ライフサイエンスコーパス: biopsy sample

1 resence of the bacterium without obtaining a biopsy sample.

2 ased on a histopathological examination of a biopsy sample.

3 epatitis (NASH) mouse models and human liver biopsy samples.

4 s of rejection in most isolated endarteritis biopsy samples.

5 nd accurate variant detection from low-input biopsy samples.

6 us normal areas of lung in IPF surgical lung biopsy samples.

7 cific antibodies [DSAs]) with 281 indication biopsy samples.

8 interstitial lung diseases in surgical lung biopsy samples.

9 system was used to image ICG fluorescence in biopsy samples.

10 e or crossmatch-positive or had C4d-positive biopsy samples.

11 erived xenografts were established from core biopsy samples.

12 ad both high-resolution CT and surgical lung biopsy samples.

13 dependently assessed anonymised CT scans and biopsy samples.

14 tivity in NAFLD mouse models and human liver biopsy samples.

15 MCs was isolated from porcine endomyocardial biopsy samples.

16 Rbm20 that is consistent with human cardiac biopsy samples.

17 ung requires immunohistochemical analysis of biopsy samples.

18 d an anti-profile for colon cancer in tissue biopsy samples.

19 A expression levels of clinical HNSCC tumour biopsy samples.

20 ies that depend on results from single tumor-biopsy samples.

21 IL-15 after organ culture of celiac duodenal biopsy samples.

22 ls of inflammatory cytokines in CD LPMCs and biopsy samples.

23 by laser-capture microdissection from renal biopsy samples.

24 -expression changes in human diabetic kidney biopsy samples.

25 , and clonal persistence for years in repeat biopsy samples.

26 ructures (CLS) in subcutaneous abdominal fat biopsy samples.

27 validated using an independent group of skin biopsy samples.

28 2, CYSLTR1 and CYSLTR2 were expressed in all biopsy samples.

29 s in lipid composition in nine breast cancer biopsy samples.

30 xpression level was also measured from liver biopsy samples.

31 results of histopathologic analysis of skin biopsy samples.

32 Histologic analyses were performed on biopsy samples.

33 mRNA expression in chronic HCV patient liver biopsy samples.

34 vated cell sorting analysis was performed on biopsy samples 1 hour after therapy.

35 [0.7-2.0] vs 1.8 [1.6-2.3], p=0.002; and in biopsy samples 1.3 [0.7-2.3] vs 3.9% [1.3-5.3%], p=0.02)

36 e gene expression patterns in 302 intestinal biopsy samples (129 from patients with ulcerative coliti

37 mples, 71.7% (81 of 113) for nasal turbinate biopsy samples, 19.5% (22 of 113) for blood samples, wit

38 Muscle and skin biopsy samples (4 skin biopsy samples with active rash)

39 al swab samples, 53.8% (56 of 104) for nasal biopsy samples, 6.7% (7 of 104) for blood samples, and 1

40 by immunofluorescence microscopy in 9 of 10 biopsy samples (90%) at 3 months, in 8 of 12 samples (66

41 in PAR levels was observed in 3 paired tumor biopsy samples; a greater than 50% reduction was observe

42 rospective review of all vitreous aspiration biopsy samples acquired because malignant neoplasm was s

43 standards relating to procedural aspects of biopsy, sample adequacy, and accuracy were prepared with

44 Adipocytes collected from subcutaneous fat biopsy samples after normal and restricted sleep conditi

45 On pathologic examination of the biopsy samples, all were positive for malignancy.

46 molecular markers of endocrine tissue in BM biopsy samples analyzed during follow-up.

47 in 1239 renal transplant sequential protocol biopsy samples and 408 biopsy for cause samples in 526 p

48 sion of GRM1/mGluR1 in a number of RCC tumor biopsy samples and cell lines, and the effects of GRM1 m

49 ilitate the analysis of miRNA in fine-needle-biopsy samples and even in single cells without enrichme

50 ting and subsequently obtained surgical lung biopsy samples and from lung explants.

51 ticle we show high production of IL-1beta in biopsy samples and Leishmania antigen-stimulated periphe

52 nomics landscape portrayed from single tumor-biopsy samples and may present major challenges to perso

53 ase2 at the apical surface of enterocytes in biopsy samples and monolayers of Caco-2 cells.

54 left ventricle dilated cardiomyopathy (DCM) biopsy samples and mouse models of DCM through BioID pro

55 ing in vitro organ culture (IVOC) of colonic biopsy samples and polarized T84 colon carcinoma cells.

56 s were prominent in nearly two-thirds of SLE biopsy samples and were distributed as broad periglomeru

57 s, primary cell cultures, ex vivo specimens, biopsy samples, and fixed post-mortem tissue.

58 CXCR4 expression requires testing of ex vivo biopsy samples, and is not routinely done in cancer mana

59 tions, paired surgical resection/core needle biopsy samples, and paired samples from 69 patients of a

60 evels of tenascin-C are elevated in SSc skin biopsy samples, and serum and SSc fibroblasts, and in fi

61 aggregates in the cortical area of LD brain biopsy samples, and there is also a dramatic loss of par

62 BKVN and normal transplant kidney biopsy samples, and whole blood samples of patients with

63 reath, urine, blood, interstitial fluid, and biopsy samples are summarized.

64 Because biopsy samples are too insensitive to reliably detect BO

65 suitable treatment for a specific patient if biopsy samples are used.

66 caused secretion of cytokines from cultured biopsy samples at levels comparable with those for gliad

67 detectable for all genes in malignant needle biopsy samples (AUC: 0.80 to 0.98), confirming previous

68 first time that EHEC colonizes human colonic biopsy samples by forming typical attaching and effacing

69 Although skin biopsy samples can be used to directly measure topical d

70 he immune microenvironment in primary tissue biopsy samples can be used to stratify patients accordin

71 Kidney biopsy samples can show definitive evidence of CKD, thro

72 on of miR-27a and miR-181c* in pre-treatment biopsy samples characterized patients who developed clin

73 We analyzed mucosal biopsy samples collected from 101 patients with IBS and

74 Total RNA was extracted from gingival biopsy samples collected from 20 patients: 10 non-obese

75 ions: Autologous keratinocytes isolated from biopsy samples collected from 4 patients with RDEB were

76 ing growth factor (TGF)-beta1, as well as in biopsy samples collected from patients with CD and then

77 nophilic esophagitis or eosinophil counts in biopsy samples compared with placebo.

78 Nineteen of 38 core biopsy samples contained cancer.

79 aled a substantial Treg population in muscle biopsy samples containing AAT-expressing myofibers.

80 Sixty-five posttransplantation kidney biopsy samples covering 41 cases with acute rejection (1

81 been used to identify features in human skin biopsy samples diagnosed for basal cell carcinoma (BCC)

82 atients in silico to evaluate the effects of biopsy sampling, diagnostic sensitivity, and treatment o

83 Histopathologic examination of biopsy samples disclosed moderate intraparenchymal fibro

84 romycin can be predicted without obtaining a biopsy sample, facilitating the choice of the right ther

85 of gadolinium in the human organism, a skin biopsy sample from a suspected NSF patient was investiga

86 Chondrocytes (isolated from a 6 mm cartilage biopsy sample from the nasal septum harvested under loca

87 Retrospective evaluation of a biopsy sample from the native kidney revealed a similar

88 t, direct immunofluorescent examination of a biopsy sample from the patient's perilesional skin demon

89 a marker of dendritic cells in 105 allograft biopsy samples from 105 kidney transplant recipients.

90 Studying 213 archival biopsy samples from 17 patients, we used somatic variant

91 Levels of autophagy were analyzed in liver biopsy samples from 22 patients with HCV infection using

92 Small-bowel mucosal biopsy samples from 39 type 1 diabetic patients, 41 cont

93 de DNA methylation profiling, as were muscle biopsy samples from 4 healthy controls.

94 of the skin showed necrotizing vasculitis in biopsy samples from 40 of 50 children.

95 We analyzed colon biopsy samples from 40 patients with IBS (IBS biopsies)

96 Archival liver biopsy samples from 43 HCV+ LT recipients were collected

97 Eighteen biopsy samples from 6 patients were retrieved from our h

98 We obtained liver biopsy samples from 69 patients with chronic HCV infecti

99 We obtained fixed liver biopsy samples from 71 consecutive patients diagnosed wi

100 We studied gastric biopsy samples from 78,985 unique patients.

101 We collected liver biopsy samples from 8 treatment-naive patients with chro

102 DGE to a non-model organism, we examine skin biopsy samples from a cheetah (Acinonyx jubatus) and ide

103 ound in areas surrounding amyloid plaques in biopsy samples from Alzheimer's disease (AD) brains.

104 eplicon-harboring cells, as well as in liver biopsy samples from chronically HCV-infected patients.

105 btained from 49 patients and 55 in vivo lung biopsy samples from computed tomographic [CT]-guided lun

106 analyzed the expression of PDGF-BB in muscle biopsy samples from controls and patients with DMD.

107 erating and necrotic muscle fibers in muscle biopsy samples from DMD patients expressed PDGF-BB.

108 rs and adipophilin in at least 1 of multiple biopsy samples from each patient.

109 lium of the esophagus, as well as in control biopsy samples from esophageal squamous epithelium of pa

110 as performed on fine needle aspiration (FNA) biopsy samples from four murine xenograft models of meta

111 he presence of DSA (P=0.041).We obtained 291 biopsy samples from graft ileum and date-matched DSA ass

112 ection and analyzed gene expression in liver biopsy samples from HCV-infected chimpanzees and patient

113 tokine in a mouse model of BA and in hepatic biopsy samples from infants with BA.

114 Ex vivo molecular MR imaging of liver biopsy samples from NASH and control patients confirmed

115 We analyzed biopsy samples from paired baseline and relapsing lesion

116 ients with gastric adenocarcinoma as well as biopsy samples from patients infected with H. pylori sho

117 Gastric biopsy samples from patients infected with VacA(+), but

118 Evaluation of late biopsy samples from patients not receiving CNI therapy r

119 cells that were essentially undetectable in biopsy samples from patients on a gluten-free diet but e

120 levels of IGF-1R and IRS-1 are increased in biopsy samples from patients progressing on crizotinib m

121 Moreover, immunohistochemical analyses of biopsy samples from patients revealed localization of TH

122 lls dying of this pathway and in human liver biopsy samples from patients suffering from drug-induced

123 Biopsy samples from patients were examined.

124 receptor (CD71) is up-regulated in duodenal biopsy samples from patients with active celiac disease

125 y, we performed microarray analyses of renal biopsy samples from patients with ANCA-associated cresce

126 proliferation in CaCo-2 cells and intestinal biopsy samples from patients with CD and control subject

127 down of Smad7, an inhibitor of TGF-beta1, in biopsy samples from patients with CD increased levels of

128 crypt enterocyte proliferation in intestinal biopsy samples from patients with CD was reduced by EGF

129 LPMCs and biopsy samples from patients with CD were cultured with

130 significantly decreased in small intestinal biopsy samples from patients with celiac disease, which

131 glycolysis were quantified and localized in biopsy samples from patients with cirrhosis and liver sa

132 Using microarray analysis of bronchial biopsy samples from patients with COPD and controls, we

133 We obtained muscle biopsy samples from patients with diabetes who were unde

134 In liver biopsy samples from patients with HCV, there was an inve

135 dies and glomerular target antigens in renal biopsy samples from patients with LN and determine wheth

136 able macrophage phenotype composition within biopsy samples from patients with locally invasive recta

137 d LCP1 mRNA was increased (by 300%) in liver biopsy samples from patients with NAFLD compared to cont

138 In kidney biopsy samples from patients with nephropathic cystinosi

139 he current study investigated endomyocardial biopsy samples from patients with TCM and compared them

140 We collected surgical lung biopsy samples from patients with various interstitial l

141 ing a cohort of randomly selected esophageal biopsy samples from pediatric patients with EoE (n = 15)

142 IELs were quantified in duodenal biopsy samples from seronegative individuals (n = 500);

143 opsy specimens from 74 patients (177 ex vivo biopsy samples from surgically resected masses were obta

144 pression of microRNA-126 (miR-126) in muscle biopsy samples from the 2 patient groups and the control

145 cription-polymerase chain reaction in muscle biopsy samples from the 3 groups.

146 oendocrine cells were detected in intestinal biopsy samples from the patient.

147 ical analyses were performed on human muscle biopsy samples from the patients.

148 crine prostate cancer (CRPC-NE); analysis of biopsy samples from the same individuals over time point

149 on and microRNA expression profiles in renal biopsy samples from tolerance-induced FCRx recipients, p

150 Muscle biopsy samples from vastus lateralis and blood samples w

151 gulated in vitiligo cell line PIG3V and skin biopsy samples from vitiligo patients, whereas its predi

152 To address this question, we analyzed muscle biopsy samples from young, lean, insulin resistant (IR)

153 t independent transplant datasets (236 graft biopsy samples) from four organs, we identified a common

154 ant levels of fat among patients whose first biopsy samples had no or trivial levels of fat, and regr

155 rk using experimental, clinical chemistry or biopsy samples has demonstrated differential expression

156 Thanks to clinically accessible biopsy samples, high-quality molecular data for psoriasi

157 and gene expression profiling from the same biopsy sample) identified the induction of regulators wi

158 gnosis requires histologic analysis of colon biopsy samples in the appropriate clinical setting.

159 RT-PCR of reperfusion biopsy samples in the SCS group showed high expression o

160 We collected 248 liquid biopsy samples including plasma, cell pellet (UCP) and s

161 We analyzed 46 fresh lymph node biopsy samples, including FL (n = 20), diffuse large B-c

162 rom 3.02 to 4.58 mg/kg was determined in the biopsy sample, indicating a considerable deposition of g

163 trations quantified from blubber attached to biopsy samples is diagnostic of pregnancy.

164 and may evade detection by random esophageal biopsy sampling methods.

165 pattern on high resolution CT, surgical lung biopsy sampling might not be necessary to reach a diagno

166 ing a pathologic diagnosis of FNH, either by biopsy sample (n = 5) or hepatic resection (n = 5).

167 Muscle biopsy samples (n=30) were examined by immunohistochemis

168 Colonization of neither biopsy samples nor T84 cells was significantly affected

169 se intragraft injury processes was better in biopsy samples obtained >3 months after transplant (AUC

170 ms, and epidermal repair was studied in skin biopsy samples obtained at precise times during the firs

171 tion transcription was performed in duodenal biopsy samples obtained by gastroduodenoscopy.

172 synthesis and breakdown, in vastus lateralis biopsy samples obtained from 10 patients and 10 age- and

173 ily members in detail, along with autopsy or biopsy samples obtained from 5 family members.

174 We evaluated the EDP signature in biopsy samples obtained from adult and pediatric patient

175 Liver biopsy samples obtained from HBV-chronic individuals wer

176 cts of increasing pacing rates in myocardial biopsy samples obtained from patients with a normal ejec

177 that Sp1 was significantly decreased in skin biopsy samples obtained from patients with atopic dermat

178 We performed exome sequencing of DNA from biopsy samples obtained from patients with the Proteus s

179 Biopsy samples obtained from vastus lateralis muscles of

180 Overall mean number of core needle biopsy samples obtained was 7.9 samples.

181 us for cancer in each patient, with adequate biopsy samples obtained with each biopsy attempt.

182 in is significantly up-regulated in the skin biopsy sample of LD patients having mutations in both ma

183 l IFNalpha treatment or between pretreatment biopsy samples of 11 IFNalpha responders and 11 non-resp

184 Paraffin-embedded liver biopsy samples of 14 patients after sex-mismatched (fema

185 ption-polymerase chain reaction (qRT-PCR) in biopsy samples of 19 patients with esophageal squamous c

186 Glomeruli were microdissected from biopsy samples of 20 patients with LN and characterized

187 ted antigens from laser-microdissected renal biopsy samples of 20 patients with LN.

188 ar quantification of steroids in core needle biopsy samples of breast tissue to inform dosage and tim

189 ndings that could also be evidenced in renal biopsy samples of diabetic patients.

190 Biopsy samples of each tumor were used to assess the Ki6

191 disrupting EBV latency has been reported in biopsy samples of EBV-associated tumors whose onset in i

192 e global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult patien

193 roducts, characteristics not seen in control biopsy samples of healthy muscle and immune-mediated myo

194 ria mononuclear cells (LPMCs) collected from biopsy samples of individuals with or without CD (contro

195 established cell culture models derived from biopsy samples of lung cancer patients whose disease had

196 tients without GC (AG/IM GC-) and in control biopsy samples of non-transformed gastric mucosa (Contro

197 ell laser capture microdissection from liver biopsy samples of patients chronically infected with HCV

198 -kit-positive hCPCs were isolated from heart biopsy samples of patients undergoing left ventricular a

199 sing T cells from blood, induced sputum, and biopsy samples of patients with asthma and control subje

200 In ileal biopsy samples of patients with CD, there was an inverse

201 ly, abnormal Notch3 staining was observed in biopsy samples of patients with crescentic GN.

202 We conducted a retrospective study using biopsy samples of psoriasis, AD, and erythroderma belong

203 ring flap refinement after 6 months, we took biopsy samples of repair tissues and histologically anal

204 At operation 2 cm(3) biopsy samples of subcutaneous and visceral adipose tiss

205 Biopsy samples of the myocardial septum collected during

206 Results from blubber biopsy sampling of adult, male humpback whales at two ti

207 ical tissues were obtained in passing during biopsy sampling of white-matter lesions.

208 The CD8+ T cells, which were present in all biopsy samples, often adhered to Bowman's capsule and in

209 compared with histopathology of core needle biopsy samples or with ultrasound follow-up data of the

210 os, tracer kinetics, and assessment of liver-biopsy samples (P</=0.004 for all comparisons).

211 mmediately after RF ablation (mean number of biopsy samples per ablation zone, 1.9) and was evaluated

212 everal confounding tissue types present in a biopsy sample, posing as major sources of diagnostic err

213 The inclusion criteria was the presence of biopsy sample proven localised amyloidosis classified as

214 We found that individual clusters on biopsy samples range in size from 4-50 infected cells.

215 We analyzed 30 liver biopsy samples ranging from 1 week to more than 3 years

216 Although the biopsy samples represented a mixed cell population, the

217 l diversity that is captured in single tumor biopsy samples represents only a small proportion of the

218 annexin AI were detected in 11 and 10 of the biopsy samples, respectively, and predominated over othe

219 nd C1q were detected in 50%, 55%, and 70% of biopsy samples, respectively.

220 rays of 136 and more than 2000 breast cancer biopsy samples, respectively.

221 hylated region methylation status in 1-month biopsy samples revealed a nonsignificant trend for highe

222 Immunohistochemistry of endomyocardial biopsy samples revealed altered expression of the trunca

223 Analysis of bronchial biopsy samples showed a very strong correlation between

224 e tolerance after deployment, an analysis of biopsy samples showed diffuse constrictive bronchiolitis

225 Human membranous nephropathy biopsy samples showed podocyte staining for active CaMKI

226 Human liver biopsy samples showed the presence of the HCV-specific f

227 of single-cell RNA sequencing data from six biopsy samples showed two major fibroblast populations,

228 a statistical justification for the research biopsy sample size was present in 50% of trials.

229 tivity changes were determined in intestinal biopsy samples; structural mucosal damage was measured b

230 value of dendritic cell density in allograft biopsy samples, suggest a new role for these cells in sh

231 ion quantification was performed on duodenal biopsy samples taken at the end of each phase of supplem

232 les were compared between seven paired liver biopsy samples taken before and 6 months after successfu

233 ced metabolic perturbation assayed in muscle biopsy samples taken from locomotor muscle.

234 asal-cell carcinoma was detectable in 83% of biopsy samples taken from sites of clinically regressed

235 unaffected relatives were recruited and skin biopsy samples taken.

236 ion previously observed in a subset of tumor biopsy samples: the persistence of het DNA in the absenc

237 ch group had a pneumothorax from a CT-guided biopsy sample; the patient from the CDS group needed int

238 infiltration and fibrosis in endomyocardial biopsy samples to assess transplant rejection.

239 d in combination with histologic analysis of biopsy samples to stratify patients for treatment.

240 Biopsy samples underwent digital image analysis and asse

241 Eleven human liver biopsy samples underwent MPO-Gd-enhanced MR imaging ex v

242 We now report a retrospective study of human biopsy samples using biomarker ratio imaging microscopy

243 ogy method and fat content was quantified in biopsy samples using stereologic point counts (SPCs).

244 IgH V regions used by the BCRs of ABC DLBCL biopsy samples varied in their ability to sustain surviv

245 A 1-clock hour limbal biopsy sample was obtained from the unaffected eye.

246 For all patients (n = 431), a liver biopsy sample was scored for grading, staging (Ishak), a

247 rrently, his previously obtained pelvic mass biopsy sample was sent for panel-based genomic profiling

248 usion PD-L1 expression in pretreatment tumor biopsy samples was correlated with response rate, PFS, a

249 Sampling error in sequential biopsy samples was frequent.

250 affects repair, microarray analysis of wound biopsy samples was performed on days 3, 7, 10, and 14 af

251 Expression of selected genes in the same biopsy samples was tested with qRT-PCR.

252 Needle biopsies samples were taken from the vastus lateralis mu

253 e 49 soldiers who underwent lung biopsy, all biopsy samples were abnormal, with 38 soldiers having ch

254 IL28A, IL28RA, and other related cytokines; biopsy samples were also analyzed by immunofluorescence

255 es of 28 TGP and 11 normal transplant kidney biopsy samples were analyzed by Affymetrix HuGene 1.0 ST

256 Biopsy samples were analyzed for mutations and protein e

257 Liver biopsy samples were available for 1201 patients (97.2% o

258 during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after

259 subjects); 232 fecal samples and 59 mucosal biopsy samples were collected and analyzed by 16S riboso

260 Biopsy samples were collected and H pylori were isolated

261 Blood and muscle biopsy samples were collected at rest and after exercise

262 Blood and muscle biopsy samples were collected before and after the inges

263 Blood and liver biopsy samples were collected before treatment and at tr

264 Abdominal subcutaneous adipose tissue biopsy samples were collected for microarray analysis.

265 ; interquartile range, 53-65 months); random biopsy samples were collected from neosquamous epitheliu

266 Gastric biopsy samples were collected from patients with H pylor

267 arterial and venous blood samples and muscle biopsy samples were collected throughout the study.

268 Repeated blood and muscle biopsy samples were collected to assess whole-body leuci

269 d and microscopic sections of lacrimal gland biopsy samples were critically re-evaluated.

270 Skin biopsy samples were evaluated by immunohistochemistry, a

271 Liver biopsy samples were evaluated for a number of pathologic

272 LV biopsy samples were obtained during coronary bypass surg

273 For this study, paired blood and rectal biopsy samples were obtained from 12 HIV noncontrollers

274 Tendon tissue biopsy samples were obtained from 20 patients with ruptu

275 Biopsy samples were obtained from subcutaneous abdominal

276 Muscle biopsy samples were obtained to determine myofibrillar a

277 Conjunctival biopsy samples were obtained to perform direct immunoflu

278 Four residual biopsy samples were obtained.

279 ajority of dendritic cells in late allograft biopsy samples were of recipient origin.

280 Esophageal biopsy samples were quantified for levels of eosinophils

281 Throughout the study, 1,007 biopsy samples were reported as malignant tumors (719 ga

282 underwent a nontargeted liver biopsy, and 97 biopsy samples were reviewed for steatosis and iron grad

283 of cells isolated from the placenta and all biopsy samples were stained positive for Cytokeratin 7,

284 The resected tumour specimen and individual biopsy samples were studied to assess the true tumour ma

285 Biopsy samples were taken before and after allergen chal

286 Biopsy samples were taken from 29 patients with locally

287 Biopsy samples were taken from patients with COPD (Globa

288 Lesional skin biopsy samples were taken from this patient and 2 others

289 Skeletal muscle biopsy samples were taken to assess intramuscular lipid

290 e, serological tests were used, and duodenal biopsy samples were taken to determine the degree of muc

291 Biopsy samples were tested for H. pylori using a reused

292 ocal anaesthesia during collection of tumour biopsy sample) were expanded, seeded, and cultured with

293 e histological confirmation of surgical lung biopsy samples when high-resolution CT images are not de

294 histopathologic descriptions for 1082 liver biopsy samples, which were then analyzed using the Unifi

295 Muscle and skin biopsy samples (4 skin biopsy samples with active rash) from 7 patients with pr

296 All renal allograft biopsy samples with concomitant data on 24-hour proteinu

297 In biopsy samples with high dendritic cell density, electro

298 elial cell marker EPCAM in unseparated whole biopsy samples with separated epithelium (i.e. EPCAM pos

299 omic hybridization analysis was performed on biopsy samples with sufficient tissue.

300 Biopsy samples yielded prescribed cell doses within 36 d