ライフサイエンスコーパス: bitter taste

1 gene directly linked to variations in human bitter taste.

2 ctyol (HED), a known inhibitor of caffeine's bitter taste.

3 ce of potentially harmful compounds by their bitter taste.

4 yllactucin-8-sulphate does not contribute to bitter taste.

5 more artificial fruit and citrus aromas, and bitter taste.

6 expands the capacity of the system to encode bitter taste.

7 -transducins, is a key mediator of sweet and bitter tastes.

8 salty tastes, and the rejection of sour and bitter tastes.

9 Groups first learned to avoid the bitter-tasting alternative of two foods.

10 particularly after US treatment, reduced the bitter taste and enhanced the antioxidant capacities of

11 n as a food ingredient is limited due to its bitter taste and hard texture.

12 al location of genes essential for sweet and bitter taste and identification of the relevant G protei

13 cessing and storage, imparting objectionable bitter taste and rancid flavour to roe products.

14 e is an association between insensitivity to bitter taste and the prevalence of malaria, which sugges

15 eral other signaling mechanisms in sweet and bitter taste, apparently unrelated to alpha-gustducin, t

16 Bitter tastes are among the most salient of life's exper

17 Pathways for sweet and bitter tastes are segregated from sensory input to motor

18 ines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to he

19 n the right temporal group rated an aversive bitter taste as more intense than did subjects in the co

20 ng a view of the representation of sweet and bitter taste at the periphery.

21 ary signal transduction, also restores grk-2 bitter taste avoidance.

22 rception, and to relate to dietary intake of bitter-tasting beverages and foods.

23 bitter-tasting (-)-epigallocatechin gallate, bitter-tasting caffeine, and the umami-tasting l-glutami

24 ral acids but does not respond to sweet- and bitter-tasting chemicals or salt.

25 sugars and amino acids, from harmful, mostly bitter-tasting chemicals present in many plants.

26 ults illustrate the fundamental principle of bitter taste coding at the periphery: dedicated cells ac

27 of these studies for understanding salt and bitter taste coding is discussed.

28 d attractive egg-laying responses toward the bitter-tasting compound lobeline.

29 mulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste typ

30 Bitter-tasting compounds can have specific physiological

31 e receptors (TAS2Rs), which are activated by bitter-tasting compounds such as those found in many foo

32 cells are more narrowly tuned to respond to bitter-tasting compounds than had been predicted from mo

33 indicate that TAS2Rs couple the detection of bitter-tasting compounds to changes in thyrocyte functio

34 y they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossoph

35 ike peptide-1) in response to stimulation by bitter-tasting compounds.

36 nd strychnine, plus a number of non-alkaloid bitter-tasting compounds: 0.1 M KCl, 0.01 M MgCl2, and 1

37 pecifically, we propose that any drug with a bitter taste could have unintended actions in the body t

38 The bitter-tasting denatonium ion has been proposed to act v

39 Bitter taste detection functions as an important sensory

40 Sweet and bitter taste distinguishes good food sources from potent

41 evaluation revealed that the astringent- and bitter-tasting (-)-epigallocatechin gallate, bitter-tast

42 Our understanding of bitter taste has advanced by combined information from d

43 Variation in the perception of bitter tastes has been associated with eating behavior,

44 quences, we infer that the sweet, umami, and bitter tastes have been lost in all penguins, an order o

45 ucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, water

46 Bitter taste in humans is believed to be mediated by a f

47 Of the genotyped children, 45% were bitter taste insensitive individuals of the genotype AVI

48 Bitter taste is a basic taste modality, required to safe

49 We provide a systematic analysis of how bitter taste is encoded by the major taste organ of the

50 Bitter taste is mediated by a different group of G prote

51 Human bitter taste is mediated by the hTAS2R family of G prote

52 tein-coupled taste receptors that bind with "bitter-tasting" ligands are coexpressed in single taste

53 enabling the simultaneous quantification of bitter-tasting mono- and bidesmosidic saponins in fresh

54 e show that acids activate neither sweet nor bitter taste neurons in tarsal taste sensilla.

55 s influenced, in part, by sensitivity to the bitter taste of 6-n-propylthiouracil (Prop), a heritable

56 considered the primary determinants for the bitter taste of cooked asparagus.

57 pends on (a) elimination of the unacceptably bitter taste of free erythromycin, (b) its stability aga

58 irst time to be the major contributor to the bitter taste of fresh asparagus spears, while the bidesm

59 The bitter taste of olives is mainly caused by the phenolic

60 Genetic sensitivity to the bitter taste of phenylthiocarbamide and 6-n-propylthiour

61 e sensitizers, are needed to mask the strong bitter taste of pyrophosphates.

62 The starter culture reduced the bitter taste of the final product.

63 luding the ability to modulate the salty and bitter tastes of sodium and potassium salts.

64 ily of mammalian taste receptors involved in bitter taste perception (the T2Rs).

65 rry introgressed mouflon alleles involved in bitter taste perception and/or innate immunity.

66 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) a

67 Bitter taste perception prevents mammals from ingesting

68 Bitter taste perception provides animals with critical p

69 A significant reduction of bitter taste perception was documented in individuals ha

70 pression accounts for the variation in human bitter taste perception, and to relate to dietary intake

71 chemistry: caffeine, a naturally occurring, bitter-tasting, pharmacologically active secondary compo

72 urrent understanding of the role of the PROP bitter taste phenotype in food selection and body weight

73 e investigated the relation between the PROP bitter-taste phenotype and acceptance and consumption of

74 These novel findings suggest that the PROP bitter-taste phenotype contributes to the development of

75 y an important role in limiting ingestion of bitter-tasting, potentially toxic compounds.

76 ing of these tubers results in dark-colored, bitter-tasting products.

77 eptor antagonists can effectively reduce the bitter taste qualities of foods, beverages, and pharmace

78 tor cells that coincide with sweet/umami and bitter taste reception to modulate local inflammatory re

79 taste tissue, abolish sweet, amino acid, and bitter taste reception, but do not impact sour or salty

80 as established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models

81 We hypothesize that human bitter taste receptor (TAS2R) genes might be relaxed fro

82 ssynaptic tracing originating from umami and bitter taste receptor cells does not selectively label t

83 We then show that expression of a bitter taste receptor confers sensitivity to selected av

84 ngle gene that encodes a member of the TAS2R bitter taste receptor family.

85 as related to common variants of the TAS2R31 bitter taste receptor gene and to NNS intake.

86 hypothesis through cross-mammal analyses of bitter taste receptor gene repertoires.

87 a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene.

88 aries among adults due to polymorphisms in a bitter taste receptor gene.

89 It is assumed that the orthologous bitter taste receptor genes mediate the recognition of b

90 lineages generated species-specific sets of bitter taste receptor genes.

91 table to smaller surviving mammals with more bitter taste receptor genes.

92 n, we show that mice engineered to express a bitter taste receptor in 'sweet cells' become strongly a

93 It is believed that the receptive ranges of bitter taste receptor repertoires match the profiles of

94 Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate

95 lactoferrin and deficient functioning of the bitter taste receptor TAS2R38.

96 A polymorphism in a bitter taste receptor was recently associated with refra

97 a clear signal of positive selection at the bitter-taste receptor gene TAS2R16.

98 Polymorphisms in the bitter-taste receptor TAS2R38 explain the majority of ph

99 In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds

100 Bitter taste receptors (T2Rs) in the human airway detect

101 -protein coupled receptors (GPCRs) including bitter taste receptors (TAS2R) agonists and prostaglandi

102 yometrial cells from human and mouse express bitter taste receptors (TAS2Rs) and their canonical sign

103 Bitter taste receptors (TAS2Rs) are G-protein-coupled re

104 Although bitter taste receptors (TAS2Rs) are important for human

105 Bitter taste receptors (TAS2Rs) enable animals to detect

106 Strikingly, activation of G-protein-coupled bitter taste receptors (TAS2Rs) in airway smooth muscle

107 Bitter taste receptors (TAS2Rs) on the tongue probably e

108 ompounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs).

109 We recently identified bitter taste receptors (taste family type 2 receptors, o

110 the remaining Gr genes are likely to encode bitter taste receptors [9-11], albeit some function as p

111 y chemosensory cells (SCCs) that express T2R bitter taste receptors along with their downstream signa

112 Bitter taste receptors as targets for tocolytics in pret

113 have demonstrated that sequence-orthologous bitter taste receptors have distinct agonist profiles.

114 that single taste bud cells express multiple bitter taste receptors have reignited a long-standing co

115 n and colleagues investigate the role of the bitter taste receptors in airway epithelial cells, and f

116 ing to multiple members of the T2R family of bitter taste receptors in the antral and fundic gastric

117 These findings (i) demonstrate that bitter taste receptors in the stomach and the oral cavit

118 These results demonstrate the expression of bitter taste receptors of the T2R family in the mouse an

119 of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin

120 By challenging 34 mouse bitter taste receptors with 128 prototypical bitter subs

121 We found that these cells express sensory bitter taste receptors, which localized on motile cilia.

122 ystem to show that specific T2Rs function as bitter taste receptors.

123 d in the oral cavity, where they function as bitter taste receptors.

124 These chemosensory cells express T2R "bitter-taste" receptors and alpha-gustducin, a G protein

125 Based on quantitative data and bitter taste recognition thresholds, dose-over-threshold

126 t have investigated the relationship between bitter-taste response and dietary behaviors and chronic

127 a history of rapid yet constrained change in bitter taste responses in the course of primate evolutio

128 and mouse) can determine the selectivity of bitter taste responses.

129 naling components that transduce or regulate bitter taste responses.

130 compelling evidence for its pivotal role in bitter taste sensation, a direct involvement of the G-pr

131 , obesity influences components of sweet and bitter taste sensing in the duodenum as well as regions

132 and palate epithelium and are implicated in bitter taste sensing.

133 Bitter taste-sensing G protein-coupled receptors (type 2

134 e taste pathways by activating the sour- and bitter-taste-sensing cells.

135 Genetic variation in bitter taste sensitivity has been well documented, and i

136 ore general, hypothesis is that variation in bitter taste sensitivity has coevolved with the use of s

137 nd food intake in healthy volunteers.Lingual bitter taste sensitivity was tested with the use of 6 co

138 a collectively suggests that RGS21 modulates bitter taste signal transduction.

139 ermore, addition of compounds widely used in bitter taste signaling (e.g., denatonium, phenylthiocarb

140 are mediated via activation of the canonical bitter taste signaling cascade (i.e., TAS2R-gustducin-ph

141 expression approach to analyze the logic of bitter taste signaling.

142 dorants and pheromones as well as sweet- and bitter-tasting small molecules are perceived through act

143 onal anatomy of neural circuits activated by bitter taste stimulation.

144 tuation phenomenon generalized to four other bitter taste stimuli (caffeine, aristolochic acid, Grind

145 could discriminate between salicin and those bitter taste stimuli that activate (1) different populat

146 s of taste cells that respond selectively to bitter taste stimuli.

147 his insect facilitates the discrimination of bitter taste stimuli.

148 enhanced ATP release evoked by sweet but not bitter taste stimuli.

149 tributes to the discrimination of different "bitter" taste stimuli in Manduca sexta caterpillars.

150 ) contribute to the discrimination of three "bitter" taste stimuli: salicin, caffeine, and aristoloch

151 olved in the transduction of both sweet- and bitter-tasting stimuli by mammalian taste receptor cells

152 at PYY signaling modulates responsiveness to bitter-tasting stimuli, as well as to lipid emulsions.

153 ar's taste-mediated aversive response to one bitter taste stimulus (salicin) and then asked whether t

154 could not discriminate between salicin and a bitter taste stimulus that activates the same signaling

155 Denatonium, one of the most bitter-tasting substances known, stimulated insulin secr

156 ubunit implicated in responses to sweet- and bitter-tasting substances.

157 cated in the transduction of both sweet- and bitter-tasting substances.

158 es the chemosensory receptor subfamilies for bitter taste (TAS2R) and pheromones (Vomeronasal, VN1R)

159 and salty tastes and reject lower levels of bitter tastes than do adults.

160 ables, particularly the vegetables that were bitter tasting, than did the taster children during a fr

161 vide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelat

162 ntrations in nectar did not exceed the bees' bitter taste threshold, implying that pollinators impose

163 ction to protect an animal from ingestion of bitter-tasting toxins.

164 of the G-protein subunit alpha-gustducin in bitter taste transduction in taste cells has not been de

165 nsive cells and thus may also play a role in bitter taste transduction.

166 wnstream signaling effectors associated with bitter taste transduction.

167 on that the recognition of sweet, umami, and bitter tastes use the same signaling molecules.

168 reflected the higher consumption of the more bitter-tasting vegetables (olives, cucumber, and broccol

169 of PROP would give higher hedonic ratings to bitter-tasting vegetables and would consume more bitter

170 ay a role in the acceptance and rejection of bitter-tasting vegetables by young children.

171 A significant predictive model for bitter taste was built by means of PLSR.

172 Bitter taste was highly correlated with the in-mouth per

173 ting the brain fields representing sweet and bitter taste we directly control an animal's internal re

174 Some vegetables and fruit have bitter tastes, which can be aversive to consumers, parti

175 esity have concentrated largely on sweet and bitter tastes, with little work on the "savory" tastes-s

176 s were led to believe that a highly aversive bitter taste would be less distasteful than it actually