ライフサイエンスコーパス: blood-retinal barrier

1 schemia, neovascularization, and incompetent blood-retinal barrier).

2 ke by glucose in the cells that comprise the blood-retinal barrier.

3 pate in the induction and maintenance of the blood-retinal barrier.

4 rotein activity in cells that form the outer blood-retinal barrier.

5 disorder associated with dysfunction of the blood-retinal barrier.

6 cyte function at sites of a breakdown in the blood-retinal barrier.

7 It can pass the blood-brain barrier and blood-retinal barrier.

8 h OIR, suggesting a protective effect on the blood-retinal barrier.

9 optosis, thereby preserving the integrity of blood-retinal barriers.

10 lly significant increase in breakdown of the blood-retinal barrier (AGE Alb versus Alb, 8.2 vs. 1.6 n

11 n identified as an important mediator of the blood-retinal barrier alteration in diabetic retinopathy

12 localized breakdown in the integrity of the blood-retinal barrier and aberrations in the organizatio

13 Breakdown of the blood-retinal barrier and leakage from the retinal vascu

14 role for Mvarphi-derived CD in altering the blood-retinal barrier and reveal a potential therapeutic

15 , which are a crucial component of the outer blood-retinal barrier and the damage is related to retin

16 suggests that there may be breakdown of the blood-retinal barrier and tight junction integrity in a

17 patial buffering of ions, maintenance of the blood-retinal barrier, and response to injury.

18 by ischemia, neovascularization, incompetent blood-retinal barrier, and vascular occlusion.

19 )], pericytes (anti-neural/glial antigen 2), blood-retinal barrier [anti-zonula occludens protein 1 (

20 ve acquired the ability to break through the blood-retinal barrier are thought to be causally involve

21 ecome more important during breakdown of the blood-retinal barrier, as seen after TNF-alpha treatment

22 not bind IGF-1 (IGFBP-3NB), to regulate the blood retinal barrier (BRB) using two distinct experimen

23 We hypothesized that Edn2 damages the blood-retinal barrier (BRB) and that this is mediated by

24 Diabetic retinopathy is characterized by blood-retinal barrier (BRB) breakdown and neurotoxicity.

25 Blood-retinal barrier (BRB) breakdown and related vascul

26 kostasis) within the retinal vasculature and blood-retinal barrier (BRB) breakdown and to determine w

27 previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice.

28 Blood-retinal barrier (BRB) breakdown is a hallmark of d

29 ial growth factor (VEGF) protein levels, and blood-retinal barrier (BRB) breakdown of the animals wer

30 role of reactive oxygen species (ROS) in the blood-retinal barrier (BRB) breakdown that characterizes

31 Blood-retinal barrier (BRB) breakdown was quantified usi

32 The blood-retinal barrier (BRB) consists of tightly intercon

33 sophosphatidylcholine (LPC), are involved in blood-retinal barrier (BRB) damage during diabetic retin

34 Here, by studying functional blood-retinal barrier (BRB) formation in mice, we found

35 lop and characterize a quantitative assay of blood-retinal barrier (BRB) function in mice and to dete

36 Blood-retinal barrier (BRB) function was assayed by dete

37 p54/PSF heterodimer may contribute to normal blood-retinal barrier (BRB) induction in vivo.

38 studies, functional MRI was used to measure blood-retinal barrier (BRB) integrity after Gd-DTPA inje

39 In a subgroup of male SD rats, blood-retinal barrier (BRB) integrity was also assessed

40 In vertebrates, a blood-retinal barrier (BRB) is established by tight junc

41 Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in

42 cular endothelial cells comprising the inner blood-retinal barrier (BRB) is mediated by the GLUT1 glu

43 scular permeability due to alteration of the blood-retinal barrier (BRB) is one of the major complica

44 In vivo, blood-retinal barrier (BRB) leakage was studied using th

45 block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies.

46 These data suggest differences in the blood-retinal barrier (BRB) of mice and rabbits and indi

47 Blood-retinal barrier (BRB) permeability in uninfected d

48 f this study was to determine to what extent blood-retinal barrier (BRB) permeability occurred during

49 Blood-retinal barrier (BRB) permeability surface area pr

50 Its absence has been related to blood-retinal barrier (BRB) permeability through delocal

51 Loss of blood-retinal barrier (BRB) properties induced by vascul

52 Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retin

53 trophin Dp71 gene induces a highly permeable blood-retinal barrier (BRB).

54 is important to measure the integrity of the blood-retinal barrier (BRB).

55 esion molecule (ICAM)-1 and breakdown of the blood-retinal barrier (BRB).

56 ntry into the endothelial cells of the inner blood-retinal barrier (BRB).

57 Blood-retinal barrier [BRB] breakdown, characteristic of

58 ffected by hyperglycemia simultaneously with blood retinal barrier breakdown, suggesting that glial a

59 ular endothelial cell injury, apoptosis, and blood-retinal barrier breakdown (P<0.0001) but did not d

60 adhesion molecule-1 (ICAM-1) and results in blood-retinal barrier breakdown and capillary nonperfusi

61 receptor apoptosis, vascular telangiectasis, blood-retinal barrier breakdown and, later, intraretinal

62 IF-1alpha and VEGF increases and the related blood-retinal barrier breakdown are suppressed by inhibi

63 oteinases (MMPs) as a potential cause of the blood-retinal barrier breakdown at the onset of angiogen

64 drops significantly reduced leukostasis and blood-retinal barrier breakdown in a dose-dependent mann

65 Blood-retinal barrier breakdown in diabetic animals trea

66 dothelial cell apoptosis as a major cause of blood-retinal barrier breakdown in early diabetes.

67 Early blood-retinal barrier breakdown in experimental diabetes

68 role in the pathogenesis of blood-brain and blood-retinal barrier breakdown in vivo.

69 Blood-retinal barrier breakdown is markedly increased wi

70 ry cytokines that initiate neuronal loss and blood-retinal barrier breakdown seen in diabetic retinop

71 y produces a transient worsening of diabetic blood-retinal barrier breakdown via an HIF-1alpha-mediat

72 Blood-retinal barrier breakdown was assessed using (3)H-

73 Diabetes-induced blood-retinal barrier breakdown was dose-dependently inh

74 Blood-retinal barrier breakdown was induced in rats with

75 Spatially, early blood-retinal barrier breakdown was localized to the ret

76 Blood-retinal barrier breakdown was quantified using the

77 circulation with an anti-platelet antibody, blood-retinal barrier breakdown worsened in the diabetic

78 rrent study, diabetic vascular permeability (blood-retinal barrier breakdown) is demonstrated to resu

79 elial growth factor (VEGF) triggers diabetic blood-retinal barrier breakdown, and (2) identify the si

80 n apoptosis, oxidative stress, inflammation, blood-retinal barrier breakdown, and neuroprotection.

81 iabetic retinal vasculature results in early blood-retinal barrier breakdown, capillary nonperfusion,

82 the diabetic retinal vasculature results in blood-retinal barrier breakdown, capillary nonperfusion,

83 adhesion molecule-1 levels, leukostasis, and blood-retinal barrier breakdown, in a relevant animal mo

84 sening of diabetic retinopathy, specifically blood-retinal barrier breakdown, that follows the instit

85 ocyte adhesion, endothelial cell injury, and blood-retinal barrier breakdown.

86 yte adhesion and endothelial cell injury and blood-retinal barrier breakdown.

87 ch reduced leukocyte adhesion and suppressed blood-retinal barrier breakdown.

88 the isotope-dilution method for quantitating blood-retinal barrier breakdown.

89 approach in the treatment of early diabetic blood-retinal barrier breakdown.

90 as the isotope-dilution method for measuring blood-retinal barrier breakdown.

91 model by determining retinal leukostasis and blood-retinal barrier breakdown.

92 titating vascular leakage and especially the blood-retinal barrier breakdown.

93 cell death and serves, in part, to suppress blood-retinal barrier breakdown.

94 appaB DNA-binding activity, leukostasis, and blood-retinal barrier breakdown.

95 urs, endothelial cell injury ensues, as does blood-retinal barrier breakdown.

96 xtracted and assayed for leukocyte adhesion; blood-retinal barrier breakdown; VEGF, TNF-alpha, IL-1be

97 etinopathy increases the permeability of the blood-retinal barrier, but the specific vessels that bec

98 TGF-beta may contribute to breakdown of the blood-retinal barrier by stimulating endothelial cell MM

99 racteristics of tight junctions in the outer blood-retinal barrier change during embryonic developmen

100 Macular oedema typically results from blood-retinal barrier disruption.

101 ontributing to the pathologic progression of blood-retinal barrier dysfunction.

102 agenase-like activity that may contribute to blood-retinal barrier dysfunction.

103 ssion of pathologic retinal angiogenesis and blood-retinal barrier dysfunction.

104 ivo was demonstrated that was accompanied by blood-retinal barrier dysfunction.

105 diabetic retinopathy and macular edema, the blood-retinal barrier fails to function properly, and th

106 Impaired blood-retinal barrier function leads to macular edema th

107 erentially contribute to the inner vs. outer blood-retinal barrier function.

108 ivo Fluorescein angiography indicated normal blood-retinal barrier function.

109 enhanced apoptotic cell death, and impaired blood-retinal barrier function.

110 in the cells comprising the inner and outer blood-retinal barriers: human retinal pigment epithelial

111 port for fluids and solutes across the inner blood-retinal barrier (iBRB).

112 lity with implications for alteration of the blood-retinal barrier in diabetic retinopathy.

113 ricyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy.

114 l pigmented epithelium (RPE) forms the outer blood-retinal barrier in the eye and its polarity is res

115 derangements observed in the diabetic inner blood-retinal barrier in vivo.

116 retinal thickness, intraocular pressure, and blood retinal barrier integrity.

117 l layer thickness, intraocular pressure, and blood retinal barrier integrity.

118 Alteration of the blood-retinal barrier is the hallmark of this disease, c

119 helium (RPE), which helps maintain the outer blood-retinal barrier, is a local source for ET-1 and wh

120 cations of diabetes is the alteration of the blood-retinal barrier, leading to retinal edema and cons

121 A may have a protective effect against outer blood-retinal barrier leakage associated with diabetic r

122 tein, the vitreous-plasma protein ratio, and blood-retinal barrier leakage by 3-, 1.7-, 3.1-, and 2.7

123 nd retinal PGE2 secretion, VEGF protein, and blood-retinal barrier leakage were estimated.

124 abetes-induced elevations in PGE2, VEGF, and blood-retinal barrier leakage.

125 , but transporters for DHA uptake across the blood-retinal barrier or retinal pigment epithelium have

126 ansport, phagocytosis and formation of outer blood-retinal barrier, or possible involvement of JN exp

127 Choroidal contribution or blood-retinal barrier permeability surface area product

128 hese results suggest that astrocytes enhance blood-retinal barrier properties, at least in part by in

129 rowth factor (VEGF)-induced breakdown of the blood-retinal barrier requires protein kinase C (PKC)bet

130 in ICAM-1, leukostasis, and breakdown of the blood-retinal barrier, suggesting that NOX2 is primarily

131 igmented epithelial (RPE) cells maintain the blood-retinal barrier, sustain retinal photoreceptor cel

132 d Fpn is expressed in cells constituting the blood-retinal barrier, the authors tested whether the re

133 lay important roles in the alteration of the blood-retinal barrier through proteolytic degradation of

134 There is no evidence of a blood-ocular or blood-retinal barrier to activated T cell blasts.

135 protein [anti-GFAP]) and to investigate the blood-retinal barrier using the tight junction markers z

136 onditions in the subretinal space, the outer blood-retinal barrier was disrupted by compromising reti

137 udy, the potential side effects on the outer blood-retinal barrier were examined.

138 esis during development and formation of the blood-retinal barrier, which is linked to significant do