ライフサイエンスコーパス: biopterin

1 terin synthesis, thereby elevating levels of biopterin.

2 ates but not by non-classical antifolates or biopterin.

3 3 x 10(6); hydroxymethylpterin, 1.2 x 10(6); biopterin, 1.0 x 10(6); d-(+)-neopterin, 3.1 x 10(5); is

4 DPH, and ternary complexes with cofactor and biopterin, 5,6-dihydrobiopterin, and 5,6,7,8-tetrahydrob

5 ects the following six urinary pteridines: 6-biopterin, 6-hydroxymethylpterin, d-neopterin, pterin, i

6 dded), Fe(III)-bound form, and 7,8-dihydro-l-biopterin (7,8-BH(2)) plus Fe(III)-bound form.

7 lts demonstrate for the first time epidermal biopterin accumulation together with significantly decre

8 We utilized a freeze-quench instrument, the biopterin analog 5-methyl-H(4)B, and a method that could

9 ne), a specific inhibitor of GCH1, prevented biopterin and NO production and invasion of E. coli K1 i

10 criminated the interferences including the 6-biopterin and pterin structural analogs of neopterin as

11 Biopterin and pterin, the fully oxidized forms of the pt

12 n mice with DAHP prevented the production of biopterin and the development of meningitis.

13 production in human vessels, whereas plasma biopterins are a marker of systemic inflammation.

14 (6R)-Tetrahydro-l-biopterin (BH(4)) is the rate-limiting cofactor in the p

15 oxidized form of the cofactor (7,8-dihydro-L-biopterin, BH(2)), has been determined at 2.0 A resoluti

16 E, had a very low (6R)-5,6,7, 8-tetrahydro-L-biopterin (BH4) content.

17 novo synthesis of (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4) in a biological system.

18 (6R)-5,6,7,8-Tetrahydro-L-biopterin (BH4) is an essential cofactor in the synthesi

19 It is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens, where it is enc

20 biopterin, and the key enzymes that regulate biopterin bioavailability, GTP cyclohydrolase and dihydr

21 P) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin biosynthesis, E. coli QueD catalyzes the conve

22 yclohydrolase I, the rate-limiting enzyme in biopterin biosynthesis, was associated with endothelial

23 PIN levels and not because of alterations in biopterin biosynthesis.

24 BH4, we hypothesize that generation of this biopterin by the intestinal microbiota contributes to it

25 e absence of reduced pyridine nucleotides or biopterin cofactors.

26 estinal flora in individuals with congenital biopterin deficiency may allow for an increase in total

27 rovide evidence of a dual redox function for biopterin during the NOHA oxidation reaction.

28 es are novel and expand our understanding of biopterin function in biology.

29 BH4, oxidised biopterins, GTP-cyclohydrolase 1 (GTPCH-1, the rate-limi

30 reconstituted with (6R)-5,6,7,8-tetrahydro-L-biopterin (H(4)B) or other pterins.

31 stand how heme and (6R)-5,6,7,8-tetrahydro-l-biopterin (H(4)B) participate in nitric-oxide synthesis,

32 alian NOS cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H(4)B).

33 purified in the absence of 6(R)-tetrahydro-l-biopterin (H(4)B).

34 absence (H4B-free NOS) of (6R)-tetrahydro-L-biopterin (H4B).

35 e levels and high concentrations of 6- and 7-biopterin in their epidermis.

36 sociation exists between plasma and vascular biopterins in patients with coronary artery disease.

37 xogenous sources, the tissue content of this biopterin increases with age in GTP cyclohydrolase 1-def

38 Biopterin is required for growth of the protozoan parasi

39 robiopterin (BH(4)), not dihydrobiopterin or biopterin, is a critical element required for NO formati

40 No significant change of biopterin level was found between healthy individuals an

41 H1overexpression significantly increased the biopterins level in left ventricular (LV) myocytes but n

42 drolase I are in the normal range, but total biopterin levels are significantly decreased in homozygo

43 he relationships between plasma and vascular biopterin levels in patients with coronary artery diseas

44 Oral BH4 treatment augments total biopterin levels in patients with established coronary a

45 Finally, plasma but not vascular biopterin levels were correlated with plasma C-reactive

46 d studied the effects on eNOS regulation and biopterin metabolism in cultured aortic endothelial cell

47 nsive mouse hearts showed increased oxidized biopterins, NOS-dependent superoxide production, reduced

48 bably due to the nonenzymatic formation of 7-biopterin or a similar derivative.

49 ion was observed between plasma and vascular biopterins (P<0.05 for both saphenous veins and internal

50 tic pathway in Bacteria and Archaea, and the biopterin pathway in mammals.

51 ng that a large proportion of the myocardial biopterin pool was oxidized; nevertheless, myocardial NO

52 ired for regeneration and maintenance of H(4)biopterin pools.

53 th the bound cofactor analogue 7,8-dihydro-L-biopterin, providing the first atomic-resolution informa

54 Significant biopterin radical (>0.5 per heme) formed during reaction

55 of final biopterin redox status showed that biopterin radical decay occurred via an enzymatic one-el

56 avoprotein domain catalyzes reduction of the biopterin radical following Arg hydroxylation.

57 Biopterin radical formation was kinetically linked to co

58 The biopterin radical then decayed within a 200-300-ms time

59 DTT, EPR showed a mixture of superoxide and biopterin radicals.

60 oxide radical or a mixture of superoxide and biopterin radicals.

61 and increased vascular BH4 and the BH4/total biopterin ratio.

62 Measures of final biopterin redox status showed that biopterin radical dec

63 of heme to zinc in (6R)-5,6,7,8-tetrahydro-L-biopterin-replete, wild-type nNOS and eNOS and show that

64 -); however, full oxidation of protein-bound biopterin required higher ONOO(-) levels.

65 nce or absence of (6R)-5,6, 7,8-tetrahydro-L-biopterin, reveal that the nu(O-O) line is insensitive t

66 triphosphate cyclohydrolase I expression and biopterin synthesis in parallel, which was reduced in mo

67 These results suggest a novel role for biopterin synthesis in the pathogenesis of E. coli K1 me

68 Phenylalanine markedly increased biopterin synthesis, whereas arginine had no effect.

69 gp96 expression prevents GCH1 activation and biopterin synthesis.

70 i, further emphasizing the importance of H(4)biopterin throughout this family of human parasites.

71 d-freeze EPR spectroscopy to follow heme and biopterin transformations during single-turnover NOHA ox

72 m the host through the activities of a novel biopterin transporter (BT1) and broad-spectrum pteridine

73 ana) ortholog At2g32040 belong to the folate-biopterin transporter (FBT) family within the major faci

74 sh conservation of function among folate and biopterin transporter family proteins from three kingdom

75 teins with some similarity to the folate and biopterin transporters of the trypanosomatid parasite Le

76 We determined plasma and vascular levels of biopterins, vasomotor responses to acetylcholine, and va

77 BH4 was the most potent of biopterins with different oxidative states.

78 ole for the circadian clock in metabolism of biopterins, with a significant impact in the vasculature