ライフサイエンスコーパス: biotransformation

1 or enhanced functions such as micropollutant biotransformation.

2 SRTs promote higher rates of micropollutant biotransformation.

3 grase and a dioxygenase were involved in BAC biotransformation.

4 ng the roles played by AOA in micropollutant biotransformation.

5 are considerably lower than expected due to biotransformation.

6 CFs are sensitive to even very slow rates of biotransformation.

7 sorption sites and excellent conditions for biotransformation.

8 ic removal processes, primarily sorption and biotransformation.

9 ependent sorption but rather of pH-dependent biotransformation.

10 e systems involved in their biosynthesis and biotransformation.

11 ly related to oxidative-stress tolerance and biotransformation.

12 s of the AD process are also involved in OMP biotransformation.

13 otope analysis (Cl- and C-CSIA) to assess CP biotransformation.

14 alpha-methyl-L-tyrosine did not inhibit the biotransformation.

15 ed in the body but is susceptible to further biotransformation.

16 it translocation of TiO2 in cucumber without biotransformation.

17 enome, none have been shown to catalyze this biotransformation.

18 -hydroxyl group of PGE2, which leads to PGE2 biotransformation.

19 II to produce stable catalysts for efficient biotransformation.

20 omatography revealed no evidence of Mn-PyC3A biotransformation.

21 etoxification of co-occurring substances via biotransformation.

22 stem-specific and mix up phase transfer with biotransformation.

23 ic processes such as uptake, elimination and biotransformation.

24 inement, we believe, multiple micro-organism biotransformations.

25 play significant roles in metal and mineral biotransformations [15-22].

26 rine) of TCE showed strong agreement between biotransformations (3.4 to 3.8) and cobalamin (3.9), but

27 vaccination, triiodothyronine (T3), hepatic biotransformation (7-ethoxyresorufin-O-deethylase activi

28 y approach to quantify industrially relevant biotransformations accurately, focusing on nitrile metab

29 a generally valid parameter for quantifying biotransformation across systems.

30 We conclude that intestinal biotransformation and bioavailability in water can modul

31 specially designed test protocols addressing biotransformation and dietary uptake.

32 Toxicokinetics, i.e. biotransformation and distribution, explain the higher t

33 bolomic approach was used to investigate the biotransformation and effects of exposure to sublethal c

34 or C(U) can be attributed to the absorption, biotransformation and elimination processes within the h

35 s that focus on the mechanisms of pyrethroid biotransformation and endocrine toxicity to fishes acros

36 diPAP at 100 mg/kg by oral gavage to monitor biotransformation and extent of protein binding within t

37 ross species and compounds needs to consider biotransformation and may be more challenging than previ

38 elated to the monoterpene-limonene secondary biotransformation and menthofuran has been identified as

39 iorefineries based on simultaneous enzymatic biotransformation and microbial fermentation could addre

40 sed to influence the rates of micropollutant biotransformation and nutrient removal.

41 The combination of biotransformation and photolysis resulted in overall tra

42 sludge treatment can mainly be attributed to biotransformation and sorption to sludge flocs, whereby

43 e resulted in increased CYP2E1-mediated APAP biotransformation and susceptibility to AILI.

44 However, biological processes, biotransformation and, likely, efflux can strongly affec

45 ormation rates, (iii) BCFs predicted without biotransformation, and (iv) BCFs predicted by a well-kno

46 surface capping agents influenced Ag uptake, biotransformation, and/or excretion.

47 The parallel cycles of organoarsenical biotransformations are less well characterized.

48 Microbial biotransformations are major contributors to the arsenic

49 Redox biotransformations are potentially attractive, but they

50 xture (NA sodium salt; TCI Chemicals), batch biotransformation assays were conducted with individual

51 s a system-independent descriptor of aerobic biotransformation at the water-sediment interface that i

52 d application of biosensor for monitoring of biotransformation based on Baeyer-Villiger oxidation.

53 ode was developed and used for monitoring of biotransformation based on Baeyer-Villiger oxidation.

54 f prochloraz is not only caused by inhibited biotransformation but even more by increased azoxystrobi

55 ates were proatherogenic and whether arsenic biotransformation by As3MT was required for arsenic-enha

56 r reduces its bioavailability, thus limiting biotransformation by bacteria in sediments.

57 nal groups, we systematically explored amine biotransformation by conducting experiments with 19 comp

58 beta-TBECH isomer were subjected to in vitro biotransformation by human liver microsomes (HLM).

59 Selenium biotransformation by lactic acid bacteria during the pre

60 e of polycyclic aromatic hydrocarbons (PAHs) biotransformation by microorganisms and plants.

61 fermentation, due to physical binding and/or biotransformation by yeast.

62 Elucidation of organoarsenical biotransformations by S. putrefaciens provides a holisti

63 Alternatively, biotransformation can be measured by in vitro methods.

64 Because biotransformation can reduce chemical accumulation in fi

65 However, their biotransformation capability (bioactivation/detoxificati

66 cal approach, we aimed to assess the hepatic biotransformation capacities of Antarctic fish species b

67 t that nutritional status can influence drug biotransformation capacity via endogenous phospholipid s

68 The capacity for biotransformations catalysed by lactobacilli is an untap

69 n regulating a myriad of processes including biotransformation, chemical transport, energy metabolism

70 Both plant uptake and biotransformation contributed to the observed decline in

71 Thus, biotransformation did not dominate toxicokinetics and on

72 CPB model parameters describe biotransformation during and after ammonia oxidation for

73 ted to toxicokinetics (uptake, distribution, biotransformation, elimination) or toxicodynamics (inter

74 idental release through chain shortening and biotransformation, emphasizing the importance of compoun

75 neuronal development) and GSTA4 (a phase II biotransformation enzyme).

76 For linear alkyl chain IOC analogues, biotransformation enzymes appeared to act directly on th

77 Biotransformation enzymes such as Glutathione S-Transfer

78 ed the thermal sensitivity of the xenobiotic biotransformation enzymes.

79 dodecanes (HBCDs) were subjected to in vitro biotransformation experiments with rat and trout liver S

80 ul for developing other new types of one-pot biotransformations for chemical synthesis.

81 significantly greater than 100%, suggesting biotransformation from higher brominated congeners.

82 ain covalently bound to the Ru ion showing a biotransformation from Ru(III)N2Cl4 to Ru(III)Clx(N/O)6-

83 pha, induced CYP3A4 (up to 4-fold) and other biotransformation genes in hepatocytes with similar sele

84 half-life (HLT) and the whole body, primary biotransformation half-life (HLB) are key parameters det

85 In contrast, aerobic biotransformation half-lives should be easier to extract

86 s step accounts for much of the reported OMP biotransformation in AD.

87 SAL biotransformation in soil microcosms yielded the same pr

88 re very efficiently absorbed after microbial biotransformation in the colon.

89 chemical C-H oxidation reactions complement biotransformation in the synthesis of drug metabolites?

90 To assess the contribution of biotransformation in this biomat to the overall attenuat

91 conversion of test HBCD diastereomers during biotransformation in trout.

92 those reported to date, are involved in BAC biotransformation in various habitats.

93 e report a label-free screening platform for biotransformations in live colonies using desorption ele

94 Here we describe organoarsenical biotransformations in the environmental microbe Shewanel

95 ore detailed and accurate information on ADC biotransformations in vivo, enabling analysis of low-dos

96 conditions affecting the efficiency (96%) of biotransformation including substrate concentration, inc

97 ately 100 kDa) fragments contain the key ADC biotransformation information, such as drug-to-antibody

98 Biotransformation interference between two atropisomers

99 Three novel biotransformation intermediates were identified for PFOA

100 easure and model the contribution of uptake, biotransformation, internal distribution, and eliminatio

101 Biotransformation is a key process that can greatly infl

102 e possible or appropriate, the contrast with biotransformation is drawn.

103 The significantly slower PFOSAmS biotransformation is hypothesized to be due to its stron

104 The susceptibility of 3-7 to fungal biotransformation is indicative of an unexpected potenti

105 We found that biotransformation is pH-dependent and correlates qualita

106 suggest that sewer biofilms can enhance the biotransformation kinetics of most selected compounds.

107 chemical reactions and genes involved in the biotransformation mechanism of AuCl4 into gold nanoparti

108 ctral databases with prediction of mammalian biotransformation metabolites, wrapper functions for in

109 of these therapeutics may be susceptible to biotransformation, most notably in vivo proteolytic trun

110 e chain as well as cyclicity, on the aerobic biotransformation of 10 model naphthenic acids (NAs) was

111 oxylation is the predominant step during the biotransformation of 1H-benzotriazole.

112 Biotransformation of 6:2 FTOH [F(CF2)6CH2CH2OH] by the w

113 Results from this study showed that the biotransformation of 8:2 FTOH yielded 26.1 (+/-3.0)% bin

114 L to proteins might be a primary fate in the biotransformation of 8:2 FTOH.

115 mine the protein binding associated with the biotransformation of 8:2 FTOH.

116 IMR-90 demonstrated a detoxifying metabolic biotransformation of [6]-shogaol.

117 The in vivo biotransformation of a novel fusion protein tetranectin/

118 conditions to study the bioaccessibility and biotransformation of anthocyanins.

119 .5-129 mug/L), our findings reveal extensive biotransformation of atmospheric As and the enrichment o

120 tly, an array of eight genes involved in the biotransformation of benzalkonium chlorides (BACs)-an ac

121 mulate certain populations and may assist in biotransformation of bioactive components found in plant

122 At the beginning of the biotransformation of BP-4, a benzhydrol analogue was for

123 9 define simulation tests aimed at assessing biotransformation of chemicals in water-sediment systems

124 The toxicity, bioaccumulation, and biotransformation of citrate and polyvinylpyrrolidone (P

125 ding CYP2C19, the hepatic enzyme involved in biotransformation of clopidogrel to its active metabolit

126 The present work studied biotransformation of DNAN in soil and sludge microcosms

127 standing of the pharmacokinetics and in vivo biotransformation of dulaglutide was obtained.

128 chored cytochrome P450 enzyme engaged in the biotransformation of endo- and xenobiotics, including >5

129 The biotransformation of fluorotelomer-based compounds such

130 first study to link the exposure and in vivo biotransformation of fluorotelomer-based compounds to co

131 re intermediate compounds that form from the biotransformation of fluorotelomer-based compounds.

132 tween consumer microbiota configurations and biotransformation of food ingredients, should have a num

133 lome directly derived from the digestion and biotransformation of foods and their constituents.

134 The biotransformation of FTOHs and PAPs yield intermediate m

135 The biotransformation of FtTAoS occurred in live microcosms

136 Since disposition and biotransformation of GalNAc-conjugated oligonucleotides

137 otope fractionation was investigated for the biotransformation of gamma- and alpha- hexachlorocyclohe

138 Biotransformation of gamma-oxoacid 5, in the culture of

139 Furthermore, the biotransformation of ginsenosides was the major reaction

140 beta-Glucuronidase is the key enzyme in the biotransformation of GL to GAMG, but its activities need

141 These data highlight that maternal biotransformation of iAs and neonatal levels of iAs and

142 role in the arsenic biogeochemical cycle by biotransformation of inorganic arsenic into organic arse

143 ethylarsenicals either result from microbial biotransformation of inorganic arsenic or are introduced

144 Biotransformation of IPAs was the main transformation pr

145 In this study, the biotransformation of irgarol and terbutryn was examined

146 ights into an isolated molecular pathway for biotransformation of iron (oxyhydr)oxide nanomaterials,

147 egrated approach to understand the in planta biotransformation of KAuCl4 into AuNPs.

148 uptake and export are important steps in the biotransformation of mercury (Hg) by microorganisms.

149 The biotransformation of MIA and RAN only occurred when ammo

150 P450 family in humans and is responsible for biotransformation of more than 50% of drugs metabolized

151 , we investigated the influence of pH on the biotransformation of MPs with cationic-neutral speciatio

152 by revealing an enzymatic mechanism for the biotransformation of multiple nitrosamines, their relati

153 In our system, NCIB 9816 was used for biotransformation of naphthalene (a model substrate) int

154 ) to provide a thorough understanding of the biotransformation of novel protein therapeutics.

155 (CSIA) is a promising approach for tracking biotransformation of organic pollutants, but isotope fra

156 Biotransformation of PCBs 91 and 136 also generated 4,5-

157 The biotransformation of perfluorooctane sulfonamide quatern

158 The biotransformation of perfluorooctaneamido quaternary amm

159 ctyl sulfonate (PFOS) through inhalation and biotransformation of PFAS precursors in air were estimat

160 s that are not routinely measured during the biotransformation of PFASs may accumulate.

161 (PFOS) at a yield of 0.3 mol % confirmed the biotransformation of PFOSAmS.

162 exchanging pool within the nematodes or that biotransformation of phenanthrene took place.

163 We use the biosensors to improve the biotransformation of pregnenolone to progesterone in yea

164 Biotransformation of pure polyphenols resulted in differ

165 monene-1,2-diol with the already established biotransformation of R-(+)-limonene into alpha-terpineol

166 In this study, uptake, elimination, and biotransformation of radiolabeled EE2 ((14)C-EE2) by the

167 Further, we explored periphyton biotransformation of Se species using X-ray absorption n

168 Thereby, the biotransformation of selenate in pakchoi was similar to

169 In this study, biotransformation of seven frequently used azole fungici

170 The colonic breakdown and human biotransformation of small molecules present in food can

171 The biotransformation of some micropollutants has previously

172 Thus the study highlights the biotransformation of stevioside present in stevia leaves

173 Our results indicate potential hepatic biotransformation of TBECH via cyctochrome P450-catalyze

174 by readily available l-histidine followed by biotransformation of the aldol adduct by an alcohol dehy

175 The rate and extent of biotransformation of the five compounds and efficiency o

176 The biotransformation of the five compounds took place via f

177 ransformation strongly affected the rates of biotransformation of the hydroxyl groups, which in some

178 No further biotransformation of the metabolites was found as conseq

179 oduce foods that support efficient microbial biotransformation of their ingredients into metabolic pr

180 Biotransformation of these polyphenols occurred in the c

181 scription factor governing the transport and biotransformation of various drugs and other chemicals.

182 lation of AMPK, suggesting a requirement for biotransformation of VPA.

183 the potential to increase access to, and the biotransformation of, contaminant mass within the subsur

184 reoselectively formed as the only product of biotransformations of 3-methyl-4-oxooctanoic acid (5) ca

185 nfluence of physical-chemical properties and biotransformation on bioaccumulation behavior of these c

186 The aerobic biotransformation over 180 days of two cationic quaterna

187 expressions of a battery of genes related to biotransformation, oxidative stress, and endocrine disru

188 ing a biomass-corrected, generalized aerobic biotransformation parameter (k'bio).

189 S9 assay is recommended to further elucidate biotransformation pathways for IOCs in fish.

190 The aerobic biotransformation pathways of 4:2, 6:2, and 8:2 fluorote

191 inhibition; fermentative, nonexoelectrogenic biotransformation pathways of the five compounds were no

192 ary biochemical mechanisms to drive 6:2 FTOH biotransformation pathways toward more degradable polyfl

193 Their tentative structures and possible biotransformation pathways were proposed.

194 hains was determined in soil microcosms, and biotransformation pathways were proposed.

195 N and SAL exhibited different inhibition and biotransformation patterns at each redox condition teste

196 es (PHHs) and HepaRG cells, whilst retaining biotransformation potential and in vivo-like ultrastruct

197 In this study, the inhibition and biotransformation potential of the most commonly used IP

198 with low relative concentrations of measured biotransformation precursors (FTCAs).

199 This work aimed to develop a whole-cell biotransformation process for the production of alpha-ke

200 The biotransformation process of (-)-PCB 136 was significant

201 xide and N-oxide functionalities is a common biotransformation process.

202 is known about the bioaccumulation dynamics, biotransformation processes, or subsequent toxicity to c

203 -bound As, or the indirect stimulation of As biotransformation processes, which are presently not con

204 ic rates describing uptake, elimination, and biotransformation processes.

205 enormous potential in bioremediation and for biotransformations producing bulk and fine chemicals, an

206 The biotransformation product of MON was also detected in th

207 A new primary biotransformation product of MON was identified in soil

208 The main biotransformation product, ATO, was degradable only in a

209 gna were conducted to quantitatively analyze biotransformation products (BTPs) of organic micropollut

210 xiconazole, prochloraz, and their respective biotransformation products (BTPs) were studied to gain i

211 oncentrations of azoxystrobin and associated biotransformation products (BTPs).

212 Globally, our results suggest that DNAN biotransformation products can be irreversibly bound to

213 Two biotransformation products corresponding to singly and d

214 Although polar biotransformation products have been implicated as causa

215 Incorporation of DNAN biotransformation products into soil as humus-bound mate

216 evaluated to maximize incorporation of DNAN biotransformation products into the nonextractable soil

217 Multiple, new primary IPA biotransformation products were observed on LC/MS, and t

218 on rates of parent antiviral drugs and their biotransformation products were similar, indicating that

219 Catechol and phenol, which were persistent biotransformation products, inhibited exoelectrogenesis

220 nts, drugs, and antibiotics as well as their biotransformation products, through its expansion with o

221 at a high concentration, as opposed to their biotransformation products, were responsible for the obs

222 nzyl alcohol were identified as potent aroma biotransformation products.

223 um to produce bioactive ginsenoside enriched biotransformation products.

224 h different combinations of partitioning and biotransformation properties at various rates of lipid l

225 ke viridicatumtoxins are resistant to fungal biotransformation, providing chemical insights that coul

226 es could be explained by their effect on the biotransformation rate but that this effect could only p

227 ilm (500 mum) presented the highest specific biotransformation rate constants (kbio, L g(-1) d(-1)) f

228 Biotransformation rate constants corrected for sorption

229 ions, we demonstrated that the estimation of biotransformation rate constants in biofilm can be signi

230 n to experimental results allowed estimating biotransformation rate constants in sewer biofilms, whic

231 Our aim was to find a way to extract biotransformation rate constants that are universally va

232 icant overestimation (up to 385%) of aerobic biotransformation rate constants.

233 ulation assessment and to develop an in vivo biotransformation rate database for QSAR development and

234 for QSAR development and in vitro to in vivo biotransformation rate extrapolation.

235 The biotransformation rate in trout was slower than in rat.

236 ransformed within 7-day batch runs and their biotransformation rate increased with increasing initial

237 anism of synergy is the azole decreasing the biotransformation rate of alpha-cypermethrin and validat

238 ical to diminish lag times and increased the biotransformation rate of NTO in nearly all cases indica

239 roduction, and was then used to maximize the biotransformation rate of the system.

240 of the mixture of the five compounds, their biotransformation rate ranged from 0.85 to 2.34 mM/d.

241 upstream pheA1 gene was subcloned, a similar biotransformation rate was attained without IPTG, confir

242 s, the model incorporating measured in vitro biotransformation rates and assuming no correction for p

243 Greater knowledge of biotransformation rates for ionizable organic compounds

244 In this study, biotransformation rates for nine fragrance ingredients w

245 monstrates the value of integrating measured biotransformation rates for prediction of chemical bioac

246 ulation in fish, models using QSAR-estimated biotransformation rates have been developed.

247 line HepaRG shared many similarities, while biotransformation rates in cell lines widely used for es

248 In microcosm experiments, biotransformation rates increased for metoprolol and pro

249 Biotransformation rates increased for trimethoprim and s

250 Adequately addressing biotransformation rates of CNTs is key toward a better u

251 BAC biotransformation rates of the enriched microbial commun

252 ed to illustrate the influence of growth and biotransformation rates on the BMF.

253 BCFs, (ii) BCFs predicted using QSAR-derived biotransformation rates, (iii) BCFs predicted without bi

254 ointestinal biotransformation rates, somatic biotransformation rates, bioconcentration factors (BCF),

255 ucted to derive the in vivo gastrointestinal biotransformation rates, somatic biotransformation rates

256 showed that the inhibition of CYP-catalyzed biotransformation reactions indeed played a role for the

257 es in kinetics of different antiviral drugs, biotransformation reactions mainly involved oxidation of

258 used to provide the necessary oxygen for the biotransformation reactions via photosynthesis.

259 The same MIA and RAN biotransformation reactions were carried out by both the

260 Known biotransformation reactions were used to link potential

261 xcept for prochloraz, which showed extensive biotransformation reactions with 18 BTPs detected that w

262 ted in a comprehensive view on initial amine biotransformation reactions.

263 Biotransformation result showed that crosslinked SCRII g

264 Biotransformation significantly influenced the internal

265 We performed batch biotransformation, sorption control, and abiotic control

266 and refine pathway prediction, comprehensive biotransformation studies for compounds exhibiting perti

267 unts for 10-90% of the measured methanogenic biotransformation, suggesting that other active enzymes

268 Besides biotransformation (sulfamethoxazole), poor membrane perm

269 Whereas beta-HBCD undergoes rapid biotransformation (t0.5 = 6.4 and 38.1 min in rat and tr

270 results suggest that ArsH catalyzes a novel biotransformation that confers resistance to environment

271 We also provide novel evidence of the biotransformations that can affect the plastics themselv

272 cteria are capable of performing a number of biotransformations that may activate or deactivate xenob

273 After 60 min stereoselective biotransformation, the EFs of both 4-OH-PCB 95 and 5-OH-

274 For substances subject to intestinal biotransformation, the same correlation did not apply.

275 In combination with whole-cell biotransformations, these stereocomplementary biocatalys

276 Herein, we compared biotransformations to classical and new chemical C-H oxi

277 nocatalytic aldol reaction with a subsequent biotransformation toward a "one-pot-like" process for th

278 on of sclerotiorin color was accomplished by biotransformation using Beauveria bassiana generating a

279 nctional continuum starting with single-step biotransformations using isolated enzymes or microbial s

280 e invention, development and optimisation of biotransformations utilising isolated enzymes.

281 factors, relative to Aroclor 1254, suggested biotransformation (via cytochrome P450) and bioaccumulat

282 that the citrus peel extract obtained after biotransformation was a good source of hesperitin and na

283 Biotransformation was further evidenced by the degradati

284 knockout mice to test whether As3MT-mediated biotransformation was required for the proatherogenic ef

285 Intestinal biotransformation was the dominant metabolic pathway for

286 Somatic biotransformation was the dominant pathway for most chem

287 Biotransformation was the dominant removal mechanism in

288 ia rat cytochrome P450 2B1 (CYP2B1) mediated biotransformation were investigated in vitro.

289 Similar patterns of BP2 and BPS biotransformation were observed among zebrafish models (

290 No significant in vitro and in vivo biotransformation were observed, underlining their remar

291 n rules for intestinal degradation and human biotransformation were systematically applied to chemica

292 ar, the major bioproducts from each of these biotransformations were found at different oxidation lev

293 dance of labeled taxa suggest that BP and BZ biotransformations were performed by microorganisms with

294 rements of in vivo activity using whole-cell biotransformations, where two Escherichia coli strains e

295 hesized to be due to the absence of in vitro biotransformation which will result in bioactivation of

296 lutants during activated sludge treatment is biotransformation, which often leads to the formation of

297 ver, the mechanisms and factors behind these biotransformations, which are essential for elucidating

298 ate flavocoenzymes, FMN and FAD, by in vitro biotransformation with better than 90% yield.

299 ze Pickering emulsions and catalyze biphasic biotransformation with superior enzymatic stability and

300 near complete mass recovery of FtTAoS after biotransformation, with 10% (mol/mol) of the amended FtT