ライフサイエンスコーパス: blood coagulation

1 an important role in regulating TF-initiated blood coagulation.

2 nt serine protease that negatively regulates blood coagulation.

3 flow, activate the endothelium, and increase blood coagulation.

4 emical network of proteolytic enzymes called blood coagulation.

5 gluconeogenesis, amino acid metabolism, and blood coagulation.

6 pts platelet function and platelet-activated blood coagulation.

7 Ca(2+)-dependent scramblase activity during blood coagulation.

8 ved in kinase activity, immune response, and blood coagulation.

9 process leading to platelet aggregation and blood coagulation.

10 c polyphosphates have been shown to activate blood coagulation.

11 n histone methylation, and genes involved in blood coagulation.

12 cal functions from regulating cell growth to blood coagulation.

13 ost widely used clinical marker of activated blood coagulation.

14 icipates in the contact activation system of blood coagulation.

15 ne (PS)-containing platelet membranes during blood coagulation.

16 contributions to our basic understanding of blood coagulation.

17 r Xa, a Na(+)-activated protease involved in blood coagulation.

18 cal functions from regulating cell growth to blood coagulation.

19 ught to be the key step in the initiation of blood coagulation.

20 cal role of the contact activation system in blood coagulation.

21 er of inhibitors of platelet aggregation and blood coagulation.

22 tissue factor (TF), the primary initiator of blood coagulation.

23 nels involved in olfaction, nociception, and blood coagulation.

24 mental processes, complement regulation, and blood coagulation.

25 ew blood vessel formation, and modulation of blood coagulation.

26 feeding, to induce vasodilation and inhibit blood coagulation.

27 rm the essential "prothrombinase" complex of blood coagulation.

28 tant for initiating the intrinsic pathway of blood coagulation.

29 The chimera exhibited biphasic effects upon blood coagulation.

30 3-O sulfated HS motif is thought to modulate blood coagulation.

31 n that functions as an essential cofactor in blood coagulation.

32 s a cofactor within the intrinsic pathway of blood coagulation.

33 re of the protein complexes that form during blood coagulation.

34 ithrombin, a protease inhibitor, to regulate blood coagulation.

35 nt noncovalently associated fibrin chains in blood coagulation.

36 both the extrinsic and intrinsic pathways of blood coagulation.

37 ction of ion-channel activity, and decreased blood coagulation.

38 cal for regulating reproductive hormones and blood coagulation.

39 , motility, adhesion, neuronal signaling and blood coagulation.

40 ial for efficient thrombin generation during blood coagulation.

41 ly apoptotic cells in addition to regulating blood coagulation.

42 h muscle relaxation as well as prevention of blood coagulation.

43 imarily in liver that is required for normal blood coagulation.

44 are generated by platelet activation during blood coagulation.

45 Factors VII, IX, and X play key roles in blood coagulation.

46 e-dependent enzyme complexes is critical for blood coagulation.

47 platelet surface in the propagation phase of blood coagulation.

48 (ATIII) is a key antiproteinase involved in blood coagulation.

49 h a well defined role in the final stages of blood coagulation.

50 e that plays an important role in initiating blood coagulation.

51 matory effects of thrombin without affecting blood coagulation.

52 othrombinase complex-the molecular engine of blood coagulation.

53 e of complement, inflammatory responses, and blood coagulation.

54 nsmembrane receptor and primary initiator of blood coagulation.

55 processes such as development, immunity, and blood coagulation.

56 tissue factor (TF), the primary initiator of blood coagulation.

57 of membrane lipid asymmetry is a hallmark of blood coagulation.

58 p.prothrombin complexes during initiation of blood coagulation.

59 responsible for the age-related increase of blood coagulation activity.

60 Tissue factor initiates blood coagulation after atherosclerotic plaque disruptio

61 Tissue factor (TF), a primary initiator of blood coagulation, also plays a pivotal role in angiogen

62 surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kal

63 that phospholipid scrambling is important in blood coagulation and apoptosis, the concomitant activat

64 nd we show that chemerin is activated during blood coagulation and attracts pDC but not mDC in ex viv

65 re shown to degrade host proteins central to blood coagulation and basement membrane integrity, sugge

66 Historically known for its role in blood coagulation and bone formation, vitamin K (VK) has

67 Analogous to blood coagulation and complement activation in mammals,

68 ulation, as exemplified by activation of the blood coagulation and complement zymogens.

69 of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagula

70 Activation of blood coagulation and fibrinolysis may be associated wit

71 ndent serine protease with putative roles in blood coagulation and fibrinolysis.

72 binase complex is a pivotal initial event in blood coagulation and has been the subject of investigat

73 enzymatic activation is the central event in blood coagulation and has important biomedical and biote

74 Serine protease cascades are involved in blood coagulation and immunity.

75 Blood coagulation and inflammation are universal respons

76 The protein C pathway plays a key role in blood coagulation and inflammation.

77 For a long time, blood coagulation and innate immunity have been viewed a

78 of proteins, including proteins involved in blood coagulation and its regulation.

79 ausing mutations at the promoters of several blood coagulation and lipid metabolism genes were also i

80 externalizing phosphatidylserine to trigger blood coagulation and mark apoptotic cells.

81 GPI is essential to maintain homeostasis of blood coagulation and neurological function.

82 Excessive activation of blood coagulation and neutrophil accumulation have been

83 nases on protein substrates is a hallmark of blood coagulation and numerous other physiological proce

84 cal networks that play a fundamental role in blood coagulation and other patho/physiological processe

85 ion of the immune system strongly influences blood coagulation and pathological thrombus formation.

86 nchoring domain found on vitamin K-dependent blood coagulation and regulatory proteins.

87 rmation, suggesting a role for the ligand in blood coagulation and supporting the hypothesis that sta

88 to all Na(+)-activated proteases involved in blood coagulation and the complement system.

89 er is unique to Na(+)-activated proteases in blood coagulation and the complement system.

90 A unique link between blood coagulation and the ECM is established.

91 the initiation of the consolidation phase of blood coagulation and the generation of thrombin at site

92 nd other Na(+)-activated enzymes involved in blood coagulation and the immune response.

93 display a bleeding diathesis, despite normal blood coagulation and the lack of thrombocytopenia.

94 s glycoproteins and regulatory components in blood coagulation and thrombosis that include von Willeb

95 eletal muscle myosins can directly influence blood coagulation and thrombosis, ex vivo studies of the

96 Tissue factor (TF), the initiator of blood coagulation and thrombosis, is up-regulated after

97 and also to suppress systemic mechanisms of blood coagulation and thrombosis.

98 ets thrombin and other proteases involved in blood coagulation, and ATIII misfolding can thus lead to

99 n septic shock, tissue factor (TF) activates blood coagulation, and cytokines and chemokines orchestr

100 ellular activities, including wound healing, blood coagulation, and immune responses.

101 pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as crit

102 proteases that affect cell growth and death, blood coagulation, and inflammation.

103 , glucose metabolism, complement activation, blood coagulation, and inflammation.

104 of proatherogenic lipoproteins, accelerates blood coagulation, and modulates inflammation.

105 ia, regulation of cell migration, effects on blood coagulation, and platelet activation.

106 the ternary TF-VIIa-Xa initiation complex of blood coagulation, and the EPCR-dependent activation of

107 iological functions, including angiogenesis, blood coagulation, apoptosis, extracellular matrix remod

108 of vascular smooth muscle and prevention of blood coagulation are mediated by ligand-induced activat

109 e critical and multiple roles of thrombin in blood coagulation are regulated by ligands and cofactors

110 ctor VIII (FVIII) has a critical function in blood coagulation as the pro-cofactor to the serine-prot

111 usly to cleave human Factor V and deregulate blood coagulation, as the most abundant type II secreted

112 ocking mEPCR and was absent in ex vivo whole blood coagulation assays, implicating a specific mFVIIa-

113 Plasma and whole blood coagulation assays, the latter measured by thrombo

114 During the process of blood coagulation, BDNF is released from platelets, whic

115 ates include vertebrate proteins involved in blood coagulation, bone mineralization, and signal trans

116 Tissue factor (TF) initiates blood coagulation, but its expression in the vascular sp

117 The metalloprotease ADAMTS13 regulates blood coagulation by cleaving von Willebrand factor (VWF

118 he bloodstream during infection, in inducing blood coagulation by direct proteolytic ProT activation.

119 Vitamin K epoxide reductase (VKOR) sustains blood coagulation by reducing vitamin K epoxide to the h

120 rotease, activated protein C (APC), inhibits blood coagulation by specific inactivation of the coagul

121 Thrombin, a key protease of the blood coagulation cascade and a potent inducer of angiog

122 ice partially restored the activation of the blood coagulation cascade and accumulation of platelets.

123 as a key enzyme for the intervention of the blood coagulation cascade and for the development of new

124 he initiator of the extrinsic pathway of the blood coagulation cascade and normally released from dam

125 ntly showed that polyphosphate modulates the blood coagulation cascade at 3 steps: it triggers the co

126 by tissue factor-initiated activation of the blood coagulation cascade at the feto-maternal interface

127 r for factor VIIa (fVIIa) that initiates the blood coagulation cascade during vascular injury.

128 It utilizes components of the blood coagulation cascade in the presence of polystyrene

129 The blood coagulation cascade includes a step in which the s

130 elet-CTC interactions inherently rely on the blood coagulation cascade including platelet activation.

131 rombin, and its activation at the end of the blood coagulation cascade results in the formation of th

132 cular understanding of a key reaction of the blood coagulation cascade where cofactor Va enhances act

133 Fibrin, a product of the blood coagulation cascade, accompanies many type 1 immun

134 inhibition of factor Xa, a proteinase of the blood coagulation cascade, and is typically achieved wit

135 flammatory protease that is regulated by the blood coagulation cascade, exerts similar effects depend

136 R, maintain vitamin K levels and sustain the blood coagulation cascade.

137 re primarily restricted to components of the blood coagulation cascade.

138 tein complexes formed, and regulation of the blood coagulation cascade.

139 se inhibitors and the major inhibitor of the blood coagulation cascade.

140 rokinase, which have opposing effects on the blood coagulation cascade.

141 d fibrin monomers in the final stages of the blood coagulation cascade.

142 th the cell membrane are critical within the blood coagulation cascade.

143 , without inhibiting serine proteases in the blood coagulation cascade.

144 Blood coagulation caused, in a thrombin-dependent manner

145 e range of biological activities, regulating blood coagulation, cell differentiation, and inflammator

146 ry event for many cellular processes such as blood coagulation, cell proliferation, and migration.

147 ncluding measurements of enzyme kinetics and blood coagulation, cell-based assays, and chemical react

148 Although blood coagulation changes such as disseminated intravasc

149 During porcine whole blood coagulation, changes in the elastic property of th

150 tion of nonlinear reaction networks, such as blood coagulation (clotting), by small quantities of act

151 lished that, apart from its distinct role in blood coagulation, coagulation factor FVIIa enhances agg

152 also emerged: genes related to inflammation, blood coagulation, detoxification, serum proteins, amino

153 al. recently identified a class of diseases--blood coagulation disorders--that were associated with a

154 omarker in characterization and treatment of blood coagulation disorders.

155 cell life, such as cholesterol homeostasis, blood coagulation, EGFR binding, p53 binding, Notch sign

156 Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplifi

157 ants capable of functionally expressing this blood-coagulation enzyme.

158 d excellent selectivity against the relevant blood coagulation enzymes.

159 ct of antibodies and mitigate the binding of blood coagulation factor (Factor X) in vitro.

160 leeding disorder hemophilia B [deficiency in blood coagulation factor IX (F.IX)] by gene replacement

161 , we carried out a systematic study on human blood coagulation factor IX (hFIX) and anti-coagulant pr

162 s for the liver-specific expression of human blood coagulation factor IX (hFIX).

163 F9, a gene on the X chromosome that encodes blood coagulation factor IX, and is predicted to alter R

164 Blood coagulation factor IXa (fIXa) is a trypsin-like se

165 Blood coagulation factor IXa has been presumed to be reg

166 Activation of blood coagulation factor V (FV) is a key reaction of hem

167 Blood coagulation factor V circulates as a procofactor w

168 The uptake and processing of blood coagulation factor VIII (FVIII) by antigen-present

169 tor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulati

170 Blood coagulation factor VIII (fVIII) is activated by th

171 Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major c

172 which shares homology with the C2 domains of blood coagulation factor VIII and factor V.

173 Blood coagulation factor VIII has a domain structure des

174 a genetic disease caused by a deficiency of blood coagulation factor VIII or IX.

175 ng disorder that is due to the deficiency of blood coagulation factor VIII or IX.

176 , and 23/26del) which cannot bind platelets, blood coagulation factor VIII, or collagen, causing VWD

177 raction between the capsid hexon protein and blood coagulation factor X (FX), whilst penton-alpha(v)i

178 Ad5 transduction requires blood coagulation factor X (FX); FX binds to the Ad5 cap

179 sAd24 virions formed unstable complexes with blood coagulation factor X and, because of that, transdu

180 protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces.

181 In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX

182 to transamidation by both TG2 and activated blood coagulation factor XIII (FXIIIa).

183 During blood coagulation, factor IXa (FIXa) activates factor X

184 Some recombinant vitamin K-dependent blood coagulation factors (factors VII, IX, and protein

185 prothrombin activator, trypsin-like enzymes, blood coagulation factors and prophenoloxidase cascade a

186 Elevated circulatory levels of many blood coagulation factors are known to be a risk factor

187 Spatial distribution of blood coagulation factors on the surface of procoagulant

188 r which tracks with reduced plasma levels of blood coagulation factors V, VII, VIII, IX, X, and XII.

189 Deficiency of blood coagulation Factors VIII, IX, or XI is associated

190 nctions as a cofactor-dependent regulator of blood coagulation factors Xa (FXa) and XIa.

191 nctions as a cofactor-dependent regulator of blood coagulation factors Xa and XIa.

192 vectors can bind several vitamin K-dependent blood coagulation factors, which contributes to virus se

193 inone to sustain gamma-carboxylation of many blood coagulation factors.

194 nvolves virus binding to vitamin K-dependent blood coagulation factors.

195 gulate complex proteolytic pathways, such as blood coagulation, fibrinolysis, and inflammation.

196 as well as proteolytic cascades that affect blood coagulation, fibrinolysis, and pericellular proteo

197 family of enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilizat

198 nd further extend the molecular link between blood coagulation/fibrinolysis and CMKLR1-mediated immun

199 ssed by eosinophils can induce activation of blood coagulation generating thrombin which in turn can

200 The biochemistry of blood coagulation has been well defined over the past 50

201 egulator of endothelial barrier function and blood coagulation, has been proposed to be involved in t

202 ly in the process of tissue factor-initiated blood coagulation; however, the catalytic sequence leadi

203 We propose that PSGL-1 plays a role in blood coagulation in addition to its known role in leuko

204 vitamin K epoxide reductase (VKOR) supports blood coagulation in humans and is the target of the ant

205 Blood coagulation in humans requires the activity of vit

206 onary artery endothelial cells and activated blood coagulation in mice.

207 ut drug leakage and can sustainably regulate blood coagulation in response to thrombin.

208 During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa)

209 The initiation of blood coagulation in vivo entailed the initial accumulat

210 ating that one pathway for the initiation of blood coagulation in vivo involves the accumulation of t

211 an essential cofactor for the activation of blood coagulation in vivo.

212 ed to activation of the extrinsic pathway of blood coagulation, in the present study we investigated

213 and differentiation, lipoprotein metabolism, blood coagulation, inflammation, tissue regeneration, tu

214 elium maintains blood fluidity by inhibiting blood coagulation, inhibiting platelet aggregation, and

215 sms include acetylation of other proteins in blood coagulation, inhibition of COX-2 activity, and oth

216 Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from t

217 Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads

218 ogate to evaluate the vascular modulation of blood coagulation initiated by relipidated recombinant t

219 digm of how MCs hinder fibrin deposition and blood coagulation internally.

220 Blood coagulation involves activation of platelets and c

221 Blood coagulation is a finely regulated physiological pr

222 The interplay between inflammation and blood coagulation is an essential part of host defense d

223 Regulation of blood coagulation is critical for maintaining blood flow

224 Blood coagulation is essential for physiological hemosta

225 led submodel of the tissue factor pathway of blood coagulation is introduced within the framework of

226 The binding of Factor IX to membranes during blood coagulation is mediated by the N-terminal gamma-ca

227 A computational model of blood coagulation is presented with particular emphasis

228 Blood coagulation is sensitive to the local concentratio

229 Blood coagulation is strongly dependent on the binding o

230 Blood coagulation is triggered when the serine protease

231 for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role

232 g tissue factor and PAI-1, diminished global blood coagulation markers (fibrinogen, fibrin-degradatio

233 ssibility that mediators of inflammation and blood coagulation may also regulate processes that invol

234 t for this class of molecules, inhibition of blood coagulation may be occurring through a mechanism i

235 invariably associated with activation of the blood coagulation mechanism, secondary to the inflammati

236 thways related to cell adhesion, chemotaxis, blood coagulation, oxidoreductases, matrix metalloprotei

237 Enzymes of the blood coagulation pathway enhance the inflammatory respo

238 mophilia occurs from deficiency of intrinsic blood coagulation pathway factor VIII or IX, pharmacolog

239 blocks thrombin generation via the extrinsic blood coagulation pathway.

240 domains is one of the essential steps in the blood coagulation pathway.

241 re the ultimate proteolytic reactions in the blood coagulation pathway.

242 n our understanding of the physiology of the blood coagulation process and the translation of this un

243 ced our understanding of the dynamics of the blood coagulation process beyond end point assays and ar

244 th and inflammatory responses as well as the blood coagulation process.

245 vation of prothrombin to thrombin during the blood coagulation process.

246 Pro-inflammatory signaling by the blood coagulation protease thrombin through protease act

247 we have directly investigated a role for the blood-coagulation protease thrombin in regulating the ad

248 Antithrombin is a key inhibitor of blood coagulation proteases and a prototype metastable p

249 Mutants of blood coagulation proteases have been reported with Glu,

250 tithrombin, a key serpin family regulator of blood coagulation proteases, is transformed into a poten

251 Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blo

252 The blood coagulation protein factor XI (FXI) consists of a

253 hence the regulation of vitamin K-dependent blood coagulation protein synthesis.

254 Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by

255 A structure-function analysis of a blood coagulation protein, antithrombin III and a protea

256 Factor XI (FXI) is a homodimeric blood coagulation protein.

257 s with sequence homology to the C domains of blood coagulation proteins factor V and factor VIII.

258 been used to explore the role of platelets, blood coagulation proteins, endothelium, and the vessel

259 onal modification of the vitamin K-dependent blood coagulation proteins, the regulation of carboxylas

260 f proteases, growth factors, chemokines, and blood coagulation proteins.

261 equirement for TF during the progress of the blood coagulation reaction and have extended these analy

262 ar cofactor tissue factor (TF) initiates the blood coagulation reactions.

263 nts of substrate affinity and specificity in blood coagulation reactions.

264 In mice lacking the blood coagulation regulator thrombomodulin, fibrinolytic

265 in to thrombin (II(a)) by factor X(a) during blood coagulation requires proteolysis of two bonds and

266 The blood coagulation scheme for the puffer fish, Fugu rubri

267 From our data, we propose a revised blood coagulation scheme in which direct FXa-mediated FV

268 Consequently, dynamic blood coagulation status can be measured quantitatively

269 Exploiting the blood coagulation system as an exquisite biological sens

270 We have developed a model of the extrinsic blood coagulation system that includes the stoichiometri

271 t can potentiate several interactions in the blood coagulation system.

272 lammatory processes and abnormalities of the blood coagulation system.

273 thological states caused by a malfunctioning blood coagulation system.

274 include abnormal ocular blood flow, abnormal blood coagulation, systemic hypotension, ischemic vascul

275 Platelets are important mediators of blood coagulation that lack nuclei, but contain mitochon

276 The inhibition of the final step in blood coagulation, the factor XIIIa (FXIIIa) catalyzed c

277 During blood coagulation, the protease factor XIa (fXIa) activa

278 of tissue factor action in the initiation of blood coagulation, the structure and membrane-binding pr

279 on mechanism requisite for the complexity of blood coagulation, they are stepping-stones towards furt

280 In blood coagulation, thrombin helps to activate factor XII

281 In blood coagulation, thrombin helps to activate factor XII

282 he physiological regulation of intravascular blood coagulation (thrombosis) by the endogenous protein

283 I) contributes substantially to pathological blood coagulation (thrombosis), whereas it contributes o

284 rocesses, ranging from nutrient digestion to blood coagulation, thrombosis, and beyond.

285 alsalva, applied research on circulation and blood coagulation to devise whole-body fasting and bleed

286 iety of physiological processes ranging from blood coagulation to embryo- and oncogenesis, tissue reg

287 tures seem endowed with multiple roles, from blood coagulation to inter-cellular communication in pat

288 potent inhibitor of tissue factor-initiated blood coagulation, to the macaques either 10 min (n=6) o

289 t that proteases of the extrinsic pathway of blood coagulation transactivate the MASP matriptase, thu

290 membrane-bound tissue factor (TF) initiates blood coagulation upon vascular injury.

291 dynamic and quantitative assessment of whole blood coagulation using acoustic radiation force orthogo

292 the proteolytic enzyme thrombin, involved in blood coagulation, utilizing a library of beta-sheet epi

293 In order of increasing fluence we observed: blood coagulation, vasoconstriction, thread-like appeara

294 tor IX, respectively, resulting in deficient blood coagulation via the intrinsic pathway.

295 Tissue factor-induced blood coagulation was studied in 20 individuals, for var

296 as shown that platelet contribution to whole blood coagulation was unrelated to the generation of act

297 rameters of tissue injury, regeneration, and blood coagulation were assessed in tissue/blood samples.

298 At low concentrations it accelerated blood coagulation, while at higher concentrations it act

299 Studies of the mechanisms of blood coagulation zymogen activation demonstrate that ex

300 C), a potent conformational activator of the blood coagulation zymogen, prothrombin (ProT).