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1 for ER body formation and MYB51/122 for IGs biosynthesis).
2 nesis pathway that lead to impaired cortisol biosynthesis.
3 suppression of pigment; and (3) Fe/S cluster biosynthesis.
4 to inappropriate derepression of cholesterol biosynthesis.
5 its regulator, CrMYC2, play key roles in TIA biosynthesis.
6 substrates and cofactors required for lignin biosynthesis.
7 ion, leukocyte extravasation and cholesterol biosynthesis.
8 ential regulatory role of ACPS in fatty acid biosynthesis.
9 bit MurA, which is involved in peptidoglycan biosynthesis.
10 reserved for re-initiation of peptidoglycan biosynthesis.
11 ucleases, nickel/cobalt uptake and cobalamin biosynthesis.
12 biosynthesis and degradation, and bile acid biosynthesis.
13 s regulating genes associated with flavonoid biosynthesis.
14 6s evolved specifically towards triterpenoid biosynthesis.
15 ECs and VSMCs, potentially facilitating SPM biosynthesis.
16 to block serine hydrolases involved in their biosynthesis.
17 leading to the tissue-specific triterpenoid biosynthesis.
18 e organization of later steps in chlorophyll biosynthesis.
19 ctors and CYPs related to camptothecin (CPT) biosynthesis.
20 transferase involved in heparan sulfate (HS) biosynthesis.
21 rowth, suggesting these compounds inhibit MK biosynthesis.
22 egradation rate, resulting in higher net Cys biosynthesis.
23 lipofuscin) via upregulation of cholesterol biosynthesis.
24 on glucose metabolism to fuel macromolecule biosynthesis.
25 dient can be established independently of GA biosynthesis.
26 for the further elucidation of mycofactocin biosynthesis.
27 lated to fiber elongation and secondary wall biosynthesis.
28 ved aspartate to maintain de novo pyrimidine biosynthesis.
29 ent inhibition of de novo thymidylate (dTMP) biosynthesis.
30 rated that it controls folate and ubiquinone biosynthesis.
31 central metabolite for membrane phospholipid biosynthesis.
32 ed sugar provides carbon skeletons for lipid biosynthesis.
33 me in the guanylate branch of de novo purine biosynthesis.
34 uring the growing season promoted carotenoid biosynthesis.
35 generation and uncouple NADH generation from biosynthesis.
36 o regain completely its ability of aflatoxin biosynthesis.
37 rogenase, an enzyme essential for pyrimidine biosynthesis.
38 nCL proteins are not involved in lanthionine biosynthesis.
39 of translation, fermentation, and amino acid biosynthesis.
40 rix octapeptidase Oct1p and coenzyme Q (CoQ) biosynthesis-a pathway essential for mitochondrial respi
41 vitamin B6, we investigate the regulation of biosynthesis across eudicot and monocot species under he
43 t of various types of plastids on carotenoid biosynthesis and accumulation, and discuss recent advanc
44 ausible regulatory role for NnCYP76B6 in CPT biosynthesis and also establish a valuable repository fo
45 gulation of enzymes involved in both protein biosynthesis and biosynthetic pathways, as well as of se
46 B12 depletion, which suppresses de novo dTMP biosynthesis and causes DNA damage, accounting for the p
49 metabolism, phenylalanine metabolism, lysine biosynthesis and degradation, and bile acid biosynthesis
53 roxylase (CYP11B1), which catalyzes cortisol biosynthesis and is highly homologous to CYP11B2, is unc
56 on metabolism, which is essential for purine biosynthesis and methionine recycling and affects methyl
57 abolism, methionine and S-adenosylmethionine biosynthesis and methionine salvage, and signs of altere
62 related with plant defense systems, hormone biosynthesis and response were particularly enriched.
63 regulated by SA and P. syringae, enhances SA biosynthesis and SA signalling responses; e.g. in respon
64 with actions including regulation of insulin biosynthesis and secretion, promotion of satiety, and pr
65 iR response reveals a modulation in ethylene biosynthesis and signaling, metal ions deficiency respon
66 ross talk between the activation of stilbene biosynthesis and the accumulation of anthocyanins in rip
67 in intermediate steps of terpenoid backbone biosynthesis and those related to secondary transformati
68 al drug by which modulation of neural glycan biosynthesis and thus function can be achieved in vivo.
69 0-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-pha
70 tal pathways as regulation of transcription, biosynthesis and transport of lipids, hormone-mediated s
73 demonstrate the proviral role of PLK1 in HBV biosynthesis and validate PLK1 inhibition a potential an
75 nctional interaction with BasA (sphingolipid biosynthesis) and StoA (apical sterol-rich membrane doma
76 e receptor activity, chemotaxis and cytokine biosynthesis, and angiogenesis and vascular development
78 howed that exogenous pABA is used for folate biosynthesis, and leads to decreased stress and elevated
79 hich stimulates protein, lipid, and ribosome biosynthesis, and mTORC2, which regulates cytoskeleton f
80 n lead to metabolic alterations of terpenoid biosynthesis, and show that these transgenic plants have
81 ne, yqiC, which is required for efficient UQ biosynthesis, and which we have renamed ubiK Using sever
82 inhibited; conversely, glycolysis and lipid biosynthesis are curtailed as sugar levels decrease and
83 th the chemical diversity in natural product biosynthesis as well as the parallels with synthetic org
84 tions, including morphogenesis and cell wall biosynthesis, as well as the activity of the cell integr
85 he observed differences in oligogalactolipid biosynthesis between the two species, we suggest that ex
86 growth and development of fungus, aflatoxin biosynthesis, binding, transport, and signaling were ide
87 , or of purF alone, abolished de novo purine biosynthesis but did not impact bacterial adherence prop
88 ochondrial AAA+ unfoldase ClpX promotes heme biosynthesis by activation of delta-aminolevulinate synt
89 posal that LanCL1 is involved in lanthionine biosynthesis by constructing LanCL1 knock-out mice and m
91 cellular redox balance, producing NADPH for biosynthesis by recycling the two other primary redox ca
92 PDR1 overexpression allowed considerable SL biosynthesis by releasing SL biosynthetic genes from an
93 ate a possible interference of selenoprotein biosynthesis by the antibiotics and elucidate potential
94 allows cells to maintain a stable rate of RA biosynthesis by utilizing a biological circuit generated
95 activity of aminoglycosides on selenoprotein biosynthesis can be severe, but depend on the Se status,
96 iD enzyme, which is implicated in ubiquinone biosynthesis, cannot be isolated in an active holoenzyme
97 Vitamin B12 depletion decreased de novo dTMP biosynthesis capacity by 5-35%, whereas de novo purine s
98 er induce multiple stress responses, reduced biosynthesis, cell viability and growth; and (6) ethanol
99 ng pathways, defense response, glucosinolate biosynthesis, cell wall modification, sugar transport, a
100 f genes related to phenylpropanoid/flavonoid biosynthesis clearly distinguished the behavior of red a
103 nd CTPS, which regulate flux into pyrimidine biosynthesis, correlates with better prognosis in pancre
104 ground absence of cpsA reduces and delays ST biosynthesis decreasing the expression of ST genes.
105 tinal degeneration associated with rhodopsin biosynthesis defects, while frameshift phenotypes were c
106 anscriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochon
107 erial strains in which modified carbohydrate biosynthesis enzymes have been knocked out, we are devel
108 seed proteins, such as storage proteins, oil biosynthesis enzymes, and transcription factors, reside
109 nt analysis identified redundancy in several biosynthesis families, we found that mutation of LjIpt4
112 equencing and qRT-PCR revealed that arginine biosynthesis genes (argR, argB, argC, argG, argH and arg
114 Co-cultured diatoms also downregulated lipid biosynthesis genes and upregulated chitin metabolism gen
115 An analysis of the expression of terpenoid biosynthesis genes confirmed that the MeJA application a
116 This, along with the upregulation of JA-biosynthesis genes in inoculated bark and core tissues f
117 ctive differences, with upregulation of heme biosynthesis genes prominently in RP-mediated DBA and fa
118 eukaryotes shared functionally modern sterol biosynthesis genes with bacteria via horizontal gene tra
120 oinduction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, a
121 ed core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake trans
123 of those are involved in glucosinolate (Gl) biosynthesis, glycosylated sulphur-containing aldoximes
125 d, the regulatory components controlling its biosynthesis have not been definitively determined.
129 We conclude that selection for high rate of biosynthesis implies a selection for aerobic glycolysis
130 s, positively regulates glycolysis and lipid biosynthesis in Arabidopsis thaliana Here, we identify m
136 ese results show the importance of cytokinin biosynthesis in initiating and balancing the requirement
137 hanisms of IgM assembly, we investigated its biosynthesis in living cells and faithfully reconstitute
138 On the basis of genomic analyses, cobalamin biosynthesis in marine systems has been inferred in thre
144 ofiling marked suppression of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading
145 ge of phenomena that accompanies anthocyanin biosynthesis in tomato, including adaptions of the plant
146 in critical yet missing steps of astaxanthin biosynthesis, including ABC transporters, cytochrome P45
147 yb60 can activate pathways beyond monolignol biosynthesis, including those that synthesize the substr
148 trate that PGC1alpha alone can support viral biosynthesis independently of the expression of addition
150 utility of abiraterone acetate, an androgen biosynthesis inhibitor, in the early treatment of metast
152 accumulated higher levels of the chlorophyll biosynthesis intermediate Mg-protoporphyrin IX monomethy
153 lts in pathological accumulation of the heme biosynthesis intermediate protoporphyrin IX (PPIX).
155 any steady-state condition by projecting all biosynthesis into three measurable variables representin
156 veness of these genes confirm that cytokinin biosynthesis is a key target of the common symbiosis pat
157 dependent nuclear de novo thymidylate (dTMP) biosynthesis is a sensitive target of arsenic trioxide (
163 is model, we demonstrate that glucocorticoid biosynthesis is suppressed by proinflammatory cytokines
165 to demonstrate that tellurite inhibits heme biosynthesis, leading to the accumulation of intermediat
166 lycolysis/gluconeogenesis, TCA cycle, starch biosynthesis, lipid metabolism, protein biosynthesis and
167 te its relevant role in extracellular matrix biosynthesis, little is known about the structural requi
168 nd suggest that channeling serine into lipid biosynthesis may not be a cardinal cellular function of
169 of great importance for understanding lignin biosynthesis mechanism and developing lignin based chemi
170 Thermomorphogenesis requires increased auxin biosynthesis, mediated by the bHLH transcription factor
171 JA receptor mutant, coi1, but not in the JA biosynthesis mutant, aos, or upon addition of JA biosynt
172 lipases (DAGLs), enzymes responsible for the biosynthesis of 2-arachidonoylglycerol (2-AG) that activ
173 synthase (QueE) catalyzes a key step in the biosynthesis of 7-deazapurine containing natural product
176 m lycopersicum) for coordinated induction of biosynthesis of anthocyanins, in a tissue- and developme
177 chrysin and apigenin and is responsible for biosynthesis of baicalein and scutellarein in roots and
178 bic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress ge
181 minase BioA catalyzes the second step in the biosynthesis of biotin in Mycobacterium tuberculosis (Mt
183 methylase is a key enzyme intermediating the biosynthesis of ergosterol in fungi, and the target of a
185 ndidate genes associated with caste-specific biosynthesis of fatty acid pheromones in the MG, includi
188 f 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human
191 n inhibiting the first committed step in the biosynthesis of lipid A, the deacetylation of uridyldiph
192 scriptional control of genes involved in the biosynthesis of maize phenolic compounds including gener
195 enzymes responsible for the "assembly line" biosynthesis of many genetically encoded small molecules
196 ication of the CYP450s genes involved in the biosynthesis of MG secretions, we analyzed by means of q
197 spite recent progress, the mechanism for the biosynthesis of most modifications is not fully understo
198 iae can be engineered to perform the complex biosynthesis of multicellular fungi, opening up the poss
199 amolecular C-C cross-linking reaction in the biosynthesis of mycocyclosin, is crucial for the viabili
203 modifications to systematically unravel the biosynthesis of one of the most densely modified and met
206 y carbon substrate for energy production and biosynthesis of phospho-sugars, nucleobases, peptidoglyc
207 E1 (HY1) that encodes the key protein in the biosynthesis of phytochromobilin, a cofactor of photocon
211 verall, these data identify key steps in the biosynthesis of pyrethrins and demonstrate the feasibili
212 from photosynthesis are used to support the biosynthesis of secondary metabolites, while the compara
217 cus on the [4 + 2] cycloaddition step in the biosynthesis of spinosyn A, a reaction catalyzed by SpnF
218 d contusion injury in adult female mice, the biosynthesis of SPM is not induced in the lesion site up
219 51) is a cytochrome P450 enzyme required for biosynthesis of sterols in eukaryotic cells and is the m
220 the crenearchaeon Sulfolobus acidocaldarius, biosynthesis of the archaellum is regulated by regulator
221 nthase (LipA) catalyzes the last step in the biosynthesis of the lipoyl cofactor, which is the attach
222 activity in Arabidopsis thaliana stimulates biosynthesis of the major phospholipid phosphatidylcholi
223 I polyketide synthase (PKS) involved in the biosynthesis of the marginolactone azalomycin F in mangr
225 The polyketide synthases responsible for the biosynthesis of the polyether antibiotics nanchangmycin
226 rSAM methyltransferase TbtI involved in the biosynthesis of the potent thiopeptide antibiotic thiomu
228 atible mild aqueous chemistries, synchronous biosynthesis of the tagged metabolite and its subsequent
230 new developments in the understanding of the biosynthesis of these molecules where dual enzymatic act
231 ne synthases, enabling future studies of the biosynthesis of this important bioactive natural product
232 to formulate a biosynthetic pathway for the biosynthesis of triptolide, a diterpenoid with pharmaceu
233 acetyltransferase enzyme, PglD, involved in biosynthesis of UDP-diNAcBac in Campylobacter jejuni.
236 either ketosynthase domains from polyketide biosynthesis or adenylation domains from nonribosomal pe
237 combination therapy primarily targets lipid biosynthesis or effects bioactive lipids that activate s
238 unctional plastids due to defects in pigment biosynthesis or translation are known to repress photosy
239 pacts glycan biosynthesis through Hexosamine Biosynthesis Pathway (HBP), as well as cellular redox ho
240 es and identified 55% with upregulated mtDNA biosynthesis pathway expression compared with normal hem
241 monstrated the presence of an intact de novo biosynthesis pathway for NAD(+) from tryptophan via QA,
243 s Cryptococcus neoformans Because the purine biosynthesis pathway is essential for many metabolic pro
245 Altogether, we demonstrate that fatty acid biosynthesis pathway manipulation can help overcome the
246 PP) is a rare inherited disorder of the heme biosynthesis pathway resulting in the accumulation of pr
247 isms that exist at every step of the protein biosynthesis pathway, such as alternative splicing and p
254 lated genes involved in reproductive hormone biosynthesis pathways and provide a framework for future
257 lycans, to study processes such as cell wall biosynthesis, polysaccharide deposition, protein-carbohy
261 es are noncoding and bind Fe(2+) to regulate biosynthesis rates of the encoded, iron homeostatic prot
262 (CAD) catalyzes the final step in monolignol biosynthesis, reducing sinapaldehyde, coniferaldehyde, a
263 erized genes involved in xylan and cellulose biosynthesis, regulators of xylem vessel and fiber diffe
265 ctrometry analysis, we demonstrated that GAC biosynthesis requires two distinct undecaprenol-linked G
266 transcription factor SREBP and thus of lipid biosynthesis, resulted in significantly retarded CNS mye
267 etabolism pathways including phenylpropanoid biosynthesis, sesquiterpenoid and triterpenoid biosynthe
269 rate-limiting step in 27-hydroxycholesterol biosynthesis, significantly reduces metastasis in releva
270 g organelle-specific regulation of jasmonate biosynthesis; simultaneous induction of synthesis and br
272 l strategy of peptide-nucleotide antibiotics biosynthesis that may help control production levels and
273 ic apparatus and one for phosphatidylcholine biosynthesis, that were not known to be essential for ph
275 first and rate-limiting step in sphingolipid biosynthesis: the condensation of serine and palmitoyl-C
276 spite progress in deciphering plant volatile biosynthesis, their release from the cell has been poorl
277 ces a cascade of events which impacts glycan biosynthesis through Hexosamine Biosynthesis Pathway (HB
278 gical processes ranging from natural product biosynthesis through to the mammalian visual cycle.
279 with acyl-ACP as a mechanism for fatty acid biosynthesis to coordinate the expression, Fe-S cofactor
280 s and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycyt
281 anding the regulatory network linking lignin biosynthesis to plant growth and defense will help ligni
282 diated by the reprogramming of peptidoglycan biosynthesis to use precursors terminating in D-Ala-D-La
283 tRNA(Cys) synthesis (tRNA-dependent cysteine biosynthesis) to prevent challenge of translational fide
284 Mutations in KDSR cause defective ceramide biosynthesis, underscoring the importance of ceramide an
285 rotein biosynthesis while not inhibiting DNA biosynthesis using (3)H-radiolabeled precursors in macro
286 electively controlling their respective core biosynthesis using CRISPR interference and antibiotics,
288 ing the final enzymatic step in solanapyrone biosynthesis was specifically associated with developmen
289 denylation domains from nonribosomal peptide biosynthesis was used to assess biosynthetic domain comp
290 lly, transcription factors regulating lignin biosynthesis were also up-regulated in resistant plants
291 pts encoding the key enzymes for secoiridoid biosynthesis were examined in different S. mussotii tiss
295 es a homeostatic mechanism that favors lipid biosynthesis when intracellular sugar levels are elevate
296 ylase (NnCYP76B6) an important enzyme in CPT biosynthesis which specifically shunts geraniol into the
299 ycosyltransferase involved in xylan backbone biosynthesis, while UPEX1 encodes a family GT31 glycosyl
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