ライフサイエンスコーパス: blood platelet

1 ectly regulating actin assembly in the human blood platelet.

2 ific proteins in the unique environment of a blood platelet.

3 rough binding to c-Mpl receptor expressed on blood platelets.

4 assembly and extension of filopodia in human blood platelets.

5 nal stems primarily from red blood cells and blood platelets.

6 pe 2B von Willebrand factor (vWF) binding to blood platelets.

7 DA is primarily stored in and transported by blood platelets.

8 ine receptor that controls the production of blood platelets.

9 is while revealing fundamental details about blood platelets.

10 ycoprotein-Ib (GPIb) receptors to cluster on blood platelets.

11 n brain and, outside the CNS, in circulating blood platelets.

12 bules maintains the discoid shape of resting blood platelets.

13 marrow cells that in turn break down to form blood platelets.

14 g, branched proplatelets, which remodel into blood platelets.

15 r genetic profiling of highly purified human blood platelets.

16 ase in megakaryocytes without an increase in blood platelets.

17 ng proplatelets, the immediate precursors of blood platelets.

18 6 associates with CD9 and integrins on human blood platelets.

19 highly expressed in brain, spinal cord, and blood platelets.

20 atelets, the microtubule-based precursors of blood platelets.

21 eceptors were similar to those described for blood platelets.

22 egakaryocyte proliferation and production of blood platelets.

23 patients secondary to transfusion with whole blood platelets (72 reactions), apheresis platelets (2),

24 tion observed, for instance, at the onset of blood platelet activation.

25 ight microscopy was used to visualize canine blood platelet adhesion and aggregation in a parallel pl

26 The inhibition of blood platelet aggregation and secretion was studied usi

27 this inhibition was borne out in whole human blood platelet aggregation assays.

28 Whole blood platelet aggregation was enhanced, and plasma fibr

29 in, activated GPIIb,IIIa and GPIb-IX), whole-blood platelet aggregation, platelet count and hematocri

30 erreactive platelets, as determined by whole blood platelet aggregometry and flow cytometric analysis

31 as well as hematologic toxicity (assessed by blood platelet and neutrophil count nadir) (P < 0.05).

32 Myocardial ischaemia activates blood platelets and cardiac sympathetic afferents, which

33 Anaplasma platys infects peripheral blood platelets and causes infectious cyclic thrombocyto

34 its ability to directly regulate binding of blood platelets and cells to extracellular substrata.

35 pression of ephrins and Eph kinases on human blood platelets and explore their role in the formation

36 red in vivo induce spontaneous activation of blood platelets and formation of aggregates, even in the

37 Both blood platelets and genetics contribute to the developme

38 a(2)beta(1) expression on megakaryocytes and blood platelets and must thereby modulate collagen-relat

39 acterized by a lack of alpha-granules within blood platelets and progressive bone marrow fibrosis.

40 n (GP) IIb-IIIa activation characteristic of blood platelets and that these cultured MKs would be cap

41 y of megakaryocytes, the marrow precursor of blood platelets, and from confusion surrounding the cyto

42 ved that bone marrow CD34(+), CD61(+) cells, blood platelets, and megakaryocytic leukemia cell lines

43 ed by formation of tumor cell complexes with blood platelets, and that metastasis can be attenuated b

44 , the results of the present study show that blood platelets are a rich source of both glycosyltransf

45 Blood platelets are anuclear cell fragments that are ess

46 Blood platelets are anucleate cell fragments that play a

47 Human blood platelets are anucleate cells whose response to ex

48 Blood platelets are critical for hemostasis and thrombos

49 crotubule coils similar to those observed in blood platelets are detected only at the ends of proplat

50 Blood platelets are functional anucleate cells generated

51 Blood platelets are involved in primary and secondary he

52 Blood platelets are produced by large bone marrow (BM) p

53 Circulating blood platelets are specialized cells that prevent bleed

54 VWF), including its binding interaction with blood platelets, are regulated by the magnitude of appli

55 -1-P), may act as an autocrine stimulator of blood platelets, as it is abundantly stored in platelets

56 ld-type control donor hearts flushed free of blood/platelets before preservation/transplantation.

57 Liver regeneration is stimulated by blood platelets, but the molecular mechanisms involved a

58 Activation of blood platelets by physiological stimuli (e.g. thrombin,

59 Cooling of blood platelets clusters the von Willebrand factor recep

60 Blood platelets contain polyphosphate, and the secretion

61 Aggregation of blood platelets contributes to the arrest of bleeding at

62 atelets per each transfusion to maintain the blood platelet count >10 x 10/L in stable nonbleeding pa

63 Whole-blood platelet count and hematocrit increased by 15% and

64 ere compared in PRP (turbidimetry) and whole blood (platelet counting with an Ultra-Flo 100 Platelet

65 oplanin-positive tumors had lower peripheral blood platelet counts (P < .001) and higher D-dimer leve

66 notyped and the latter were assessed by cord blood platelet counts and cerebral ultrasound scans.

67 clodronate-encapsulated liposomes increases blood platelet counts in FlnA(loxP) PF4-Cre mice and rev

68 To assess critically both the blood platelet counts that prompt a platelet transfusion

69 ate the bone marrow, completely reconstitute blood platelet counts, and contribute to multiple haemat

70 Peripheral blood platelet counts, following rhTPO and G-CSF, were i

71 elets daily to maintain normal physiological blood platelet counts.

72 tions are instituted for obesity and reduced blood platelet counts.

73 ring the late stages of megakaryopoiesis and blood platelet development.

74 ed by the heart during hypoxic stress and by blood platelets during thrombus formation.

75 The human blood platelet fibrinogen receptor, integrin alphaIIbbet

76 n of megakaryocytes (MKs)--the precursors of blood platelets--from human pluripotent stem cells (hPSC

77 Specifically, we evaluated blood platelet function, nervous system development, and

78 n, a 100-kDa protein on the surface of human blood platelets has been identified as an ADP receptor.

79 standing of thrombopoiesis--the formation of blood platelets--has improved greatly in the last decade

80 The crucial function of blood platelets in hemostasis is to prevent blood loss b

81 Isolated from human blood platelets in octyl glucoside, the alphaIIbbeta3 co

82 acellular ligand binding to alphaIIbbeta3 on blood platelets induces a transmembrane conformational c

83 The discoid form of blood platelets is important to their function in hemost

84 nalysis of megakaryocytes, the precursors of blood platelets, is limited by their rarity in vivo, and

85 und that T(-)GR(-) F2 mice displayed similar blood platelet levels as that seen in T(-) mice, indicat

86 taPP is enriched in brain and in circulating blood platelets, little is understood of its physiologic

87 akaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenito

88 As activated blood platelets mediate the primary response to vascular

89 Activated blood platelets mediate the primary response to vascular

90 To produce blood platelets, megakaryocytes elaborate proplatelets,

91 phoresis of the samples of solubilized human blood platelets modified by WR-K and then reduced by tri

92 morrhagic necrosis and a precipitous drop in blood platelets observed at 6 h.

93 Blood platelets play an essential role in ischemic heart

94 Factor (VWF), which mediates coagulation of blood platelets (primary hemostasis) especially when it

95 Our results indicate that blood platelets provide a valuable platform for pan-canc

96 Circulating blood platelets regulate the initial phase of the hemost

97 ch could be observed and quantified in whole blood, platelet-rich and platelet-free plasma and in leu

98 Tumor-educated blood platelets (TEPs) are implicated as central players

99 ed liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomar

100 ors are present in both blood leukocytes and blood platelets, the relative levels of P2X1 receptor ex

101 ession levels of the integrin alpha2beta1 on blood platelets through a mechanism that is probably med

102 Mammalian megakaryocytes release blood platelets through a remarkable process of cytoplas

103 l cells and activation-dependent adhesion of blood platelets through direct interaction with integrin

104 Willebrand factor (VWF) mediates adhesion of blood platelets to fibrillar collagen types I, II, and I

105 Various agonists but also chilling cause blood platelets to increase cytosolic calcium, polymeriz

106 plays a fundamental role in the adhesion of blood platelets to the extracellular matrix.

107 ransplant candidates often leads to multiple blood/platelet transfusions and subsequent development o

108 and FAK proteins in megakaryocytic cells and blood platelets was observed.

109 variation in alpha2beta1 expression by human blood platelets was previously described.

110 Because the major source of Sph1P is from blood platelets, we speculate that Edg-mediated Sph1P ne

111 oxygenase activity levels in umbilical cord blood platelets were higher, whereas biliverdin reductas

112 horylation/dephosphorylation events in human blood platelets were investigated during their adhesion

113 Myocardial ischaemia activates blood platelets, which in turn stimulate cardiac sympath

114 s 1a and 1b induced the aggregation of human blood platelets with a potency similar to type I collage