ライフサイエンスコーパス: blockage

1 ertaken to confirm the role of interleukin-1 blockage.

2 provide a clear visual warning of impending blockage.

3 ons or provide warning of impending catheter blockage.

4 proliferation and erythroid differentiation blockage.

5 y 1-10 MPa) that likely stemmed from conduit blockage.

6 ha (GPIbalpha) receptor, thereby causing its blockage.

7 hindering effect on Hg(0) uptake due to pore blockage.

8 more resilient cake layer and membrane pore blockage.

9 administered mice and was reduced upon PAR-2 blockage.

10 d version of para-coumarate, can bypass this blockage.

11 mogeneous solution in order to preclude pore blockage.

12 o small experimental effects and a precolumn blockage.

13 x pump inhibitors (EPIs) to control catheter blockage.

14 he G-rich stretch dramatically increased the blockage.

15 mposition and single-stranded breaks on this blockage.

16 n, which accounts for the high efficiency of blockage.

17 d forecasts a danger over one month ahead of blockage.

18 in mouse lungs, which was reduced upon PAR-2 blockage.

19 nocytosine (epsilonC) causes transcriptional blockage.

20 s well as apoptotic cells in the lungs after blockage.

21 esence of species that do not cause catheter blockage.

22 f Proteus mirabilis infection and subsequent blockage.

23 s are essentially hollow with practically no blockages.

24 ctivation of Chk1 in response to replication blockages.

25 ome species have the ability to remove these blockages.

26 ence VAS -10 mm (95% CI -18 to -2) P = 0.02, blockage -0.7 (95% CI -1.3 to -0.1) P = 0.02, with recov

27 st doses: VAS 15 mm (95% CI 4-25) P = 0.009, blockage 1.1 (95% CI 0.5-1.6) P = 0.001.

28 IL-10R blockage abolished PPAR-gamma-mediated inhibition of MyD

29 m the 3' or 5' end produced distinct current blockages, allowing directional effects on unzipping kin

30 The blockage also becomes less pronounced upon reduced RNA p

31 cule, since the event residence times and/or blockage amplitudes for these metal chelates are signifi

32 dual inhibitors along with their ion channel blockage and antiviral activities.

33 xazole compound with potent AM2-S31N channel blockage and antiviral activity, in this study we report

34 Pharmacological blockage and genetic deletion of D2R in DA neurons preve

35 ed codons instead of stops for translational blockage and have relaxed matching rules for takeoff/lan

36 case Rep, resulting in increased replication blockage and thus increased reinitiation away from oriC,

37 II)-catalyzed transformation by surface-site blockage and/or organic Fe(II) complexation.

38 e of alphaHL, resulting in decreased current blockages and slower unzipping.

39 atings provide up to 12h advanced warning of blockage, and are stable both in the absence of infectio

40 luding spontaneous ruptured membranes, shunt blockage, and dislodgement.

41 influenced by cannabinoid or opioid receptor blockage, and euphoria cannot be studied in mouse models

42 symptoms (rhinorrhea, mucus in throat, nasal blockage, and sense of smell), patient-reported outcomes

43 ligonucleotide effective charges and current blockages, and between their diffusion constants and DNA

44 us researchers also observed bacteria in the blockages, and this study demonstrated the same findings

45 determined not to cause cardiac ion channel blockage are more likely to pass successfully through cl

46 Bypassing requires translational blockage at a "takeoff codon" immediately upstream of a

47 hin approximately 10 min of replication fork blockage at a site-specific barrier in fission yeast, le

48 d data support the notion that transcription blockage at homopurine-homopyrimidine sequences is cause

49 ell as inappropriate replication stalling or blockage at Ter sites outside of the terminus trap regio

50 nd they suggest that the Gac system senses a blockage at the aconitase step of the tricarboxylic acid

51 We found that VEGFR2 blockage attenuates steatosis and inflammation in a diet

52 queduct are critical for preventing physical blockage between the third and fourth ventricles and the

53 n factor IIS, which is in contrast to pol II blockage by a nucleosome barrier.

54 , the CPP modified drug is released from the blockage by a second triggering agent, while remaining i

55 ocess was dependent on integrin alpha(V), as blockage by antagonist echistatin (RGD peptide) or alpha

56 Replication blockage by DPC did not produce damaged forks or detecta

57 The channel activity is susceptible to blockage by known drugs and structurally diverse compoun

58 bited new protein synthesis, indicating that blockage by NPPB enhances the degradation of ABCB transp

59 duce the dangers associated with replication blockage by protein-DNA complexes, aiding clearance of b

60 nsing mechanism was based on the nanochannel blockage caused by MS2 binding to immobilized capture an

61 er in the channels, whereas the time between blockages characterizing the binding reaction on-rate st

62 of landing locations, the extent of current blockage, collision frequency, motion of beads on the el

63 Capillary blockages colocalised strongly with pericytes, where cap

64 The autophagic cascade triggered by AR blockage, correlated with the increased light chain 3-II

65 Pharmacological xCT blockage counteracts NAC prophylactic effects.

66 The noise associated with the blockage current also depends on the stability of the du

67 il identified significant differences in the blockage current and the unzipping duration between the

68 We investigated variations in blockage current as a function of temperature (12-35 deg

69 ture), where a greater noise in the measured blockage current is observed for less stable duplexes.

70 centrations, where the noise in the measured blockage current is significantly lower.

71 urrent fluctuations that reflects a discrete blockage current level structure.

72 complex inducing a 3 fold increase in ionic blockage current relative to unmethylated DNA.

73 ion of guanine by any other base reduced the blockage, cytosine and thymine reduced the blockage more

74 The phenotypic results of this blockage define patterns of communication among distant

75 stis biofilm formation that is important for blockage-dependent plague transmission from fleas to mam

76 Surprisingly, the effect of ACAT1 blockage does not alter mTOR signaling or endoplasmic re

77 ation of the nanochannels (20 nm pore sized) blockage due to the immunocomplex formation.

78 of both electrostatic/steric effects in this blockage due to the subsequent formation of the aptamer-

79 e found to be the determining factor for the blockage efficiency of M3 receptor signaling under durat

80 GCGR antibody blockage expanded alpha-cell mass 5.7-fold, and S961 had

81 ents who had bladder cancer, bladder stones, blockage, false passage, gross hematuria, accidental rem

82 diffusion constants and DNA-induced current blockage fluctuations.

83 m(-1) to 15.1+/-2.6 bar m(-1) due to spacer blockage from the developing biofilm.

84 Amount of UV-A blockage from windshields and side windows.

85 cations to prevent methane clathrate hydrate blockages from forming in oil and gas pipelines.

86 We confirmed the blockage function of Tbf1 using synthetic promoters.

87 y tuft input and (simulated) calcium-channel blockage functionally acts as a composite sigmoidal func

88 A high level of side-window UV-A blockage (>90%) was found in 4 of 29 automobiles (13.8%)

89 al enhancement in comparison to the membrane blockage has been observed.

90 ased pumping energy requirements from spacer blockage highlight the serious challenges of using high

91 active cancer vaccination, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T

92 Further analysis indicates a blockage in autophagic flux associated with lysosomal dy

93 Furthermore, this blockage in cell surface expression was correlated with

94 onstruct markedly reduced APP-induced axonal blockage in Drosophila.

95 antiviral activity based on percent channel blockage in electrophysiological assays.

96 leading edge, the latter is consistent with blockage in membrane trafficking.

97 The extensive vessel blockage in PD-susceptible grapevines was correlated to

98 t cells and antagonized tubulin-induced VDAC blockage in planar bilayers.

99 ed conditional reduced growth, near complete blockage in PSII supercomplex formation, and concomitant

100 Chronic autophagy blockage in several conditions, including DRPLA and Vici

101 ilm formation in vitro and biofilm-dependent blockage in the oriental rat flea Xenopsylla cheopis res

102 xidation of [Fe(CN)(6)](4-), is based on the blockage in the pores which affects the diffusion of [Fe

103 betaIII-Tubulin blockage in vivo reduced tumor incidence and growth.

104 bidopsis (Arabidopsis thaliana) mutants with blockages in the pathway simply redirect carbon flux to

105 at losses in pedicel kh were associated with blockages in vessel elements, whereas air embolisms were

106 correlated with direct competition and pore blockage indicators.

107 nfocal microscopy to show that the secretion blockage is due to the stabilization of open fusion pore

108 during recovery from arterial restriction or blockage is essential for health, but mechanisms are poo

109 Notably, this blockage is exacerbated in Cockayne Syndrome and xeroder

110 This transcription blockage is much less pronounced for a C-rich sequence,

111 Remarkably, the blockage is not pronounced if transcription is performed

112 om control experiments, we conclude that the blockage is primarily due to the formation of stable RNA

113 ts prevent ion currents indicating that pore blockage is primarily responsible.

114 ticularly from ovulation disorders and tubal blockage, is associated with an increased GDM risk.

115 Detailed analysis of the blockage kinetics of VDAC reconstituted into planar lipi

116 Interestingly, IL-17 blockage led to an increase in the expression of IL-27 s

117 Comparison of current-blockage levels of each protein yields volumetric inform

118 We further presented evidence that the blockage mechanism is widely used among genome-wide DGPs

119 biosynthesis pathway by chemical and genetic blockage mimicked these transcriptional responses, indic

120 e blockage, cytosine and thymine reduced the blockage more significantly than adenine substitutions,

121 nfer identical defects, including late onset blockage near the terminal cell-stalk cell junction and

122 In vitro assays indicated blockage of (11)C-sarcosine uptake into PC-3 and LNCaP t

123 tion of RvD1 and RvD5, an action reversed by blockage of a key SPM biosynthesis enzyme 15-lipoxygenas

124 tudies suggest that this crisis is caused by blockage of a single elongated cell, recent experiments

125 her 4R-Me-Pro or 3S-OH-4S-Me-Pro, indicating blockage of a step upstream of Me-Pro formation.

126 that induces cell loss in NM and persistent blockage of afferent excitatory action potentials, revea

127 Blockage of angiotensin II receptor type 1 with 0.1 mg/k

128 s in attenuation of caspase 3 activation and blockage of apoptosis.

129 features were phenocopied by pharmacological blockage of Arf6 activation.

130 c deregulates the autophagic pathway through blockage of autophagic flux, resulting in accumulation o

131 f ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and

132 Blockage of Axl gene expression by small interfering RNA

133 Blockage of B cell-specific PD-L1 restored Th1 responses

134 Moreover, blockage of B1R inhibited neuroinflammation, as evidence

135 o signaling inactive central clusters, and a blockage of BCR internalization.

136 and the potential benefits arising from the blockage of both inflammation-related enzymes were thoro

137 estigate whether the enhancement of ADCML by blockage of CD59 function is mediated by nAbs, non-nAbs,

138 After blockage of CD59 function, the reactive Abs, regardless

139 have led to different models, including (i) blockage of cell wall synthesis, (ii) membrane pore form

140 Furthermore, blockage of CMA leads to hyperphosphorylation and destab

141 ent its massive aggregation, and we show how blockage of conserved protective features by endogenous

142 Lack of Cx43 expression or blockage of Cx43 channels resulted in increased ROS-indu

143 Specific blockage of Cx43 HC function by TAT-Gap19, a Cx43 mimeti

144 Blockage of Cx43 hemichannels incompletely inhibited H2O

145 Blockage of Cx43-GJIC inhibited NK cell activation, thou

146 Induction or blockage of CYP3A1 by a miR-23b inhibitor or mimic could

147 m the ER, a process that correlates with LFG blockage of cytochrome c release to the cytosol and casp

148 Blockage of Delta-like 4 (DLL4)-directed Notch signaling

149 ive strain that fails to remove Pxr-mediated blockage of development and reintroduced variably trunca

150 ting in uncontrolled cell proliferation, and blockage of differentiation and chondrodysplasia in mice

151 tional twin-boundary (TB) strengthening from blockage of dislocations impinging on TBs, coupled with

152 Blockage of DNA recognition by the innate immune system

153 analysis studies support the mode-of-action, blockage of DNA synthesis by dual target topoisomerase i

154 yl-DL-tyrosine methyl ester hydrochloride or blockage of DOP1 receptor with antagonist SCH23390 impai

155 lerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.

156 tical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of ch

157 of both enzymes appears more promising than blockage of either protein alone.

158 Blockage of endogenous TGF-beta with either a TGF-beta-b

159 DAMB-231 and MDAMB-468 cells and resulted in blockage of ER stress-mediated GRP78 up-regulation.

160 Blockage of ETAE distinguishes Fe(III) reduction of laye

161 absence of other viral proteins resulted in blockage of exogenous IFN-mediated STAT1 phosphorylation

162 Deletion of ilp had no effect on bacterial blockage of flea blood feeding or colonization.

163 The blockage of FP with AL8810, a selective antagonist, hamp

164 Pharmacological blockage of fructose uptake ameliorates leukemic phenoty

165 ea pig auditory cortex, we show that partial blockage of GABAA receptors by gabazine (GBZ) applicatio

166 binding to lagging strand ssDNA relieves the blockage of Gp43 polymerase activity by Gp59, whereas th

167 ding to ectopic Dpp signaling and consequent blockage of GSC differentiation.

168 Blockage of H. ducreyi uptake by cytochalasin D signific

169 The blockage of H4R could be a new therapeutic modality for

170 naptic connectivity; chronic pharmacological blockage of Ih channels reproduced these phenotypes, sug

171 The results of this small study suggest that blockage of IL-1beta using gevokizumab may be beneficial

172 However, blockage of IL-1R signaling did not abolish the deleteri

173 ioprotective effects against DCM through the blockage of inflammation, oxidative stress, and apoptosi

174 Blockage of K33-chain formation, Crn7 ubiquitination, or

175 erol accumulation, we propose that AnxA6 and blockage of LE cholesterol transport are critical for en

176 wth sharply declines with increasing sea-ice blockage of light from the benthic algal habitat.

177 Pharmacological and genetic blockage of LPA receptor 1 (LPAR1) or autotoxin (ATX), a

178 cytosis was attributable to a combination of blockage of lymphocyte homing and the release of thymocy

179 The blockage of m(6)A inhibited splicing of the pre-mRNA enc

180 Using pharmacological and genetic blockage of macroautophagy both in vitro and in vivo, we

181 Coprecipitation led to a complete blockage of mineral surface sites and pores with >/=177

182 Moreover, blockage of miR-30b or 378 by locked nucleic acid inhibi

183 ntribution to peroxide metabolism during the blockage of mitochondrial electron transport.

184 Blockage of more than one oncoprotein or pathway is now

185 Improving potencies through concomitant blockage of multiple epitopes and avid binding by fusing

186 Blockage of NOS activity with the inhibitor L-NG-nitroar

187 ling that was more potent than pharmacologic blockage of Notch activation via gamma-secretase inhibit

188 Therefore, blockage of one of these molecules might represent a nov

189 ese cases, inhibition was shown to be due to blockage of passive H(+) translocation through F0 as ass

190 enhanced in Itk(-/-)Btk(-/-) mast cells, and blockage of phosphatidylinositol-4,5-bisphosphate 3-kina

191 nally, we find that neuronal death is due to blockage of plasma membrane recycling processes that uti

192 Blockage of PLCgamma2 function by inhibitors or knockdow

193 static synaptic plasticity elicited by acute blockage of postsynaptic receptors.

194 R4 internalization and it was related to the blockage of preformed TNF secretion.

195 meliorated the inflammatory response through blockage of proliferation of activated B cells, inhibiti

196 Thus, blockage of RCA function represents a novel approach to

197 mediated by mechanisms distinct from steric blockage of receptor binding.

198 olution resulting in complete and incomplete blockage of reproductive tract in infertile and fertile

199 Abscisic acid-induced blockage of seed germination and cotyledon greening is r

200 moval of mature microRNAs or pharmacological blockage of signalling pathways drives PSCs into a low-n

201 Blockage of some ion channels and in particular, the hER

202 l to vitamin A-deficient (VAD) mice; (2) the blockage of spermatogonial differentiation by impaired r

203 and germ cells in juvenile mice results in a blockage of spermatogonial differentiation, similar to t

204 For blockage of spontaneous proton back-leak, the water chan

205 the observations by Sulzberger et al on the blockage of sweat ducts in AD.

206 findings by earlier investigators about the blockage of sweat ducts in miliaria, showing eosinophili

207 -pool is gradually silenced, leading to full blockage of synaptic transmission.

208 high levels of Dio3 provides double-pronged blockage of T3 action during glial lineage commitment.

209 Blockage of tetrapyrrole biosynthesis in the AtHEMN1 mut

210 To permit selective blockage of the accessory site, alpha4 threonine 126 loc

211 ly used in the clinics, and most of them use blockage of the active site for their mode of inhibition

212 hibition that until now has mainly relied on blockage of the active site or occupation of a regulator

213 iers inactivating the proviral promoter, and blockage of the assembly of the host elongation factor P

214 iting phosphoinositide production leads to a blockage of the autophagy flux in LSD chondrocytes.

215 sidue 132 with phenylalanine caused a steric blockage of the B-type channel and no other material str

216 data, for the first time, demonstrated that blockage of the biological function of RCA members rende

217 Blockage of the biological function of RCA members, part

218 f circumventing the physical and biochemical blockage of the blood-brain barrier, could be a precious

219 Blockage of the c-met/hepatocyte growth factor axis atte

220 evated oxidative stress, cellular death, and blockage of the cell cycle.

221 occlusion (RVO) can cause vision loss due to blockage of the central retinal vein (CRVO) or a branch

222 Transient, ~95% blockage of the channel current by alpha-syn was observe

223 Blockage of the cholecystokinin-1 receptor or the nicoti

224 hibitor of gamma-secretase (DAPT) led to the blockage of the expressions of reprogramming factors and

225 inhibiting apoptosis and necrosis, including blockage of the Fas receptor, neuroprotective peptides a

226 s a pivotal role in cell cycle regulation by blockage of the G1-to-S-phase transition.

227 iated interruption of the GABA signaling and blockage of the GABAA receptor by the specific inhibitor

228 lication of reverse voltages or irreversible blockage of the macroscopic conductance of lysenin chann

229 Blockage of the mGluRs alone only modestly reduced the m

230 Blockage of the mTORC2 signal pathway prevented cytokine

231 Here, we show that blockage of the N-methyl-D-aspartate receptor impairs th

232 Complete blockage of the nanopore with Pt metal forms a closed bi

233 our previous studies showing that concurrent blockage of the NF-kappaB and Akt signaling pathways sen

234 ses chemoresistance, which is accompanied by blockage of the PD-L1 immune checkpoint.

235 tion for a substrate analogous inhibitor and blockage of the predicted ubiquinone binding site provid

236 the hematopoietic compartment resulted in a blockage of the progenitor B-cell-to-precursor B-cell de

237 in the bone can be effectively inhibited by blockage of the STAT3 signaling.

238 In addition, blockage of the STIM1-Orai pathway effectively abolishes

239 Inhibition of TLR4 resulted in differential blockage of the targets.

240 d repression is not due to the simple steric blockage of the transcriptional machinery.

241 of other IDTS, consistent with it causing a blockage of the translocation channel.

242 of dendritic beading during pharmacological blockage of these cotransporters.

243 We hypothesize that blockage of these interactions through SAM contacts cont

244 Blockage of these pathways may improve muscle quality an

245 flux pumps were required for fuel tolerance; blockage of these pumps precluded growth in fuel.

246 Pharmacologic blockage of these target pathways reduced CSLCs, and thi

247 bryos in vitro and in vivo demonstrated that blockage of this pathway accelerated myogenic differenti

248 transmission of TCR signals, a developmental blockage of thymocytes at the transition from double-neg

249 due to (124)I-BTT-1023 was 0.55 mSv/MBq, if blockage of thyroid uptake is assumed.

250 cted against anaphylaxis and was superior to blockage of tissue mast cell degranulation.

251 Blockage of TLR2-mediated endocytosis inhibited IL-10 pr

252 e-homopyrimidine sequences cause significant blockage of transcription in vitro in a strictly orienta

253 Blockage of TREM-1 signaling caused a more severe proinf

254 s as a dual-targeting agent that invokes the blockage of two signal transduction pathways that are ce

255 Blockage of ubiquitination at Lys124 was proposed to abr

256 activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a

257 Mutants identified as defective in blockage of urethral catheters had disruptions in genes

258 ET activation also mainly contributes to the blockage of vascular invasion and metastasis of HCC.

259 Our results suggest, in fact, that blockage of VEGF through the use of an anti-VEGFA antibo

260 Results demonstrated a significant blockage of VEGF-VEGFR binding by bevacizumab.

261 Chal-24 robustly activated JNK and ERK and blockage of which effectively suppressed Chal-24-induced

262 ns must occur without fault to prevent fatal blockages of the airway.

263 lyses with lifetimes limited by irreversible blockages of the microchannels.

264 NA-PKcs is necessary to relieve the physical blockage on end-ligation imposed by the DNA-PKcs protein

265 pped on the paper leads to the ion diffusion blockage on microelectrodes, therefore cell concentratio

266 Blockage or activation of TREM-1 signaling lowered or ra

267 Corroborating these data, blockage or knockdown of P2 x 7 only slightly reduced AT

268 Pharmacological blockage or knockdown of STIM1 or ORAI1 reduced ENO-1-de

269 be a promising approach to control catheter blockage, or biofilm formation on other medical devices.

270 that voltage sensitivity of the tubulin-VDAC blockage practically does not depend on the lipid charge

271 dinated apical constriction nor its complete blockage prevent internalization and tube formation, alt

272 region, can be detected based on the current blockage prior to duplex unzipping.

273 mbination of antiretroviral therapy with RCA blockage, provirus activators, and therapeutic vaccines

274 of accessible focusing parameters, including blockage ratio, volumetric flow rate, cell concentration

275 activation pharmacological protein synthesis blockage results in mnemonic failure in hippocampus-depe

276 52, 95% CI: 1.23, 1.87; P < 0.001) and tubal blockage (RR = 1.83, 95% CI: 1.20, 2.77; P = 0.005).

277 ence between doxazosin and placebo for nasal blockage score and heart rate after single but not chron

278 Nasal visual analogue scale (VAS) and blockage scores were worse between baseline vs. first do

279 he non-template strand result in much weaker blockage signals extending downstream from the break eve

280 citive device is able to detect and forecast blockages, similar to early detection procedures in canc

281 We found multiple transcription blockage sites adjacent to and within sequences engaged

282 by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching.

283 (starvation or mammalian target of rapamycin blockage) stimulated RACK1-ATG5 interaction.

284 Analysis of the detailed pattern of the blockage suggests that RNA polymerase is sterically hind

285 low inhibitory activity in hERG K(+) channel blockage testing, negativity in the Ames test, and 5/5 c

286 port into alpha-cells link glucagon receptor blockage to alpha-cell hyperplasia.

287 To correlate the AT1 receptor blockage to anticancer effects, VEGF levels and microves

288 However, the beneficial actions of ACAT1 blockage to treat Alzheimer's disease remained not well

289 inhibition of JNK was, similar to NF-kappaB blockage, toxic to autonomously proliferating CARD11(L22

290 Triplex-mediated transcription blockage varied significantly with changes in ambient co

291 average percentage of front-windshield UV-A blockage was 96% (range, 95%-98% [95% CI, 95.7%-96.3%])

292 This blockage was not observed in DM1 fibroblasts, demonstrat

293 This blockage was quantified by measuring the oxidation curre

294 by FFSS was blocked by PGE2 and CM and this blockage was reversed by U0126 and the CM depleted of PG

295 r than the average percentage of side-window blockage, which was 71% (range, 44%-96% [95% CI, 66.4%-7

296 perturbed axonal transport by causing axonal blockages, which were enhanced by reduction of kinesin-1

297 Furthermore, PAPPA blockage with antibody inhibited embryo implantation in

298 Androgen deprivation or AR blockage with inhibitor MDV3100 (Enzalutamide) leads to

299 erated that display a reduced sensitivity to blockage with quinidine.

300 ring ischemia of various severity or channel blockage with realistic timescales.