective lab

87 on the analysis of atomistic simulations of biomolecular dynamics such as protein folding and confor

88 relaxation dispersion experiments to reveal biomolecular dynamics.

89 lar simulation and experiment in quantifying biomolecular dynamics.

90 osynthetic reaction centres show promise for biomolecular electronics as nanoscale solar-powered batt

91 nthetic biologists have begun to focus their biomolecular engineering approaches toward this goal, of

92 iome-the combination of microbiota and their biomolecular environment and ecology-specifically with r

93 g the structural and dynamic determinants of biomolecular enzyme catalysis of all major states involv

94 system to detailed pathway diagrams showing biomolecular events like membrane transport or phosphory

95 Biomolecular experiments demonstrated that low concentra

96 fer various advantages, enabling label-free, biomolecular fingerprinting in the native state.

97 o-immunoprecipitation with tagged receptors, biomolecular fluorescence complementation, and merged co

98 A biomolecular fluorescent complementation (BiFC) analysis

99 rophobic surfaces, to hydrophobically driven biomolecular folding and assembly.

100 or individual residues, which correlate with biomolecular function and were previously inaccessible.

101 for understanding conformational disorder in biomolecular function.

102 o permitted the introduction of reactive and biomolecular groups for further conjugation and targetin

103 low a better understanding of the origins of biomolecular homochirality.

104 dels or hydropathy scales for characterizing biomolecular hydrophobicity and the associated driving f

105 An overview of optical biomolecular imaging is provided.

106 ght, photostable fluorophore with utility in biomolecular imaging.

107 surface modification of the sensor prior to biomolecular immobilization.

108 proteins, DNA, etc., can analyze presence of biomolecular inputs according to Boolean logic and under

109 own refractive indices as well as of a model biomolecular interaction (i.e. IgG-AntiIgG) we demonstra

110 A proteomic analysis and subsequent biomolecular interaction assay reveals that the carboxyl

111 esion, the biophysical mechanism of specific biomolecular interaction can be divided in slip and catc

112 have been proposed to facilitate the use of biomolecular interaction data in a broad range of applic

113 h integrates gene co-expression modules with biomolecular interaction network analysis to identify ne

114 ects CMP self-assembly with a broad range of biomolecular interaction phenomena, providing general pr

115 nts for the quantitative characterization of biomolecular interactions and establish fluorescence ani

116 Docking is widely used for the study of biomolecular interactions and mechanisms, and it is appl

117 ithin proteins are critical elements in many biomolecular interactions and signaling pathways.

118 gnition is an important initial step for the biomolecular interactions and their functional proceedin

119 Transient biomolecular interactions are the cornerstones of the ce

120 The study of biomolecular interactions at the single-molecule level h

121 Understanding the biomolecular interactions between graphene and human imm

122 rce is a fundamental regulatory mechanism of biomolecular interactions driving many cellular processe

123 functionalized nanomotors based on different biomolecular interactions have thus been shown extremely

124 ect transient protein interactions and other biomolecular interactions in situ.

125 The study of biomolecular interactions is central to an understanding

126 rface plasmon resonance (LSPR) for analyzing biomolecular interactions under flow and static conditio

127 approach enables the multiplex detection of biomolecular interactions with state-of-the-art sensitiv

128 osensor techniques, both highly sensitive to biomolecular interactions, namely quartz crystal microba

129 ic, thermodynamic and kinetic information on biomolecular interactions, which can be extracted throug

130 on a substrate is crucial for understanding biomolecular interactions.

131 ing their ability to fold and participate in biomolecular interactions.

132 proaches that directly assess the underlying biomolecular interactions.

133 (PDB) contains a wealth of data on nonbonded biomolecular interactions.

134 o determine the thermodynamic profile of the biomolecular interactions.

135 grated, quantitative ITC characterization of biomolecular interactions.

136 and nature utilizes H-bonding in nearly all biomolecular interactions.

137 r probes that correlate with the presence of biomolecular interactions.

138 w post-translational modifications can alter biomolecular interactions.

139 lished optical label-free technique to study biomolecular interactions.

140 gents, self-assembled from nanoparticles via biomolecular interfaces such as proteins, DNA, etc., can

141 We experimentally illustrate the biomolecular interplay that G-rich DNA single-strands wi

142 the data that is able to better resolve the biomolecular intratumor heterogeneity.

143 to probe the stoichiometry and structure of biomolecular ion complexes, including megadalton-sized a

144 e-jump mixing device for investigating rapid biomolecular kinetics with confocal single-molecule spec

145 specific structural investigation of complex biomolecular layers and biological surfaces.

146 etailed structural insight into the involved biomolecular layers is required.

147 Biomolecular layers play also important roles in context

148 focus on assembling building blocks from the biomolecular level to the millimeter scale.

149 formation of the MDL remains elusive at the biomolecular level.

150 erning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanosc

151 most effective ways to regulate functions in biomolecular machinery, involves the transfer of informa

152 Biomolecular machines consume free energy to break symme

153 ction of a large variety of biomolecules and biomolecular machines.

154 ssect the complex conformational dynamics of biomolecular machines.

155 essential for structural characterization of biomolecular mechanisms across the broad spectrum of sca

156 However, the biomolecular mechanisms by which shock waves interact wi

157 on, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from

158 Adequate understanding of biomolecular mechanisms inherently involves our ability

159 reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear.

160 th accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related

161 ncer, it is critical to couple genetics with biomolecular mechanisms.

162 numerical framework, this work provides new biomolecular mechanistic perspectives through which many

163 Due to their unique biomolecular membrane shell and narrow size distribution

164 res of the phase diagram of a multicomponent biomolecular mixture.

165 ility of NMR investigations to heterogeneous biomolecular mixtures.

166 To extend existing methods in the Rosetta biomolecular modeling suite for membrane proteins, we re

167 providing a powerful resource for predictive biomolecular modeling.

168 t developments in chemoselective methods for biomolecular modification.

169 mprehensive information on hyperoxia-induced biomolecular modifications in neonatal mouse lung fibrob

170 Such devices require interfacing complex biomolecular moieties as the sensing units to an electro

171 Engineering biomolecular motors can provide direct tests of structur

172 Many biomolecular motors catalyze the hydrolysis of chemical

173 momechanical group transfer theory of rotary biomolecular motors is applied to treat single-molecule

174 d, comparable to the transport velocities of biomolecular motors.

175 Inspired by biology, exquisite biomolecular nanoarchitectures have been formed on solid

176 A novel combinatorial biomolecular nanopatterning method is reported, in which

177 Although many methods for self-assembling biomolecular nanostructures have been developed, few can

178 eralded as autonomous entities but rather as biomolecular networks composed of the host plus its asso

179 Simulation of biomolecular networks is now indispensable for studying

180 the main tasks in the analysis of models of biomolecular networks is to characterize the domain of t

181 examine the common perception that events in biomolecular networks occur sequentially, in a cascade-l

182 Large, naturally evolved biomolecular networks typically fulfil multiple function

183 r modelling large-scale evolved or synthetic biomolecular networks.

184 er models of the cell cycle engine and other biomolecular networks.

185 nts new functions reflecting advances in the biomolecular NMR field.

186 Here, using solution-state biomolecular NMR in conjunction with other biophysical m

187 To simplify access to and use of biomolecular NMR software, foster persistence, and enhan

188 ll nuclear magnetic resonance is a branch of biomolecular NMR spectroscopy that allows macromolecules

189 he rich and dynamic software environment for biomolecular NMR, NMRbox fosters the development and dep

190 gated cell-cell statistical distances within biomolecular pathways.

191 curated and peer-reviewed knowledge base of biomolecular pathways.

192 miniaturized metal semiconductor metal (MSM) biomolecular photodetector was developed as the core pho

193 of this novel, flexible and miniaturized MSM biomolecular photodetector with excellent mechanical fle

194 Our freeze-dried biomolecular platform resolves important practical limit

195 They have been used extensively as biomolecular platforms, e.g., nanocarriers or vaccines,

196 ionality of TDNs, one can tailor the type of biomolecular probes appended on individual TDNs for the

197 nalyses that study the relationships between biomolecular processes and phenotype across diverse dise

198 ic membrane proteins play key roles in vital biomolecular processes at cellular membranes.

199 Revealing the details of biomolecular processes in solution needs tools that can

200 Most biomolecular processes rely on tightly controlled stoich

201 ular mechanobiology has been to link dynamic biomolecular processes underpinning disease or morphogen

202 e sources, such as inherent stochasticity of biomolecular processes, random partitioning of resources

203 ce been extended to probe a diverse range of biomolecular processes, spanning from protein and RNA fo

204 the potential to revolutionize the study of biomolecular processes.

205 ular biology, helping visualize cellular and biomolecular processes.

206 the function of the individual cell with its biomolecular profile remains elusive.

207 related well with the temporal regulation of biomolecular progenitor versus mature neural marker expr

208 Enzymes can increase the rate of biomolecular reactions by several orders of magnitude.

209 Biomolecular receptors are able to process information b

210 Thus DeNAno particles are a novel biomolecular recognition agent whose orthogonal use of a

211 Devices and strategies for biomolecular recognition and detection should be develop

212 nt fields spanning from material sciences to biomolecular recognition and drug design.

213 quantitatively assess the thermodynamics of biomolecular recognition between a human antibody and it

214 receptor sensor based on the amalgamation of biomolecular recognition elements and molecular imprinti

215 Biomolecular recognition entails attractive forces for t

216 ugation of AgNPs with aptamers and assessing biomolecular recognition events with high sensitivity an

217 The biomolecular recognition induced polymeric network shrin

218 ucture-based programmable engineering of the biomolecular recognition interface, which provides a uni

219 The intrinsic specificity for biomolecular recognition measures the degree of discrimi

220 r the use of nanoparticles for molecular and biomolecular recognition within chemically complex envir

221 In situ monitoring of biomolecular recognition, especially at surfaces, still

222 ining the features of nanoscale objects with biomolecular recognition.

223 biologically inert but rather are capable of biomolecular recognition.

224 still a challenge compared to other types of biomolecular recognition.

225 nductance change upon specific aptamer-based biomolecular recognition.

226 )) for 21 days, and evaluated the tissue and biomolecular responses in the kidney.

227 ported due to the environment presented by a biomolecular scaffold for any hybrid catalyst, to date.

228 ariety of physical processes in chemical and biomolecular science.

229 Biomolecular self-assemblies are of great interest to na

230 ydrophobic interactions drive many important biomolecular self-assembly phenomena.

231 ing of antibiotics, we used highly sensitive biomolecular sensor systems for the simultaneous detecti

232 act, reliable, high-sensitivity and low-cost biomolecular sensors.

233 ved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionari

234 brane proteins that allosterically transduce biomolecular signals across the cell membrane.

235 plore how the spatial and dynamic context of biomolecular signals influences important cell functions

236 urce for understanding protein dynamics with biomolecular simulation.

237 aphy, biophysical affinity determination and biomolecular simulations unanimously deliver a remarkabl

238 modeling is a powerful approach for studying biomolecular site dynamics.

239 species, which simultaneously attack various biomolecular sites in the pathogenic target and therefor

240 ortance of (17)O for studies of structure in biomolecular solids.

241 on metamaterials that can sort chemical and biomolecular species by cloaking one compound while conc

242 intrinsic vibrational contrast of endogenous biomolecular species.

243 skeletal structures in 3D with unprecedented biomolecular specificity for vibrational microspectrosco

244 gments - ideally single nucleotides - in the biomolecular strand.

245 Recent promising alternative biomolecular strategies are toward promoting pro-osteoge

246 their applications to three-dimensional (3D) biomolecular structural data sets have been hindered by

247 understanding of human diseases, elucidating biomolecular structural information and characterizing c

248 t and computation into integrative models of biomolecular structure and dynamics.

249 Both biomolecular structure and motion can be studied using a

250 nium ion plays a key role in determining the biomolecular structure as well as local structure of wat

251 y of diffract-before-destroy measurements of biomolecular structure at X-ray-free electron lasers.

252 re, we propose a novel technique for probing biomolecular structure based on the changes in photophys

253 Biomolecular structure elucidation is one of the major t

254 , we describe a new undergraduate program in biomolecular structure prediction and design in which st

255 s, which still can be used as constraints in biomolecular structure prediction.

256 g is a sensitive and fast gas-phase probe of biomolecular structure that can be directly linked to so

257 ra-motif dependencies and intuitively reveal biomolecular structure.

258 s provides a curated introduction to the 3-D biomolecular structures available in the Protein Data Ba

259 for assessing the conformational dynamics of biomolecular structures with the development of a user-f

260 of magic angle spinning frequencies used for biomolecular studies and discuss their benefits and limi

261 possibility of using antibodies as bivalent biomolecular substrates for the templated assembly of a

262 t of sugars, metabolites and other essential biomolecular substrates of this ubiquitous transporter s

263 ics within 5-10 A of a label tethered to the biomolecular surface on two separate time scales of moti

264 network structure as well as the wetting of biomolecular surfaces.

265 ergy barriers of water diffusion next to the biomolecular surfaces.

266 ependence on the chemistry and topography of biomolecular surfaces.

267 We co-opted Escherichia coli for biomolecular synthesis and assembly of this nanomaterial

268 found consequences on the self-assembly of a biomolecular system.

269 Biomolecular systems are able to respond to their chemic

270 Biomolecular systems can undergo a range of active movem

271 Biomolecular systems exhibit many dynamic and biological

272 s that can deliver values of observables for biomolecular systems have been steadily increasing.

273 The complexity of biomolecular systems inevitably leads to a degree of com

274 tereodynamic atomic mimics in the context of biomolecular systems is unknown.

275 rful tools to simulate the dynamics of large biomolecular systems on micro- to millisecond timescales

276 Simulating the functional motions of biomolecular systems requires large computational resour

277 new doors for further exploration of complex biomolecular systems using non-invasive intravital chemi

278 Heretofore, the visualization of large biomolecular systems, comprising e.g. hundreds of thousa

279 tations of atomistic simulations in sampling biomolecular systems, we use an enhanced sampling techni

280 ents to characterize the various dynamics of biomolecular systems.

281 was found, that is also realized in certain biomolecular systems.

282 resent conformational transitions in complex biomolecular systems.

283 e field of structure determination for large biomolecular systems.

284 determine equilibrium binding properties of biomolecular systems.

285 limited by peak overlap inherent to complex biomolecular systems.

286 ism of complex allosteric processes in large biomolecular systems.

287 lization of quantum dots (QDs) with a single biomolecular tag using traditional approaches in bulk so

288 hore simultaneously to a photostabilizer and biomolecular target via unnatural amino acids.

289 clic peptides can interfere with challenging biomolecular targets including protein-protein interacti

290 of biorecognition and real time detection of biomolecular targets using nano-impact electrochemistry.

291 s of low-molecular-weight compounds to their biomolecular targets.

292 h specificity of peptide sequences for their biomolecular targets.

293 Advances in applied biomolecular technology and bioinformatics have enabled

294 through the interaction of the mineral with biomolecular templates and additives.

295 equent studies using new pharmacological and biomolecular tools provided conclusive evidence supporti

296 The measured biomolecular traits are in agreement with the lower-reso

297 Biomolecular transport systems based on cytoskeletal fil

298 ography, opens broad perspectives to control biomolecular transport systems for bioanalytical and sen

299 colorectal tissues and to assess distinctive biomolecular variations of different anatomical location

300 Chirality, as present in the biomolecular world, is therefore also common for biomine