ライフサイエンスコーパス: bloc

1 sis of lysosome-related organelle complexes (BLOCs).

2 is of lysosome-related organelles complexes (BLOCs).

3 idneys should be used as single grafts or en bloc.

4 2 locus and the capture of the cps island en bloc.

5 uncovered novel allele-specific features of BLOCs.

6 esis of lysosome-related organelles complex (BLOC)-1, -2, and -3.

7 esis of lysosome-related organelles complex (BLOC)-1, a protein complex with no known function.

8 These results suggest that AP-3 and BLOC-1 act, either in concert or sequentially, to specif

9 We discuss similarities and differences of BLOC-1 activity in the biogenesis of gut granules as com

10 Deficiencies in AP-3 and BLOC-1 affect synaptic vesicle composition.

11 itive to genetic dosages of loss-of-function BLOC-1 alleles.

12 BLOC-1 also interacts with BLOC-2 to facilitate Tyrp1 tr

13 Both BLOC-1 and -2 localize mainly to early endosome-associat

14 These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of t

15 novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neurona

16 PI4KIIalpha copurified with BLOC-1 and AP-3 in neuronal cells.

17 These results indicate that the BLOC-1 and AP-3 protein complexes affect the targeting o

18 Dysbindin/BLOC-1 and ATP7A genetically and biochemically interact.

19 eam endosomal intermediates, suggesting that BLOC-1 and BLOC-2 act sequentially in the same pathway.

20 quent observations that AP-3, as well as the BLOC-1 and BLOC-2 Hermansky-Pudlak syndrome proteins are

21 mediated by AP-3 and one pathway mediated by BLOC-1 and BLOC-2, that are deficient in several forms o

22 BLOC-1 and BLOC-2, together with the AP-3 clathrin adapt

23 Dennis et al. report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of

24 hypopigmentation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky-Pudlak syndrom

25 e that the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulator

26 BLOC-1 and Msb3 interacted in vivo, and both mutants res

27 omal sorting mechanisms mediated by AP-3 and BLOC-1 are perturbed in Hermansky-Pudlak Syndrome, a hum

28 ient mice suggesting that genetic defects in BLOC-1 are upstream of the BDNF phenotype in Mecp2 defic

29 or (GEF) of Ypt7 (the Mon1-Ccz1 complex) and BLOC-1 both localize to the same endosomes.

30 2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo so

31 dies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecul

32 We previously identified the hexameric BLOC-1 complex as an effector of the yeast Rab5 Vps21, w

33 that Arp2/3, dysbindin, and subunits of the BLOC-1 complex biochemically and genetically interact, m

34 E AP-3 cargoes and suggest a function of the BLOC-1 complex in membrane protein sorting.

35 ed prevalent and novel cellular roles of the BLOC-1 complex in neuronal cells by performing large-sca

36 subunits, some of which are shared with the BLOC-1 complex involved in the biogenesis of lysosome-re

37 These results indicate that the BLOC-1 complex is conserved in C. elegans.

38 Our analysis indicates that BLOC-1 complex modulates the association of PI4KIIalpha

39 Here, we show that the BLOC-1 complex resides on microvesicles that also contai

40 and its product dysbindin, a subunit of the BLOC-1 complex, and describe a neuronal pathway modulati

41 entified 24 proteins that associate with the BLOC-1 complex, many of which were altered in content/di

42 Of importance, BLOC-1 complex, WASH complex, RhoGEF1, or PI4KIIalpha de

43 an be caused by mutations in subunits of the BLOC-1 complex.

44 ssembles, with dysbindin, into the octameric BLOC-1 complex.

45 SNAREs; subunits of the AP-3, retromer, and BLOC-1 complexes; lysosomal enzymes; CHC22; and five nov

46 The yeast BLOC-1 consisted of six subunits, which localized interd

47 We thus conclude that BLOC-1 controls the lifetime of active Rab5/Vps21 and th

48 We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling

49 Human dysbindin/BLOC-1 coprecipitates with NSF and vice versa, and both

50 In fact, BLOC-1 deficiencies selectively reduced AP-3 and AP-3 ca

51 ntent in the dentate gyrus of dysbindin-null BLOC-1 deficiency and AP-3-null mice.

52 hinery as factors downregulated in dysbindin/BLOC-1 deficiency in neuroectodermal cells and iPSC-deri

53 ts into the metabolic consequences caused by BLOC-1 deficiency in pallid mice, which carry a null mut

54 Furthermore, BLOC-1 deficiency selectively altered the subcellular di

55 Here, we have generated a fly model of BLOC-1 deficiency.

56 NF content was reduced in the hippocampus of BLOC-1 deficient mice suggesting that genetic defects in

57 However, here we report that AP-3 and BLOC-1 differentially regulate the composition of presyn

58 Our results demonstrate that dysbindin/BLOC-1 expression defects result in altered cellular con

59 -1- and AP-3-favoring OCA2 variants required BLOC-1 for melanosomal transport.

60 rry the cargo protein TYRP1 and that require BLOC-1 for their formation.

61 ogaster as a powerful model for the study of BLOC-1 function and its interactions with modifier genes

62 Epistatic analyses revealed that BLOC-1 function in pigment granule biogenesis requires t

63 Here, we show that BLOC-1 functions in selective cargo exit from early endo

64 as compared to mammalian melanosomes, where BLOC-1 has been most extensively studied for its role in

65 -3(-) and BLOC-1(-) phenotypes revealed that BLOC-1 has some functions independent of the AP-3 adapto

66 his is the first demonstration of a role for BLOC-1 in ciliary assembly and highlights the complexity

67 Consistent with the role of BLOC-1 in sorting from the endosome, we find that disrup

68 New findings include BLOC-1 interactions with the COG complex, a Golgi appara

69 Here, we report that BLOC-1 interacts physically and functionally with AP-3 t

70 Importantly, BLOC-1 interacts with the HOPS on vacuoles, suggesting a

71 We now demonstrate that BLOC-1 is an endosomal Rab-GAP (GTPase-activating protei

72 Additionally, our data show that BLOC-1 is both a Vps21 effector and an adapter for its G

73 of the Arp2/3 complex were downregulated by BLOC-1 loss of function, thus affecting actin dynamics i

74 ound 491 proteins sensitive to dysbindin and BLOC-1 loss of function.

75 e cellular content is sensitive to dysbindin/BLOC-1 loss of function.

76 Dysbindin/BLOC-1 loss-of-function alleles do not affect cell and t

77 We focused on BLOC-1 mutants affecting synapse composition and functio

78 Mouse mutants that cause BLOC-1 or AP-3 deficiencies affected the targeting of LA

79 elocalization is prevented by loss of either BLOC-1 or Msb3, but it also occurs in mutants lacking en

80 o test the hypothesis that NSF and dysbindin/BLOC-1 participate in a pathway-regulating synaptic func

81 and complex adaptive behavior in response to BLOC-1 perturbation.

82 We biochemically confirmed BLOC-1 presence in Drosophila neurons, and measured syna

83 y with an increase in the expression of both BLOC-1 related complex subunit 7 (BORCS7) and a previous

84 ks, or interactomes, downstream of dysbindin/BLOC-1 remain partially explored despite their potential

85 However, the molecular function of BLOC-1 remains unknown.

86 nterneuron markers, as well as expression of BLOC-1 subunit gene products, were affected differently

87 n glo-2 and snpn-1,or RNAi targeting 5 other BLOC-1 subunit homologues in a genetic background sensit

88 no acid identity, encode Pallidin and Snapin BLOC-1 subunit homologues, respectively.

89 BLOC-1 subunit interactions involving Pallidin and Snapi

90 We defined the distribution of the BLOC-1 subunit pallidin in human and mouse hippocampus a

91 are corrected by restoration of the missing BLOC-1 subunit.

92 Moreover, because BLOC-1 subunits are mutated in subtypes of the genetic d

93 Mutations in BLOC-1 subunits underlie an inherited disorder character

94 In the absence of BLOC-1 subunits, the balance between recycling and degra

95 genes encoding dysbindin and its interacting BLOC-1 subunits.

96 In metazoan cells, three complexes, termed BLOC-1 to -3, mediate protein sorting from the early end

97 egulate dysbindin, compromise the ability of BLOC-1 to traffic DRD2 toward degradation, but has littl

98 BLOC-1(-) intestinal cells missorted gut granule cargo t

99 utant analysis and comparison of AP-3(-) and BLOC-1(-) phenotypes revealed that BLOC-1 has some funct

100 is of lysosome-related organelles complex-1 (BLOC-1) for ciliary delivery.

101 is of Lysosome-Related Organelles Complex 1 (BLOC-1) is a protein complex containing the schizophreni

102 is of lysosome-related organelles complex 1 (BLOC-1) is a protein complex formed by the products of e

103 is of lysosome-related organelles complex-1 (BLOC-1) is a protein complex involved in the formation o

104 is of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenes

105 is of lysosome-related organelles complex-1 (BLOC-1), and associated interacting proteins.

106 is of lysosome-related organelles complex 1 (BLOC-1), increased the content of characteristic synapti

107 is of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid ki

108 is of lysosome-related organelles complex 1 (BLOC-1), which interacts with the adaptor protein comple

109 is of lysosome-related organelles complex-1 (BLOC-1)-dependent manner.

110 is of lysosome-related organelles complex 1 (BLOC-1).

111 is of lysosome-related organelles complex 1 (BLOC-1).

112 ypic fusion and vacuole protein sorting, and BLOC-1, -2, and -3.

113 Our results imply that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosom

114 AP-3 was co-isolated with BLOC-1, BLOC-2, and homotypic fusion and vacuole protein

115 udlak syndrome complexes, we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI

116 , and down-regulation of either PI4KIIalpha, BLOC-1, or AP-3 complexes led to similar LAMP1 phenotype

117 BLOC-1, PI4KIIalpha, and AP-3 belong to a tripartite com

118 Loss-of-function alleles of BLOC-1, Pldn(pa/pa), and Muted(mu/mu) revealed that this

119 of lysosome-related organelles complex-1, or BLOC-1, proteins in these individuals.

120 To address the function of C. elegans BLOC-1, we assessed the intracellular sorting of CDF-2::

121 assemble into five distinct complexes (AP-3, BLOC-1-3, and HOPS) that either sort membrane proteins o

122 fecting actin dynamics in early endosomes of BLOC-1-deficient cells.

123 BLOC-1-deficient melanocytes accumulate the melanosomal

124 mory and behavioural impairments observed in BLOC-1-deficient mice.

125 decreased in cells that were either AP-3- or BLOC-1-deficient.

126 However, whether AP-3-BLOC-1-dependent sorting events that control synapse mem

127 n, we examined the role for NSF in dysbindin/BLOC-1-dependent synaptic homeostatic plasticity in Dros

128 r data suggest that VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, il

129 les, our data reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the

130 dent factors in the hippocampus of dysbindin/BLOC-1-null mice.

131 However, the striatum did not exhibit these BLOC-1-null phenotypes.

132 show that Ragulator directly interacts with BLOC-1-related complex (BORC), a multi-subunit complex p

133 C-terminal domain of lyspersin, a subunit of BLOC-1-related complex (BORC), is essential and sufficie

134 Here we show that part of the BLOC-1-related complex (BORC), previously shown to regul

135 ntent and/or subcellular distribution of the BLOC-1-sensitive cargoes PI4KIIalpha, ATP7A, and VAMP7.

136 ical molecular pathways contained within the BLOC-1-sensitive proteome.

137 istribution in cells or tissues deficient in BLOC-1.

138 some biogenesis requires the protein complex BLOC-1.

139 ach neurites in cells lacking either AP-3 or BLOC-1.

140 osome-related organelles complex (BLOC)-3 or BLOC-1.

141 , a subunit of the endosomal sorting complex BLOC-1.

142 ng: LE transport regulates SV pool size, and BLOC-1/AP-3-dependent sorting fine-tunes the Ca(2+) sens

143 tion regulates SV positional priming through BLOC-1/AP-3-dependent sorting.

144 nderwent transthoracic esophagectomy with en bloc 2-field lymphadenectomy after neoadjuvant therapy w

145 le after transthoracic esophagectomy with en bloc 2-field lymphadenectomy in patients post neoadjuvan

146 nesis of lysosome-related organelle complex (BLOC)-2.

147 al intermediates, suggesting that BLOC-1 and BLOC-2 act sequentially in the same pathway.

148 ranule biogenesis requires the activities of BLOC-2 and a putative Rab guanine-nucleotide-exchange fa

149 eatures of HPS-3 melanocytes; HPS3 is also a BLOC-2 component.

150 These results support a model in which BLOC-2 functions to direct recycling endosomal tubular t

151 vations that AP-3, as well as the BLOC-1 and BLOC-2 Hermansky-Pudlak syndrome proteins are essential

152 ed predominantly with the HPS-5 component of BLOC-2 in normal human melanocytes.

153 omplexes, we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI4KIIalpha inclus

154 BLOC-1 also interacts with BLOC-2 to facilitate Tyrp1 trafficking by a mechanism ap

155 t melanocytes from mouse HPS models to place BLOC-2 within a cargo transport pathway from recycling e

156 sis of lysosome-related organelle complex-2 (BLOC-2) (HPS-5), BLOC-3 (HPS-1), and adaptin-3 (HPS-2).

157 is of lysosome-related organelles complex-2 (BLOC-2).

158 ubtypes result from mutations in subunits of BLOC-2, a protein complex with no known molecular functi

159 el mice lacking a different protein complex, BLOC-2, accumulate Tyrp1 in distinct downstream endosoma

160 AP-3 was co-isolated with BLOC-1, BLOC-2, and homotypic fusion and vacuole protein sorting

161 BLOC-2, AP-3, and AP-1 coimmunoprecipitated with Rab38 a

162 steady state levels of known cargoes of the BLOC-2, AP-3, and AP-1 pathways, the melanin-synthesizin

163 BLOC-2, AP-3, AP-1, and clathrin partially colocalized w

164 AP-3 and one pathway mediated by BLOC-1 and BLOC-2, that are deficient in several forms of HPS.

165 BLOC-1 and BLOC-2, together with the AP-3 clathrin adaptor complex,

166 uring melanosomes; in contrast, tubules from BLOC-2-deficient cells were shorter in length and made f

167 In BLOC-2-deficient melanocytes, the melanosomal protein TY

168 eys not recovered, 21 not transplanted, 8 en bloc, 23 with extrarenal organs, and 6 with missing reco

169 e gallbladder and extrahepatic bile ducts en bloc 3, 7, and 14 days later, generated biotinylated RNA

170 esis of lysosome-related organelles complex (BLOC)-3 or BLOC-1.

171 esis of lysosome-related organelles complex (BLOC)-3, and patients with BLOC-3 or AP-3 deficiency dev

172 elated organelle complex-2 (BLOC-2) (HPS-5), BLOC-3 (HPS-1), and adaptin-3 (HPS-2).

173 ing Rab-32 or its nucleotide exchange factor BLOC-3 are permissive to S. Typhi infection and exhibit

174 New work identifies BLOC-3 as a guanine nucleotide exchange factor for two R

175 In addition, we show that BLOC-3 can promote specific membrane recruitment of Rab3

176 earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) prote

177 al. report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of melanosoma

178 tation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky-Pudlak syndrome variants.

179 Our results imply that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosomes to suppor

180 Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of

181 We now demonstrate that BLOC-3 is a Rab32 and Rab38 guanine nucleotide exchange

182 In this paper, we show that BLOC-3 is required for biogenesis of Drosophila LROs cal

183 These characteristics indicate that BLOC-3 might function as a Rab9 effector in the biogenes

184 receptor CRTH2, which trafficked normally in BLOC-3 mutant HPS.

185 ganelles complex (BLOC)-3, and patients with BLOC-3 or AP-3 deficiency develop pulmonary fibrosis.

186 molecular functions of the Hps1-Hps4 complex BLOC-3 remain mysterious.

187 Silencing of the BLOC-3 subunits Hps1 and Hps4 results in the mislocaliza

188 BLOC-3 therefore defines a novel Rab GEF family with a s

189 reveals a specific and strong interaction of BLOC-3 with the GTP-bound form of the endosomal GTPase,

190 is of lysosome-related organelles complex-3 (BLOC-3).

191 sis of lysosome-related organelle complex 3 (BLOC-3).

192 we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI4KIIalpha inclusion into A

193 educed virulence, which is fully restored in BLOC-3-deficient mice.

194 -13Ralpha2 as a consequence of dysfunctional BLOC-3-dependent membrane trafficking.

195 ARE recycling from melanosomes as a critical BLOC-3-dependent step, and likely explain the distinct h

196 rom defects in a mysterious protein complex, BLOC-3.

197 the absence of any other protein as part of BLOC-3.

198 on is dependent on the RAB38 exchange factor BLOC-3.

199 review was performed on all 72 pediatric en bloc and 75 live adult donor kidney recipients transplan

200 Teeth with defects were excised en bloc and analyzed by microcomputed tomography (microCT)

201 tient survival rates were similar between en bloc and live donor groups (97.3% vs. 98.6%, P = 0.585 a

202 were repeated, and the teeth were removed en bloc and prepared for histomorphologic analysis.

203 The coagulation zones were excised en bloc and sectioned into approximately 4-mm slices for me

204 cranial vena cava were dissected, removed en bloc, and fixed in formalin.

205 ace forms before Ca(2+) triggering, moves en bloc as Ca(2+) influx promotes the interactions between

206 two monkey orbits were serially sectioned en bloc at 10-mum thickness in the coronal plane and staine

207 and subsequently transferred to proteins en bloc by an OTase.

208 Rpn11 catalyzes en bloc chain removal, and Ubp6 interferes with degradation

209 rench and by eventual alignment with eastern bloc Communist countries, thus isolating much of his wor

210 n of Rab32 or of an essential component of a BLOC complex was sufficient to allow S. Typhi to survive

211 urvive in macrophages from mice defective in BLOC components.

212 ith increased frequency as single (SK) or en bloc (EBK) kidneys.

213 ) patients were resected by transthoracic en bloc esophagectomy and 2-field lymphadenectomy.

214 paring esophagectomy with transhiatal and en bloc esophagectomy in patients with intramucosal adenoca

215 a conventional right-sided transthoracic en bloc esophagectomy was performed.

216 All patients had undergone transthoracic en bloc esophagectomy, with a median of 27 resected lymph n

217 wed 6 to 8 weeks later by a transthoracic en bloc esophagectomy.

218 All patients underwent an en bloc esophagectomy.

219 orter hospital stay than a transhiatal or en bloc esophagectomy.

220 eocortical enhancers did not originate by en bloc exaptation of transposons.

221 Open adrenalectomy with en-bloc excision has been the mainstay for primary and recu

222 En bloc excision of these lesions was successful and avoide

223 ordomas of the mobile spine and sacrum is en-bloc excision with wide margins and postoperative extern

224 three patients were surgically extracted en bloc for histologic and microcomputed tomography (micro-

225 essels and draining lymph nodes) obtained en bloc from 72 individual donors.

226 n of Poh1, which removes ubiquitin chains en bloc from proteasomal substrates prior to their degradat

227 Resections were en bloc, full thickness, and had complete margins.

228 was detected later posttransplantation in en bloc group (45.6 +/- 33.6 months vs. 23.4 +/- 16.3 month

229 suppressed during gaze saccades made with en bloc, head and body together, rotations.

230 satisfactory when transplanted as SKs or en bloc; however, the absence of an aortic patch in SK tran

231 genomes are transmitted from cell-to-cell en bloc in membrane-bound PS vesicles instead of as single

232 und along Kcnq1ot1, interrupting a biallelic BLOC in the Kcnq1-Cdkn1c domain.

233 Whole orbits were then serially sectioned en bloc in the quasi-coronal plane, stained for connective

234 re capable of removing neoplastic lesions en bloc in the upper gastrointestinal tract.

235 e segment from chromosome 15 was inserted en bloc into the second intron of the RARA gene on chromoso

236 whereas broad local enrichment of H3K27me3 (BLOC) is a domain-wide feature at imprinted clusters.

237 tudy is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other d

238 En bloc kidney donors were on average younger (12+/-10 vs.

239 consisted of 195 recipients of pediatric en bloc kidney grafts throughout a 10-year period.

240 ted with vascular thrombosis of pediatric en bloc kidney grafts.

241 c single kidney transplant (SKT, n=3712), en bloc kidney transplant (EBK, n=1517), or adult standard

242 cellent long-term outcome after pediatric en bloc kidney transplantation from donors weighing less th

243 Pediatric en-bloc kidney transplantation into adult recipients is an

244 pact later renal function after pediatric en-bloc kidney transplantation into adults.

245 there has been hesitancy in transplanting en bloc kidneys from donors weighing less than 10 kg due to

246 En bloc kidneys from pediatric donors have been considered

247 elp stratify patients receiving pediatric en bloc kidneys into risk categories for vascular thrombosi

248 Use of pediatric en bloc kidneys should be encouraged continuously to addres

249 leviate burden on waiting list, pediatric en bloc kidneys should be transplanted more often when avai

250 Nine en bloc kidneys thrombosed at a mean of 4.2 days posttransp

251 thogenicity locus presumably acquired via en bloc mobilization from a direct predecessor of equine pV

252 y-associating domains (TADs) that undergo en bloc movements, and identify dynamically coupled distal

253 ive morbidity and mortality rates, and an en bloc multivisceral resection should be performed in pati

254 ed seventy-one patients had transthoracic en bloc (n = 161) or transhiatal esophagectomy (n = 10) for

255 ormed to compare outcomes after pediatric en bloc (n=20, mean donor weight 11.4 kg), standard criteri

256 gal-sparing (n=49), transhiatal (n=39) or en bloc (n=21) esophagectomy.

257 weight, 27 kg); SCDKT (n=283); pediatric en bloc (n=21), living-donor (n=275), and extended criteria

258 Tumors are removed either en bloc or in a piecemeal fashion with retrieval of all tis

259 An en bloc partial hepatectomy (n = 87) and an R0 resection (n

260 Because en bloc pediatric kidneys double nephron numbers, it would

261 graft losses can be minimized when using en bloc pediatric kidneys from donors weighing less than or

262 lthough pancreaticoduodenectomy (PD) with en-bloc portal vein/superior mesenteric vein (PV/SMV) resec

263 rhythmic inspiratory activity in isolated en bloc preparations even after acidic or serotonergic stim

264 llowed to extend membrane protrusions in the BloC-Printing device for 3 h, multiple biophysical chara

265 BloC-Printing has a minimum turnaround time of 0.5 h, a

266 In light of this discovery, BloC-Printing may serve as a rapid and high-throughput c

267 ing technique, termed "Block-Cell-Printing" (BloC-Printing), allows for convenient, precise, multiple

268 re, primary neurons are also compatible with BloC-Printing.

269 find that it removes chains from cyclin B en bloc, proceeding until a single chain remains.

270 Pediatric en bloc recipients had significantly higher GFR up to 8 yea

271 h albendazole was instituted and surgical en bloc removal of the cyst was obtained, allowing the pati

272 ombosis remain a challenge with pediatric en bloc renal transplants, but once the allografts survive

273 lar polysaccharides has proceeded through en bloc replacement of individual glycosyltransferase genes

274 cosal resection was developed to increase en-bloc resection (less residual disease) of a flat colorec

275 En-bloc resection (P = 0.005) but not resection margin stat

276 s includes local resection (EA or SA) and en bloc resection (pancreaticoduodenectomy).

277 En bloc resection and reconstruction of involved vessels is

278 ve lymph-nodes, who may be candidates for en bloc resection and/or neoadjuvant treatment.

279 En bloc resection at the time of initial surgery appears to

280 Most agree that en bloc resection entails a significant morbidity and morta

281 En-bloc resection is done for lesions smaller than 2 cm in

282 al time, but is promising due to the high en-bloc resection rates and the very low recurrence rates.

283 phagectomy compared with a transhiatal or en bloc resection.

284 ophageal cancer and its treatment with an en bloc resection.

285 Nine months after surgical correction, en bloc resections were obtained and examined histologicall

286 detection of synapses from conventionally en-bloc stained 3D electron microscopy image stacks.

287 To avoid this problem, we tested several en bloc staining techniques to contrast tissue in serial se

288 this step with other classic heavy metal en bloc stains, including uranyl acetate (UA), lead asparta

289 The 5-year graft survival after en bloc, standard deceased, and LDKT were 92%, 70%, and 88%

290 to a polyisoprenyl donor, followed by the en bloc transfer of the glycan to particular asparagine res

291 n undecaprenyl diphosphate and subsequent en bloc transfer of the glycan to serine residues of select

292 rase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor a

293 nd attached to Cys(820) before stochastic en bloc transfer to the target protein.

294 smatch, cold ischemia time, and double or en bloc transplant.

295 The outcomes after en bloc transplantation from young donors weighing less tha

296 We reviewed 20 pediatric en-bloc transplants performed at our institution between 20

297 tions, and urine leak was seen in 1 of 20 en bloc transplants.

298 Pancreata were removed by en bloc viscerectomy from 65 female Landrace pigs.

299 A maternally biased BLOC was found along the H19-Igf2 domain.

300 ed that the left-handed dimer gets tilted en bloc, whereas conformational transitions to alternative