ライフサイエンスコーパス: bistable

1 cells validated that TGF-beta1 activation is bistable.

2 that sigma(d) -dependent gene expression is bistable.

3 d early stationary phases and appeared to be bistable.

4 ption of visual inputs that are perceptually bistable.

5 und that the response was continuous and not bistable.

6 dels, where typically each neuron is at most bistable.

7 which changes the system from monostable to bistable.

8 itching of two bistable [2]rotaxanes and one bistable [2]catenane composed of CBPQT(4+) rings encircl

9 On average, close to two bistable [2]catenanes can be incorporated per repeating

10 Two redox-active bistable [2]catenanes composed of macrocyclic polyethers

11 These bistable [2]catenanes exemplify a design strategy for ac

12 The reversible redox-switching of the bistable [2]catenanes is retained inside the MOF, as evi

13 table [2]rotaxane, as well as in a couple of bistable [2]catenanes of the donor-acceptor vintage--can

14 2 is calculated, (ii) in the case of the two bistable [2]catenanes--one containing a crown ether with

15 (IET) can be subjected to redox control in a bistable [2]rotaxane comprised of a dumbbell component c

16 he ground-state coconformation (GSCC) of the bistable [2]rotaxane molecules also depends on chi, as w

17 r the relaxation process associated with the bistable [2]rotaxane molecules in solution and (ii) the

18 diameter of the MNPs, (ii) the amount of the bistable [2]rotaxane molecules on the surface of the MNP

19 quat-p-phenylene) (CBPQT(4+)) rings, and (c) bistable [2]rotaxane molecules where the dumbbell compon

20 lational isomers--present, for example, in a bistable [2]rotaxane, as well as in a couple of bistable

21 Whereas, (i) in the case of the bistable [2]rotaxane, composed of a dumbbell component c

22 and digital simulations of the tristable and bistable [2]rotaxanes and [2]catenane reveal a mechanism

23 redox-induced mechanism of switching of two bistable [2]rotaxanes and one bistable [2]catenane compo

24 istinct neural assemblies, each with locally bistable activity, operating far from the collective equ

25 ulation sizes, the evolutionary dynamics are bistable and either solution may result.

26 local sensory adaptation and showed the same bistable and mnemonic dynamics as sensory perception.

27 ork of organic reactions with autocatalytic, bistable and oscillatory behaviour, we identify principl

28 pression of the pneumococcal type 1 pilus is bistable and positively regulated by the transcription f

29 zed LimGluR2, on which we focused, was fast, bistable and supported multiple rounds of on/off switchi

30 try, we show that our engineered systems are bistable and that inherent gene expression stochasticity

31 zed that the response of this circuit may be bistable and thus a possible mechanism for phase variati

32 Herein, we report that bistable and tristable [2]rotaxanes can be switched by a

33 cell of this crease pattern is mechanically bistable, and by switching between states, the compressi

34 Here we report a room-temperature bistable antiferromagnetic (AFM) memory that produces ne

35 e investigate photoinitiated snap-through in bistable arches formed from samples composed of azobenze

36 analysis predicted that MAPK activation was bistable as a function of ATRA exposure.

37 Here we show that expression of the pilus is bistable as a result of the molecular interaction betwee

38 First, the CaMKII model system is never bistable at resting calcium concentrations, which sugges

39 ree genomically integrated circuits that use bistable autoregulatory transcriptional feedback to reta

40 class of architected materials that contain bistable beam elements and exhibit controlled trapping o

41 hitected soft system composed of elastomeric bistable beam elements connected by elastomeric linear s

42 We reconstitute this bistable behavior and hysteresis using purified componen

43 The development and the ionic nature of bistable behavior in lumbar motoneurons were investigate

44 c fluctuations in transcript numbers, nor of bistable behavior in transcript distributions.

45 and biochemical reconstitution show that the bistable behavior of the Gwl-ENSA pathway emerges from i

46 of both positive feedback loops resulted in bistable behavior over a broad range of inducer concentr

47 eC, CckA and its response regulators exhibit bistable behavior, thus providing a scenario for robust

48 oads to the genetic switch can also abrogate bistable behavior.

49 ihood that the resulting system will exhibit bistable behavior.

50 and features a completely new way to create bistable behavior.

51 To conclude, bistable behaviors are, to a large extent, determined by

52 ical modelling reveals that the TCS can show bistable behaviour for a given range of parameter values

53 The potential energy profile of a bistable binary switch is a 'symmetric' double well.

54 of a robust morphogen gradient, enabling the bistable BMP signaling outputs required for early Drosop

55 Here, we describe optical properties of bistable bubble domain (BD) texture torons in a thin lay

56 On its own, this network can be bistable, but in a larger system, where ERK accelerates

57 the branched polymerization of pH-sensitive bistable [c2] daisy chain rotaxanes by using copper(I)-c

58 ved and employed to prepare doubly threaded, bistable [c2]daisy chain compounds, is described.

59 In this article we show that bistable [c2]daisy chain rotaxanes (i.e., molecular musc

60 because, in contrast with more conventional bistable catenanes and rotaxanes, the mechanical movemen

61 nature of vernalization is a reflection of a bistable cell autonomous switch in an increasing number

62 that couples adaptive directional sensing to bistable cellular memory.

63 mple, analytically solvable, one-dimensional bistable chemical system to demonstrate the validity of

64 at all pyridine-terminated molecules exhibit bistable conductance signatures, signifying that the nat

65 er space for fast excitation, inhibition and bistable control.

66 Our findings provide evidence of bistable cortical networks that exhibit non-rhythmic sta

67 exhibit enormous and sharp room-temperature bistable current-voltage behaviour possessing stable, re

68 change and recovery of the PLEDs to various bistable curvatures result in minimal loss of electrolum

69 g mechanism of a family of electrochemically bistable 'daisy chain' rotaxane switches based on a deri

70 d their feedbacks are sufficient to create a bistable developmental fate switch in Arabidopsis seeds.

71 The template-directed synthesis of a bistable donor-acceptor [2]catenane wherein both transla

72 A bistable donor-acceptor [2]catenane, which is composed o

73 of the resonant frequency are used to devise bistable dynamic states that can be reversibly switched

74 We therefore model mRNA production using a bistable dynamical systems whose behaviour is described

75 ory dynamics facilitated by IMAC opening, or bistable dynamics facilitated by MPTP opening; 2), in a

76 cise control of the nonlinear and stochastic bistable dynamics of a levitated nanoparticle in high va

77 m/s) cellwide PsiM oscillations, whereas the bistable dynamics of MPTP-mediated RIRR results in slow

78 on PAR-6/PKC-3 endows this core circuit with bistable dynamics, while transport of CHIN-1 clusters by

79 noparticles as a model system for stochastic bistable dynamics, with applications to a wide variety o

80 ct that local neuron assemblies will express bistable dynamics, with spontaneous active-inactive tran

81 The bistable electroactive polymer is a new smart material c

82 The combination of the composite and a bistable electroactive polymer produces electrically-ind

83 periments with networks of discrete reactive bistable electrochemical elements organized in regular a

84 ental impacts of a developmental nonvolatile bistable electromechanical CNT switch through its fabric

85 g membrane to investigate the origin of fast bistable engulfment in absence of the cell wall.

86 n of telomeric gene expression is due to the bistable enrichment/depletion of H3K79me and not the flu

87 e impetus for heritable phenotypic change in bistable epigenetic regulatory networks that are suscept

88 ucleation region is capable of switching the bistable epigenetic state of an individual locus, with t

89 We use a bistable epigenetic switch sensitive to transcription er

90 type 1 persistence, and we propose that the bistable expression of both transformability and the gro

91 These cell types arise due to bistable expression of CsgD, the central biofilm regulat

92 lus expression steadily, suggesting that the bistable expression of the pilus observed in wild-type c

93 Here we present evidence that bistable expression of the type 1 pilus is mediated by t

94 A paradigmatic example is the bistable expression of virulence genes in Salmonella typ

95 n experimental model of a self-sustained and bistable extracellular signal-regulated kinase 1/2 (ERK1

96 This fate decision involves a bistable feedback loop between Melted, a PH-domain prote

97 ically stable enantiotropic SmC* phase and a bistable ferroelectric switching in a surface stabilized

98 VTA DA neurons are bistable, firing in two modes: one characterized by burs

99 Bistable flagellar and virulence gene expression generat

100 We demonstrate sustained bistable fliC expression in virulent Salmonella 14028 an

101 ture, Salmonella Typhimurium populations are bistable for the expression of flagellin.

102 synaptic connections putatively implement a bistable gain control mechanism that either computes odo

103 ing network recapitulates these variable and bistable gastrulation profiles and emphasizes the import

104 elation leads to the experimentally observed bistable gating.

105 onse in single cells has been a paradigm for bistable gene expression.

106 use synthetic biology approaches to engineer bistable gene networks to demonstrate that stochastic an

107 e mechanism to stochastic gene expression in bistable gene regulatory circuits.

108 Although a bistable gene regulatory network has been proposed to re

109 e, we investigate the possible structures of bistable genetic networks that can allow two identical c

110 A common topology found in many bistable genetic systems is two interacting positive fee

111 -way junction with an excited state, a 25-nt bistable hairpin, and a 112-nt three-state adenine ribos

112 the structural relationships between the two bistable hairpins, the conformational switch can follow

113 d points at each level of the hierarchy, and bistable Hebbian dynamics enables the learning of such t

114 ne, they can be coupled to create a strongly bistable, hysteretic switch between normal and toxic sta

115 They are bistable in function, and are, in a sense, the electrofl

116 T3SS expression is bistable in the homogeneous environment of nutrient-limi

117 ment front, in which vegetation dynamics are bistable: in this zone, vegetation can be stable both as

118 Focusing on the bistable kinase network that governs progesterone-induce

119 However, so far bistable lac induction has only been observed using grat

120 e question about the biological relevance of bistable lac induction in the natural setting with lacto

121 ymmetry through Fgf8-dependent regulation of bistable left- or right-sided migration of the parapinea

122 ingle-cell analysis confirmed monostable and bistable-like behavior.

123 at is permanently reinforced by a repressive bistable loop between sens and ro.

124 o far, the smallest individually addressable bistable magnetic bits have consisted of 3-12 atoms.

125 d between the streamed and fused states in a bistable manner.

126 We describe the incorporation of a bistable mechanically interlocked molecule (MIM) into a

127 opsin and may function through a reversible, bistable mechanism.

128 Our results demonstrate that two interlinked bistable mechanisms provide a robust solution for irreve

129 Recently, experimental bistable memories have been realized using fully compens

130 e for applications in spintronics as well as bistable memory devices and sensing materials.

131 This research demonstrates that bistable MIMs are capable of exhibiting robust dynamics

132 information through switching collections of bistable MIMs contained in arrays of MSTJs.

133 is a direct consequence of the switching in bistable MIMs that leads to a relatively small remnant m

134 ion of MEDs, it is likely that monolayers of bistable MIMs will be replaced by robust crystalline ext

135 rein the switchable components, derived from bistable MIMs, are organised precisely in a periodic man

136 and remnant molecular signatures produced by bistable MIMs.

137 -negative feedback loops that constitute the bistable mitotic trigger.

138 Growing cells of Bacillus subtilis are a bistable mixture of individual motile cells in which gen

139 of the regulatory core and two subordinated bistable modules responsible for cell cycle arrest and a

140 lation properties of CaMKII could underlie a bistable molecular switch that maintains LTP, and there

141 The cell cycle is composed of bistable molecular switches that govern the transitions

142 e molecules, and also how to integrate these bistable molecules into organized, hierarchical assembli

143 On the other hand, when the bistable molecules switch "out of phase," the assemblies

144 In this regard, situations where all the bistable molecules switch synchronously appear desirable

145 by analogy with single-molecule magnets, as bistable molecules with a toroidal magnetic state, and s

146 We used a novel bistable motion illusion that induced alternating and mu

147 When hyperpolarized, bistable motoneurons displayed a characteristic slow aft

148 the knot on the landscape, the origin of the bistable nature of the knotted protein, and broaden the

149 Some bistable networks are entirely based on posttranscriptio

150 Cell-autonomous bistable networks have been previously sampled using an

151 We obtain a variety of simple bistable networks that we classify into major subtypes.

152 we discuss the possible roles of interlinked bistable networks, epigenetic inheritance, and bet-hedgi

153 switch stochastically between epigenetically bistable ON and OFF expression states.

154 transition between these 2 states, forming a bistable on-off switch of EADs.

155 tate to storage charges and cause reversible bistable (ON and OFF states) switching upon application

156 We have prepared a bistable, optically triggered, metal-organic framework (

157 Moreover, bistable optokinetic responses cannot be entirely attrib

158 progenitor cells leads to the appearance of bistable or bi-modal growth behaviors, ultrasensitivity

159 to activate these molecular switches between bistable or even multiple states by manipulating molecul

160 ng can be used to understand and predict the bistable or multistable behavior of such networks.

161 e feedback loop architecture, which exhibits bistable or oscillatory network dynamics depending on ir

162 icroscopic ratchets can explain the observed bistable orientation of the actin-propelled ellipsoidal

163 the signaling pathway is linear, rather than bistable, over a broad range of extracellular pheromone

164 lished and generalized across several visual bistable paradigms.

165 MP-receptor interactions reveals a spatially bistable pattern of BMP signaling centered on the dorsal

166 Thus, the model predicts a bistable pattern of FLC gene expression in individual ce

167 er-increasing asymmetry between blastomeres (bistable pattern), supposedly controlled by negative or

168 whether higher-order visual stimuli such as bistable perception and attention tasks involving visual

169 an brain to decode perceptual content during bistable perception and simple unambiguous perception.

170 s, we find that the activity dynamics during bistable perception are well described as fluctuating be

171 onger durations of perceptual transitions in bistable perception compared with replay conditions.

172 d predominantly to posterior visual regions, bistable perception involved additionally many higher-or

173 plaid stimuli revealed that mice demonstrate bistable perception, sometimes tracking individual stimu

174 ortical structure and behaviour underpinning bistable perception.

175 ain activity link focal brain structure with bistable perception.

176 influences were dramatically enhanced during bistable perception.

177 etal cortex in perceptual transitions during bistable perception.

178 frontoparietal areas for transitions during bistable perception.

179 of the alternating representations of their bistable perception.

180 Bistable perceptual phenomena and attention tasks asymme

181 Models of such bistable perceptual phenomena posit spontaneous fluctuat

182 novel paradigm in which human subjects view bistable perceptual stimuli or perform complex attention

183 The present transducer records bistable pH modulation from an "enzymatic flip-flop" cir

184 pilus expression in pneumococcus exhibits a bistable phenotype, which is dependent upon the molecula

185 nome-wide microarray analysis shows that the bistable phospho-ERK1/2 (pERK1/2) does not induce a high

186 hought not to exist since the rhodopsins are bistable photopigments, which consist of a chromophore t

187 vers experienced a consistent aftereffect: a bistable PL walker, which could be perceived in the adap

188 we used an adaptation paradigm together with bistable point-light (PL) animations whose perceived dir

189 al ranges of cell density when compared with bistable quorum-sensing systems.

190 cell fates were also observed outside of the bistable range, evidenced by bimodality and hysteresis.

191 terminant of the transition rates inside the bistable range.

192 al-radical recognition motif is harnessed in bistable redox-active MIMs in order to achieve close to

193 nhibitory (I) populations exhibiting a novel bistable regime between a quiescent and an inhibition-st

194 , milling and polarized states co-exist in a bistable regime with transitions largely driven by pertu

195 netochore, the force-velocity relation has a bistable regime with two possible steady-state velocitie

196 cI repressor would drive the system into the bistable regime.

197 Kinetochore phosphorylation shifts the bistable region to higher tensions, so that only the rap

198 eta frequencies; (2) the network can reach a bistable region, between the low firing frequency networ

199 and cis-aconitate, generating a potentially bistable regulatory switch.

200 s than 6 kV/cm induce large, reversible, and bistable remanent strains.

201 results in the observation of an all-or-none bistable response over a much wider range of external si

202 zation, structurally modulated layers, and a bistable response to applied electric field which origin

203 iferation and death in T cells establishes a bistable response: the population is driven to either ex

204 sitive feedback loops may produce the robust bistable responses required in cellular networks that re

205 n concert with a reaction-transport model of bistable reversible charge and fluorescence photoswitchi

206 nism for the conformational switches between bistable RNA hairpins.

207 ate with individuals' alternation rate for a bistable, rotating structure-from-motion stimulus [10].

208 A halogen-bonding and hydrogen-bonding bistable rotaxane is prepared and demonstrated to underg

209 interlocked molecules (MIMs)--specifically, bistable rotaxanes and catenanes--which exhibit reset li

210 movements backward in a homologous series of bistable rotaxanes.

211 the first structurally defined magnetically bistable semiconductors assembled with the TCNQ(.delta-)

212 This suggests that melanopsin employs a bistable sequential photon absorption mechanism typical

213 relies on the balance between a propagating bistable signal that is opposed by an advective flow gen

214 ted Ubiquitin- Cyclin E- Retinoblastoma- E2F bistable-signalling pathway controlling restriction poin

215 We show that bistable skyrmionic textures undergo hysteretic behaviou

216 from interphase to mitosis and suggest that bistable spatiotemporal switches may be widespread in bi

217 We further find a novel bistable state of a hexagonal structure and concentrical

218 otoreceptor and bipolar genes, existing in a bistable state.

219 dence that noise-induced transitions between bistable states (i.e., between an action potential with

220 ve fabricated a display unit that has on/off bistable states by embedding the magnetochromatic micros

221 rough positive feedback mechanisms, generate bistable states.

222 field and current, proving the existence of bistable states: droplet and non-droplet states.

223 hallenge the assumed privileged link between bistable stimuli and visual awareness.

224 the interstimulus interval (ISI), we created bistable stimuli that caused subjects to perceive either

225 asy-axis melts long-range order, revealing a bistable, strongly correlated spin state.

226 order in gamma-lithium iridate and reveal a bistable, strongly correlated spin state.

227 The loop is a bistable switch and exists in a SlrR(LOW) state in which

228 trial-and-error oscillation and a stochastic bistable switch as two elegant mechanisms with the poten

229 isense regulation are essential for a robust bistable switch behavior in the control of conjugation i

230 ministic model, we show that an irreversible bistable switch between a transformed and a non-transfor

231 Thus, MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) dur

232 endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a subs

233 The bistable switch exists primarily (97%) as the E configur

234 mory and appears to be controlled by another bistable switch further upstream that determines cell fa

235 system heterogeneity, without the need for a bistable switch in the underlying regulatory network.

236 hows that APC(Cdh1) inactivation is a rapid, bistable switch initiated shortly before the start of DN

237 te the utility of the approach by creating a bistable switch library that programmatically samples th

238 nd an "all-or-none" behavior, hallmarks of a bistable switch mechanism with stochastic noise.

239 hence entry into sporulation is subject to a bistable switch mediated by one or more feedback loops.

240 A bistable switch model has been invoked to explain how pa

241 Tissue simulations showed that this bistable switch of cellular EADs provided both a trigger

242 sm involving a Nucleolin-dependent Nanog-p53 bistable switch regulating the homeostatic balance betwe

243 ls have suggested that CaMKII functions as a bistable switch that could be the molecular correlate of

244 an inhibitor of MyoD, our results revealed a bistable switch that exists either in a Pax7-driven myob

245 controlled by a low-barrier, noise-sensitive bistable switch that involves random transitions in the

246 sitive feedback in Cdk1 activation creates a bistable switch that makes mitotic commitment irreversib

247 s study emphasizes the function of Tbx6 as a bistable switch that turns mesoderm fate 'on' and progen

248 matin-modifying activities that can act as a bistable switch to drive cells into either the CSC or th

249 or activation by creating an ultrasensitive, bistable switch to selectively enhance responses to fore

250 definitive hematopoiesis, is an irreversible bistable switch whose dynamical properties are modulated

251 sequestering by stathmin, this establishes a bistable switch with two stable states: one stable state

252 rial-and-error oscillation; and a stochastic bistable switch), and assess their impact on the bi-orie

253 show that this transition is an irreversible bistable switch, and we map the point of commitment to d

254 Mathematical modelling reveals that a bistable switch, created by CRL4(Cdt2), promotes irrever

255 ed with the stochastic dynamics of an Rb-E2F bistable switch, jointly and quantitatively explain quie

256 6, which in turn acts to irreversibly flip a bistable switch, leading to maintenance of the mesoderma

257 n the sister kinetochores can give rise to a bistable switch, which allows robust distinction between

258 that allows Warts-Yki-Melted to operate as a bistable switch.

259 hereby ensuring that mitotic commitment is a bistable switch.

260 odal pattern of expression as expected for a bistable switch.

261 as an ionic diode with electrolyte-dependent bistable switchable states.

262 Such coupled bistable switches are robust to parameter variation and

263 of cell fate decision in which a network of bistable switches controls inducible production of linea

264 e report the construction of robust, tunable bistable switches in Escherichia coli using three hetero

265 e generally, they hint at a broader role for bistable switches in the initial establishment of patter

266 Building simple bistable switches, synthetic biologists have learned the

267 k with slower downstream transcription-based bistable switches, we can construct synthetic dual-times

268 erned by coupled reversible and irreversible bistable switches.

269 by a phosphatase that also participates in a bistable switching mechanism.

270 iscovered to conduct electricity and display bistable switching.

271 ice for physiological state constructed from bistable synapses that are flipped between two sustained

272 d quantitatively characterized an inducible, bistable synthetic gene circuit controlling the expressi

273 to reproduce experimental data obtained on a bistable system and to interpret discrepancies between m

274 lication of a high-amplitude stimulus to the bistable system can temporarily render it quiescent befo

275 Mitosis is initiated by a bistable system of regulatory proteins centred on Cdk1,

276 of tension sensitive SAC and Cdk1 creates a bistable system that ensures complete activation of sepa

277 oblem is the interpretation of the flow as a bistable system with nonlinear propagation (advection) o

278 ginated from the kinase synchronization in a bistable system with slow transitions, as reported here.

279 n essential feature with the transition in a bistable system.

280 e also find for a closely related model that bistable systems tend to have a specific kinetic conform

281 atures that are consistent with behaviors of bistable systems.

282 The refolding kinetics of a bistable terminator antiterminator segment involved in t

283 A bistable toggle switch is a paradigmatic model in the fi

284 motif responds to signals in the manner of a bistable toggle switch, and then we discuss how this tog

285 biquitous gene regulatory network motif, the bistable toggle switch, in which two mutually repressive

286 nstruction and testing to build single-copy, bistable toggle switches with improved performance and r

287 teady-state analysis predicted a switch-like bistable transition between two levels of active TGF-bet

288 BACH1 and RKIP involving both monostable and bistable transitions that can potentially give rise to n

289 ow transport with a single velocity; and 3), bistable transport, where the filament velocity stochast

290 motors is associated with the occurrence of bistable transport.

291 Bistable, tristable and multistable switching of well-de

292 results hold promise for a new generation of bistable, ultrahigh-resolution, and flexible display tec

293 ollective activity of a finite population of bistable units (i.e., a generalized Ehrenfest process) q

294 ght-activated chloride channels (iC++) and a bistable variant (SwiChR++) with net photocurrents incre

295 he visual perception of the flies, we used a bistable variant called ChR2-C128S.

296 During bistable vision, perception oscillates between two mutua

297 nstrate for the first time that mice exhibit bistable visual perception of plaid stimuli, and that th

298 d prefrontal cortex predict the stability of bistable visual perception.

299 ed "globetrotter" was sufficient to bias the bistable walker's direction, as were full-body adaptors.

300 ich spontaneous hair bundle oscillations are bistable, with sporadic transitions between the oscillat