コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 ers and low in the daughters of the anterior blastomere.
2 e, rafts were also apically enriched in each blastomere.
3 orm anterior pharyngeal muscles from the ABa blastomere.
4 d hypodermis, tissues normally made by the C blastomere.
5 ntrated in the late-dividing, two-cell-stage blastomere.
6 s a result of G2 cell cycle arrest of the P4 blastomere.
7 e) determines the developmental fate of each blastomere.
8 in misorientation of the spindle of the ABar blastomere.
9 mic fashion unique for each protein and each blastomere.
10 is seen with features of totipotent two-cell blastomeres.
11 distributed equally to somatic and germline blastomeres.
12 ely repressing transcription in all germline blastomeres.
13 ly in oocytes and segregated to all germline blastomeres.
14 pendent upon the unequal division of vegetal blastomeres.
15 es high PIE-1 levels in oocytes and germline blastomeres.
16 Similar results are seen with isolated blastomeres.
17 lar programs of the embryo and of individual blastomeres.
18 regulated by the unequal division of vegetal blastomeres.
19 throughout the presumptive endoderm and B7.5 blastomeres.
20 etric distribution of Cdx2 mRNA in polarized blastomeres.
21 at the blastula stage from the most marginal blastomeres.
22 become the retina by injection into Xenopus blastomeres.
23 scription in both somatic and later germline blastomeres.
24 t mature differently in somatic and germline blastomeres.
25 n that blocks mRNA transcription in germline blastomeres.
26 ad4 homo- and heteromers in isolated Xenopus blastomeres.
27 e structures within the cytoplasm of vegetal blastomeres.
28 erated in the apical membrane of early stage blastomeres.
29 human embryonic stem (hES) cells from single blastomeres.
30 tive pathway both in NSM cells and in animal blastomeres.
31 furrow, and remains enriched in animal pole blastomeres.
32 essential to set the identities of the early blastomeres.
33 ture, including the identity of the columnar blastomeres.
34 ng that hES cells can be derived from single blastomeres.
35 ributed in the clear apical cytoplasm of the blastomeres.
36 riched at the surface of all non-mesenchymal blastomeres.
37 mulation of its message in macromere-derived blastomeres.
38 lastomere and to mutant embryos with extra C blastomeres.
39 the apical aPKC in the polarisation of frog blastomeres.
40 es with GlsA, both in interphase and mitotic blastomeres.
41 activation of HIPPO signaling in the outside blastomeres.
42 y to suppress HIPPO signaling in the outside blastomeres.
43 olarity proteins to contact-free surfaces of blastomeres.
44 d, ANE regulatory state to the most anterior blastomeres.
45 MEX-3, enabling ZIF-1 expression in somatic blastomeres.
46 or proper nuclear division in large dividing blastomeres.
51 indicate that in vivo, PDCD2 is critical for blastomere and ESC maintenance by contributing to the re
52 l inhibition of Xbves activity within the A1 blastomere and its derivatives completely randomizes mov
54 vision orientation of the endomesoderm (EMS) blastomere and the endoderm fate of the posterior EMS da
55 type embryos with mutant embryos lacking a C blastomere and to mutant embryos with extra C blastomere
56 s destabilized/degraded in animal hemisphere blastomeres and became localized to the nuclei of the fo
60 pecific transcriptional program in the inner blastomeres and prevents segregation of the TE and ICM l
61 150 nonredundant protein groups between all blastomeres and replicate measurements, we found signifi
62 gion of the embryo but is inactive in animal blastomeres and show that the inability of LvDsh to func
63 ginine methyltransferase CARM1 in individual blastomeres and show that this directs their progeny to
64 data suggest heterogeneity among early-stage blastomeres and that the UCSFB lines have unique propert
65 Thirteen uniquely identifiable individual blastomeres and two double cell combination deletions we
66 an be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic
67 adherin, the major cell-adhesion molecule of blastomeres, and present evidence that this modification
68 yos, nos-2 translation is repressed in early blastomeres, and this inhibition depends on a second reg
69 e exchange of cytoplasm and membrane between blastomeres; and (b) they are active in caveolar endocyt
71 e and fragmentation parameters of individual blastomeres are diagnostic of ploidy, amenable to automa
77 When CD divides, the larger D and smaller C blastomeres arise invariantly on the left and right side
80 , H3K4me3 deposition is poor in the germline blastomere, as expected, but surprisingly three somatic
83 d annelids), it has long been known that one blastomere at the four-cell stage, the D cell, and its d
84 d that GlsA is about equally abundant in all blastomeres at all cleavage stages examined but that Hsp
85 m specification: appropriate polarisation of blastomeres at the 8- and 16-cell stage and then the mai
86 n of different histone modifications between blastomeres at the morula stage and cell sub-populations
87 sed the experimental potential of individual blastomeres based on their level of Cdx2-eGFP expression
88 human embryos to address the hypothesis that blastomere behaviour may reflect ploidy during the first
89 ation further elevated overall blastomere-to-blastomere biases during the two- to 16-cell embryo stag
90 , we revealed that the initial blastomere-to-blastomere biases emerge as early as the first embryonic
92 rs, showed ever-increasing asymmetry between blastomeres (bistable pattern), supposedly controlled by
93 nd sufficient for cas expression in marginal blastomeres, Bon and Gata5 are unable to induce cas in a
95 is switch occurs asynchronously in different blastomeres but is independent of clonal cell heritage a
96 epresses transcription in the later germline blastomeres but not in the earlier germline blastomeres
97 in was found at the apex of outer, polarized blastomeres but was undetectable in blastomeres of the i
98 o block serine 2 phosphorylation in germline blastomeres, but unexpectedly is not essential for trans
100 canonical Wnt pathway to the dorsal marginal blastomeres by defining the domain where the Wnt8a activ
101 omes promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcript
102 ZIF-1 continues to be repressed in germline blastomeres by POS-1, a germline blastomere-specific pro
103 ttern of symmetric/asymmetric divisions of a blastomere can be influenced by its origin in relation t
104 also show that the genetic lineage of early blastomeres can be traced by DNA methylation analysis.
105 g CTNNB1 undergo fission and these separated blastomeres can become small trophoblastic vesicles, whi
106 f all species, yet how neighboring embryonic blastomeres can contribute to different germ layers has
107 ndogenous VegT and/or Vg1 in ventral vegetal blastomeres can induce a neural fate, but only allows ex
110 n from blastocyst inner cell mass and single blastomere cells without a need to destroy the embryo.
111 nic trophectoderm are established when eight blastomeres compact to form polarized morulae in preimpl
112 m human embryos at the blastomere, polyploid blastomere, compaction, morula and blastocyst-like stage
113 e remarkable genomic heterogeneity among the blastomeres comprising a single embryo during human prei
114 opy number of parental genomes in 116 single blastomeres comprising entire preimplantation bovine emb
115 opposing lineage specifiers within an early blastomere constantly compete with each other based on t
116 een blastomere progeny so that the loss of a blastomere could be compensated for during development.
117 hen the mass of yolk-free proteins in single blastomeres decreased from approximately 0.8 mug (16-cel
118 ge is not exactly symmetric, the content per blastomere decreases roughly by half with each cell divi
120 ding proteins, with expression in a specific blastomere dependent upon the precise combination of the
124 e-cell gene expression analysis reveals that blastomeres develop cell autonomously, with some cells a
125 altered subcellular localization of TEAD4 in blastomeres dictates first mammalian cell fate specifica
126 tomeres, we report highly reproducible inter-blastomere differences among 10 2-cell and five 4-cell m
128 se data substantiate the hypothesis of inter-blastomere differences in 2- and 4-cell mouse embryos, a
130 rically dividing embryos may determine which blastomeres divide asymmetrically and which do not.
132 rtebrate development, apicobasally polarised blastomeres divide to produce inner non-polarised cells
133 such asymmetric division occurs when the EMS blastomere divides to produce MS, a mesoderm precursor,
134 D-modeling framework that iteratively infers blastomere division positions and orientations, and cons
135 tribute cells to the retina; ventral vegetal blastomeres do not form retina even when provided with n
136 ntain long-term contacts between nonadjacent blastomeres during expansion of the interstitial space i
137 s than in posterior (symmetrically dividing) blastomeres during the period of asymmetric division.
138 modification expression was detected between blastomeres earlier in human embryos at the four- to eig
142 f either factor in dorsal-animal retinogenic blastomeres expands expression of neural/retinal genes a
143 n response to stabilized betacatenin, dorsal blastomeres express the closely related transcriptional
144 olk syncitial layer was normal, the marginal blastomeres failed to migrate toward the vegetal pole an
146 ontrast, chimaeras made from four-cell stage blastomeres from early meridional divisions develop norm
147 dual four-cell blastomeres are surrounded by blastomeres from random positions, they are able to cont
149 cal and growth-rate heterogeneity, and mouse blastomeres from the same embryo have stochastic differe
150 Controversy exists as to whether individual blastomeres from two-cell-stage mouse embryos have ident
152 pindle into the apicobasal axis of polarised blastomeres generates inner and outer cells with differe
153 d how in the majority of embryos, individual blastomeres give rise to distinct blastocyst regions.
154 ell division failure in early Xenopus embryo blastomeres has been attributed to a role of maskin in r
156 s of DNA synthesis and mitosis, and arrested blastomeres have abnormal spindles, clustered centrosome
157 stomeres, we observed that the blastomere-to-blastomere heterogeneity in 8-, 16-, 32-, and 50-cell em
160 gh we have identified isolated examples of a blastomere imparting a statistically significant bias, w
161 3K4me3 are descendants of the first germline blastomere, implying an activity that impedes on H3K4me3
162 ated in oocytes and localize to one or a few blastomeres in a spatially and temporally dynamic fashio
165 maging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy
166 hat the orientation of division of polarised blastomeres in the 8- and 16-cell stage embryo determine
167 endoderm (ME) cells are the two most vegetal blastomeres in the early developing embryo of the marine
170 ation dynamics specifically in the posterior blastomere, independently of regulators previously impli
171 f the dominant-negative mRNA into individual blastomeres indicated that the effect was exerted on the
172 dle polarization during division of the ABar blastomere, indicating that these cell surface proteins
174 fined to half of the embryo via 2-cell stage blastomere injections, the latter does not produce the o
177 ther study it resulted in differentiation of blastomeres into trophoblast giant cells (TGCs), suggest
178 known if this lineage pattern means a given blastomere is committed to its specific fate, indicative
179 t of clonal cell heritage and of whether the blastomere is within the inner cell mass or the trophoec
180 we performed bottom-up proteomics on single blastomeres isolated by microdissection from 2-, 4-, 8-,
182 prehensive quantitative proteomics on single blastomeres isolated from these early stage embryos can
184 hen taken together, our results suggest that blastomere lineage does not impart a widespread bias for
186 s, human zygotes and perhaps human embryonic blastomeres may be useful supplements to human oocytes f
187 s able to influence positional allocation of blastomeres, mediating preferential localization to the
189 he extent of asymmetry was minimized between blastomeres (monostable pattern), whereas other genes, i
192 the late-dividing but not the first-dividing blastomere of two-cell embryos and, by lineage tracing a
196 ell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell embry
199 ing highly heterogeneously expressed between blastomeres of the 4-cell embryo, with Sox21 showing one
200 fusion proteins are overexpressed in single blastomeres of the 4-cell stage embryo, the progeny of t
201 By ectopically expressing hlh-1 in early blastomeres of the C. elegans embryo, we show that CeMyo
202 We found that Vasa protein is present in all blastomeres of the early embryo and that its abundance o
207 ion of TPX2 or its C terminus (TPX2-CT) into blastomeres of two-cell embryos led to potent cleavage a
209 tation techniques to investigate whether the blastomeres of two-cell-stage mouse embryos can reprogra
210 express Pax7, but overexpression of Pax7 in blastomeres of whole embryos that populate the myogenic
211 nerates Ca(2+) transients in the superficial blastomeres of zebrafish blastulae when the nuclear accu
212 onstrate that ZO-1 siRNA delivery inside the blastomeres of zona-weakened embryos using electroporati
213 inclined 'lineage strength' that pushes the blastomere onto a predisposed, yet flexible, lineage tra
215 expressed at least two isoforms in the same blastomere or oocyte, which unambiguously demonstrated t
216 ount either the spatial origin of individual blastomeres or the spatial allocation and fate of their
222 enerate transcriptionally repressed germline blastomeres (P1-P4) and somatic sisters that become tran
224 angle of division, such as the position of a blastomere, play a major role in the specification of TE
225 indistinguishable from human embryos at the blastomere, polyploid blastomere, compaction, morula and
227 st mouse embryos the progeny of one two-cell blastomere primarily populate the embryonic part of the
228 ion and premature division in early germline blastomeres, processes that are independent of PIE-1 fun
230 elopment, or if regulation can occur between blastomere progeny so that the loss of a blastomere coul
235 tion, while overnight culture of dissociated blastomeres resulted in formation of re-aggregated embry
238 lating early embryonic fate specification by blastomere separations, exposure to lithium, and dominan
239 ing from the major ectodermal progenitor (AB blastomere) several cell divisions later, thereby preven
240 ngth-dependent microtubule forces that probe blastomere shape and yolk gradients, biased by cortical
241 y of these equatorially or obliquely derived blastomeres show developmental abnormalities in both lat
247 gle-cell transcriptome reveal enrichment for blastomere-specific signature and a dynamic DNA methylom
249 no oligonucleotides (MOs) microinjected into blastomeres suppressed hnRNP K expression from neural pl
250 tment, the progeny of the resulting two-cell blastomeres tend to populate the respective embryonic an
251 undant in anterior (asymmetrically dividing) blastomeres than in posterior (symmetrically dividing) b
252 a asymmetric divisions of eight- and 16-cell blastomeres that allocate cells to inner and outer posit
254 equatorial or oblique allows us to identify blastomeres that differ in their fate and in their devel
255 homeobox factor PAL-1 can activate hlh-1 in blastomeres that either lack POP-1/TCF or that have down
257 Altered spindle orientations occurred in blastomeres that had direct contact with one of the ME c
258 ects of chimaeras made from the most vegetal blastomeres that result from later second cleavages are
259 <0.2% of the total protein content in single blastomeres that were isolated from the 16-cell frog (Xe
260 c arginine residues are maximal in four-cell blastomeres that will contribute to the inner cell mass
261 bryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner
263 ) is detected in wild-type-arrested prophase blastomeres, the inactive state is not detected in the a
264 that PGCCs represent somatic equivalents of blastomeres, the most primitive cancer stem cells report
265 TE-specific transcriptional program in inner blastomeres, thereby allowing their maturation toward th
267 s unsettled whether the contribution of each blastomere to these two lineages can be accounted for by
268 levels of H3 arginine methylation predispose blastomeres to contribute to the pluripotent cells of th
270 ess the ability of dorsal-animal retinogenic blastomeres to form retina, converting the lineage from
272 es, might modulate the response of embryonic blastomeres to growth factors and other signals that gov
273 NC-120/SRF and HND-1/HAND, can convert naive blastomeres to muscle when overproduced ectopically in t
276 d on the intrinsic ability of the individual blastomeres to respond to signals directing epiboly and
278 To investigate the contribution of early blastomeres to the veliger larva, we used intracellular
279 iptional activation further elevated overall blastomere-to-blastomere biases during the two- to 16-ce
280 tation embryos, we revealed that the initial blastomere-to-blastomere biases emerge as early as the f
281 different blastomeres, we observed that the blastomere-to-blastomere heterogeneity in 8-, 16-, 32-,
289 however, by creating embryos with over-sized blastomeres we present evidence of a developmental progr
290 our mRNA-Seq assay with only a single mouse blastomere, we detected the expression of 75% (5,270) mo
291 aring the protein expression among different blastomeres, we observed that the blastomere-to-blastome
292 g deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible inter-blastom
294 l lineage specification of MS and its sister blastomere, whereas the inductive interaction promotes t
295 ed reproducible bimodal expression in sister blastomeres, which cannot be explained by random fluctua
297 single pair of endomesoderm cells, the A6.3 blastomeres, which form part of the anterior endoderm, h
298 em (TS) cell lines were produced from single blastomeres, which maintained normal karyotype and marke
299 gl2 localises to the basolateral membrane of blastomeres, while Crumbs3 localises to the apical and b
300 ntirely from a single progenitor cell, the E blastomere, whose identity is specified by GATA type tra
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。