ライフサイエンスコーパス: bioreactor

1 erogeneous at different scales (molecular to bioreactor).

2 was observed as an important reaction in the bioreactor.

3 etc.) and results in their enrichment in the bioreactor.

4 (MF) membrane are operated in parallel in a bioreactor.

5 actone) 3D scaffolds within a flow perfusion bioreactor.

6 iscible extractant and aqueous phases of the bioreactor.

7 d by the FO membrane and enriched within the bioreactor.

8 t of the 10-m-long ( approximately 1.5 m(2)) bioreactor.

9 for ethanol production by yeast in the same bioreactor.

10 hese cell-seeded constructs in a whole-organ bioreactor.

11 hypoxia, and glucose deprivation in a custom bioreactor.

12 a microbial fuel cell (MFC) inside an algal bioreactor.

13 t to operations downstream of the production bioreactor.

14 posed to coronary artery flow in a perfusion bioreactor.

15 tly obtained by cultivation in a bench-scale bioreactor.

16 s using a magnetic resonance (MR) compatible bioreactor.

17 in response to cyclic strains imparted in a bioreactor.

18 fter treatment in a laboratory-scale aerobic bioreactor.

19 a novel hemodynamically-equivalent pulsatile bioreactor.

20 ibution of biochemical substances inside the bioreactor.

21 mical changes caused by MICP in a laboratory bioreactor.

22 mccartyi-containing consortium in an upflow bioreactor.

23 d endothelial cells, either on discs or in a bioreactor.

24 re analyzed in the gastight headspace of the bioreactor.

25 s but as components of an incompletely mixed bioreactor.

26 hic bacteria from a laboratory-scale anammox bioreactor.

27 taminated soil after treatment in an aerobic bioreactor.

28 without compromising the performances of the bioreactors.

29 freshwater ecosystems, and in the design of bioreactors.

30 are two main cell types used for large-scale bioreactors.

31 ld higher output than provided by industrial bioreactors.

32 when held in a steady metabolic state using bioreactors.

33 pH, and other variables were similar across bioreactors.

34 rn highly efficient miniature biosensors and bioreactors.

35 conditions, as well as in turbulently mixed bioreactors.

36 gh-temperature processing, drop dynamics and bioreactors.

37 UV radiation in specifically designed photo-bioreactors.

38 A extracted from activated sludge in the two bioreactors.

39 -scale and a full-scale wastewater treatment bioreactors.

40 ontaminated sites, extreme environments, and bioreactors.

41 uently oxidized to sulfate in oxygen-limited bioreactors.

42 rs and for culturing artificial cartilage in bioreactors.

43 ates under conditions encountered in typical bioreactors.

44 atidylcholine) vesicles for realizing porous bioreactors.

45 tests in shake flasks and 1 L spinner-flask bioreactors.

46 ve and not easily integrable with low-volume bioreactors.

47 sewage transport, can also be considered as bioreactors.

48 Silica microbead bioreactors (0.5 microm diameter) coated with DNA and en

49 wastewater treatment using aerobic membrane bioreactors (1-2 kWh/m3).

50 tly removed PAHs from the contaminated soil (bioreactor 69% removal, column 84% removal), bioreactor

51 The inability to consistently develop such bioreactors affects the way growth approaches for Dehalo

52 earlier manual processing with nanoparticle bioreactors, allowing a range of significant enzyme reac

53 The distal colon functions as a bioreactor and harbors an enormous amount of bacteria in

54 namics for a continually operated mesophilic bioreactor and highlight the enormous potential of delta

55 eks of sequential culture in a rotating wall bioreactor and perfusion at 6.8 dynes/cm(2).

56 otential as advanced drug delivery vehicles, bioreactors and artificial cells.

57 Using continuous-flow sediment bioreactors and batch incubations, we characterized (i)

58 ort, electronics, energy production, optics, bioreactors and catalysis.

59 rs on osteoconductive scaffolds in perfusion bioreactors and confirmed their phenotype stability in a

60 er in high-aspect ratio rotating wall vessel bioreactors and examined throughout the early stages of

61 proximately 3 mm beads that were packed into bioreactors and fed ad libitum.

62 in cell cultures, 3D models of live tissue, bioreactors and fluidic chips; ex vivo and in vivo O2 me

63 ecosystems ranging from oceans and soils to bioreactors and humans.

64 te the rapid commissioning of iron-oxidizing bioreactors and illustrated how microbial communities wi

65 The results are not restricted to bubbles in bioreactors and may be relevant to a variety of applicat

66 creasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with

67 sments of cellular functions in microfluidic bioreactors and organs-on-chips.

68 ed equipment including large stainless steel bioreactors and tanks to hold product intermediates and

69 Both the low animal cell density of bioreactors and their ability to post-translationally pr

70 ics (in the MFC) and nutrients (in the algal bioreactor), and the production of bioenergy in electric

71 consisting of a primary clarifier, membrane bioreactor, and five post-treatment technologies includi

72 ineralization: zinc as ZnS in a sulfidogenic bioreactor, and iron as schwertmannite by microbial iron

73 such as waters, soils, extreme environments, bioreactors, and human microbiomes.

74 called an anaerobic electrochemical membrane bioreactor (AnEMBR).

75 thodes in anaerobic electrochemical membrane bioreactors (AnEMBRs) operated at different applied volt

76 was to evaluate emerging anaerobic membrane bioreactor (AnMBR) technology in comparison with convent

77 n of dissolved methane in anaerobic membrane bioreactors (AnMBRs) treating a synthetic dilute wastewa

78 s-cast Mg-Zn-Mn, and extruded Mg-Zn-Mn) in a bioreactor applying cyclical loading and simulated body

79 scopic mineral deposits that form within the bioreactor are consistent with bone hydroxyapatite.

80 peed, and the hydrodynamic conditions in the bioreactor are shown to affect not only the overall rate

81 In-field bioreactors are a powerful tool for capturing natural mi

82 Artificial bioreactors are desirable for in vitro biochemical studi

83 These bioreactors are implanted in an ectopic site in the body

84 Bioreactors are typically composed of billions of cells,

85 est that denitrification in an aged woodchip bioreactor at constant temperature can effectively be mo

86 unds into a microfluidic human primary liver bioreactor at desired time points while monitoring their

87 imilar Monod growth kinetics when grown in a bioreactor at varying H(2) concentrations.

88 e-treatment plant (sequencing batch membrane bioreactor) at two solids retention times (SRTs): 20 and

89 Porcine AV cusps were cultured in a stretch bioreactor, at 10% (physiological) or 15% (pathological)

90 A specialized bioreactor based on the principle of simultaneous growth

91 In vitro bioreactor-based cultures are being extensively investig

92 vitro from mouse ESCs using either static or bioreactor-based cultures, with that of native LKS cells

93 ue-engineered cartilage as an alternative to bioreactor-based mechanical stimulation.

94 on for vascular tissue engineering are still bioreactor-based, extremely expensive, laborious and tim

95 ion of the yeast Saccharomyces cerevisiae in bioreactor batch cultures yielded variants that grow as

96 The bioreactors became rapidly colonized by this bacterium,

97 is bleed stream can be treated in a separate bioreactor by reducing thiosulfate to sulfide and recycl

98 short duration dose of NO3(-) to an anammox bioreactor can rapidly restore the activity of NO2(-)-st

99 h(-1), and microbial communities within the bioreactors changed over time, with Atx. ferrooxidans be

100 is study, seven pilot-scale sulfate-reducing bioreactor columns containing varying ratios of alfalfa

101 A null model demonstrated that bioreactor communities were driven in part not only by e

102 ore the need for more detailed assessment of bioreactor community ecology and justify pilot- and full

103 ictions suggest that a large portion of each bioreactor community is autotrophic, relying not on mola

104 uced in W and WH in a further scale-up to 5L bioreactors, confirming the suitability of the low-cost

105 Laboratory-scale bioreactors containing bauxite residue (an alkaline, sal

106 al evidence toward the feasibility of upflow bioreactors containing D. mccartyi as high-density cultu

107 steps of unsaturated LCFA was studied in 10 bioreactors continuously operated with saturated or unsa

108 In the first stage, an anaerobic bioreactor converts mixtures of gases of CO2 and CO or H

109 crobial communities for wastewater treatment bioreactors, could inspire development of mechanistic ma

110 nterpreting acetate metabolite trends from a bioreactor cultivation of Chinese hamster ovary cells ex

111 accharomyces cerevisiae during two different bioreactor cultivations.

112 In bioreactor culture, when syngas flowrate increased from

113 affolds (templates for tissue formation) and bioreactors (culture systems providing environmental con

114 Perfusion bioreactor cultures of primary human hepatocyte spheroid

115 Further, when compared to cells derived from bioreactor cultures, static culture-derived LKS cells sh

116 In contrast, bioreactor-derived LKS cells, when differentiated under

117 e is to introduce the concept of the in vivo bioreactor, describe important preclinical models in the

118 The aim of this study was to develop a bioreactor design for continuous milk coagulation using

119 00 mL gdcw(-1) h(-1)) were achieved in a new bioreactor designed and optimized for H2 production.

120 eriments in a novel high-temporal-resolution bioreactor, DOC concentration decreased by an average of

121 cult to characterize samples pulled from the bioreactor due to the low levels of product during the e

122 the same excellent quality as with membrane bioreactors due to the much lager pore sizes of the mesh

123 d on a cross-flow continuous membrane enzyme bioreactor (EMR).

124 ltivation in a 5 L continuously stirred tank bioreactor enabled production of 0.8 g lactate/L, repres

125 % respectively) over a 7-day period in a CDC bioreactor environment.

126 technological and biomedical applications in bioreactors, environmental sensing, drug monitoring, con

127 ined thermodynamic geochemical modeling with bioreactor experiments using Shewanella oneidensis MR-1.

128 rlong monthly time series of nine full-scale bioreactor facilities treating brewery wastewater (>20,0

129 Silica nanoparticle bioreactors featuring thin films of enzymes and polyions

130 e established and operated a continuous-flow bioreactor fed increasing loadings of SCN(-).

131 extents of pH neutralization were higher in bioreactors fed with simpler organic carbon substrates (

132 achate using four laboratory-scale anaerobic bioreactors filled with municipal solid waste (MSW) and

133 cate) (PGS) and cultured in a pulsatile flow bioreactor for 3 wk.

134 olumn for application as a biosensor or as a bioreactor for continuous destruction of DNAN.

135 e-emulsion (DE) droplets as pico-liter sized bioreactor for rapid cell assembly and well-controlled m

136 ked environmental samples and samples from a bioreactor for sulfate reduction to sulfide were measure

137 ved the operating conditions of an anaerobic bioreactor for the conversion of complex yeast-fermentat

138 ermit good results and can be used to make a bioreactor for various applications in food industries.

139 ignificance in the design of one-step, green bioreactors for stereoselective drug metabolite synthesi

140 ubstrates/inhibitors and fabrication of nano-bioreactors for synthesis of high value natural products

141 lastoid cells in a high aspect ratio vessel (bioreactor) for 72 h either in the rotating condition to

142 n fluorescent protein, which when grown in a bioreactor generated more than 20 L of supernatant with

143 ficiency based on operational parameters and bioreactor geometry, and we verified it with experimenta

144 NMR experiments using advanced bioreactors have advantages with respect to having full

145 To address these problems, in vivo bioreactors have been explored as an approach to generat

146 ) bioreactor operating conditions; and (iii) bioreactor history (after perturbations during the opera

147 e composition after biomass pretreatment and bioreactor history are also important.

148 A horizontal rotating tubular bioreactor (HRTB) is a combination of a thin layer and a

149 e body, where ossified tissue grows into the bioreactor in predefined geometries and local vessels ar

150 PHBV cell accumulation were observed in both bioreactors in excess of nitrogen.

151 ed values that would kill many cells used in bioreactors, including Chinese Hamster Ovary (CHO) cells

152 oprecipitation of the phosphate added to the bioreactor influent.

153 We carried out experiments with gas lift bioreactors inoculated with haloalkaliphilic sulfide-oxi

154 In sediment bioreactors, inorganic carbon stable isotope mass balanc

155 n the selectivity for sulfur production in a bioreactor integrated with a gas absorber.

156 t needed for the stimulations in a one-liter bioreactor is only one-tenth of a US penny.

157 The capacity to serve as microscale bioreactors is established by demonstrating a ribozyme c

158 batches of organic-rich sediments in a novel bioreactor (IsoCaRB) that permitted continuous observati

159 arable with efficient incineration, MBT, and bioreactor landfilling technologies.

160 Samples were drawn along the bioreactor length for monitoring the metal contents on s

161 lactate oxidase were immobilized in ABS flow bioreactors (manufactured through low-cost three-dimensi

162 yngas fermentation, and its implication with bioreactor mass transfer.

163 robial product (SMP) extracted from membrane bioreactor (MBR) feedwater, backwashed membrane, and che

164 acid) was investigated employing a membrane bioreactor (MBR) integrated with either ozonation or UV/

165 s applying oxidation ditch (OD) and membrane bioreactor (MBR) processes harbored a majority of shared

166 this article, the current status of membrane bioreactor (MBR) technology for wastewater treatment is

167 A pilot-scale membrane bioreactor (MBR) was installed and operated for one year

168 A pilot-scale membrane bioreactor (MBR) was tested for bioremediation of 1,2-di

169 It is a modification of the membrane bioreactor (MBR), in which a membrane filtration process

170 embranes in a bench-scale submerged membrane bioreactor (MBR).

171 s were investigated in a full-scale membrane bioreactor (MBR; nominal pore size 0.04 mum): (i) attach

172 tions in batch reactors and membrane-coupled bioreactors (MBRs).

173 gging probe to monitor MICP in a sand-filled bioreactor, measuring NMR signal amplitude and T2 relaxa

174 be mitigated by lowering the salinity of the bioreactor medium.

175 rid microfiltration-forward osmosis membrane bioreactor (MF-FOMBR) for direct phosphorus recovery fro

176 ells and an anaerobic fluidized bed membrane bioreactor (MFC-AFMBR), was examined here to produce hig

177 air-biocathode microbial fuel cell-membrane bioreactor (MFC-MBR) system was developed to achieve sim

178 ng microbial community in a laboratory-scale bioreactor model that closely mimicked estuary or bracki

179 We review the state of the art in bioreactor modeling and current efforts in modeling the

180 umn (BCR) and an internal loop airlift (ALR) bioreactors of 2.3 L for the abatement of N2O from a nit

181 nfigurations, while also enabling the use of bioreactors of greater optical depth operating at lower

182 The osmotic membrane bioreactor (OMBR) is an emerging technology that uses wa

183 In order to design a green microsomal bioreactor on suitably identified carbon electrodes, it

184 ulfate conversion to sulfide in a H2/CO2 fed bioreactor operated at haloalkaline conditions was inves

185 Continuous bioreactors operated at low hydraulic retention times ha

186 experiments in laboratory-scale chemostatic bioreactors operated through a series of pH values (2.1-

187 f the best-suited assays for each industrial bioreactor operating condition, discuss next-generation

188 the factors: (i) biomass pretreatment; (ii) bioreactor operating conditions; and (iii) bioreactor hi

189 biomass, it was possible to achieve a stable bioreactor operation at which 80% of the supplied H2S (6

190 itude and that new approaches might optimize bioreactor operation.

191 Utilizing the bioreactor or immobilized human cells, the production of

192 s has led to the concept of using plants as "bioreactors" or "biofactories" for the production of pha

193 We report bioreactor performance and dehalogenation kinetics of a

194 uences for 112 samples) with function (i.e., bioreactor performance) and environment (i.e., operating

195 The impact of cadmium perturbation on the bioreactor performance, bacterial activity, bacterial co

196 are taxa likely play an unrecognized role in bioreactor performance.

197 Bioreactor perturbations were shown to create cell abund

198 e the toxicity of carboxylic acids at acidic bioreactor pH levels even more, and this can, for exampl

199 Advances in upstream processing (the bioreactor phase) have been successful in achieving high

200 resonance spectroscopy (MRS) combined with a bioreactor platform and interrogated the biochemical bas

201 (MGP) site was treated in a laboratory scale bioreactor (postbioremediation) and extracted using pres

202 adsorption unit and a periphyton-based photo-bioreactor (PPBR), was built and applied for the first t

203 ll model that could be used to develop novel bioreactors, primitive artificial cells and plausible pa

204 etic groundwater at 11-3.6 h HRT, the upflow bioreactor removed >99.7% of the influent trichloroethen

205 biotechnology industry, as production scale bioreactors require continuous injection of oxygen bubbl

206 d-up production of these strains in benchtop bioreactors resulted in almost ten- and fivefold increas

207 anner either using spinner flasks or cellbag bioreactors, resulting in a final purified yield of appr

208 maturation of bone substitutes in perfusion bioreactors results in global repression of cell prolife

209 wastewater, and its conversion in anaerobic bioreactors results in palmitate (C16:0) accumulation.

210 r performance in a trichloroethene-degrading bioreactor, revealing population structures as well as t

211 of a lab-scale submerged anaerobic membrane bioreactor (SAnMBR), and their role in membrane fouling,

212 heterologous host Pichia pastoris on the 5L bioreactor scale (reUmChlE; 45.9UL(-1)).

213 ation of these beads into a novel swirl flow bioreactor (SFB), of low capital and running costs and o

214 d and ventilated cell-seeded constructs in a bioreactor simulating the physiologic environment of dev

215 The bioreactor simultaneously consumed sulfide, methane and

216 omplished by extracting the product from the bioreactor solutions.

217 Here, we developed a miniaturized spinning bioreactor (SpinOmega) to generate forebrain-specific or

218 trategy is evaluated for use in microfluidic bioreactor studies specifically aimed at characterizing

219 rations including three-dimensional culture, bioreactor studies, as well as microfabricated co-cultur

220 bioremediation processes: a sequencing batch bioreactor system and a continuous-flow column system.

221 nate, and sulfate was treated in a fixed-bed bioreactor system consisting of two reactors (reactors A

222 The simple to use bioreactor system provides an in vitro model that permit

223 We used a rotating wall vessel bioreactor system to create 3-dimensional (3-D) epitheli

224 An in-field bioreactor system was developed to assess oxic versus an

225 ltured for up to 21 days in a flow perfusion bioreactor system wherein alpha-MEM (supplemented with 1

226 ltured for up to 21 days in a flow perfusion bioreactor system wherein alpha-MEM (supplemented with 1

227 em cells (hMSCs) and a "biomimetic" scaffold-bioreactor system.

228 e continuously perfused with nutrients via a bioreactor system.

229 ies, such as fecal microbiota transplant and bioreactor systems' optimization, suggest a promising ro

230 edia formulations, and potentially different bioreactor systems.

231 jective of this work was to develop a tissue bioreactor (TBR) enabling modulation of the microenviron

232 icacy, and will enable future development of bioreactor technologies at full field scale.

233 hicles to regenerative medicine, inexpensive bioreactor technology and tissue engineering therapies.

234 Now, advances in bioreactor technology, metabolic engineering, and analyt

235 cell line and the rotating wall vessel (RWV) bioreactor technology.

236 planted and maintained for 24 h ex vivo in a bioreactor that preserves EMB viability and function.

237 have developed a microfluidic human platelet bioreactor that recapitulates bone marrow stiffness, ext

238 ts for up to 28 d by coronary perfusion in a bioreactor that simulated cardiac physiology.

239 d paddy fields are efficient denitrification bioreactors that can achieve decontamination of nitrate-

240 refinements of the model, we also developed bioreactors that enable intravital nonlinear optical mic

241 rming make some aquatic ecosystems behave as bioreactors that trigger rapid and massive cyanobacteria

242 production rate of 0.47 g COD l(-1) d(-1) in bioreactors that were fed with dilute-acid pretreated co

243 hod for controlling the oxygen supply to the bioreactor, that is, by maintaining a redox potential se

244 Compared to control bioreactors, those with 11-12 mM of toluene in the oil (

245 rom industrial off-gases in two-liquid phase bioreactors (TLPBs).

246 cellularize rat oesophagi inside a perfusion bioreactor to create biocompatible biological rat scaffo

247 rioallantoic membrane (CAM) can be used as a bioreactor to culture and study the regeneration of huma

248 We then used a bioreactor to culture pulmonary epithelium and vascular

249 The use of bioengineered human skin as a bioreactor to deliver therapeutic factors has a number o

250 We developed microfluidic bioreactors to enable the investigation of the effects o

251 mals have great potential to act as powerful bioreactors to produce human therapeutic proteins.

252 y plant-based systems have been developed as bioreactors to produce recombinant proteins.

253 We operated six thermophilic (55 degrees C) bioreactors to test how the factors: (i) biomass pretrea

254 n hydrogels rich in maturogens and placed in bioreactors to undergo the fusion process of self-assemb

255 dimensional organoids, using a fluidised bed bioreactor, together with single-use bioprocessing equip

256 om no-surfactant controls, incubation of the bioreactor-treated soil with all surfactants increased P

257 t genes (ARG) in anaerobic, aerobic, and AAS bioreactors treating domestic wastewater.

258 bioreactor 69% removal, column 84% removal), bioreactor treatment resulted in an increase in toxicity

259 gues were shown to accumulate as a result of bioreactor treatment, and the C15H8O2 compound purified

260 load of 125 mg/L of each metal underwent the bioreactor treatment.

261 A hybrid ultrafiltration-osmotic membrane bioreactor (UFO-MBR) was investigated for over 35 days f

262 spiratory pathway mutants in three-electrode bioreactors under controlled flavin concentrations.

263 ifying enrichment cultures from a continuous bioreactor, up to 59.89 +/- 1.12 mg COD/L of CH(3)OH was

264 trafiltration permeate (UFP) from a membrane bioreactor used to treat municipal wastewater.

265 nalysis of samples from two laboratory-scale bioreactors used to study SCN(-) and CN(-) degradation.

266 We have constructed a small intestinal bioreactor using 3-D printing and polymeric scaffolds th

267 butanol and 3-methyl-1-butanol in an electro-bioreactor using CO(2) as the sole carbon source and ele

268 nd biotrickling filters depends on three key bioreactor variables: the support medium; gas molecule s

269 on, and light delivery throughout the entire bioreactor volume by using light-directing waveguides.

270 The concentration of NCO in the bioreactor was 11 mug g(-1) dry soil, corresponding to 1

271 Stable co-culture in the same bioreactor was achieved by designing a mutualistic relat

272 as defined and a technically-friendly enzyme bioreactor was developed in order to carry out a continu

273 An anaerobic membrane bioreactor was retrofitted with polyvinylidene fluoride

274 ocal N2O emissions of a wastewater treatment bioreactor was sampled by a dedicated mobile sampling de

275 ent in the effluent of an anaerobic membrane bioreactor was then carried out using these assay method

276 In this work, an automated perfusion bioreactor was used to obtain and maintain human hepatoc

277 lis (rAvPAL) and their ability to perform as bioreactors was assessed in vivo in adult BTBR-Pah(enu2)

278 The performance of the bioreactors was monitored throughout and the speciation

279 nization into an ecosystem (activated sludge bioreactor) was measured through a disturbance gradient

280 Woodchip bioreactors (WBRs) are increasingly being applied to rem

281 with sulfide produced in a sulfate-reducing bioreactor were studied at pH 3, 5, and 7.

282 ch human primary hepatocytes cultured in the bioreactor were treated with acetaminophen.

283 Enzyme turnover rates using the microsomal bioreactors were 2-3 fold larger compared to using conve

284 Continuous-flow bioreactors were commissioned and tested for their capac

285 id product is fed as a substrate to a second bioreactor, where it is converted aerobically into lipid

286 However, the "best bioreactor", which would be able to achieve maximum prod

287 was achieved through suspension culture in a bioreactor, which enabled the preparation of >10 mg of m

288 t option is anaerobic-aerobic sequence (AAS) bioreactors, which use an anaerobic pretreatment step (e

289 in the nutrient-rich upstream portion of the bioreactor, while the lower part of the system, which la

290 A bioreactor with a chamber in the exact shape of a human

291 digestion (CAS+AD), and an aerobic membrane bioreactor with anaerobic digestion (AeMBR+AD).

292 In an acetate-fed anaerobic-aerobic membrane bioreactor with deteriorated enhanced biological phospho

293 In the present study, a bioreactor with gas sparging was used, where we observed

294 In this work, we developed a bioreactor with living cultures of human respiratory epi

295 n low- and high-pressure, water-wet sandpack bioreactors with 0.5 pore volumes of residual oil in pla

296 In this work, continuous experiments in bioreactors with anammox bacteria closely related to "Ca

297 We show that semipermeable, size-controlled bioreactors with aqueous, macromolecularly crowded inter

298 ogenitors on 3D osteoconductive scaffolds in bioreactors with medium perfusion leads to the formation

299 In wastewater treatment, bioreactors with microbial biofilms are widely used.

300 good manufacturing practices (GMP)-compliant bioreactor yielded effector cells that in a neuroblastom