ライフサイエンスコーパス: birth defect

1 olated clefts (those occurring without other birth defects).

2 nital diaphragmatic hernia (CDH) is a severe birth defect.

3 ic hernias (CDHs), a common and often lethal birth defect.

4 ding to neural tube defects (NTDs), a common birth defect.

5 ragmatic hernia (CDH) is a common and severe birth defect.

6 , the excess risk varied markedly by type of birth defect.

7 age 15 years, by type of cancer and type of birth defect.

8 mation of the head and the third-most common birth defect.

9 ic hernia (CDH) is a common life-threatening birth defect.

10 (CHD) is the leading cause of mortality from birth defects.

11 ch comprise over one-third of all congenital birth defects.

12 ns in which result in highly prevalent human birth defects.

13 ilure underlies several clinically important birth defects.

14 ), comprise over one-third of all congenital birth defects.

15 alies (CPAs) are among the most common human birth defects.

16 ression and is a leading cause of congenital birth defects.

17 to a higher incidence of diabetes-associated birth defects.

18 ategy for intervention in certain classes of birth defects.

19 ncer and prevention of human miscarriage and birth defects.

20 ated with cerebellar abnormalities and other birth defects.

21 sure and thus might underlie some congenital birth defects.

22 ngenital HCMV infection is a major cause for birth defects.

23 n to efforts to prevent isotretinoin-induced birth defects.

24 Cardiac abnormalities are the most common birth defects.

25 r viral etiology of congenital infection and birth defects.

26 ces of the adoptive parents of children with birth defects.

27 sion, is one of the most common craniofacial birth defects.

28 al pesticide exposures and risks of selected birth defects.

29 ative mutations associated with nonsyndromic birth defects.

30 infectious cause of congenital developmental birth defects.

31 omplex etiologies of nonsyndromic structural birth defects.

32 hedgehog signaling, causing many structural birth defects.

33 heart disease (CHD) is among the most common birth defects.

34 ections during pregnancy causes a pattern of birth defects.

35 eight, spontaneous abortion, stillbirth, and birth defects.

36 thy controls and 0.3% of patients with other birth defects.

37 s between prenatal nitrosatable drug use and birth defects.

38 in children and young adolescents with major birth defects.

39 mal stability in order to prevent cancer and birth defects.

40 ic mechanisms underlying common craniofacial birth defects.

41 decongestants increases the risks of several birth defects.

42 associations between nitrosatable drugs and birth defects.

43 rrors in meiosis can lead to infertility and birth defects.

44 , which represent the most common structural birth defects.

45 s, and congenital HCMV infection can lead to birth defects.

46 be a key mediator of multiple metal-induced birth defects.

47 imal model to study certain human congenital birth defects.

48 nts and the risk of some infrequent specific birth defects.

49 ed lower doses increase the risk of specific birth defects.

50 ological pathway that associates metals with birth defects.

51 tinues to be the leading infectious cause of birth defects.

52 a synergistic effect on the risk of selected birth defects.

53 ppears to increase the risk further for some birth defects.

54 of this process leads to a variety of human birth defects.

55 sis is essential to prevent miscarriages and birth defects.

56 highly associated with an increased risk of birth defects.

57 ng that CL/P is among the most common of all birth defects.

58 s or infants had evidence of Zika-associated birth defects.

59 t exposures and the risk of specific cardiac birth defects.

60 ne flavivirus, causes devastating congenital birth defects.

61 e world's population and is a major cause of birth defects.

62 n and is the most common infectious cause of birth defects.

63 n and aneuploidy, contributing to cancer and birth defects.

64 ts (CHDs) are the most common group of major birth defects.

65 after ART had a higher prevalence of certain birth defects.

66 has been associated with increased risks for birth defects.

67 9-fold (95% CI, 2.3 to 3.7) in children with birth defects (123 cases of cancer) compared to the refe

68 omen), stillbirth (1915 vs. 7660), any major birth defect (1233 vs. 4932), preterm delivery (1792 vs.

69 atio, 0.42; 95% CI, 0.10 to 1.73), any major birth defect (2.9% and 2.9%, respectively; prevalence od

70 cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016).

71 jects with CHD and 10 832 with no structural birth defects, 2807 (50%) and 6355 (59%) were linked, re

72 ntly higher risks than no exposure for major birth defect (65 cases among 1665 exposed pregnancies an

73 atios with in vitro fertilization (IVF) (165 birth defects, 7.2%) were 1.26 (95% CI, 1.07 to 1.48) an

74 osure to drinking-water nitrate and selected birth defects, accounting for maternal water consumption

75 Birth defects affect 3% of children in the United States

76 tal heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births.

77 nital heart disease (CHD) is the most common birth defect, affecting about 0.8% of live births.

78 ty in childhood and is the most common human birth defect, affecting nearly 1% of all live births wor

79 al heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births; the in

80 t patients and is the leading viral cause of birth defects after congenital infection.

81 lant patients and the leading viral cause of birth defects after congenital infection.

82 the utility of AXL inhibitors for preventing birth defects after infection and suggest that further s

83 minary proportion of fetuses or infants with birth defects after maternal Zika virus infection by tri

84 There were 21 infants with birth defects among 395 live births and 5 fetuses with b

85 cts among 395 live births and 5 fetuses with birth defects among 47 pregnancy losses.

86 increased risk of birth defects overall (210 birth defects among 7352 fluconazole-exposed pregnancies

87 d pregnancies [prevalence, 2.86%] and 25,159 birth defects among 968,236 unexposed pregnancies [preva

88 periconceptional period), with no reports of birth defects among fetuses or infants with prenatal exp

89 omegalovirus (CMV) is a significant cause of birth defects among newborns infected in utero and morbi

90 dietary glycemic index (DGI) and the risk of birth defects among nondiabetic women.

91 use of assisted hatching was associated with birth defects among singleton births (aRR, 1.55; 95% CI,

92 Among the 53 birth defects analyzed, high DGI, categorized by spline

93 It is the most common human birth defect and yet, even with the application of moder

94 galovirus (HCMV) is the major viral cause of birth defects and a serious problem in immunocompromised

95 ernal DNA during meiosis causes infertility, birth defects and abortions.

96 of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome ha

97 s account for approximately one-third of all birth defects and are a significant cause of infant mort

98 (retinol) deficiency poses a risk for ocular birth defects and blindness.

99 ome preservation mechanism might explain why birth defects and bone marrow failure occur in Fanconi a

100 terations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the

101 its misregulation is implicated in numerous birth defects and cancers.

102 k factors could increase the risk of overall birth defects and cardiovascular system malformation amo

103 ation, given that HCMV is a leading cause of birth defects and causes severe infection in immunocompr

104 current state of the genetic epidemiology of birth defects and comment on future challenges and oppor

105 HCMV is a major cause of birth defects and disease in immunosuppressed population

106 entiation as well as in neural crest related birth defects and diseases.

107 netic origins of CIN that lead to congenital birth defects and early pregnancy loss, as well as the m

108 ase, but is linked to devastating congenital birth defects and Guillain-Barre syndrome in adults.

109 emic in the Americas is linked to congenital birth defects and Guillain-Barre syndrome.

110 ) infection is the major infectious cause of birth defects and hearing loss globally.

111 the international adoption of children with birth defects and identify areas for further research.

112 reas reduced capacity for migration leads to birth defects and immunodeficiencies.

113 cause aneuploidies responsible for cancers, birth defects and infertility, this new insight into cen

114 uires exceptionally high fidelity to prevent birth defects and infertility.

115 Cleft palate is one of the most common human birth defects and is associated with multiple genetic an

116 Human cytomegalovirus (HCMV) causes birth defects and it can cause life-threatening diseases

117 ay have implications for understanding renal birth defects and kidney reprogramming.

118 to many of the structural and developmental birth defects and medical problems seen in individuals w

119 ngs that ZIKV infections are associated with birth defects and neurologic disease, and that the virus

120 in signaling may have implications for renal birth defects and other diseases.

121 se their fetuses to an infection that causes birth defects and other problems.

122 opment and its deregulation in humans causes birth defects and several types of cancer.

123 isk in the manifestation of diabetes-related birth defects and shed light on environmental risk facto

124 Genetic errors in meiosis can lead to birth defects and spontaneous abortions.

125 Congenital heart disease is the most common birth defect, and because of major advances in medical a

126 ry 33 United States newborns presents with a birth defect, and worldwide the estimate approaches 6% o

127 disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferat

128 ic disease resulting in bone marrow failure, birth defects, and cancer that is thought to encompass a

129 rbation can lead to developmental disorders, birth defects, and cancers.

130 ) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine

131 ergistic effects of multiple risk factors on birth defects, and examine temporal trend of the synergi

132 the leading cause of infant mortality among birth defects, and later morbidities and premature morta

133 ever, the genetic mechanisms underlying this birth defect are poorly understood, largely due to limit

134 Birth defects are a leading cause of infant morbidity an

135 Human birth defects are a major public health burden: The Cent

136 Birth defects are an increasing health priority worldwid

137 Human birth defects are highly variable and this phenotypic va

138 ich environmental metals are associated with birth defects are largely unknown.

139 The vast majority of birth defects are nonsyndromic, and although their etiol

140 e United States each year, and children with birth defects are overrepresented in this population.

141 ng the most common and debilitating of human birth defects are those affecting the formation of the n

142 rs had a higher prevalence of nonchromosomal birth defects (aRR, 1.53; 95% CI, 1.13-2.06) than those

143 tify key pathways that mediate metal-induced birth defects as well as potential targets for preventio

144 ed high risk for cardiac, as well as neural, birth defects, as the woman usually is not aware of her

145 ses and prevention of a suite of devastating birth defects, as well as basic evolutionary and develop

146 Understanding the risk of birth defects associated with Zika virus infection durin

147 fection during pregnancy is linked to severe birth defects, but mother-to-fetus transmission routes a

148 ildren with some structural, non-chromosomal birth defects, but not others, have a moderately increas

149 Methods for ascertaining birth defect cases varied by state.

150 Cleft palate is a common birth defect caused by disruption of palatogenesis durin

151 (CMV) vaccine could prevent the majority of birth defects caused by congenital CMV infections.

152 ident by severe limb malformations and other birth defects caused by T-box3 mutations in humans.

153 Craniosynostosis is a prevalent human birth defect characterized by premature fusion of calvar

154 in the context of developmental disorders or birth defects commonly seen in clinics.

155 Among the birth defects, congenital heart disease and craniofacial

156 ng data from mothers of babies without major birth defects (controls) from the National Birth Defects

157 Rubella virus (RV) is a leading cause of birth defects due to infectious agents.

158 -null embryos are born with an "eyes open at birth" defect due to a delay in epithelial sheet extensi

159 f childbearing age and assessing the risk of birth defects during pregnancy.

160 n cause severe disease, including congenital birth defects during pregnancy.

161 terology literature suggest that the rate of birth defects following antenatal TNFi exposure does not

162 Cleft palate is a common major birth defect for which currently known causes account fo

163 comes, including Guillain-Barre syndrome and birth defects, has brought an urgent need for animal mod

164 KV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention,

165 to teratogenic compounds can lead to various birth defects; however current animal-based testing is l

166 in miscarriages and are the leading cause of birth defects; however, the molecular origins of these d

167 ated with increased risks for nonchromosomal birth defects; however, these associations may be caused

168 Microglossia is a congenital birth defect in humans and adversely impacts quality of

169 Cleft palate is a common birth defect in humans.

170 be defects (NTDs) are the second most common birth defect in humans.

171 dy, a population-based case-control study of birth defects in 10 US states.

172 OGT could be a candidate approach to prevent birth defects in diabetic pregnancies.

173 tal heart defects, which are the most common birth defects in human newborns.

174 Orofacial clefts are among the most common birth defects in humans worldwide.

175 eft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 70

176 Congenital heart defects are the most common birth defects in humans, and those that affect the prope

177 OFC), which are the most common craniofacial birth defects in humans.

178 p and/or palate (CL/P) are common structural birth defects in humans.

179 ions are thus unlikely to mediate NC-related birth defects in humans.

180 roductive tract and results in genitourinary birth defects in humans.

181 ults in cleft palate, one of the most common birth defects in humans.

182 Cleft palate is one of the most common birth defects in humans.

183 of the causes of the frequent lateral facial birth defects in humans.

184 agues, which provides a detailed analysis of birth defects in infants with in utero antiretroviral dr

185 dds ratios (aORs) in a case-control study of birth defects in Massachusetts with complete quarterly 1

186 itourinary defects are among the most common birth defects in newborns, little is known about their e

187 natal exposure to drinking-water nitrate and birth defects in offspring have not accounted for water

188 r nitrate intake was associated with several birth defects in offspring, but did not strengthen assoc

189 Structural birth defects in the kidney and urinary tract are observ

190 d from a multisite population-based study of birth defects in the United States, the National Birth D

191 cytomegalovirus (HCMV) is a leading cause of birth defects in the United States.

192 h weight of at least 400 g and registries of birth defects (including cerebral palsy and terminations

193 lefts, and individual patients with multiple birth defects (including clefts) have been shown to carr

194 mutagenized mice expected to be enriched for birth defects, including CHD.

195 ncer risk was not increased with many common birth defects, including hypospadias, cleft lip with or

196 lovirus (HCMV) is the leading viral cause of birth defects, including microcephaly, neurological defi

197 Diabetes mellitus in early pregnancy causes birth defects, including neural tube defects (NTDs).

198 c mechanisms that underlie folate-associated birth defects, including NTDs.

199 formation underlies a series of devastating birth defects, including popliteal pterygium syndrome, c

200 kout mice and show that they have structural birth defects indicative of hedgehog signaling dysfuncti

201 rtance: Giving birth to a child with a major birth defect is a serious life event for a woman, yet li

202 A leading cause of human birth defects is the incomplete fusion of tissues, often

203 tal bony syngnathia, a rare but severe human birth defect, is characterized by bony fusion of the man

204 break in Singapore, and the first reports of birth defects linked to ZIKAV in the region.

205 iology used to study nonsyndromic structural birth defects, many new approaches have become available

206 uctural aberrations commonly associated with birth defects, mental disabilities and growth retardatio

207 these processes in humans can lead to severe birth defects, mental retardation, and epilepsy.

208 Case-control studies of birth defects might be subject to selection bias when th

209 ort study using data from the North Carolina Birth Defects Monitoring Program, North Carolina Departm

210 us associated pathologies, including cancer, birth defects, neuropathy, cardiovascular disease, chron

211 Cleft palate (CP) is a common birth defect occurring in 1 in 2,500 live births.

212 Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results

213 ft lip and/or palate (NSCL/P) is a prevalent birth defect of complex etiology.

214 Neural tube defects (NTDs) are common birth defects of complex etiology.

215 defects overall or of 14 of the 15 specific birth defects of previous concern.

216 ing spina bifida and anencephaly, are severe birth defects of the central nervous system that origina

217 of age) with selected major, non-chromosomal birth defects or chromosomal anomalies was compared to a

218 Infants with extracardiac birth defects or genetic disorders were excluded.

219 They often have specific birth defects or other physical abnormalities that sugge

220 Both scenarios can result in severe birth defects or pregnancy loss.

221 adoptive parents of children with a specific birth defect, orofacial clefting, and discuss areas for

222 pation, could not be reached by mail, or had birth defects other than clefts.

223 Some relate to birth defects other than neural tube defects, neurologic

224 was not associated with an increased risk of birth defects overall (210 birth defects among 7352 fluc

225 er oral fluconazole exposure and the risk of birth defects overall and of birth defects previously li

226 iated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth

227 infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urg

228 nce of possible recent Zika virus infection, birth defects potentially related to Zika virus were ide

229 Birth defects potentially Zika associated: brain abnorma

230 eroids of any potency with mode of delivery, birth defects, preterm delivery, fetal death, and low Ap

231 al heart defects (CHDs) in the U.S. National Birth Defects Prevention Study (1997-2005).

232 llustrative example using data from National Birth Defects Prevention Study (1997-2009) to examine th

233 h defects in the United States, the National Birth Defects Prevention Study (NBDPS).

234 ld Cohort Study, 1999-2009; and the National Birth Defects Prevention Study (United States), 1999-200

235 Data from the National Birth Defects Prevention Study (United States, 1997-2006

236 ng data directly available from the National Birth Defects Prevention Study and other published infor

237 considered major as defined by the National Birth Defects Prevention Study but without laterality de

238 Data from the National Birth Defects Prevention Study from 1997 to 2007 were us

239 997 to 2005 and participated in the National Birth Defects Prevention Study, a multistate, population

240 Mothers from the National Birth Defects Prevention Study, a nine-state case-contro

241 pects of interview responses in the National Birth Defects Prevention Study, a population-based case-

242 nd hypospadias, using data from the National Birth Defects Prevention Study, a population-based case-

243 r birth defects (controls) from the National Birth Defects Prevention Study, we examined the relation

244 With data from the National Birth Defects Prevention Study, we linked addresses of 3

245 a targeted biological pathway for examining birth defects prevention.

246 ficantly increased risk of 14 of 15 types of birth defects previously linked to azole antifungal agen

247 and the risk of birth defects overall and of birth defects previously linked to azole antifungal agen

248 s or infants had evidence of Zika-associated birth defects, primarily brain abnormalities and microce

249 virus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological dis

250 reference cohort of 147,940 children without birth defects randomly sampled from each state's births

251 or infants' height, weight, Apgar scores, or birth defect rates between infants from the treated and

252 Study subjects were ascertained from birth defect registries in Massachusetts, New York, and

253 , we linked state educational records with a birth defects registry and birth certificates.

254 hese relationships using data from the Texas Birth Defects Registry and statewide vital records for d

255 ed ART surveillance, birth certificates, and birth defects registry data for 3 states (Florida, Massa

256 Using Texas Birth Defects Registry data, 1999 through 2007, which mo

257 bility in the occurrence and severity of the birth defect remain unexplained.

258 the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent.

259 of the most important recent discoveries in birth defect research, the mechanism by which folic acid

260 al to understanding the neuropathogenesis of birth defects resulting from congenital infection.

261 Variations in birth defect risks according to type of ART procedure ha

262 uded spontaneous abortion, stillbirth, major birth defect, small size for gestational age, low birth

263 disorder characterized by a complex array of birth defects so named for its cardinal features of ocul

264 To our knowledge, this is the first birth defect study to develop multi-DBP adjusted regress

265 controls from the Slone Epidemiology Center Birth Defects Study (1993-2012) who were interviewed wit

266 sing data from the Slone Epidemiology Center Birth Defects Study collected from 1998 to 2012, we comp

267 a collected in the Slone Epidemiology Center Birth Defects Study, we examined the association between

268 2010 data from the Slone Epidemiology Center Birth Defects Study, we tested those hypotheses among 12

269 important part in the development of common birth defects such as oral clefts, and individual patien

270 y pregnancy increases the risk in infants of birth defects, such as neural tube defects (NTDs), known

271 provide insights into the etiology of human birth defects, such as spina bifida and congenital kidne

272 ital diaphragmatic hernia (CDH) is a serious birth defect that accounts for 8% of all major birth ano

273 syndrome), an X-linked dominant multisystem birth defect that is frequently accompanied by ocular ab

274 e (HSCR) is a partially penetrant oligogenic birth defect that occurs when enteric nervous system (EN

275 nital diaphragmatic hernia (CDH) is a common birth defect that results in a high degree of neonatal m

276 processes could cause cleft palate, a common birth defect that significantly affects patients' qualit

277 and timing to target segmentation disorders, birth defects that affect the spinal column.

278 e of selected chromosomal and nonchromosomal birth defects that are usually diagnosed at or immediate

279 Yet many pregnancy complications and birth defects that become more frequent in older mothers

280 n cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits,

281 rus (HCMV) infection is the leading cause of birth defects that primarily manifest as neurological di

282 Congenital hydrocephalus is an important birth defect, the genetics of which remains incompletely

283 palate-one of the most common of congenital birth defects-treatment following surgery is prolonged o

284 Hug mutants exhibit multiple birth defects typical of ciliopathies, including skeleta

285 A major birth defect was diagnosed in 18 of 330 infants (5.5%) e

286 h tooth agenesis and 328 individuals with no birth defect were recruited from the same institution.

287 Birth defects were reported for 16 of 271 (6%; 95% CI, 4

288 Birth defects were reported in 9 of 85 (11%; 95% CI, 6%-

289 No birth defects were reported.

290 idespread opportunistic pathogen that causes birth defects when transmitted transplacentally and seve

291 ningocele (MMC) is a devastating spinal cord birth defect, which results in significant life-long dis

292 art disease (CHD) is the most common type of birth defect with family- and population-based studies s

293 late (nsCL/P) is among the most common human birth defects with multifactorial etiology.

294 t-sided lesions (LSLs) are relatively common birth defects with substantial morbidity and mortality.

295 idence intervals were estimated for specific birth defects, with controlling for potential confounder

296 Failure to close the neural tube results in birth defects, with severity ranging from spina bifida t

297 tal heart defects (CHDs) are the most common birth defect worldwide and are a leading cause of neonat

298 anencephaly, which are among the most common birth defects worldwide.

299 orofacial clefts are one of the most common birth defects worldwide.

300 Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms t