ライフサイエンスコーパス: biophysics

1 the most fundamental issues in the field of biophysics.

2 n in evolutionary biology, biochemistry, and biophysics.

3 oretical/computational approaches in protein biophysics.

4 -fertilization with other domains, including biophysics.

5 at least when studying its biochemistry and biophysics.

6 stem cell characterization, and single-cell biophysics.

7 sights in their 3D motion and the underlying biophysics.

8 ng models are a cornerstone of computational biophysics.

9 h-resolution measurements in single-molecule biophysics.

10 in/DNA complexes are challenging problems in biophysics.

11 olutionized the new field of single-molecule biophysics.

12 pact on a wide range of research in cellular biophysics.

13 sensing, biocontrolled photonic devices, and biophysics.

14 ess on membranes is of primary importance in biophysics.

15 stants for application within the toolbox of biophysics.

16 and Scatchard equations in biochemistry and biophysics.

17 g, is a classic grand challenge in molecular biophysics.

18 , exerts a strong influence upon ion channel biophysics.

19 h minimal experience in molecular biology or biophysics.

20 me a powerful tool in structural biology and biophysics.

21 related temporal data currently prevalent in biophysics.

22 rticle behavior with the governing nanoscale biophysics.

23 ase (CcO) is one of the challenges of modern biophysics.

24 ly it in the context of single-molecule (SM) biophysics.

25 eper understanding of in vivo phase boundary biophysics.

26 nsiderable interest in the field of membrane biophysics.

27 eptors has been a long-standing challenge in biophysics.

28 ssion, with no significant effect on channel biophysics.

29 ures and processes in molecular and cellular biophysics.

30 ase (COX) is one of the challenges of modern biophysics.

31 ular rulers is an important leap forward for biophysics.

32 tive approach that combines biochemistry and biophysics.

33 exation remains an open problem in molecular biophysics.

34 in studies of vascular biology and receptor biophysics.

35 y are so large in their influences on global biophysics.

36 has become a standard practice in molecular biophysics.

37 tinent to many other areas of physiology and biophysics.

38 cades, synaptic transmission and ion channel biophysics.

39 ein, is a commonly accepted idea in membrane biophysics.

40 n the hallmark of classical biochemistry and biophysics.

41 between underlying dynamical principles and biophysics.

42 cation of microfluidic approaches to protein biophysics.

43 ikely to find future application in cellular biophysics.

44 tertiary structure is an unsolved problem in biophysics.

45 y, in geochemistry, solid-state physics, and biophysics.

46 to atherosclerotic foci by altering monocyte biophysics.

47 y have, and can, impact the field of protein biophysics.

48 molecules has greatly advanced the field of biophysics.

49 and meiosis is a major puzzle of biology and biophysics.

50 of these methods in the context of cellular biophysics.

51 techniques and their application to cellular biophysics.

52 oretical/computational approaches in protein biophysics.

53 pses between local neurons and single-neuron biophysics.

54 several diverse settings in single-molecule biophysics.

55 also be helpful in other fields of cellular biophysics.

56 ce, but adoption has been somewhat slower in biophysics.

57 ucture from sequence is a major challenge in biophysics.

58 never before presented itself in ion channel biophysics.

59 ble advances in our knowledge of ion channel biophysics.

60 e cell membrane is an emerging topic of cell biophysics.

61 (FRAP) and binding, which is widely used in biophysics.

62 s about protein evolution and the underlying biophysics.

63 luding molecular cell biology, biochemistry, biophysics and bioengineering.

64 ms that might link defects in GABAA receptor biophysics and biogenesis to patients with EOEE.

65 nisms has attracted considerable interest in biophysics and biomedical engineering.

66 g to answering many outstanding questions in biophysics and chemical biology.

67 Here, using solution biophysics and coated-bead aggregation experiments, we d

68 e compared temporally to changes in membrane biophysics and composition.

69 ng mutants using a combinatorial approach of biophysics and cryo-EM.

70 n gradients, a subject of active research in biophysics and developmental biology.

71 , little is known about the role of membrane biophysics and dynamics in integrin adhesion.

72 provides insight into analogous behavior in biophysics and enzymology and aims to inform the design

73 performing gene construction, DNA computing, biophysics and even standard molecular cloning.

74 rates the importance of considering cellular biophysics and frequency-dependent effects in developing

75 However, biophysics and functional studies showed that the first

76 embrane potential that is a function of cell biophysics and geometry.

77 mplications of our findings for the field of biophysics and implicit solvent models.

78 ritic complexity along with altered membrane biophysics and increased frequency of GABAergic synaptic

79 uture applications including single-molecule biophysics and integrated photonic, electronic, and micr

80 halsky, where his research involved membrane biophysics and irreversible thermodynamics.

81 ial lying at the interface between nanoscale biophysics and landscape evolutionary ecology.

82 s that are independent of their roles in the biophysics and localization of Ca(2+) channels and that

83 trate some of their applications to neuronal biophysics and mammalian circuit analysis.

84 This paper reviews recent advances in biophysics and mathematical engineering that provide a n

85 ies from ecology and evolutionary biology to biophysics and mathematical modelling.

86 ls the missing gap between studies on enzyme biophysics and network level dynamics, and reveals that

87 or offers a new opportunity to integrate the biophysics and neuroscience of sensory systems with ecol

88 mental and cell biology, anatomical science, biophysics and neuroscience.

89 er-increasing integration with biochemistry, biophysics and other disciplines.

90 n, visualization, and investigation of their biophysics and perturbations and suggest that the field

91 Here we characterize the biophysics and phylogeny of this enzyme and report the 1

92 pes, which would facilitate research in cell biophysics and physiology.

93 to geophysics and environmental science, to biophysics and protein crystallography.

94 ay towards studying optimization problems in biophysics and statistical mechanics using quantum devic

95 tions employed for in vitro investigation of biophysics and structural biology make use of purified m

96 Although there is a long history of muscle biophysics and structural biology, many of the mechanist

97 he focal points of activity in computational biophysics and structural biology.

98 pted important achievements in the fields of biophysics and synthetic biology.

99 eep brain regions, opening a frontier in the biophysics and technology of brain stimulation.

100 s serve both fundamental studies of membrane biophysics and the production of surface-based bioanalyt

101 esults to be of significance for small-scale biophysics and trait-based ecological modeling.

102 kinetic isotope effects, molecular biology, biophysics, and bioinformatics provides means to link ev

103 cience, cell biology, developmental biology, biophysics, and biomedicine and is particularly importan

104 ications in the areas of structural biology, biophysics, and biopharmaceutical characterization.

105 ction in terms of trafficking, localization, biophysics, and consequences for neurotransmission is a

106 anscriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell ant

107 sistent with the general principles of blast biophysics, and further, could account for aspects of th

108 ics, electron and NMR spectroscopy, membrane biophysics, and immunology.

109 science, as for instance structural biology, biophysics, and molecular nanotechnology.

110 of lipid metabolism and catabolism, membrane biophysics, and pathogenesis of diseases but are challen

111 l and quantitative branches of biochemistry, biophysics, and population genetics.

112 ate many aspects of Kv channel biochemistry, biophysics, and structure.

113 g experiments: neuroscience, plasma membrane biophysics, and subcellular clinical diagnostics.

114 heoretical model that combines mechanics and biophysics, and that is constrained by the observations

115 Using a combination of sequence analysis, biophysics, and x-ray crystallography, we obtained new i

116 cular interactions of NEMO using a molecular biophysics approach, incorporating rapid-mixing stopped-

117 ctural and functional characterization using biophysics approaches.

118 He began his career in biophysics as a postdoc at the Weizmann Institute under

119 DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer an

120 Here, we developed a predictive biophysics-based fitness landscape of trimethoprim (TMP)

121 al diagnosis in this first ever study of the biophysics behind the characteristic shape of the urine

122 utility as tools for addressing questions in biophysics, biochemistry and biology of nucleic acids.

123 ble, time-dependent processes that abound in biophysics, biochemistry, and physiology.

124 residues, d(th)G will transform nucleic acid biophysics by allowing, for the first time, to selective

125 iscosity plays an essential role in cellular biophysics by controlling the rates of diffusion and bim

126 , our study sheds light on cellular membrane biophysics by underscoring the nonequilibrium metabolic

127 e fundamental heterogeneity of cell membrane biophysics can be analyzed.

128 ail with which questions in membrane protein biophysics can be explored.

129 ng, illustrate how subtle changes in channel biophysics can have significant and distinct effects in

130 ields (that is, polymer mechanochemistry and biophysics) can be harnessed to guide the rational desig

131 lifetimes can have numerous applications in biophysics, clinical diagnostics, DNA analysis, and drug

132 Almost everything we know about protein biophysics comes from studies on purified proteins in di

133 ng software (IC-ITC; freely available to the biophysics community), which simultaneously fits ligand

134 of association reactions of interest to the biophysics community.

135 bsite, which is open to contributions by the biophysics community.

136 Our web server http://biophysics.cs.vt.edu/H++ provides access to a tool that

137 We have applied a structure- and biophysics-driven fragment-based ligand design strategy

138 ns would provide insight into the underlying biophysics, enable mathematical analysis of the behavior

139 ogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechan

140 develop novel devices and methods in protein biophysics for sample manipulation, functional and struc

141 elp answer key questions in cell biology and biophysics from a quantitative viewpoint.

142 He received an MD and PhD (in biophysics) from Stanford University School of Medicine.

143 A persistent challenge in membrane biophysics has been to quantitatively predict how membra

144 an genetics to physiology, cell biology, and biophysics has cast light on the special function of fiv

145 biochemistry, genetics, and single-molecule biophysics has provided a renewed impetus for the constr

146 The fast growth of single-molecule biophysics has resulted from its benefits in probing het

147 netics, molecular biology, biochemistry, and biophysics has spanned more than half a century-from the

148 structural bioinformatics and computational biophysics has undergone a revolution in the last 10 yea

149 neuromodulation of biochemical signaling and biophysics have been investigated separately in modeling

150 Recent advances in computational systems biophysics have provided promising avenues to reliably i

151 ich combine evolutionary theory with protein biophysics, have completely revolutionized our view of t

152 To shed light on the underlying biophysics here we developed and explored a detailed Mon

153 cements in the fields of polymer physics and biophysics, how applicable they are to life inside the c

154 o one of the fundamental questions in muscle biophysics: how are the free energies of the chemical sp

155 lectrostatics is a well established model in biophysics; however, its application to large-scale biom

156 b initio model of living cells where protein biophysics (i.e., folding and protein-protein interactio

157 ility to quantitatively analyze nucleic acid biophysics in free solution.

158 rovide crucial information of the underlying biophysics in TES applications in humans and the optimiz

159 tructures that have illuminated the field of biophysics in the 54 years since the first excitement of

160 extract precise information about regulatory biophysics in the face of experimental noise is made pos

161 e many challenging problems in computational biophysics, including protein folding and binding.

162 the critical unanswered questions in genome biophysics is how the primary sequence of DNA bases infl

163 molecular biology, protein biochemistry and biophysics is particularly powerful, resulting in novel

164 ing paradigm in the field of in vivo protein biophysics is that nascent-protein behavior is a type of

165 A principal goal of molecular biophysics is to show how protein structural transitions

166 An open question of great interest in biophysics is whether variations in structure cause prot

167 a new and efficient NMR method, BLUU-Tramp (Biophysics Laboratory University of Udine temperature ra

168 Protein solution rheology data in the biophysics literature have incompletely identified facto

169 analysis, computer modeling, and structural biophysics methods support this hypothesis.

170 understand how single-molecule and multibond biophysics modulate the macroscopic cell behavior in div

171 n, the continuum field description of tissue biophysics must be linked to discrete descriptions of mo

172 ct of these and other new imaging methods in biophysics, neuroscience, and developmental and cell bio

173 Understanding the biophysics of adhesion mediated by the I-domain of LFA-1

174 states in vitro by studying the myofilament biophysics of amino acid substitutions that act as const

175 d potassium ion channel pharmacology and the biophysics of ancillary subunits.

176 how that, because the method is based on the biophysics of binding rather than on empirical parametri

177 useful insights into the thermodynamics and biophysics of biological membranes and binding of small

178 ctivity could be a simple consequence of the biophysics of burst generation.

179 These findings provide new insight into the biophysics of chromatin formation, both in the context o

180 pens further approaches to understanding the biophysics of cytokinesis signaling.

181 ion and require strong assumptions about the biophysics of DNA to transform interaction frequencies t

182 mathematical model developed to describe the biophysics of epithelial tissue to explore this problem.

183 All of this recent activity in the biophysics of erythrocyte structure-function is certain

184 The biophysics of force production by various kinesins is kn

185 The fundamental biophysics of gliding microtubule (MT) motility by surfa

186 , and contribute to the understanding of the biophysics of information transfer of single neurons in

187 We report on recent progress in the biophysics of knotting-the formation, characterization,

188 Previous work on the growth biophysics of maize (Zea mays L.) primary roots suggeste

189 oteins, are important tools for studying the biophysics of motility.

190 rdered domain, and little is known about the biophysics of mtSSB-ssDNA interactions.

191 ificant advances in our understanding of the biophysics of myofilament activation, coupled to the eme

192 The biophysics of nucleic acid hybridization and strand disp

193 in Huntington's disease, suggesting that the biophysics of poly(Gln) aggregation nucleation may play

194 hanism of aggregation because the underlying biophysics of polyglutamine-mediated association can be

195 rotocell research, fueled by advances in the biophysics of primitive membranes and the chemistry of n

196 tal data on viruses and (ii) is based on the biophysics of protein folding.

197 w one to quantify fundamental aspects of the biophysics of protein folding.

198 map from genotype to phenotype based on the biophysics of protein-DNA binding.

199 ch to resolve a long-standing problem in the biophysics of protein/DNA interactions.

200 earch over the past decade, ranging from the biophysics of sound reception to molecular aspects of au

201 nderstanding in the molecular physiology and biophysics of synaptic transmission.

202 of Neuron, Remme and colleagues examine the biophysics of synchronization between oscillating dendri

203 e model a telomere state on the basis of the biophysics of t-loop formation, allowing us to develop a

204 egulatory sequences, making use of the known biophysics of the binding of regulatory proteins to DNA

205 ular Ca(2+) is universally acknowledged, the biophysics of the Ca(2+) flux responsible for the effect

206 helical rotor mechanism, which differ in the biophysics of the cell-substrate interactions.

207 One of the central questions in the biophysics of the mammalian cochlea is determining the c

208 ture challenges concerning the structure and biophysics of the needle apparatus.

209 effects of each of the gamma subunits on the biophysics of the T-type VSCC encoded by the alpha(1I) s

210 Unlike ciliary or flagellar motility, the biophysics of this mode is not well understood, includin

211 investigations aimed at fully clarifying the biophysics of this unique genome editing machinery and a

212 Thus, our data characterize the biophysics of TN-XXL in detail and may form a basis for

213 ight shed more light onto the statistics and biophysics of various micro-swimmers' 3D motion.

214 -standing areas of investigation such as the biophysics of water permeation across cell membranes, th

215 lled by L-type Ca(V)1.3 Ca(2+) channels, the biophysics of which are still unknown in native mammalia

216 the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular

217 Cooperativity in classical biophysics originates from molecular interactions; nonli

218 hat have been applied to problems in protein biophysics over the last 15 years.

219 d membranes is of key importance in membrane biophysics, primarily since cholesterol enriched regions

220 ic lipids further our understanding of lipid biophysics, promote targeted drug delivery and improve l

221 e tracking has seen numerous applications in biophysics, ranging from the diffusion of proteins in ce

222 s, and should have broad utility in membrane biophysics research.

223 Our improved analysis of canopy-scale biophysics rules out satellite artifacts as significant

224 cal foundation for understanding how protein biophysics shapes the process of evolution.

225 magnetoencephalography-or been restricted to biophysics studies of excised neurons probed with cryoge

226 The traditional approach to computational biophysics studies of molecular systems is brute force m

227 tablish the singe-cell computation that this biophysics supports, we show that the combination of fre

228 cation in fields such as structural biology, biophysics, synthetic biology and photonics.

229 ctopus cells have dendritic morphologies and biophysics tailored to accomplish the precise encoding o

230 mbining molecular biology, biochemistry, and biophysics techniques, we discover that ACT has intrinsi

231 are relatively new additions to the field of biophysics that allow one to manipulate individual molec

232 ed to have a deep impact across the field of biophysics: the infinite HMM (iHMM).

233 s abnormalities in surfactant components and biophysics, these responses are exacerbated by IRD.

234 stions at the many levels of inquiry linking biophysics to behavior.

235 a means to translate complex single-molecule biophysics to macroscopic cell behavior.

236 reat importance in a variety of fields, from biophysics to micro-/nanofluidics.

237 s is central to fields ranging from cellular biophysics to regenerative medicine.

238 heoretical and experimental biochemistry and biophysics, to computer simulations.

239 The fundamental biophysics underlying the selective movement of ions thr

240 ist between reptilian and mammalian auditory biophysics, understanding lizard OAE generation mechanis

241 George Oster is Professor of Biophysics, University of California, Berkeley.

242 The variation in Q-type channel biophysics was correlated with beta subunit expression.

243 KII phosphorylation of Kv4.2 affects channel biophysics, we expressed wild-type or mutant Kv4.2 and t

244 bination of genetics, molecular biology, and biophysics, we have identified Halo, a novel regulator o

245 , followed by a discussion of the underlying biophysics; we consider actin treadmilling, actin-myosin

246 s a fundamental question in cell biology and biophysics whether sphingomyelin (SM)- and cholesterol (