ライフサイエンスコーパス: bitransgenic

1 lular carcinoma (HCC) progression in X/c-myc bitransgenics.

2 loidy was frequently observed in tumors from bitransgenic and p53172R-H mice, but not from mice expre

3 overexpressed in hepatic tumors from X/c-myc bitransgenics and WHV-infected woodchucks.

4 silencing expression of DeltaFosB by feeding bitransgenic animals doxycycline (Dox).

5 Bitransgenic animals, generated from a cross of FVB/N al

6 ormation over what is observed in uninfected bitransgenic animals.

7 C57Bl/lambda lacZ and bitransgenic c-myc (albumin promoter)/lambda lacZ mice w

8 This variability was not detected in bitransgenic CFTR(m1Unc-/-)(FABP-hCFTR) mice in which th

9 uced in triple transgenic mice compared with bitransgenic controls.

10 Both biological and foster pups nursed by bitransgenic dams exhibited a dramatic decrease in survi

11 Beginning at about 3 months of age, the bitransgenic E(+)R(+)(C57BL/6 x FVB/n) F1 mice developed

12 ithelial cells resulted in carcinomas in all bitransgenic females.

13 sults were found in mammary tumors from mice bitransgenic for the neu and transforming growth factor-

14 Bitransgenic glands contained higher levels of phosphory

15 mplete correction of alveolar proteinosis in bitransgenic GM-/-, SP-C-GM+ mice.

16 different CF mouse (DeltaF508 homozygous and bitransgenic gut-corrected but lung-null) models.

17 similar in WT, hemizygous SP-C-hCFTR+/-, and bitransgenic gut-corrected FABP-hCFTR+/+-mCFTR-/-, the l

18 Corneal epithelial cells from bitransgenic Krt12Cre/+/ROSA(EGFP) mice were examined by

19 of several reporter genes in the corneas of bitransgenic Krt12cre/+/ROSA(EGFP), Krt12Cre/+/ZEG, and

20 rns of EGFP were observed in young and adult bitransgenic Krt12Cre/+/ZEG mice, respectively.

21 ferative and preneoplastic stages in X/c-myc bitransgenic livers, whereas BAMBI and PLK1 were overexp

22 Furthermore, bitransgenic males but not females had a dramatically ac

23 alactosidase activity in the cornea of adult bitransgenic mice (Krt12(rtTA/+)/tet-O-lacZ).

24 Significantly, liver tumors from HBx/c-myc bitransgenic mice and chronically HBV-infected patients

25 nd Suz12/Znf198 in liver tumors from X/c-myc bitransgenic mice and woodchuck hepatitis virus (WHV)-in

26 Tumors from bitransgenic mice are characterized by a higher frequenc

27 latency, however, was reduced by 8 months in bitransgenic mice as compared to mice of the other three

28 In contrast, tumors that develop in bitransgenic mice bearing both the v-Ha-ras gene and a h

29 e expression of the LacZ gene was induced in bitransgenic mice by administration of doxycycline in th

30 Bitransgenic mice carrying both WAP-TGFalpha and WAP-c-m

31 Thus, we generated bitransgenic mice carrying in an Igf1 null background a

32 ant p53 in mammary tumorigenesis by creating bitransgenic mice carrying MMTV-neu and 172Arg-to-His p5

33 the lung tumors were lung adenocarcinomas in bitransgenic mice compared to only 3% in wild-type mice.

34 and cerebrovascular Abeta deposition in the bitransgenic mice compared with their singly transgenic

35 Moreover, cataracts were observed in bitransgenic mice derived from two independent TetOp-Del

36 ell lines derived from MMTV-c-Rel x CK2alpha bitransgenic mice displayed a highly invasive phenotype.

37 CD4+ T cells from doxycycline-treated bitransgenic mice displayed reduced proliferation and ly

38 Bitransgenic mice displayed several overt and acute epit

39 Tal1/Lmo2 and MutTAL1/Lmo2 bitransgenic mice exhibit perturbations in thymocyte dev

40 Notably, liver tumors from X/c-myc bitransgenic mice exhibited downregulation of SUZ12 and

41 gillus species extract-challenged CC10-IL-15 bitransgenic mice exhibited significantly reduced levels

42 mous epithelia, the resulting Bi-L E7/K5-tTA bitransgenic mice expressed E7 and luciferase in the ski

43 tently expressed in NPC and can cooperate in bitransgenic mice expressed from the keratin-14 promoter

44 rmed RIDNs on amyloid deposition, we crossed bitransgenic mice expressing APP and presenilin 1 (PS1)

45 Bitransgenic mice expressing MIA under the control of th

46 ion was limited to the corneal epithelium of bitransgenic mice fed doxycycline.

47 epatocellular carcinomas (HCCs) derived from bitransgenic mice harboring TGF-alpha and c-myc transgen

48 lial cells in CCSP-rtTA/(tetO)(7)-CMV-Stat3C bitransgenic mice induces chronic inflammation and lung

49 transforming growth factor (TGF)-alpha/c-myc bitransgenic mice leads to inhibition of NF-kappaB and p

50 ithelial cells of CCSP-rtTA/(tetO)(7)-Stat3C bitransgenic mice leads to severe pulmonary inflammation

51 After 30 weeks on diet, only male bitransgenic mice on MeIQx developed hepatocellular carc

52 Bitransgenic mice overexpressing either Pim-1 or Pim-2 a

53 Bitransgenic mice overexpressing PKCbetaII and constitut

54 lacZ mutation reporter gene (Muta mice) and bitransgenic mice overexpressing the c-myc oncogene.

55 LK in mammary tumors from MMTV-Wnt1/MELK-GFP bitransgenic mice resulted in a significant enrichment o

56 -1(+) cells from lung of doxycycline-treated bitransgenic mice strongly inhibited proliferation and f

57 This synchrony of tumor development in the bitransgenic mice suggests that trophic maintenance of t

58 We generated bitransgenic mice that overexpress human heme oxygenase-

59 However, bitransgenic mice that were generated by breeding MMTV-N

60 Here, we use novel bitransgenic mice to determine the relative importance o

61 actosidase enzyme activity by doxycycline in bitransgenic mice took place in 24 hours and reached a p

62 Mammary tumor incidence in WAP-DES/p53 bitransgenic mice was similar to that of WAP-DES and 2 -

63 Tumors arising in the p53-172H/neu bitransgenic mice were anaplastic and aneuploid and exhi

64 Bitransgenic mice were generated that carried both a bac

65 ression, lung adenocarcinoma was observed in bitransgenic mice with a 35% incidence rate.

66 endocrine or neural features, and Atp4b-Cre bitransgenic mice with a Cre reporter confirmed that the

67 ofiles of Kras(G12D)-induced lung cancers in bitransgenic mice with and without Sp1 inhibition, 542 g

68 t5B were significantly suppressed in MECs of bitransgenic mice with constitutive miR-150 expression a

69 ranial self-stimulation (ICSS) and inducible bitransgenic mice with enriched expression of mCREB in f

70 chanism of Rb effects on the somatic growth, bitransgenic mice with tetracycline-regulated Rb express

71 , and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by ad

72 sed in lung and blood of doxycycline-treated bitransgenic mice, but CD4(+) and CD8(+) T cells were de

73 vage fluid and plasma of doxycycline-treated bitransgenic mice, concentrations of MDSC-stimulating cy

74 was elevated in tumors from WAP-DES, but not bitransgenic mice, indicating an alteration in the p53/I

75 Instead, when coexpressed in NK2-HGF/SF bitransgenic mice, NK2 antagonizes the pathological cons

76 n of deltaFosB in NAc and dorsal striatum of bitransgenic mice, or specifically in the NAc core of ra

77 In bitransgenic mice, SRA also antagonized ras-induced tumo

78 In the bitransgenic mice, the increased steady-state levels of

79 In these bitransgenic mice, tumor latency is shortened to 154 day

80 In these bitransgenic mice, we have recapitulated two common gene

81 ared with non-doxycycline-exposed CC10-IL-15 bitransgenic mice.

82 in the lung of CCSP-rtTA/(tetO)7-CMV-Stat3C bitransgenic mice.

83 cycline-treated CCSP-rtTA/(tetO)7-CMV-Stat3C bitransgenic mice.

84 eased in bronchoalveolar lavage fluid of the bitransgenic mice.

85 ession in Kras(G12D)-induced lung cancers of bitransgenic mice.

86 alidated in doxycycline-inducible CC10-IL-15 bitransgenic mice.

87 h nodes were observed in doxycycline-treated bitransgenic mice.

88 ations were decreased in doxycycline-treated bitransgenic mice.

89 (+) immature cells from MMP12-overexpressing bitransgenic mice.

90 s from lung and blood of doxycycline-treated bitransgenic mice.

91 loid lineage cells in multiple organs of the bitransgenic mice.

92 onchoalveolar adenocarcinoma was observed in bitransgenic mice.

93 , PRL induced mammary tumors in 100% of male bitransgenic mice.

94 ble desmoplastic stromal responses in all 25 bitransgenic mice.

95 ansforming growth factor alpha (TGFalpha) in bitransgenic mice.

96 epithelial debridement of Krt12(Cre/Cre)/ZAP bitransgenic mice.

97 progression during lung tumorigenesis using bitransgenic mice.

98 rter mice to obtain Krt12(rtTA/+)/tet-O-LacZ bitransgenic mice.

99 duce overexpression of LacZ as it did in the bitransgenic mice.

100 caine-induced locomotor activity in the CREB bitransgenic mice.

101 ssion after administration of doxycycline to bitransgenic mice.

102 Specifically, in female bitransgenic MMTV-c-myc/p53 null mice (MMTV-myc/p53(-/-)

103 In bitransgenic MMTVrat-erb-B2/MMTV-human-erb-B-3 mice, lun

104 modeling, a murine CCSP-rtTA/(tetO)(7)-MMP12 bitransgenic model was created.

105 Aberrantly expressed genes in the bitransgenic model were identified and served as biomark

106 ieved overexpression of DeltaFosB by using a bitransgenic mouse line that inducibly expresses the pro

107 tion between Myc and E2Fs in vivo, we used a bitransgenic mouse model of Myc-induced T cell lymphomag

108 In addition, a bitransgenic mouse model of severe cardiomyopathy, which

109 eloid-specific c-fms-rtTA/(TetO)(7)-CMV-Api6 bitransgenic mouse model under the control of the c-fms

110 loid-specific c-fms-rtTA/(TetO)(7)-CMV-MMP12 bitransgenic mouse model was created.

111 Here we demonstrate, using a bitransgenic mouse model, that misexpression of human Si

112 and HBsAg coexpression in the liver using a bitransgenic mouse model.

113 mma) was overexpressed in a myeloid-specific bitransgenic mouse model.

114 proliferative response using a Tet-inducible bitransgenic mouse model.

115 cre expression, tumors develop by design in bitransgenic mouse progeny derived by crossing Cre-produ

116 we developed a K14-rtTA/TetRE-ErbB2 'Tet-On' bitransgenic mouse system.

117 tors PKI 166 and erlotinib and a conditional bitransgenic mouse that expressed a constitutively activ

118 Resultant bitransgenic, multiparous, female progeny expressing bot

119 ew, we address two distinct c-myc-containing bitransgenic murine mammary tumor models and discuss the

120 ively repressed in primary thyrocytes from a bitransgenic murine model (Bi-Tg) of thyroid-specific PB

121 ssive progenitor cell lymphomas derived from bitransgenic myc/bcl-2 mice.

122 Western blot analysis was performed on bitransgenic NSE-tTA, TetOp-DeltaFosB, and single-transg

123 xpressed in primary and secondary lesions of bitransgenic offspring and its expression is particularl

124 rom a bicistronic message is accomplished in bitransgenic progeny by Cre-mediated excision of a segme

125 Bitransgenic progeny expressed lacZ exclusively in renal

126 traditional K14-PTHrP (KrP) and an inducible bitransgenic PTHrP mice.

127 R2 receptor activation in vivo by generating bitransgenic reporter mice in which the chemokine recept

128 e and male reproductive tract, we employed a bitransgenic system to target FGF-3 to these organs.

129 In this bitransgenic system, induction of MMP12 abnormally eleva

130 In this bitransgenic system, overexpression of the dnPPARgamma-F

131 In this bitransgenic system, the Api6-Flag fusion protein was ex

132 hesized by the de novo pathway in L2 MECs of bitransgenic versus control mice.