ライフサイエンスコーパス: bipotential

1 early-gestation (6-8 wk) human placentas are bipotential, a phenotype that is lost with increasing ge

2 2 activation results in the proliferation of bipotential adipocyte precursors (APs) and their subsequ

3 We have shown that EpCAM(+) oval cells are bipotential adult hepatic epithelial progenitors.

4 esistant Nkx3-1-expressing cells, CARNs) are bipotential and can self-renew in vivo, and single-cell

5 which normally become parapineal cells, are bipotential and require Fgf8a to maintain parapineal ide

6 pos):Lin(neg):THY1(neg):DDR2(neg) cells were bipotential as the majority expressed collagen 1 alpha-1

7 utilized three cell models: the uncommitted bipotential C2C12 cells, the pre-osteoblastic cell line

8 Implantation of these human bipotential CD34(+) progenitors into nonobese diabetic/s

9 specify hypochord from a notochord/hypochord bipotential cell population.

10 mesoderm, given that this pathway acts as a bipotential cell-fate switch on equipotent progenitor po

11 These bipotential cells likely serve as a reservoir for the ep

12 Y initiates development of a testis from the bipotential cells of the early gonad.

13 Immature thymocytes are bipotential cells that are signalled during positive sel

14 ic rat spinal cord can give rise in vitro to bipotential cells that express defining characteristics

15 within a population of notochord/floor plate bipotential cells through negative transcriptional regul

16 ions also suggest a novel mechanism by which bipotential cells throughout development can determine t

17 on of C/EBPalpha alone in stably transfected bipotential cells triggers neutrophilic differentiation,

18 Double-positive thymocytes are short-lived bipotential cells whose developmental fate is determined

19 HPCs are known to be bipotential cells, capable of forming both hepatocytes a

20 x2/Cbfa1-expressing preosteoblasts are still bipotential cells.

21 Here we used bipotential CG-4 cells to examine the impact of agnoprot

22 We found that normal tip cells are bipotential, contributing to both tips and trunks.

23 del system to identify factors that regulate bipotential differentiation in the liver.

24 embryos and demonstrated their capacity for bipotential differentiation in vivo.

25 The bipotential differentiation of liver progenitor cells un

26 Both domains are initially bipotential, each capable of giving rise to either neuro

27 d RapGEF2(-/-) yolk sacs indicating that the bipotential early progenitors were in fact generated in

28 Our results indicate that bipotential endothelial/erythroid precursor cells do ind

29 hroleukemic pathology with transformation of bipotential erythro-megakaryocytic cells.

30 Finally, we demonstrate that bipotential erythroid-megakaryocyte progenitor and CD150

31 We define a bipotential erythroid-megakaryocyte progenitor populatio

32 ropose that FOG-1 may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell.

33 or FOG in megakaryocyte development from the bipotential erythroid/megakaryocytic progenitor.

34 ncipally regulates ductal differentiation of bipotential exocrine progenitors.

35 epatocytes can function as or be a source of bipotential facultative hepatic stem cells (hepatoblasts

36 The liver contains a population of small bipotential facultative progenitor cells that reconstitu

37 a temporal window during which PGCs retain a bipotential fate.

38 Cs that are committed to spermatogenesis and bipotential female PGCs.

39 The K562 leukemia cell line is bipotential for erythroid and megakaryoblastic different

40 The bipotential Ganglion Mother Cells, or GMCs, in the Droso

41 e expression of Sry in the undifferentiated, bipotential genital ridges of mammalian XY fetuses initi

42 hways that are initially co-expressed in the bipotential gonad and subsequently become male- or femal

43 The bipotential gonad expresses genes associated with both t

44 control of female sex differentiation from a bipotential gonad in mammals is poorly understood.

45 We suggest that migration of cells into the bipotential gonad may have a critical role in initiating

46 pression of the Y-linked gene Sry shifts the bipotential gonad toward a testicular fate by upregulati

47 The cells in the early bipotential gonad undergo de novo organization to form t

48 ce between patterns (male and female) in the bipotential gonad.

49 ertoli cells shortly after commitment of the bipotential gonads to testicular differentiation, causes

50 tis rather than ovary development from early bipotential gonads.

51 ch to promote granulocyte differentiation in bipotential granulocyte-macrophage progenitors (GMPs), i

52 ipotential progenitors to differentiate into bipotential granulocyte/macrophage progenitors and their

53 definitive erythroid (CFU-E), mast cell and bipotential granulocyte/macrophage progenitors in the yo

54 d that exhibited granulocytic, monocytic, or bipotential (granulocytic and monocytic) differentiation

55 ineage-depleted mouse bone marrow cells, and bipotential (granulocytic/monocytic) human acute myeloid

56 sion and function in human primary cells and bipotential (granulocytic/monocytic) myeloid cell lines.

57 human embryonic stem cells to define a novel bipotential hematopoietic progenitor that gives rise to

58 ngiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs).

59 These characteristics clearly identify bipotential hepatic progenitor cells in the developing h

60 FGF4 enrich the embryonic liver cultures for bipotential hepatic progenitors.

61 exhibit a similar transcriptomic profile to bipotential hepatobiliary progenitors, the latter do not

62 rs known to affect lineage commitment in the bipotential hepatoblast progenitor cell (BHPC) populatio

63 Impaired Notch signaling in bipotential hepatoblast progenitor cells (BHPCs) dose-de

64 Thus, HBC-3 cells behave in culture as bipotential hepatoblasts and provide a model system to i

65 rovide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate th

66 The negative effect was observed in bipotential human cells (K562 and human erythroleukemia

67 These cells are believed to be bipotential, i.e., able to differentiate into hepatocyte

68 we discovered that Ngn3(+) progenitors were bipotential in vivo and in vitro.

69 CD34+ BM precursors can generate a post-CFU bipotential intermediate in the presence of c-kit ligand

70 vealed that one subset of multipotential and bipotential intermediate progenitors did not increase af

71 multipotential progenitor cells, as well as bipotential intermediates, manifest mixed-lineage patter

72 n can alter protein-protein interactions and bipotential lineage decisions.

73 It is widely believed that DRs contain bipotential liver progenitor cells (LPCs) that serve as

74 rived without carcinogens or mutagens, these bipotential LPC lines provide novel tools for models of

75 ber is via generation and stimulation of the bipotential megakaryocyte precursors.

76 rming capacity of the bone marrow, including bipotential megakaryocyte-erythroid colony-forming capac

77 ony-forming cells (Meg-CFCs) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs).

78 eoblastogenesis and inhibits adipogenesis of bipotential mesenchymal precursors.

79 ds and ECM proteins in the fate decisions of bipotential mouse embryonic liver (BMEL) progenitor cell

80 lar markers in mutants, our data support the bipotential nature of the progenitor cells for paraxial

81 ry and sufficient to specify mesoderm from a bipotential neural/mesodermal precursor.

82 ueled by a posteriorly located population of bipotential neuro-mesodermal progenitor cells.

83 Bipotential neuromesoderm progenitors (NMPs) ensure axia

84 dy axis formation depends on a population of bipotential neuromesodermal cells along the posterior wa

85 ls increases oligodendrocyte generation from bipotential oligodendrocyte-type-2 astrocyte/oligodendro

86 The results support the view that the bipotential optic neuroepithelium is characterized by ov

87 positional cues provided by FGF organize the bipotential optic vesicle into specific neural retina an

88 e rise to clonal oval cell proliferation and bipotential organoids, but rarely produce hepatocytes in

89 The appearance of bipotential oval cells in chronic liver injury suggests

90 to specify the identity of V2b neurons from bipotential p2 progenitors.

91 After the bipotential period, SOX9 was abruptly down-regulated at

92 The bipotential precursor cell population for pancreas and l

93 chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicula

94 tes in the fetal gonad with specification of bipotential precursor cells into male Sertoli cells or f

95 w provided evidence for the presence of this bipotential precursor in vivo, the precise mechanism for

96 s a myeloid differentiation switch acting on bipotential precursors and directing them to mature to g

97 oreover, induced expression of C/EBPalpha in bipotential precursors blocks their monocytic differenti

98 as been postulated to induce hemangioblasts, bipotential precursors for blood and endothelial cells.

99 ome of Notch signaling is differentiation of bipotential precursors into one cell type versus another

100 e specification of haemangioblasts, putative bipotential precursors of blood and endothelium.

101 the erythroid lineage limits development of bipotential precursors toward an endothelial fate.

102 CD9(hi)endoglin(lo) fraction, which contains bipotential precursors with characteristics of increased

103 expression to HSCs and endothelium and their bipotential precursors, the haemangioblast.

104 are mast cell, monocyte, and mast/monocyte (bipotential) precursors.

105 and erythroid lineages derive from a common bipotential progenitor and share many transcription fact

106 or for these two lineages, the presence of a bipotential progenitor cell has yet to be demonstrated i

107 ive enterocytes suggested reprogramming of a bipotential progenitor cell.

108 alignancy in this model and may develop from bipotential progenitor cells at an early stage of prosta

109 been any single gene that can define mammary bipotential progenitor cells, and as such it has not bee

110 rovide direct evidence that K6a(+) cells are bipotential progenitor cells, and the first demonstratio

111 eam mesodermal genes, but also by repressing bipotential progenitor genes, in part through a direct r

112 progenitors were CK-19-positive (biliary and bipotential progenitor marker) only in the presence of F

113 r) and FLK1 (a marker of hemangioblasts, the bipotential progenitor of endothelial and hematopoietic

114 t may be a state of competence rather than a bipotential progenitor state that exists in vivo.

115 of the mesodermal fate and repression of the bipotential progenitor state, even as cells leave the in

116 how ERY and MEG lineages arise from a common bipotential progenitor via overlapping and divergent fun

117 suggesting that transformation occurred in a bipotential progenitor.

118 ge committed (unipotential) and uncommitted (bipotential) progenitor cells exerting different repopul

119 ted the molecular steps during maturation of bipotential progenitors along both alveolar lineages and

120 These bipotential progenitors arise along the entire extent of

121 k between committed alphabeta thymocytes and bipotential progenitors for normal gammadelta T cell dif

122 closely related to liver stem cells, act as bipotential progenitors for the two main hepatic lineage

123 There are fewer committed bipotential progenitors in C/EBPalpha(-/-) FL, whereas m

124 the generation of different cell types from bipotential progenitors in order to facilitate orderly a

125 The subsequent selection of fate from such bipotential progenitors is then governed by lateral inhi

126 n vertebrates, pancreas and liver arise from bipotential progenitors located in the embryonic gut end

127 erein that mice lacking Foxo1, -3, and -4 in bipotential progenitors of osteoblast and adipocytes (ex

128 training effect of FOXOs on Wnt signaling in bipotential progenitors suggests that FOXO activation by

129 show that megakaryocytes arise from CD150(+) bipotential progenitors that display both platelet- and

130 CD140a(+) cells were isolated as mitotic bipotential progenitors that initially expressed neither

131 l mesoderm fate, or if transplanted into the bipotential progenitors that normally give rise to somit

132 iver (hepatocytes, cholangiocytes, and their bipotential progenitors) are heritably labeled at high e

133 The erythroid lineage was arrested early in bipotential progenitors, which did not give rise to matu

134 method for generating large numbers of these bipotential progenitors-known as hemangioblasts-from hum

135 tic lineages, suggesting that they represent bipotential progenitors.

136 nt for this process, they do not explain the bipotential result.

137 Patterning of the bipotential retinal primordia (the optic vesicles) into

138 ogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather th

139 nation, an oocyte-derived signal acts on the bipotential somatic gonad to promote the female-specific

140 els and that ectopic expression of Wnt10b in bipotential ST2 cells suppresses expression of CCAAT/enh

141 d that early cardiogenic mesoderm contains a bipotential stem cell that can give rise to both the myo

142 e in early biliary lineage commitment of the bipotential stem cells and also seems to be important in

143 These lesions show properties of bipotential stem cells and co-express markers of epithel

144 lted in loss of CK19 immunoreactivity of the bipotential stem cells.

145 view considers the unusual plasticity in the bipotential system of sex determination and some of the

146 d "oval cells," have long been thought to be bipotential, that is, produce both biliary ducts and hep

147 genous estrogen feminizes the medulla of the bipotential turtle gonad by inhibiting SOX9 expression.

148 troduction of constitutively active Fes into bipotential U937 cells induced the appearance of fully d

149 In mammals, Sry expression in the bipotential, undifferentiated gonad directs the support

150 t a common progenitor exists that can remain bipotential up to its final mitotic division.

151 These findings suggest the presence of bipotential valve progenitor cells with ability to diffe

152 I and DLP demonstrated that both regions are bipotential with respect to primitive and definitive hem

153 alf of the c-kitLo B-lineage precursors were bipotential, yielding myeloid and lymphoid progeny, wher