ライフサイエンスコーパス: blood concentration

1 substrate, to obtain the cyclosporin target blood concentration.

2 ed vasoactivity and increase nitrate/nitrite blood concentration.

3 venous CMT-3 dosed to obtain a 25-micromol/L blood concentration.

4 ous Abeta concentration compared to arterial blood concentration.

5 rly rank individuals with respect to 25(OH)D blood concentrations.

6 , few studies have examined the relation for blood concentrations.

7 h intravenous and oral fluconazole alter CNI blood concentrations.

8 ites did not affect healing or produce toxic blood concentrations.

9 cyclosporine emulsion to achieve acceptable blood concentrations.

10 han Caucasian patients to achieve comparable blood concentrations.

11 n of drugs such as lithium, leading to toxic blood concentrations.

12 al transplant recipients correlates with CsA blood concentrations.

13 at the same time as increasing GLP-2 portal blood concentrations.

14 istics are able to withstand individual drug blood concentrations.

15 maximizes the likelihood of achieving target blood concentrations.

16 exposure being approximately 71% of maternal blood concentrations.

17 sing mucormycosis associated with inadequate blood concentrations.

18 ty was approximately 50% inhibited at trough blood concentrations (148 microg/L); moreover, inhibitio

19 aplotype were able to withstand lumefantrine blood concentrations 15-fold higher than those with the

20 nstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was asso

21 ry outcome was within-person GLP-1 in venous blood (concentrations and area under the curve).

22 stigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older

23 e steroid hormone bioavailability (decreased blood concentration and increased sex hormone-binding gl

24 were used to estimate threshold steady state blood concentration and occupancy required to elicit a c

25 effect of matrix metalloproteinase 7 (MMP-7) blood concentration and other demographic and clinical c

26 d a significant correlation between mean CsA blood concentration and the mean degree of inhibition of

27 , guided by close monitoring of cyclosporine blood concentrations and frequent assessments of renal f

28 rolimus, with close monitoring of tacrolimus blood concentrations and frequent assessments of renal f

29 lation was observed between tacrolimus whole blood concentrations and PDC frequencies (Spearman r=-0.

30 valuate the relation between dietary intake, blood concentrations, and retinal concentrations of caro

31 The lower fetal blood concentrations are likely due to active efflux tra

32 ted with many health conditions, but optimal blood concentrations are still uncertain.

33 n was seen between DC subsets and tacrolimus blood concentration at any time point.

34 Mean (+/- SD) blood concentrations at 12 and 24 months were, respectiv

35 bserved a 1,000:1 ratio between IP fluid and blood concentrations at 20 mg CsA/kg.

36 Miltefosine steady-state blood concentrations at the end of treatment were analyz

37 Systemic exposure to sirolimus was low, with blood concentrations below levels necessary for systemic

38 ormalized) of greatest interest were maximum blood concentration (C(max)/dose), time to reach maximum

39 ailability (F), clearance rate (CL), average blood concentration (C[av]), peak concentration (Cmax),

40 (AUC(inf) ) and maximum observed plasma (or blood) concentration (C(max) ) of cyclosporine with geom

41 harmacokinetic evaluations (maximum observed blood concentration [C(max) ], concentration before dosi

42 ration-vs.-time curve (AUC/dose), and trough blood concentrations (Co h/dose).

43 iven orally on a 28-day schedule resulted in blood concentrations comparable to those following low-d

44 ved twofold lower dose-normalized tacrolimus blood concentrations compared with CYP3A5*3/*3 homozygot

45 Sirolimus blood concentration correlated positively with dose and

46 Higher blood concentrations correlated with the achievement of

47 After a short infusion, patupilone blood concentrations declined in a multiphasic manner wi

48 cally correlated closely with the creatinine blood concentration detected by the UCLA Ronald Reagan M

49 infusion of prostacyclin to pathophysiologic blood concentrations did not reproduce such changes.

50 ped chemical similarities after weighting by blood concentrations, disease-risk citations, and number

51 experimental data to the simulated values of blood concentration for 10 target chemicals with various

52 might be sufficient to maintain therapeutic blood concentration for 4-5 days.

53 (RT) reaction, corresponding to an estimated blood concentration from 6.2 x 10(-5) to 6.2 x 10(1) ng/

54 All patients had PSC 833 blood concentrations greater than 1, 000 ng/mL before, d

55 were adjusted individually by assessing SRL blood concentrations, immune function, and clinical stat

56 We measured blood concentrations in 30 relapsed patients treated wit

57 on; however, there is a need for data on TFA blood concentrations in the population.The objective of

58 was a significant delay in achieving target blood concentrations in those with at least one CYP3A5*1

59 to the age of 12 years if the phenylalanine blood concentration is between 360 mumol/L and 600 mumol

60 apeutic index and the correlation of dose to blood concentration is poor as a result of moderate vari

61 the blood activity concentration curve, and blood concentration itself at 40 min, resulting in sever

62 RIIb on LSEC, a major scavenger, keeps SIC blood concentrations low and minimizes pathologic deposi

63 hoprim-sulfamethoxazole with capillary whole blood concentrations <200 ng/mL had a 3-fold higher haza

64 Low maternal choline intake and blood concentration may be risk factors for having a chi

65 y diseases, but associations with intakes or blood concentrations may arise from other constituents o

66 B-type natriuretic peptide blood concentration measurement appears to be a sensitiv

67 dosimetry method was more effective than the blood concentration method in determining the optimal ti

68 In contrast, the simple blood concentration method suggested an interval about 7

69 odds ratios for different exposure levels to blood concentrations normalised to a percentile scale.

70 Enhanced marrow perfusion, an increased blood concentration of (99m)Tc-MAG3, and marrow hyperpla

71 At a blood concentration of 80 pg/ml, BNP was an accurate pre

72 The blood concentration of [5-(15)N]-glutamine (microM) was

73 ALL patients by adjusting doses based on the blood concentration of active drug metabolite could sign

74 onic diseases in which low dietary intake or blood concentration of alpha-tocopherol have been implic

75 often have impaired renal function, and the blood concentration of cardiac troponin often increases

76 y was paralleled by a reduction in the basal blood concentration of corticosterone.

77 ilure is characterized by an increase in the blood concentration of creatinine and nitrogenous waste

78 (AUC ratios) did not increase with the mean blood concentration of CsA, indicating a near-maximal P-

79 ation-versus-time curve and the mean maximum blood concentration of cyclosporine-both normalized for

80 s of Abs and pharmacokinetic fluctuations in blood concentration of drug are not essential to inducin

81 The blood concentration of fibrocytes expressing the chemoki

82 The blood concentration of HbF, or the number of cells with

83 The mean trough blood concentration of ISATX247 was 120 +/- 32 ng/mL and

84 nophen-induced liver damage, assessed by the blood concentration of liver enzymes and liver histology

85 ies, rejection episodes, renal function, and blood concentration of medications.

86 iable and high-efficiency measurement of the blood concentration of most common PET and SPECT radiotr

87 ange in plasma glucose and cortisol, and the blood concentration of neutrophils (F[14, 112] = 5.13, P

88 insulin resistance appears to be an elevated blood concentration of plasminogen activator inhibitor t

89 The blood concentration of soluble CD14 (sCD14) increases du

90 ells (DU145) spiked into a sample with whole blood concentration of the peripheral blood mononuclear

91 oodstream work together to amplify the total blood concentration of these tiny biomarkers.

92 timulating hormone (TSH), an increase in the blood concentration of thyroid hormone (T4), increased e

93 From the literature we obtained human blood concentrations of 1,561 small molecules and metals

94 Blood concentrations of 122 persistent environmental pol

95 ntial exposures to environmental toxins, and blood concentrations of 122 persistent environmental pol

96 ioxidants was assessed, and the summed molar blood concentrations of 14 POPs were positively related

97 Higher blood concentrations of 17-betaE, higher accumulation in

98 Blood concentrations of 19 persistent organic pollutants

99 Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmo

100 Elevated blood concentrations of asymmetric dimethylarginine (ADM

101 Compared with men with high blood concentrations of beta-carotene or cholesterol-adj

102 In this study, telaprevir increased the blood concentrations of both cyclosporine and tacrolimus

103 of prospective studies of dietary intake and blood concentrations of carotenoids and breast cancer ri

104 assessment has compared dietary intake with blood concentrations of carotenoids and breast cancer ri

105 Blood concentrations of carotenoids are more strongly as

106 Blood concentrations of carotenoids have been proposed a

107 In contrast, the summary RR for blood concentrations of carotenoids was 0.78 (95% CI: 0.

108 eing oxidative stress and alterations in the blood concentrations of compounds that influence oxidati

109 Elevated blood concentrations of corticosterone (CORT), an adrena

110 or weakness combined with large increases in blood concentrations of creatine kinase), new-onset diab

111 Blood concentrations of CsA at 15 min after the 45-min i

112 In contrast to EPA and DHA, blood concentrations of DPA were not correlated with die

113 Blood concentrations of ferritin, transferrin receptor,

114 associations of toenail selenium levels with blood concentrations of fibrinogen, high-sensitivity C-r

115 Blood concentrations of folate and UMFA were measured wi

116 ere assessed for their association with cord blood concentrations of folate and UMFA.

117 ctive study, we determined maternal and cord blood concentrations of folate and unmetabolized folic a

118 RTE or SUP increases usual daily intakes and blood concentrations of folate and vitamin B-12.

119 ogic studies indicate that higher intakes or blood concentrations of folate are associated with a low

120 High blood concentrations of folic acid may be related to dec

121 w nanomolar concentrations, corresponding to blood concentrations of free genistein attained after di

122 se FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial

123 findings from observational studies relating blood concentrations of hyperinsulinemia markers to brea

124 T cells of wild-type (N) mice, have elevated blood concentrations of IgE, IgG1, and eosinophils; enha

125 ale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict t

126 Overall, these results emphasize that blood concentrations of individual long-chain polyunsatu

127 a cascade of events associated with abnormal blood concentrations of insulin, glucose, or lipids that

128 Blood concentrations of interleukin 1ra (IL-1ra), IL-6,

129 Whole-blood concentrations of ISATX247 and cyclosporine, compl

130 FAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using dat

131 Blood concentrations of lipoproteins and lipids are heri

132 uggest that higher dietary intake and higher blood concentrations of lutein are generally associated

133 er suppression of spermatogenesis, and lower blood concentrations of luteinising hormone at baseline.

134 tem disorders have been associated with high blood concentrations of manganese.

135 d its connection to disease, we sought human blood concentrations of many chemicals, along with their

136 containing thiomersal does not seem to raise blood concentrations of mercury above safe values in inf

137 In the presence of blood concentrations of Mg(2+) , a PhoQ mutant bound mor

138 notherapy resulted in elevated and sustained blood concentrations of MIS, which significantly inhibit

139 ancy (maternal PKU), untreated phenylalanine blood concentrations of more than 360 mumol/L need to be

140 MGDF at 0.5 micrograms/kg/d produced similar blood concentrations of Mpl-ligand and platelets as 10 t

141 Because blood concentrations of n-3 (or omega-3) fatty acids (FA

142 wever, they had metabolic acidosis, elevated blood concentrations of Na(+) and Cl(-), reduced blood p

143 ncreased folic acid intake leads to elevated blood concentrations of naturally occurring folates and

144 Higher blood concentrations of organochlorine compounds were no

145 Blood concentrations of oxaliplatin were similar in the

146 Associations between cord blood concentrations of p,p -DDE and PCBs and sperm diso

147 type of cytochrome P450 3A4 displayed higher blood concentrations of parent (inactive) cyclophosphami

148 ociations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfl

149 Blood concentrations of Phe across time were not signifi

150 de and B-type natriuretic peptide) and lower blood concentrations of plasminogen activator inhibitor-

151 Blood concentrations of polychlorinated biphenyl (PCB)-1

152 by liquorice (Glycyrrhiza glabra); decreased blood concentrations of prednisolone when taken with the

153 Patients who developed neuropathy had lower blood concentrations of riboflavin, vitamin E, selenium,

154 plementation, and iron status as measured by blood concentrations of several indicators.

155 nzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by

156 The dose-normalized blood concentrations of tacrolimus at 3 months after ren

157 There is marked heterogeneity in blood concentrations of tacrolimus following standard bo

158 contribute to interindividual variability in blood concentrations of the active metabolite of dabigat

159 rapeutic drug monitoring in achieving target blood concentrations of the immunosuppressive drugs duri

160 In a pharmacokinetics study, the blood concentrations of the radiolabeled antibodies decr

161 Blood concentrations of these drugs may rise to harmful

162 Blood concentrations of these TAT-NSF peptides rapidly d

163 tect LDL from oxidation, and high intakes or blood concentrations of these vitamins have been linked

164 olesterol-adjusted vitamin E, those with low blood concentrations of these vitamins were 2.5 times as

165 olybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory a

166 lind, placebo-controlled trial, we evaluated blood concentrations of total arsenic, InAs, MMAs, and D

167 Seven months after surgery, blood concentrations of total bile acids, taurocholic ac

168 Elevated blood concentrations of total homocysteine (tHcy) have b

169 ian birth cohort (n = 743), we measured cord blood concentrations of tumor necrosis factor (TNF), TNF

170 ed furosemide; and slower in those with high blood concentrations of unmeasured anions (all, p < .05)

171 Blood concentrations of vitamin B-12, folate, homocystei

172 ntake, vitamin C supplementation, and higher blood concentrations of vitamin C are associated with lo

173 t compared with the lowest tertile of lutein blood concentration or intake.

174 in the mean values between plasma and whole blood concentrations (p < .0004; n = 19; paired t-test).

175 Tissue uptake was expressed relative to the blood concentration (percentage of injected activity per

176 Peak cobalt whole blood concentrations ranging between 9.4 and 117 mug/L w

177 th a half-life of 3 to 6 hr and maximum drug blood concentration reached after 0.5 to 1 hr), treatmen

178 dietary genistein before implantation led to blood concentrations similar to those measured in genist

179 Blood concentrations spanned 11 orders of magnitude and

180 ine dialysis patients displaying much higher blood concentrations than the two healthy control subjec

181 ties of many compounds lie within achievable blood concentrations, these results offer an invaluable

182 Blood concentration time curves showed a biexponential d

183 This likelihood was assessed using a maximum blood concentration to in vitro response ratio approach

184 on, including measurements of serial hs-cTnT blood concentrations twice: once using the uniform 99th

185 aximum concentration (t(max), area under the blood concentration-vs.-time curve (AUC/dose), and troug

186 concentration [T(max) ], and area under the blood concentration-vs.-time curve [AUC]) occurred on da

187 The time that the blood concentration was >10 times the half maximal effec

188 The mean maximum blood concentration was 292 ng/mL for temsirolimus and 3

189 Arterial blood concentration was derived from the PET scans by dr

190 The average calcineurin inhibition at trough blood concentrations was 80 +/- 11% for ISATX247 and 48

191 al administration was sufficient to maintain blood concentrations well above the IC(50).

192 m quantitative imaging of (111)In, and (90)Y blood concentrations were determined from (90)Y in seria

193 A total of 1711 tacrolimus whole blood concentrations were evaluated.

194 SRL, but not EVL blood concentrations were inversely correlated with urin

195 er approximately 90 d of dosing, mean cobalt blood concentrations were lower in men than in women.

196 xposure time windows and environmental toxin blood concentrations were separately fit by logistic reg

197 Efficacy is related to blood concentrations, which are determined mainly by hep

198 contrast medium results in its satisfactory blood concentration with potentially good image quality.

199 ol) showed clear linear trends of increasing blood concentrations with higher self-reported supplemen