ライフサイエンスコーパス: blood-borne

1 depending on whether an agonist is tissue or blood borne.

2 d by cells that were neither endothelial nor blood borne.

3 To more directly test whether blood-borne Abeta peptides can cross a defective BBB, we

4 (saline-injected controls) blocked entry of blood-borne Abeta peptides into the brain.

5 sions reached a plateau within 20 min as the blood-borne activity was consumed.

6 inal zone B (MZB) cells, which produce Ab to blood-borne Ag.

7 For blood borne Ags, cells localized in situ in the spleen s

8 the ability of the MZM compartment to clear blood-borne Ags and mount proper T-independent immune re

9 for clearance of and rapid response against blood-borne Ags entering the spleen.

10 Internalization of blood-borne allogeneic exosomes by splenic DCs does not

11 associated with a smaller ability to capture blood-borne amino acids as protein, the results of a dec

12 e investigated the possibility that soluble, blood-borne amyloid beta (Abeta) peptides can cross a de

13 ly identified from adult male, adult female, blood-borne and uterine microfilariae, and infective L3

14 It has been proposed that blood-borne Ang II can influence the RVLM via a neural c

15 barrier and known to be a primary sensor for blood-borne Ang II.

16 in the MZ and RP facilitates their access to blood-borne antigen and enables the rapid initiation of

17 oss of MZ B cells, deficiencies in capturing blood-borne antigen and suppression of circulating IgM.

18 dies have shown that circulating DCs capture blood-borne antigen and transport it into the extra-vasc

19 st that the BM supports crosspresentation of blood-borne antigens similar to the spleen; uniquely, al

20 Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell an

21 supports secondary immune responses against blood-borne antigens, but it is unsettled whether primar

22 t has an important role in responses against blood-borne antigens, lymphocyte migration in the margin

23 of MZ B lymphocytes that respond rapidly to blood-borne antigens.

24 ed to the capture and follicular delivery of blood-borne antigens.

25 at produces T-cell-independent antibodies to blood-borne antigens.

26 d and lymphoid tissue, detect and respond to blood-borne antigens.

27 Blood-borne B cells predominately used CCR7 signaling to

28 Life-long latent EBV persistence occurs in blood-borne B lymphocytes, while EBV intermittently prod

29 We found that Kupffer cells directly capture blood-borne bacteria and subsequently nucleate formation

30 rious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain b

31 To study the host response towards blood-borne bacteria in the absence of the ongoing pulmo

32 In particular, the role played by blood-borne bacteria is controversial.

33 In order to produce meningitis, blood-borne bacteria must interact with and breach the b

34 uring sepsis, one immediate host response to blood-borne bacteria was induction of a refractory perio

35 Approximately 10% of the blood-borne bacteria were found outside of host cells.

36 -/-) animals displayed a 10-fold increase of blood-borne bacteria, C5(-/-) animals exhibited a 400-fo

37 responses, leading to an inability to clear blood-borne bacteria.

38 s play an important role in the clearance of blood-borne bacterial infections via rapid T-independent

39 estis and possibly for those caused by other blood-borne bacterial pathogens.

40 er evaluation of PTX3 as a tissue biopsy and blood-borne biomarker to discriminate BPH from prostate

41 r continuous or instantaneous measurement of blood borne biomarkers without compromising sensitivity.

42 and blood-brain barrier markers) as well as blood borne biomarkers.

43 The identification of blood-borne biomarkers correlating with melanoma patient

44 We discuss putative mechanisms for blood-borne brain rejuvenation and suggest promising ave

45 regulatory mechanism for polyFn assembly on blood-borne breast cancer cells and depict its effect on

46 Blood-borne Brugia malayi microfilariae survived for sig

47 proach has been achieved in the treatment of blood-borne cancers, but the advances with solid tumours

48 uring hematogenously disseminated infection, blood-borne Candida albicans invades the endothelial cel

49 ovel tool that can be utilized for targeting blood borne cells for experimental immunology and drug d

50 e in-depth discussion of human Tfh cells and blood borne cells with similar features and the role of

51 d activation of Fc receptors on infiltrating blood-borne cells and tissue resident cells amplifies an

52 om Tie1-YFP embryos showed that up to 30% of blood-borne cells are Tie1 positive; though cells expres

53 Removing blood-borne cells from analysis by the simple technique

54 logistical limitations on the utilization of blood-borne cells in medical diagnostics and scientific

55 ay discriminate between tissue-localized and blood-borne cells in the mouse lung.

56 is characteristic of fibrocytes, specialized blood-borne cells involved in wound healing and immunity

57 e capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic compartmen

58 ted sites, a process initiated by binding of blood-borne cells to E-selectin displayed at target endo

59 aining to discriminate tissue-localized from blood-borne cells, we find substantial accumulation of C

60 ls are mediated by DC-induced recruitment of blood-borne cells.

61 s from multiple tissues as they phagocytosed blood-borne cellular material.

62 Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovasc

63 re especially selective in determining which blood-borne components gain access to neurons.

64 induces CXCL9 and -10 that support homing of blood-borne CXCR3-expressing NK cells to the liver predo

65 icating that lack of both liver-resident and blood-borne DC ameliorated hepatic warm IR injury.

66 that liver-resident DC and locally recruited blood-borne DC might have distinctive roles in hepatic I

67 differential roles of liver-resident versus blood-borne DC, and points to the importance of the loca

68 By contrast, blood-borne DCs represent a heterogeneous population, th

69 enic cases will be small, the risk of future blood-borne disease transmissions could be entirely elim

70 entify cellular pathways contributing to the blood-borne dissemination of cancer.

71 These data support a role for EMT in the blood-borne dissemination of human breast cancer.

72 l replication in the respiratory system, and blood-borne dissemination to other organ systems.

73 ic regulation of EMT-associated genes during blood-borne dissemination.

74 arget specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to a

75 Blood-borne ecdysis-triggering hormone (ETH) activates t

76 IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with b

77 oduce antibody in response to infection with blood-borne encapsulated pathogens.

78 y are transported to their site of action as blood-borne endocrine hormones but can also be produced

79 Blood-borne endothelial cells originating from adult bon

80 This ubiquitously expressed and blood-borne enzyme is the target autoantigen in the K/Bx

81 Transfer of blood-borne EVs from brain-injured animals was also enou

82 However, recent studies performed with blood-borne EVs have been hindered by the lack of effect

83 tudy, we examined the ability of endogenous, blood-borne exosomes to regulate the immune response.

84 inhibitor of metalloproteinases 2 (TIMP2), a blood-borne factor enriched in human cord plasma, young

85 sduction of some other metabolically derived blood-borne factor rather than glucose per se and that t

86 avioral effects of parabiosis, implicating a blood-borne factor.

87 with wild-type mice, suggesting a relay by a blood-borne factor.

88 However, it is unclear how blood-borne factors dynamically access the islets of Lan

89 decline, and highlight a new model in which blood-borne factors in aged animals act through local ni

90 cently published study in Cell proposes that blood-borne factors in the adult systemic environment ar

91 using heterochronic parabiosis we show that blood-borne factors present in the systemic milieu can i

92 eing can be in part attributed to changes in blood-borne factors.

93 genitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs).

94 The incorporation of blood-borne forms of tissue factor (TF) into a growing b

95 f the two cDC subsets in the presentation of blood-borne HEL.

96 able from animals to humans and an important blood-borne human parasitic infection.

97 A novel blood-borne human pegivirus (HPgV), HPgV-2, was recently

98 e altered in various diseases, the origin of blood-borne IL-6R is still poorly understood.

99 ury, resident immune cells are activated and blood-borne immune cells are recruited to the site of in

100 Hepatitis C virus is a blood-borne infection and the leading cause of chronic l

101 s (HCV) infection is the most common chronic blood-borne infection in the United States and a leading

102 tis C virus (HCV) is the most common chronic blood-borne infection in the United States and will beco

103 s C virus (HCV) infection is the most common blood-borne infection in the United States, with estimat

104 Although efforts to reduce blood-borne infection incidence have had impact, this wo

105 Hepatitis C virus (HCV) is a blood-borne infection readily transmitted by transfusion

106 Hepatitis C virus (HCV) is a blood-borne infection that can lead to progressive liver

107 sis is a systemic inflammatory response to a blood-borne infection that is associated with an extreme

108 rus infection is well-recognized as a common blood-borne infection with global public health impact a

109 Occupational acquisition of blood-borne infections has been reported following expos

110 utrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through

111 s (eg, methadone and buprenorphine) prevents blood-borne infections via reductions in injection in pr

112 Ninety-eight individuals at risk of blood-borne infections were tested for PARV4 IgG.

113 Beyond acute injuries and blood-borne infections, back and neck pain is a poorly r

114 nfection is common in individuals exposed to blood-borne infections, independent of their HCV or HIV

115 ant role in mounting protective responses to blood-borne infections.

116 Because HIV is a blood-borne infectious disease, from the early days of t

117 ss to OTC syringes would potentially prevent blood-borne infectious diseases among IDUs.

118 In animal studies, central and blood borne inflammatory cytokines that can be elevated

119 es engage the complement cascade, recruiting blood-borne inflammatory cells and initiating tissue inf

120 that is independent of either leukocytes or blood-borne inflammatory molecules.

121 we observed no increase in the oxidation of blood-borne lactate in the T1D subjects, as reflected by

122 usively from migratory LCs, but also include blood-borne langerin(+) DCs that transit through the der

123 s in the skin result in their replacement by blood-borne LC progenitors.

124 a collagen matrix in vitro, suggesting that blood-borne leukocyte penetration through the arterial b

125 degrading elastin and collagen and regulates blood-borne leukocyte transmigration and lesion progress

126 Tat protein released from HIV-infected blood-borne leukocytes can contribute to the breakdown o

127 +/- 3 mm(3); n = 10; p < 0.01), implicating blood-borne leukocytes in the damage.

128 In many of these responses, infiltration of blood-borne leukocytes into the kidney is central to the

129 Capture of blood-borne leukocytes onto vascular endothelium proceed

130 Selective recruitment of blood-borne leukocytes to tissues and their proper posit

131 ident cells (e.g., mast cells), migration of blood-borne leukocytes, mirrored by blood neutrophilia.

132 Sphingosine 1-phosphate (S1P) is a blood-borne lipid mediator implicated in the regulation

133 on of lipid species, a process that requires blood-borne lipids to initially traverse the blood vesse

134 Blood borne Listeria monocytogenes enter the CNS via mig

135 Despite the importance of oxidation of blood-borne long-chain fatty acids (Fa) in the cardiomyo

136 s are novel pulmonary vascular addresses for blood-borne, lung-metastatic cancer cells.

137 Blood-borne lymphocyte trafficking to peripheral lymph n

138 Blood-borne lymphocytes home to lymph nodes by interacti

139 EVs) that are chief portals for the entry of blood-borne lymphocytes into lymphoid organs.

140 Sphingosine 1-phosphate (S1P) is a blood-borne lysosphingolipid that acts to promote endoth

141 helial junctions in steady-state and capture blood-borne macromolecules.

142 Phagocytosis activity of blood-borne macrophages decreased with age at 18 months

143 Human blood-borne macrophages repopulated the meninges and per

144 hat ART carriage could be facilitated within blood-borne macrophages traveling across the blood-brain

145 Thymic lymphopoiesis depends on blood-borne, marrow-derived progenitors, but characteriz

146 Here we show that splenic or, unexpectedly, blood-borne MDSC execute far-reaching immune suppression

147 obilised from the bone marrow in response to blood-borne mediators and subsequently recruited to the

148 synchronously throughout the lung, caused by blood-borne mediators of inflammation, voluminous aspira

149 Blood-borne metastasis accounts for the vast majority of

150 ferentially promote single cell motility and blood-borne metastasis and therefore activation of this

151 d up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal cancer model.

152 act mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understoo

153 ritical to the processes of inflammation and blood-borne metastasis, respectively.

154 ls, mediating a cytoprotective effect during blood-borne metastasis.

155 ls are capable of being activated in situ by blood-borne microbes in a T-independent manner to genera

156 ve essential roles as primary defenders from blood-borne microbes.

157 r filarial infection status as determined by blood-borne microfilariae and filarial antigenemia.

158 constitute the first line of defense against blood-borne microorganisms, viruses and toxins in the sp

159 To determine the source and role of blood-borne microparticle TF, we studied arterial thromb

160 mph node (MLN) and continuing recruitment of blood-borne migrants into the lung airways during antige

161 is: raw data of 1539 microarrays and 705 NGS blood-borne miRNomes were statistically evaluated, sugge

162 Delivery of blood-borne molecules and nanoparticles from the vascula

163 tricting entry of circulating leukocytes and blood-borne molecules into the CNS.

164 the ventricular side allows the diffusion of blood-borne molecules into the parenchyma of the ME whil

165 Blood-borne molecules must therefore be able to circumve

166 e signals responsible for differentiation of blood-borne monocytes into tissue macrophages are incomp

167 FBGC derive from blood-borne monocytes that enter the implantation site a

168 assumed that they have a high turnover from blood-borne monocytes.

169 that EBV latently infects a unique subset of blood-borne mononuclear cells that are direct precursors

170 laque macrophages are thought to derive from blood-borne myeloid cells.

171 e that SAP inhibits the differentiation of a blood-borne, myeloid cell population into fibroblasts by

172 Blood-borne neurohormonal signals reflect the intermitte

173 To reach sites of inflammation, a blood-borne neutrophil first rolls over the vessel wall,

174 Blood-borne neutrophils are excluded from entering lymph

175 ow that HEVs are the major route of entry of blood-borne neutrophils into TDLNs through interactions

176 f hIL-37tg mice, along with lower numbers of blood-borne neutrophils, macrophages, and activated micr

177 throughout the lung, mediated by inhaled or blood-borne noxious agents.

178 ffinity, interpreted as the likelihood for a blood-borne NP to firmly adhere to the vessel walls, is

179 e and the specific, vascular accumulation of blood-borne NPs.

180 mains unclear, they are likely released from blood borne or distant cells.

181 ood but also as the major lymphoid organ for blood-borne or systemic infections.

182 To invade the deep tissues, blood-borne organisms must cross the endothelial cell li

183 The blood-borne origin of these cells was confirmed in exper

184 gen atmosphere, raising the possibility that blood-borne oxygen itself might induce astrocyte differe

185 rne and other pathogenic bacteria, and other blood-borne parasites.

186 Margination occurs when blood borne particles attach to the vessel wall.

187 bridging channels promotes DC encounter with blood-borne particulate antigen.

188 in facilitating capture and presentation of blood-borne particulate antigens.

189 no evidence of myocardial regeneration from blood-borne partner-derived cells.

190 tutes an interesting approach to investigate blood-borne pathogen diversity in wild vertebrates and c

191 nfected fibrin clot-and show that the common blood-borne pathogen Staphylococcus epidermidis influenc

192 Hepatitis B virus (HBV) is an important blood-borne pathogen that causes hepatic inflammation an

193 Hepatitis C virus (HCV) is a common blood-borne pathogen that relies heavily on nucleic acid

194 operations (142/373) were found to involve a blood-borne pathogen when tested: HIV (26%), hepatitis B

195 rne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question abou

196 the priming of splenic T-cell responses to a blood-borne pathogen.

197 ercent of men tested positive for at least 1 blood-borne pathogen.

198 timal timing of live donor testing for these blood borne pathogens has not been determined.

199 say for the multiplexed identification of 20 blood-borne pathogens (Staphylococcus epidermidis, Staph

200 leen is an important site for the capture of blood-borne pathogens and a gateway for lymphocytes ente

201 een play an important role in the capture of blood-borne pathogens and are viewed as an essential com

202 using severe malaria syndromes as well other blood-borne pathogens and blood-related diseases.

203 an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance.

204 idly generate Ag-specific IgM in response to blood-borne pathogens and play an important role in the

205 ism and the phagocytosis of erythrocytes and blood-borne pathogens are significantly reduced prior to

206 ining the risk of iatrogenic transmission of blood-borne pathogens by less invasive routes, such as s

207 The spread of blood-borne pathogens by mosquitoes relies on their taki

208 Meningitis occurs when blood-borne pathogens cross the blood-brain barrier (BBB

209 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatenin

210 es have hampered the identification of novel blood-borne pathogens in these animals.

211 While the incidence of these blood-borne pathogens is increasing in the general popul

212 y, 380 000-400 000 occupational exposures to blood-borne pathogens occur annually in the United State

213 ings, risks of occupational infection with 3 blood-borne pathogens remain in the health care workplac

214 number of recipients becoming infected with blood-borne pathogens such as HIV and hepatitis C.

215 Testing for blood-borne pathogens was performed in 53% (N = 373) of

216 ify, in a multiplexed fashion, a panel of 20 blood-borne pathogens with high sensitivity and specific

217 require the rapid and accurate detection of blood-borne pathogens, including human immunodeficiency

218 nsidered to be important for TI responses to blood-borne pathogens, MZ B cells were not responsible f

219 erences in transmission of the 3 most common blood-borne pathogens, the natural history of early HCV

220 re part of the first line of defense against blood-borne pathogens, their increase following a breach

221 independent humoral immune responses against blood-borne pathogens.

222 ons requiring rapid and reliable testing for blood-borne pathogens.

223 sk for allergic reactions and infection with blood-borne pathogens.

224 ific procedure days were offered testing for blood-borne pathogens.

225 hus restricting their capacity to respond to blood-borne pathogens.

226 role of the complement system in response to blood-borne pathogens.

227 ) (P < 0.01) were most often associated with blood-borne pathogens.

228 ted and implemented to protect surgeons from blood-borne pathogens.

229 B cells, providing early immune responses to blood-borne pathogens.

230 It functions as a chemosensor for blood-borne peptides and solutes, and converts this info

231 the basal lamina, which are then engulfed by blood-borne phagocytes.

232 caused by Borrelia spirochetes with distinct blood-borne phases of infection.

233 nts, including hemoglobin and bilirubin, are blood-borne photoreceptors, regulating gasotransmitters

234 ic technique for assessing relative rates of blood-borne precursor recruitment, we examined Mphi and

235 ietic stem cells (HSCs), nor which potential blood borne precursors lead to the formation of histiocy

236 - to 14-day period and were replenished from blood-borne precursors at a rate of nearly 4,300 cells p

237 n important input for the risk assessment of blood-borne prion disease transmission and for refining

238 n important input for the risk assessment of blood-borne prion disease transmission and for refining

239 Observations that show the efficacy of blood-borne prion transmission is more dependent on the

240 c, and radioablated mice to demonstrate that blood-borne prothymocytes are imported in a gated and co

241 in the blood and that tissue damage exposes blood-borne Pvf1 to Pvr receptors on wound-edge epiderma

242 In addition, the blood-borne RNA molecules were correlated with SLE disea

243 NA inputs, we are able to detect three major blood-borne RNA viruses - HIV, HCV and HEV.

244 nation with previous efforts to characterize blood-borne RNA viruses in wild primates across sub-Saha

245 e central nervous system (CNS) by a strictly blood-borne route.

246 The spleen and C3 provide resistance against blood-borne S. pneumoniae infection.

247 a genome-based investigation of a recurrent blood-borne Salmonella enterica serotype Enteritidis (S.

248 us, we proposed that RIIb of LSEC eliminates blood-borne SIC, thereby controlling immune complex-medi

249 Testing the capacity of liver RIIb to clear blood-borne SIC, we infused mice intravenously with radi

250 sponse to SHU9119, or alternatively, whether blood-borne signals that emerge only after an extended p

251 By contrast, we show here that blood-borne Sindbis viral vectors systemically and speci

252 racellular and transcellular barrier to many blood-borne solutes via tight junctions (TJs) and scarce

253 were found among week-to-week assessments of blood-borne SPC HIF factors.

254 c regression demonstrated that the number of blood-borne SPCs and the cellular content of HIFs at stu

255 These results demonstrate that blood-borne spirochetes activate MZB cells to produce pa

256 The blood-borne ST6Gal-1 produced and secreted by the liver

257 ng-disk intravital microscopy to monitor the blood-borne stage in a murine bacteremic model of P. aer

258 pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivat

259 2003, and first detected a case of probable blood-borne subclinical vCJD in July, 2004.

260 The restricted or regulated entry of most blood-borne substances into the brain has been recognise

261 es, such as the brain that is impermeable to blood-borne substances.

262 othesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be enginee

263 Thus, the blood-borne T cell pool serves to maintain the homeostas

264 3 components of the thrombi: circulating or blood-borne TF (cTF), fibrin, and platelets.

265 Although blood-borne TF accumulates into the developing thrombus

266 y be the optimal location for it to abrogate blood-borne TF activity that incorporates within the blo

267 ring thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation

268 This demonstrates that blood-borne TF associated with hematopoietic cell-derive

269 owing thrombi, such as platelet factor XI or blood-borne TF, appears essential for rapid thrombus gro

270 Blood-borne therapeutics, which rely on diffusion and co

271 subset that represented approximately 15% of blood-borne Tmem cells.

272 at the blood-brain barrier prevents unwanted blood-borne toxins and signalling molecules from enterin

273 AIV H5N1 infection may increase the risk of blood-borne transmission between humans.

274 e of early events of HTLV-1 spread following blood-borne transmission of the virus in vivo hinders a

275 on pathway, but not in Bartonella, which use blood-borne transmission pathways.

276 is not, by itself, sufficient to remove all blood-borne TSE infectivity.

277 The UK announced its first case of probable blood-borne vCJD transmission in December, 2003, and fir

278 merged as a relevant model for assessing the blood-borne vCJD transmission risk.

279 iors that increase the risk of transmissible blood-borne viral (BBV) infection, but the impact of thi

280 om seronegative donors at increased risk for blood-borne viral infection (DIRVI).

281 tis C virus (HCV) is the world's most common blood-borne viral infection for which there is no vaccin

282 meta-analysis to estimate the prevalence of blood-borne viral infection in people with serious menta

283 nlikely to be a sole risk factor and risk of blood-borne viral infection is probably multifactorial a

284 The prevalences of blood-borne viral infections in people with serious ment

285 al illnesses have a high risk of contracting blood-borne viral infections, sexual health has largely

286 e with serious mental illness are at risk of blood-borne viral infections.

287 cause of disease burden and a contributor to blood-borne virus transmission.

288 opulation in regions with high prevalence of blood-borne viruses (Africa for HIV and southeast Asia f

289 The elevated risk of blood-borne viruses (BBVs) in people with severe mental

290 outinely discuss sexual health and risks for blood-borne viruses (including risks related to drug mis

291 c or molecular markers for various unrelated blood-borne viruses (n = 6) and sera obtained from healt

292 Blood-borne viruses detected through large-scale routine

293 iency virus (SIV) (family Retroviridae), the blood-borne viruses harbored by these animals in the wil

294 for detection and identification of multiple blood-borne viruses that infect millions of people world

295 population in places with low prevalence of blood-borne viruses, such as the USA and Europe, and on

296 ut nucleic acid amplification test (NAT) for blood-borne viruses, suitable for use in the screening o

297 role in the surveillance and diagnostics of blood-borne viruses.

298 rategy could help reduce the transmission of blood-borne viruses.

299 ial interest for assessment of the impact of blood-borne viruses.

300 latory factor (IRF) as a model, we show that blood-borne ZIKV administration can lead to pronounced e