ライフサイエンスコーパス: blood island

1 velopment of the embryonic primitive ventral blood island.

2 a marked absence of erythrocytes in yolk sac blood islands.

3 method to the analysis of embryonic yolk sac blood islands.

4 ences for morphogenesis and formation of the blood islands.

5 tructures similar in appearance to embryonic blood islands.

6 tral type, such as lateral plate and primary blood islands.

7 press PECAM before the development of mature blood islands.

8 d some hematopoietic cells of differentiated blood islands.

9 l cells and their precursors in the yolk sac blood islands.

10 c changes with formation of the yolk sac and blood islands.

11 y in heart and brain, as well as the ventral blood island and adult spleen.

12 inently in the brain, eyes, somites, ventral blood island and branchial arches.

13 erythromyeloid progenitors in the posterior blood island and c-myb/cd41(+) cells in the ventral wall

14 l mesoderm, which contributes to the ventral blood island and primitive (yolk sac stage) hematopoiesi

15 ula marginal zone appear to mark presumptive blood island and somite, respectively.

16 ation, FOXF1 expression is excluded from the blood islands and blood cells.

17 angioblasts and the subsequent formation of blood islands and blood vessels by angioblasts in the co

18 expression of CD41 was detected in yolk sac blood islands and in fetal liver.

19 rmal cells prior to the establishment of the blood islands and in the embryoid body (EB)-derived blas

20 learly present in the erythroblasts of early blood islands and of the fetal liver, but absent in the

21 We examined the origins of the ventral blood islands and primitive blood from the vegetal regio

22 ur results demonstrate that both the ventral blood islands and primitive blood routinely arise from a

23 used to determine the origin of the ventral blood islands and primitive blood, injection of either b

24 , we showed that some of the erythrocytes in blood islands and small vascular tubes were progeny of t

25 The earliest erythroblasts arise in yolk sac blood islands and subsequently enter the embryo proper t

26 Two regions of the vertebrate embryo, the blood islands and the dorsal lateral plate (DLP), partic

27 nesis as evidenced by a lack of recognizable blood islands and vascular channels and a reduction in t

28 molecule-1 (PECAM-1) during the formation of blood islands and vessels from clusters of extraembryoni

29 mals, showed that Gata4-/- ES cells can form blood islands and vessels when juxtaposed to visceral en

30 n the formation and organization of yolk sac blood islands and vessels.

31 structures, including the chorion, yolk sac blood islands, and allantois appear to develop normally,

32 at divide infrequently, populate the rostral blood islands, and differentiate into macrophages.

33 ved from these cell lines are unable to form blood islands, and express reduced levels of both PECAM1

34 logically unique cells that give rise to the blood islands, and then later within the hepatic primord

35 essed in extraembryonic mesoderm, from which blood islands are derived.

36 In most vertebrates, yolk sac blood islands are the initial sites of appearance of hem

37 TA-2 mRNA expression is downregulated in VYS blood islands as terminal primitive erythroid differenti

38 cient to generate lacZ expression within the blood islands as well as the fetal liver during embryoni

39 Because Hhex is expressed in the developing blood islands at E7.0 in the endothelium of the developi

40 ith primitive erythroblasts first evident in blood islands at the headfold stage (E8.0).

41 and vitelline veins in the anterior ventral blood island (aVBI), and to the endocardium of the heart

42 It is proposed that the blood islands become restricted to the ventralmost mesod

43 Light microscopic examination revealed free blood islands (BI) in the embryonic vitreous cavity (5.5

44 ecursor cells do indeed exist in the Xenopus blood island, but BMP signaling normally acts to constra

45 ng strategy, we demonstrate that circulating blood island-derived cells contribute to the genesis of

46 poietic and vascular commitment occur before blood island development in the yolk sac.

47 we find that precursor cells in the Xenopus blood island do not normally differentiate into ECs, sug

48 imitive hematopoiesis occurs in the yolk sac blood islands during vertebrate embryogenesis, where abu

49 d as angioblasts; (2) hematopoietic cells of blood islands express TAL1, but not Flk1; (3) vasculogen

50 Blood island formation was reduced by half in hemizygous

51 AP domain is sufficient to reproduce ectopic blood island formation, cardiac defects, and overgrowth

52 ree stages of yolk sac vascular development (blood island formation, primary capillary plexus formati

53 During blood island formation, the endoderm produced NO and inh

54 olk sac hematopoiesis, and exuberant cardiac blood island formation.

55 in adults and also participates in yolk sac blood island formation.

56 Angiogenesis and blood-island formation were impaired, resulting in sever

57 ve receptor resulted in the expansion of the blood island-forming territory with a concomitant loss o

58 few vessels evident and numerous, persistent blood islands found throughout the epicardium.

59 is expressed early in the developing ventral blood island in a pattern that anticipates that of later

60 11-14, the message was expressed strongly in blood islands in the area opaca.

61 ssential for all hedgehog signaling, to form blood islands in vitro.

62 n that zebrafish EMPs arise in the posterior blood island independently from hematopoietic stem cells

63 f ventral posterior mesoderm and the ventral blood islands, indicating that this negative regulation

64 ronous grafting of donor yolk sac containing blood islands into blood islands of headfold-stage host

65 indicates that the formation of the ventral blood island is more complex than previously thought and

66 hematopoietic and endothelial cells form in blood islands located between layers of visceral endoder

67 rly (embryonic days 8.0-9.5) in the yolk sac blood islands, no Epo expression can be detected in this

68 Cells within the blood island of Xenopus also coexpress predifferentiatio

69 In the extra-embryonic blood islands of birds and mammals, ECs and blood cells

70 donor yolk sac containing blood islands into blood islands of headfold-stage host conceptuses provide

71 enesis and observed robust expression in the blood islands of the E8.5 yolk sac and in developing tis

72 Hex is transiently expressed in the nascent blood islands of the visceral yolk sac and later in embr

73 e embryos appear in close association in the blood islands of the yolk sac (YS).

74 genesis, GMFG was expressed predominantly in blood islands of the yolk sac, where endothelial and hem

75 ammalian embryogenesis and emerge within the blood islands of the yolk sac.

76 bryonic structures, including the allantois, blood islands of the yolk sack, primordial germ cells an

77 rs for both cell types are present in the YS blood islands, only primitive cells are formed in the YS

78 omyeloid progenitors (EMPs) in the posterior blood island (PBI) that arise independently of HSCs.

79 and blood cells are closely intermixed, and blood island precursor cells in the primitive streak exp

80 Differentiating embryoid bodies form blood islands, providing an in vitro model for studying

81 , contrary to predictions of this model, the blood islands remain ventrally restricted even in the ab

82 or FGF signaling in specifying somite versus blood island territories was observed as early as midgas

83 loid cells originate in the anterior ventral blood islands, the equivalent of the mammalian yolk sac,

84 Blood islands, the precursors of yolk sac blood vessels,

85 ed this by sequestering erythroblasts in the blood islands, thereby lowering the hematocrit and reduc

86 factor Biklf is preferentially expressed in blood islands throughout zebrafish embryogenesis, markin

87 is essential for restriction of the ventral blood islands to ventral mesoderm.

88 We find that cell clusters of primitive blood islands undergo an inappropriate program of apopto

89 interpretations based on mapping the ventral blood islands using Lac Z mRNA as a tracer.

90 pg at the four-cell stage suppresses ventral blood island (VBI) formation, whereas expression of the

91 e other mesoderm fates, for example, ventral blood island (VBI), are specified at the ventral pole.

92 ne, which is highly expressed in the ventral blood island (VBI), cranial ganglia, and hatching and ce

93 hrocytes are derived solely from the ventral blood islands (VBI), while definitive hematopoietic cell

94 ne dephosphorylation during the formation of blood islands/vessels from clusters of extra-embryonic a

95 and LMO-2 act synergistically to expand the blood island when overexpressed in whole embryos.

96 ity in mammalian development is the yolk-sac blood island, which originates from the hemangioblast.

97 f differentiating into RBCs via formation of blood islands with extramedullary hematopoiesis.