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1 DDR is establishment of a potent premitotic block.
2 and reestablishment of NMDA receptor Mg(2+) block.
3 nactivated state, resulting in use-dependent block.
4 and increase the time taken for catheters to block.
5 nd fundamental electronic structure in the f-block.
6 o sinus node dysfunction or atrioventricular block.
7 tures of adjustable length as basic building blocks.
8 nome chromosomes, which formed 878 haplotype blocks.
9 nd selectivity of their constituent building blocks.
10 response direction across a series of trial blocks.
11 rmalin-fixed paraffin-embedded primary tumor blocks.
12 ild conditions from a wide array of building blocks.
13 mplex reaction networks from simple building blocks.
14 mma-nitroketones from three simpler building blocks.
15 which endothelial autophagy flux is already blocked.
16 g reporter genes while viral replication was blocked.
17 ated when MCU was absent or its activity was blocked.
18 We have also provided proof of concept that blocking 12-HETE production is a promising strategy for
20 hese results, we investigated the effects of blocking 5-HT and beta-adrenoceptor transmission in DH o
22 ounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for
28 4 (23%) lacked BSACI compliant neuromuscular blocking agent (NMBA) panels and 17/44 (39%) lacked a NA
29 ffects of various gene deletions or chemical blocking agents were tested by investigating the express
30 aximal atropine pretreatment that completely blocked all the Cch-evoked responses did not affect any
32 n-pretreated wild-type mice, these compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropi
33 identify and analyze the conserved syntenic blocks among reconstructed ancestral genomes and present
34 ate an association between the Eda haplotype block and the expression pattern of key immune system ge
36 r results strongly suggest that resection of blocked and clean DSBs is initiated via distinct mechani
38 the preparation of oxalyl boronate building blocks and their application for the construction of het
40 n cancer therapy to a similar degree as PD-1 blocking antibodies, offering a next-generation approach
41 nizing Siglec-8 in combination with integrin blocking antibodies, pharmacologic inhibitors, phosphopr
42 n cancer therapy to a similar degree as PD-1-blocking antibodies.Significance: These findings show ho
43 On the other hand, the persistence of IgE blocking antibody 1 year after discontinuation might be
46 of multiple sclerosis (MS), we administered blocking antibody to CLEC12A that significantly ameliora
47 nd safety of pembrolizumab, a humanized PD-1-blocking antibody, at a dose of 200 mg every 3 weeks in
48 nd collaborative functions of M36 and M45 in blocking apoptotic and necroptotic cell death responses.
51 eby atomically thin two-dimensional building blocks are vertically stacked, and held together by van
54 analysis followed by inhibitor and antibody-blocking assays revealed that the arthropod HSP70-like m
55 demonstrated that MZ B cell development was blocked at the transitional-1 to transitional-2-MZ precu
56 profile was used in the ST region, ions are blocked at the TT-ST interface and accumulated in the TT
58 AR S81 is also phosphorylated by CDK1, and blocking basal CDK1-mediated S81 phosphorylation markedl
61 nt-induced afferent input by saphenous nerve block before, but not after, hindlimb movement blocked m
62 underlying stimulus-stimulus learning can be blocked behaviorally and reinstated by optogenetically a
68 For example, when type I IFN signaling was blocked by Abs in Rag1(-/-) mice, the mice showed dramat
73 ch the LOS ranges from partially to entirely blocked by introducing slits, s = 95, 195, 245, 295 and
74 by cultured RPE cells was almost completely blocked by pharmacological inhibition of phosphorylation
78 e dorsal striatum, and the latter effect was blocked by the dopamine D2-like receptor antagonist halo
79 epolarization-induced calcium transients was blocked by the IP3 antagonist, and not observed in the a
81 extracellular regulated kinase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicati
82 embrane stretch-induced cation currents were blocked by the TRPM4 inhibitor 9-phenanthrol in both gro
84 a large cell population, revealing diagonal blocks called Topological Associating Domains (TADs) tha
87 ical stage CDK-selective inhibitor, potently blocks CDK9, the transcriptional regulator of MCL-1.
88 ibition of Rpn11 with O-phenanthroline (OPA) blocks cellular proteasome function, induces apoptosis i
89 oxo-coupled homo- and heterometallic poly(f-block) chains to better understand fundamental electroni
93 ns of SELP 815K (which contains 6 repeats of blocks comprised of 8 silk-like units, 15 elastin-like u
94 Here, an ink-jet printable and rewritable block copolymer (BCP) SC display is demonstrated, which
96 higher mechanical and chemical stability of block copolymer membranes and their chemical versatility
97 on an indium tin oxide (ITO) substrate via a block copolymer template was developed for highly sensit
98 s using direct attachment and formation of a block copolymer were prepared and demonstrated for the s
99 tyrene (PS)-b-polymethyl methacrylate (PMMA) block copolymers (BCP)) using either ultralow energy ces
103 oice and web response system with a permuted block design (block size of four), to receive atezolizum
104 ard approaches that use segmented speech and block designs, which report more laterality in speech pr
106 normal pattern of embryonic gene expression blocking development at the morula-blastocyst transition
107 values for (S)-orteronel were identical for blocking DHEA formation from pregnenolone and for 17alph
108 l cells reveal that a slow AHP is reduced by blocking different components of the CaV1.3-densin-CaMKI
109 or pharmacologic inhibition of LOX activity blocked dissemination of colorectal cancer cells in the
113 he high molecular precision of the dendritic block enabled us to systematically tune the hydrophobici
114 activator of ERalpha that can be targeted to block ERalpha gene expression is a critical topic of end
116 sequence is used to detect ligand binding as blocking events during DNA unzipping, allowing determina
121 , brefeldin A, diphenyleneiodonium, DNase or blocking F(ab')2 fragments to CD16, CD18, CD32 and CD64.
126 l organic triplet that represents a building block for organic molecule-based magnets and also serves
127 platform may serve as a fundamental building block for various functional photonic components and be
130 d variants thereof may be promising building blocks for the synthesis of electron transport materials
132 e that anti-gHgL neutralizing antibodies can block gHgL-mediated activation of gB through different s
134 ning CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed st
135 tent between urban and suburban/rural census block groups, and for daytime and nighttime noise and ro
136 ycle threading kinetics, and (c) sialic acid blocking groups that prevent macrocycle threading until
138 is strategy relies on the design of a spacer-blocking hairpin (SBH) structure at the 5' end of the si
140 T-WQ-IDL were also more effective than WQ in blocking HIV-1 Env-mediated membrane fusion and had high
141 crophages as well as resting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydro
144 for substrate binding to IKKbeta and thereby blocks IkappaBalpha phosphorylation and NF-kappaB nuclea
146 between the exsA mRNA and Sr0161 leads to a block in the synthesis of a component of the T3SS appara
148 ccessful coassembly of biomolecular building blocks in a noninvasive approach with high temporal reso
156 ansparent p-AlGaN contact layer, an electron blocking layer and using this high quality AlN template:
157 e by excess expression of CXCR4, which, when blocked, led to HSC mobilization and prolonged islet all
159 hat RE-MOFs based on 12-c molecular building blocks (MBBs), d6R building units, have been deliberatel
160 x chemistry can be performed reversibly by f-block metals, and that uranium can thus mimic elementary
163 r-dependent Ad (HDAd) that expresses a PD-L1 blocking mini-antibody (mini-body; HDPDL1) as a strategy
175 to distil multiple signatures from the same block of data, thus reducing the statistical fluctuation
176 have identified a mutant that overcomes the block of lateral root (LR) formation under osmotic stres
181 ble for SIV infection of SM in vivo and that blocking of CCR5 does not prevent ex vivo infection of p
183 es in functionality of CD4 T cells following blocking of different inhibitory receptors, and we confi
186 assigned patients to one of three groups in blocks of 15 to receive placebo (normal saline), low-dos
188 ghts into molecular convergence and building blocks of CAM and will facilitate CAM-into-C3 photosynth
190 tion of enzymes that synthesize the building blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Gluco
191 tary processes in a picture naming task with blocks of semantically heterogeneous (HET) or HOM stimul
192 a computer generated randomisation sequence (blocks of six) to receive either two intranasal doses (0
194 rm bandit task that had randomly interleaved blocks of stimulus-based and action-based reinforcement
195 of translocation allows helicases to bypass blocks on the strand that is excluded from the central c
196 f affords efficient syntheses using building blocks optimized for interactions with subtype-specific
200 velop genes encoding effector molecules that block parasite development within the vector, and then u
202 ate December, it was followed by a prolonged blocking period in early 2016 that sustained the extreme
206 acids in the PKR eIF2alpha binding site and blocking PKR kinase activity.IMPORTANCE The antiviral ki
207 ug conjugate, methoxy-poly (ethylene glycol)-block-poly (2-methyl-2-carboxyl-propylene carbonate-graf
208 quid) diblock copolymers, poly(acrylic acid)-block-poly(4-vinylbenzyl)-3-butyl imidazolium bis(triflu
209 excitatory amino acid transporter 3 (EAAT3) blocks potentiation, suggesting that EAAT3 internalizati
210 ersely, inhibition of NEDDylation by MLN4924 blocked proinflammatory gene expression and NF-kappaB ac
211 HTS assays designed to identify ligands that block protein binding are much more challenging to devel
213 with sequence generation defined by permuted block randomisation (block size two) was used to randoml
214 perience (experienced vs naive) and included block randomisation at nurse level with randomly ordered
216 interactive response system under a permuted block randomisation scheme (block size of four), stratif
217 Patients were randomly assigned (1:1) via block randomisation using a random number generator to r
219 this work presents evidence that classical d-block redox chemistry can be performed reversibly by f-b
220 ly intricate structures from simple building blocks remains one of the most difficult challenges in c
221 ions as a promiscuous transactivator, and it blocks repressor complexes to enable viral gene transcri
222 Sting, phosphorylated Tbk1 and, importantly, blocking reverse transcriptase activity suppressed the e
225 subset expectation maximization and Q.Clear (block-sequential regularized expectation maximization wi
227 under a permuted block randomisation scheme (block size of four), stratified by hormone receptor stat
228 esponse system with a permuted block design (block size of four), to receive atezolizumab 1200 mg or
229 ion defined by permuted block randomisation (block size two) was used to randomly assign patients (1:
230 via a web-based random number generator with block sizes of four and six, to listen to either the Inf
232 show the mutation localizes tropomyosin in a blocked-state position on actin defined by a deeper ener
233 ts were randomly assigned (1:1) via permuted blocks stratified according to hormone receptor status (
237 two inhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding groove.
239 nds induce misfolding of chromatin fibre and block the binding of the regulator of chromatin condensa
243 ently it has been demonstrated that PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3
245 ation of PZ(Vgat) neurons could attenuate or block the wake-promoting effects of two widely used wake
246 ing the Gbetagamma-interacting domain of DAT blocked the ability of mSIRK to induce DA efflux, consis
248 ine-induced conditioned place preference and blocked the cocaine-induced reduction of GABAergic inhib
249 er loss, diminished tubular iron deposition, blocked the development of interstitial fibrosis, and pr
252 2 inhibitor UO126, or ERK1/2 siRNA knockdown blocked the H2O2-induced shift of MLK3, while MLK3 inhib
253 deletion of Ifng (Sphk2(-/-)Ifng(-/-) mice) blocked the protective effect of SphK2 deficiency in fib
254 anscription during terminal differentiation, blocking the action of a promiscuous activator on crypti
256 cipitate cancer by perturbing S phase and by blocking the Chk1-dependent response to replication fork
259 taking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPalpha with CD47 preferen
261 C6 maintains Ku70 in a hypoacetylated state, blocking the translocation of Bax to mitochondria and pr
262 Moreover, knocking down of p21(Waf1/Cip1) blocks the ability of Foxp1 to protect neurons from mut-
263 nterleukin-23 and interleukin-12 and thereby blocks the activity of these cytokines, inhibiting inter
264 iR-146a as an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differ
266 lecules, we report a synthetic strategy that blocks the major deactivation pathway: excited-state tra
267 e show that signaling of CyaA-generated cAMP blocks the oxidative burst capacity of neutrophils by tw
268 egions separated by an electron barrier that blocks the transport of majority carriers to reduce the
269 rs and decreased p53 protein turnover, which blocked their tumorigenic capacity through cellular sene
270 endoscopic remission), with the final aim of blocking their progression and preventing bowel damage a
271 ithin populations, and perhaps within forest blocks, their contribution to gene flow on the regional
273 l rate was observed, together with a molting block, These findings confirm the important regulatory r
275 ed that selinexor causes thrombocytopenia by blocking thrombopoietin (TPO) signaling and therefore di
276 kilohertz electrical stimulation (KES) nerve block to preferentially activate efferent pathways while
277 uminuria were randomized (1:1) with permuted blocks to 6 months of a 25% calorie restricted (CR) or s
278 yladenosine (m1A) and m1G constituted robust blocks to both Escherichia coli and wheat germ extract t
280 ctive pharmacological inhibition effectively blocks transformation driven by partial p85alpha loss bo
283 tion of maternal immune responses capable of blocking transmission of autologous HIV to the infant.
286 a small molecule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuri
288 AhR may serve to adjust liver repair and to block tumorigenesis by modulating stem-like cells and be
289 embly step that organizes six total building blocks, two CoTPyP units and four arene-Ru clips, into a
291 ofilms on indwelling urethral catheters that block urine flow and lead to serious clinical complicati
292 ded DNA, inhibit vaccinia virus infection by blocking viral DNA replication and abrogating postreplic
295 lattice structures using DNA-NPs as building blocks were identified almost a decade ago, yet the role
297 from a threonine containing peptide building block, which, by itself, only forms trimers and tetramer
298 were repaired, windows screened, open eaves blocked with bricks and mortar, cement floors repaired o
299 lin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenali
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