ライフサイエンスコーパス: biomolecule

1 e geometrical features of a surface-attached biomolecule.

2 al resonances to specific locations within a biomolecule.

3 enable reversible binding of this important biomolecule.

4 thermal treatments and on-chip detection of biomolecules.

5 oblematic due to its unique complexity among biomolecules.

6 cell lysates with minimal interference from biomolecules.

7 ery system for mosquitocidal or malariacidal biomolecules.

8 evolution and function of proteins and other biomolecules.

9 ith affinity towards biotin and biotinylated biomolecules.

10 cesses, and also act as a precursor for many biomolecules.

11 used to enhance the MALDI-based detection of biomolecules.

12 erful tool to improve the characteristics of biomolecules.

13 plicates the biomedical use of this class of biomolecules.

14 atalysts, and side reactions with unintended biomolecules.

15 to understand the structure and function of biomolecules.

16 rbation of the tautomeric equilibrium within biomolecules.

17 the biosynthesis of a broad category of key biomolecules.

18 for assembly and control of nanodevices and biomolecules.

19 montmorillonite surface charges and vitamin biomolecules.

20 ion of the structure and dynamics of complex biomolecules.

21 tage of AD by comparing spectral profiles of biomolecules.

22 ility to specifically bind large and complex biomolecules.

23 ically in detection of fluorescently labeled biomolecules.

24 t can selectively and intimately probe these biomolecules.

25 lysis, model building and rational design of biomolecules.

26 dynamic behavior of RNA in relation to other biomolecules.

27 as been used for labeling proteins and other biomolecules.

28 d organized and how they interact with other biomolecules.

29 erials for the storage and release of active biomolecules.

30 ve suitable for the conjugation with various biomolecules.

31 bio-sensing, as well as nanoelectronics with biomolecules.

32 on-demand manufacturing of therapeutics and biomolecules.

33 the real structural disorder of the labeled biomolecules.

34 m for the screening of libraries of modified biomolecules.

35 expensive method for label-free detection of biomolecules.

36 te coordinating groups or for conjugation to biomolecules.

37 aqueous environment affect the stability of biomolecules.

38 cesses in the atmosphere to the hydration of biomolecules.

39 molecules, nanostructures and spin-labelled biomolecules.

40 trostatic potentials generated by charges of biomolecules.

41 pth understanding of how they interface with biomolecules.

42 ary, tertiary, and higher-order structure of biomolecules.

43 ide unique access to the dynamic behavior of biomolecules.

44 d-based system for the directed evolution of biomolecules.

45 idely applied to studying other bacteria and biomolecules.

46 rivatization of phenolic moieties in complex biomolecules.

47 oped to simultaneously analyze adsorption of biomolecules.

48 nprecedented coverage of system-wide, native biomolecules.

49 ccommodation and specific detection of large biomolecules.

50 s hidden structure-function relationships in biomolecules.

51 ectivity, and identification of the detected biomolecules.

52 ryogel monoliths functionalized with various biomolecules.

53 as tools for detection of targeted ions and biomolecules.

54 lop novel biosensor electrode for variety of biomolecules.

55 idate recognition layers to detect important biomolecules.

56 ass spectrometry (LC-MS) for the analysis of biomolecules.

57 ic excess (EE) between right and left-handed biomolecules.

58 y expressing and varying surface and soluble biomolecules.

59 ans to characterize mechanical properties of biomolecules.

60 s highly amenable to a wide range of complex biomolecules.

61 e from interference due to the absorbance of biomolecules.

62 widely used for the label-free detection of biomolecules across medical, biotechnology, and environm

63 t development in metabolic labeling of small biomolecules allows the study of these metabolisms at th

64 characteristics and are widely employed for biomolecule and cell isolations in research laboratories

65 culation of EE uses published data for CD of biomolecules and accepted magnitude for Archaean earth's

66 tile reactions available for conjugations of biomolecules and biomaterials.

67 bioaffinity sensing and for isolating target biomolecules and cells from complex biological samples.

68 the fast and accurate profiling of specific biomolecules and cells in a non-invasive manner.

69 this regard, the possibilities of patterning biomolecules and cells on nanofibrous matrices are explo

70 chitectures offer an opportunity to organize biomolecules and chemical reactions in unique, nanoscale

71 is frequently used by the cell to sequester biomolecules and compartmentalize their function.

72 chanistic interactions between intracellular biomolecules and cooperation between signaling pathways

73 ications: the interaction of solutes such as biomolecules and drugs with lipids.

74 es is key to the mechanism of action of many biomolecules and drugs.

75 e the geometry-induced trapping of nanoscale biomolecules and examine a generation of surface plasmon

76 ctively in the presence of other interfering biomolecules and metal ions.

77 suited due to its stable incorporation into biomolecules and minimal kinetic isotope effect.

78 loyed to follow intracellular trafficking of biomolecules and nanoparticulate delivery systems such a

79 itectures built in a layer-by-layer fashion, biomolecules and nanostructures (metallic or not) may am

80 rds CC in the presence of potentially active biomolecules and phenolic compounds.

81 to expand communication 'bandwidth' by using biomolecules and providing electrochemical access to red

82 Biomolecules and reagents are introduced at each of a se

83 ibutions, are explored in several classes of biomolecules and structural motifs.

84 e approach is particularly suited to complex biomolecules and systems with significant chemical-shift

85 or exploring free energy landscapes of large biomolecules and the simulations provide important insig

86 s in biological networks consist of numerous biomolecules and their complicated interactions.

87 nucleation in the atmosphere to hydration of biomolecules and wetting of solid surfaces.

88 ndly procedures for the preparation of these biomolecules, and a critical comparison of the different

89 ity to generate identical copies of relevant biomolecules, and are thought to have been crucial for t

90 Specific transport of biomolecules, and notably transport against a concentrat

91 Covalent binding of capturing biomolecule (anti-TNF-alpha antibody) on off-surface mat

92 These biomolecules are able to bind to materials with relative

93 ecules that detect the presence of different biomolecules are also briefly discussed.

94 clear magnetic resonance for the analysis of biomolecules are conveyed in this SnapShot.

95 carbonyl groups and alpha-nucleophiles into biomolecules are described.

96 ding the development of Fmoc-modified simple biomolecules are discussed, and corresponding strategies

97 Chromophoric biomolecules are exploited as reporters of a diverse set

98 The majority of biomolecules are intrinsically atomically precise, an im

99 tions, noninvasive manipulation of cells and biomolecules are significantly important, which are addr

100 The structure and function of biomolecules are strongly influenced by their hydration

101 , including organothiol and thiol-containing biomolecules, are among the most important classes of ch

102 T can at its limits characterize the fastest biomolecules as they interact with subcellular environme

103 ing colloidal stability and high affinity to biomolecules as well as support materials, thereby enabl

104 f nucleic acids, proteins, lipids, and other biomolecules, as well as in epigenetic control, folates

105 ng the shape and size, i.e., conformation of biomolecules at an interface.

106 the limited availability of growth-promoting biomolecules at CNS injury sites.

107 is by providing the ability to detect intact biomolecules at high spatial resolution.

108 uture to unravel the mode of action of these biomolecules at the molecular level.

109 structures hold great promise for organizing biomolecules at the nanoscale.

110 -H activation processes, cycloadditions, and biomolecule-based chemical transformations.

111 able only to a small class of photosensitive biomolecules because of strong and ultrafast perturbatio

112 Owing to the large biomolecule biding on the electrode, an electron transfe

113 urrent in a fused silica capillary as target biomolecules bind to immobilized receptors on the inner

114 ons, it will allow for the fast screening of biomolecule binding in low volume multiwell formats.

115 so serve as probes of tautomeric form within biomolecules, both by monitoring NMR chemical shifts and

116 biomolecule interacting with a complementary biomolecule bound to a magnetic field sensor.

117 structural analysis of organic compounds and biomolecules but typically requires macroscopic sample q

118 uctural and chemical information from single biomolecules, but it can be directly applied to other qu

119 that sharply increases the reaction rate of biomolecules by guiding them to form discrete species al

120 tion on the conformation of surface attached biomolecules by using simple techniques such as biosenso

121 Biomolecules can act as functional templates for the org

122 We show that specific binding of these biomolecules can be reliably monitored using a very simp

123 n of [C2mim][OAc] with a cysteine-containing biomolecules can be tuned or even suppressed through the

124 Among other classes of biomolecules, carbohydrates and glycoconjugates are wide

125 eration in liquid, the native environment of biomolecules, causes, however, significant degradation o

126 become a powerful tool for cell imaging and biomolecule, cell and protein interaction studies, but a

127 scuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environ

128 The biomolecule concentration is measured by fluorescence an

129 t that single-molecule imaging of individual biomolecules could almost be within reach.

130 that vibrational spectroscopy of nitriles in biomolecules could be predominately sensitive to their l

131 acellular sensing of pathologically relevant biomolecules could provide essential information for acc

132 e NP's orientation, the rotational motion of biomolecules coupled to the NP can be detected.

133 Liquid-based applications of biomolecule-decorated field-effect transistors (FETs) ra

134 l applications including tissue engineering, biomolecule delivery, cell delivery, and cell culture.

135 ight become a potential alternative tool for biomolecule detection in medical research and early clin

136 Biomolecule-driven assembly of nanoparticles is a powerf

137 ere followed by chirally selective damage of biomolecules due to circular dichroism (CD) can generate

138 cross-linking with defined groups in complex biomolecules due to its unique reactivity.

139 sed on intrinsic physical characteristics of biomolecules (e.g., size and polarizability).

140 contrast imaging of nanoscopic aggregates of biomolecules, e.g., of enzyme Cu/Zn-superoxide dismutase

141 we discuss all alternatives to conventional biomolecules employed in the detection of various toxin

142 number of crucial sensing domains, including biomolecules, environmental toxins, explosives, ionic sp

143 lations and bistability using highly evolved biomolecules (enzymes and DNA) or inorganic molecules of

144 lectivity and stability for the detection of biomolecules, especially glucose is one of the major cha

145 g off surface matrix modified with capturing biomolecule for on-chip electrochemical biosensing.

146 and for high-throughput screening of various biomolecules for stem cell differentiation and cancer th

147 Of the 244 biomolecules studied, 52 and 14 biomolecules from BAL fluid and serum, respectively, wer

148 For (13)C spins on biomolecules frozen in a glassy matrix, electron decoupl

149 tional and network-based characterization of biomolecules (genes, proteins and metabolites) that are

150 art detection tool for fluorescently labeled biomolecules greatly expands dynamic range and enables r

151 Chemoselective modification of complex biomolecules has become a cornerstone of chemical biolog

152 The covalent modification of therapeutic biomolecules has been broadly explored, leading to a num

153 hydration shells that surround proteins and biomolecules have a substantial influence upon their fun

154 Natural biomolecules have potential as proton-conducting materia

155 sists at much higher loading rates, at which biomolecules have reached their kinetic regime, illustra

156 amers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution

157 imaging of the localization and dynamics of biomolecules helps to understand their function and reve

158 sequencing (RNA-seq) technologies, RNA-based biomolecules hold expanded promise for their diagnostic,

159 n exploited in the structural study of large biomolecules, however reliable calibrants for large anio

160 ible to the background optical absorption of biomolecules, i.e., hemoglobins.

161 Specific binding between biomolecules, i.e., molecular recognition, controls virt

162 e of SiNx which can then be readily used for biomolecule immobilization.

163 e of the strong binding forces between these biomolecules, immunosensors present high selectivity and

164 ers.Background optical absorption of several biomolecules impedes an effective in vivo pH imaging in

165 ogen sulfide (H2 S) has emerged as a crucial biomolecule in physiology and cellular signaling.

166 SpringSaLaD models biomolecules in a coarse-grained manner as a group of li

167 Recent studies have shown that biomolecules in a functional module tend to have similar

168 The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional

169 nts of the bioimaging toolbox, as they label biomolecules in cells and tissues.

170 ation for dynamic measurement and control of biomolecules in cells.

171 ce and thereby enable real-time detection of biomolecules in high-ionic-strength solutions.

172 ximately 70-nm-resolution imaging of diverse biomolecules in intact tissues using conventional diffra

173 act selectively with albumin among different biomolecules in intracellular environment with high degr

174 nderstanding of the gating effect of charged biomolecules in ionic solution and how this influences t

175 or their great utility in the conjugation of biomolecules in live cells.

176 greatly facilitate the selective labeling of biomolecules in living system.

177 following the fate of tagged metabolites and biomolecules in living systems.

178 e high-resolution structure determination of biomolecules in solution." Achieving this goal, which re

179 d numbers of neutrophils and proneutrophilic biomolecules in the airways.

180 electronic structures and dynamics of these biomolecules in the gas phase with beta-carotene as a pa

181 nsitive, and selective detection of targeted biomolecules in their native environment by prospective

182 t probes for long-term tracking of cells and biomolecules in vitro and in vivo.

183 Such biomolecules include amyloidogenic peptides, such as the

184 water effluent contains a complex mixture of biomolecules including DNA.

185 e strong absorption of this UV wavelength by biomolecules including nucleic acids and proteins has fu

186 to evaluate the mineralising capabilities of biomolecules including peptides.

187 tightly regulated by different intermediate biomolecules including proteins that interact with hypox

188 aging induces a change in the appearance of biomolecules (including degradation and storage of waste

189 gh selectivity to DA over common interfering biomolecules (including some amino acids, ascorbic acid,

190 athway used for the extracellular release of biomolecules, including extracellular vesicles called ex

191 ture to modify the structure and function of biomolecules, including proteins, DNA, RNA, and metaboli

192 ty-mass trend lines for structurally similar biomolecules, increased peak capacity, reduction of chem

193 he magnetic field of a magnetically labelled biomolecule interacting with a complementary biomolecule

194 Nanomaterial-biomolecule interactions result in the formation of the

195 structural defects resulting in altered CNT-biomolecule interactions.

196 suggest that aqueous electrons at the water/biomolecule interface may possess the appropriate energe

197 h as metal and metal oxide nanoparticles and biomolecules) into ZIFs, and hybridization with polymeri

198 The biomolecule is among the most important building blocks

199 The natural environment of a biomolecule is inside a living cell, hence, this is the

200 e plasma membrane towards large, hydrophilic biomolecules is a major obstacle in their use and develo

201 le-molecule imaging of fluorescently labeled biomolecules is a powerful technique for measuring assoc

202 anistic description of structural changes in biomolecules is an increasingly important topic in struc

203 The rational design of biomolecules is becoming a reality.

204 ng the interaction between nanoparticles and biomolecules is crucial for improving current drug-deliv

205 Chirality of biomolecules is decided by the direction of magnetic fie

206 e influences the function and interaction of biomolecules, it is important to develop structure sensi

207 ata for the reactions of nitroxyl (HNO) with biomolecules (k approximately 10(3) -10(7) m(-1) s(-1) )

208 ctural changes during folding transitions in biomolecules like nucleic acids and proteins.

209 ions following surface functionalization and biomolecule loading by generating a spectral signature o

210 excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level of ox

211 Magnetic solid phase substrates for biomolecule manipulation have become a valuable tool for

212 The significant degradation that fossilized biomolecules may experience during burial makes it chall

213 y and geometry of interfaces where water and biomolecules meet.

214 Herein, a biomolecule/metal-organic framework (MOF) approach to de

215 idity and tunability between nanoribbons and biomolecules might enable the design and fabrication of

216 al molecules remains limited since the input biomolecule needs to have the appropriate chemical struc

217 to easily determine the Cu(II) affinity for biomolecules of moderate affinity is important.

218 for the exogenous introduction of synthetic biomolecules often result in short-lived presentations,

219 ntrol the distribution of cells and relevant biomolecules on an extracellular matrix (ECM)-like subst

220 study, including the effect of co-occurring biomolecules on detection limits.

221 aphene; thereby facilitating the assembly of biomolecules on the electrode surface.

222 draw conclusions on the conformation of any biomolecule or nanoentity upon specific binding on the s

223 r example, in the case of weakly interacting biomolecules or cellular imaging.

224 tive analysis of specific interactions among biomolecules or of biomolecules with drugs, as well as f

225 rbing, low-background glass walls to confine biomolecules, our nanofluidic platform facilitates quant

226 rement of SMLM data, providing insights into biomolecule patterning, clustering and oligomerization i

227 ecent advances in anion recognition based on biomolecules, polymers, and nanoparticles.

228 , we prevented the nonspecific adsorption of biomolecules present in saliva by brushes of poly[(N-(2-

229 y, we briefly describe some of the important biomolecules produced by gut microbiota and the role tha

230 Conventional biomolecule purification strategies achieve target captu

231 e in biofilm could be observed, the specific biomolecules reacting with the disinfectant and the mech

232 of their rheological properties, erosion and biomolecule release in vitro.

233 ondestructive platform for a wide variety of biomolecule separation applications.

234 e of strong and ultrafast perturbations from biomolecule-solvent interactions.

235 Electron paramagnetic resonance (EPR) of biomolecules spin-labeled with nitroxides can offer uniq

236 Of the 244 biomolecules studied, 52 and 14 biomolecules from BAL fl

237 errestrial environments, including important biomolecules such as amino and fatty acids, will require

238 al to be low-cost and robust alternatives to biomolecules such as antibodies and receptors.

239 d other nanoshells easily self-assemble from biomolecules such as lipids or proteins, but not from in

240 hanistic information of folding processes of biomolecules such as proteins and nucleic acids.

241 ittle known on its interactions with various biomolecules such as proteins.

242 Many naturally occurring biomolecules, such as amino acids, sugars and nucleotide

243 major goal of natural computing is to design biomolecules, such as nucleic acid sequences, that can b

244 all and low-polarity organics but also polar biomolecules, such as peptides and proteins.

245 easy method to study oxidation reactions of biomolecules, such as peptides.

246 rization of these weak interactions in large biomolecules, such as proteins, is experimentally challe

247 ves can be conjugated with other interesting biomolecules, such as tumor-associated carbohydrate anti

248 t is used to exert forces on many individual biomolecules tethered to microspheres using a single col

249 e most heavily post-translationally modified biomolecules that are derived from amino acids.

250 nctional nucleic acids (FNAs) are a class of biomolecules that can exhibit either ligand binding or e

251 es as structural and metabolic cofactors for biomolecules that compose living systems.

252 Biomolecules that control physiological function by chan

253 ingolipids make up a highly diverse group of biomolecules that not only are membrane components but a

254 nique, PLIMB (Plasma Induced Modification of Biomolecules), that generates micros bursts of hydroxyl

255 dy fragments that are specific to the target biomolecule, the new methodology can be extended to the

256 been performed decorating cell surfaces with biomolecules, the engineering of cell surfaces with part

257 containing information about interactions of biomolecules, the existing network information may be in

258 ipid bilayer membranes to enclose functional biomolecules, thus defining a "protocell," was a seminal

259 echnique and an amine group for immobilizing biomolecules; thus, it is ideal for the fabrication of b

260 lity relies upon the nonspecific adhesion of biomolecules to a surface and a cantilever and, for prot

261 ation of noncovalent interactions that bring biomolecules to be colocalized in a designated restricte

262 hesis chemistry has allowed many organic and biomolecules to be produced with known synthetic history

263 simple electrogenetic device that uses redox biomolecules to carry electronic information to engineer

264 irection for the site-specific attachment of biomolecules to device platforms.

265 ) the efficient site-specific conjugation of biomolecules to PEG-coated surfaces.

266 directly couple the charging status of bound biomolecules to readout of liquid-phase FETs fabricated

267 Delivery of biomolecules to the correct subcellular locales is criti

268 polyelectrolyte gel, anchoring key labels or biomolecules to the gel, mechanically homogenizing the s

269 out controlling the adsorption properties of biomolecules to the montmorillonite for preparation of n

270 s to characterize binding equilibria between biomolecules under native solution conditions.

271 r exploitation for the recovery of important biomolecules used in the food and health industry.

272 lyzed BAL fluid and serum for a total of 244 biomolecules using a multiplex assay and correlated them

273 strategies for labelling and functionalizing biomolecules using AdoMet-dependent MTases and AdoMet an

274 ular electrical field gradients for trapping biomolecules via dielectrophoresis.

275 ation on (dynamic) conformational changes in biomolecules via measuring a single molecular distance i

276 ess in characterization of nanoparticles and biomolecules was enabled by the development of advanced

277 rus- (P) and nitrogen (N)-demanding cellular biomolecules, we test the hypothesis that a key influenc

278 a cationic bridge was formed and the vitamin biomolecules were adsorbed at the edges of montmorilloni

279 Arginine derived biomolecules were found to involve in many of the events

280 er to produce surfaces with discretely bound biomolecules where their native conformation is maintain

281 orm is very promising for multi-detection of biomolecules which can dramatically decrease the time of

282 However, there exists a class of biomolecules which have been designed by nature to guide

283 be readily extendable to other proteins and biomolecules, which could facilitate their labeling with

284 uid-like droplets of protein, RNA, and other biomolecules, which form in the absence of a delimiting

285 ops a nanoparticle in layers of proteins and biomolecules, which has a profound impact on the nanopar

286 d reporter probes recognize TDN-bound target biomolecules, which then allow binding of horseradish-pe

287 approximate the molecular kinetics of large biomolecules while keeping full structural resolution in

288 hod that can ionize small organics and large biomolecules with different properties for MS analysis i

289 ecific interactions among biomolecules or of biomolecules with drugs, as well as for quantitation of

290 very short DNA and conformational changes of biomolecules with much improved temporal resolution than

291 d circular dichroism (CD) spectra of typical biomolecules with thousands of atoms is presented.

292 lth, nutrition and cosmetic) to discover new biomolecules with various physico-chemical and bioactive

293 nm for inorganic species and under 2 mum for biomolecules) with the high mass-resolving power of an O

294 logists and general users to evolve improved biomolecules within approximately 7 weeks.

295 SI) has primarily been applied in localizing biomolecules within biological matrices.

296 es to vibrationally image proteins and other biomolecules within cells is also discussed.

297 tive functional groups allow the labeling of biomolecules without modification of emissive properties

298 hich can nondestructively isolate the target biomolecules without sacrificing the other components in

299 ies are published as selective modulators of biomolecules without sufficient validation and then prop

300 , assemblages of multiple proteins and other biomolecules, yet network visualizations usually only sh