ライフサイエンスコーパス: bloodstream

1 and its individual domains circulate in the bloodstream.

2 ocytes, the sexual stages circulating in the bloodstream.

3 he bone marrow and their mobilization to the bloodstream.

4 s with undetectable levels of virus in their bloodstream.

5 NA): DNA released from cancer cells into the bloodstream.

6 ed by the recruitment of leukocytes from the bloodstream.

7 between the insect midgut and the mammalian bloodstream.

8 tly affect bacterial growth in the brain and bloodstream.

9 question about how the virus gets into human bloodstream.

10 tially other cancers that spread through the bloodstream.

11 ons due to relatively lower clearance to the bloodstream.

12 rapeutic window and limited passage into the bloodstream.

13 sm for increasing glucose clearance from the bloodstream.

14 a central role in clearing bacteria from the bloodstream.

15 ls about how the malaria parasite enters the bloodstream.

16 intestinal barrier, and enter the lymph and bloodstream.

17 t the nonspecific interactions of TAT in the bloodstream.

18 of thousands of invasive merozoites into the bloodstream.

19 helps maintain neutrophil quiescence in the bloodstream.

20 ly mature while circulating in the embryonic bloodstream.

21 ed in a decreased circulation of EBOV in the bloodstream.

22 lly increased bacterial dissemination to the bloodstream.

23 nal lumen, from the BC which represented the bloodstream.

24 arrier cells that directly contact the fetal bloodstream.

25 olytic digestion and fast clearance from the bloodstream.

26 uring ART may not be readily apparent in the bloodstream.

27 transporters of dietary fats throughout the bloodstream.

28 uine, and mature gametocytes reappear in the bloodstream 10 days after the initial appearance of game

29 In the bloodstream, a small percentage of pneumococci appeared

30 Bloodstream African trypanosomes produce membranous nano

31 d from microcapsules were then absorbed into bloodstream and accumulated in liver.

32 cus aureus enterotoxin A rapidly entered the bloodstream and induced T cells to orchestrate systemic

33 some was thought to primarily develop in the bloodstream and interstitial spaces of its mammalian hos

34 duced fructose transport into the peripheral bloodstream and liver, as well as the severity of advers

35 nously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into t

36 ctor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt

37 e thymocytes leaving the thymus to enter the bloodstream and the trafficking of T cells through lymph

38 a variety of pathogens in gastrointestinal, bloodstream, and respiratory infections may be used.

39 ogen, the third most abundant protein in the bloodstream, and yet avidly bind immobile fibrinogen on

40 d against sexual stage proteins in the human bloodstream are taken up with the blood meal of the mosq

41 R2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD.

42 of mercury that is absorbed and reaches the bloodstream (bioavailability).

43 associated with persistent infections of the bloodstream, bones, and prosthetic devices.

44 leaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling.

45 ls (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well

46 transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks

47 val of circulating tumor cells (CTCs) in the bloodstream by conferring resistance to the shear stress

48 ulating tumor cells (CTCs) are shed into the bloodstream by invasive cancers, but the difficulty inhe

49 at beta-carotene is transported in the adult bloodstream by lipoproteins and that the placenta acquir

50 The presence of varying levels of cTx in the bloodstream can hence be indicative of abnormal bone met

51 (NETs) can secrete bioactive amines into the bloodstream, causing carcinoid syndrome, with symptoms i

52 cated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and dea

53 T. brucei cycles between its mammalian host (bloodstream cell), in which it scavenges cholesterol, an

54 th an earlier spread of pneumococci into the bloodstream, compared with wild-type mice.

55 ry tract infections; others were treated for bloodstream, complicated intraabdominal infections, or c

56 onversely, 53% of extensively drug-resistant bloodstream CRGNIs at 2 of these hospitals met colistin

57 s believed topical corticosteroids pass into bloodstream, damage the skin and affect future health.

58 set, from airway exposure, colonization, and bloodstream dissemination.

59 ing for <10 days was associated with Candida bloodstream dissemination.

60 d the dissemination of both organisms to the bloodstream during coinfection.

61 acterial proteases, possibly released in the bloodstream during infection, in inducing blood coagulat

62 rane space of mitochondria and released into bloodstream during pathological conditions.

63 hematopoietic JAM-A facilitates reovirus T1L bloodstream entry and egress.

64 persistence of lethal secreted toxins in the bloodstream, even after antibiotic treatment.

65 ls of CD20 than the cells circulating in the bloodstream for a longer time (CXCR4(bright)CD5(dim) cel

66 in (RBP) is the sole specific carrier in the bloodstream for hydrophobic retinol, the main form in wh

67 the mammal it resides extracellularly in its bloodstream form (BF) and is densely covered with highly

68 rRNA by Psi-seq in procyclic form (PCF) and bloodstream form (BSF) trypanosomes.

69 d screen numerous conditional null T. brucei bloodstream form cell lines that express randomly mutage

70 The bloodstream form of T. brucei excretes significant amoun

71 The bloodstream form of the human pathogen Trypanosoma bruce

72 h, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite.

73 nversion of pyruvate to CO2 in the T. brucei bloodstream form provides new support for the presence o

74 onised populations of both the procyclic and bloodstream form stages of Trypanosoma brucei that yield

75 on of functional levels of VSG expression in bloodstream form T. brucei.

76 wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antif

77 kinome-wide RNAi screen with 176 individual bloodstream form Trypanosoma brucei lines identified PKs

78 itochondrial integrity in both procyclic and bloodstream form trypanosomes, decreased ATP production

79 Depletion of PNT1 by RNAi in the T. brucei bloodstream form was lethal both in in vitro culture and

80 perform genome-scale RNAi library screens in bloodstream-form African trypanosomes, a family of paras

81 product ultimately required for viability in bloodstream-form trypanosomes.

82 tome, and thus are programmed to translate a bloodstream-form type proteome upon entry into the mamma

83 Metacyclics have a largely bloodstream-form type transcriptome, and thus are progra

84 Metabolic differences between insect and bloodstream forms of T. brucei were also investigated.

85 Bloodstream forms unable to produce inositol pyrophospha

86 ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included pu

87 monstrates that this process is essential in bloodstream forms, is mediated by a specialized isoform

88 acyclics with features of both procyclic and bloodstream forms, suggesting that this intermediate-typ

89 richment and analysis of rare cells from the bloodstream have allowed for detection and characterizat

90 ailure to recirculate from the tissue to the bloodstream have sustained this idea.

91 eutrophils are functionally quiescent in the bloodstream, have a short lifespan, and exit the circula

92 ovides cues for neutrophil egress out of the bloodstream in a manner dependent upon its unique cellul

93 glucose level by secreting insulin into the bloodstream in a pulsatile manner.

94 nse, escape the lung, and persist within the bloodstream in order to reach and invade the brain.

95 e neutrophil subset that is recruited to the bloodstream in response to acute inflammation.

96 helial cells in directing monocyte egress to bloodstream in response to infections.

97 More SPCs entered the bloodstream in the first 2 weeks of care in patients who

98 ccur in the extracellular environment of the bloodstream independently of the B-cell secretory pathwa

99 P < .001) and more frequently manifested as bloodstream infection (31% vs 6%; P = .002).

100 , 0.29 [95% CI, 0.10-0.82]; P = .02) and new bloodstream infection (ARR, 0.05 [95% CI, 0.00-0.09]; RR

101 s for vancomycin-resistant enterococci (VRE) bloodstream infection (BSI) are limited.

102 We examined P. aeruginosa bloodstream infection (BSI) isolates for the ability to

103 Bloodstream infection (BSI) to due vancomycin-resistant

104 nt Staphylococcus aureus (MRSA) carriage and bloodstream infection (BSI), which shows a male predomin

105 vancomycin dosing on patient outcome in MRSA bloodstream infection (BSI); (2) defining, testing, and

106 We describe central line-associated bloodstream infection (CLABSI) pathogens and antimicrobi

107 linically diagnosed sepsis, catheter-related bloodstream infection (CRBSI), and all-cause mortality.

108 Frequency of enterococcal bloodstream infection (E-BSI) is increasing, and the num

109 he primary endpoint in patients with E. coli bloodstream infection (hazard ratio, 0.78; 95% CI, 0.40-

110 The development of bloodstream infection (OR: 18.76; 95% CI: 1.04-339.37; p

111 ent conditions increased risk of PVC-related bloodstream infection (PVCR-BSI).

112 theters (hazard ratio [HR] for time to first bloodstream infection 0.71, 95% CI 0.37-1.34).

113 Intensive care unit cost per bloodstream infection accounted for the largest share of

114 We report long-term trends in bloodstream infection and antimicrobial resistance from

115 To compare catheter-related bloodstream infection and colonization risk between the

116 al of 314 propensity score-matched S. aureus bloodstream infection and in 268 E. coli bloodstream inf

117 ally invades normally sterile sites to cause bloodstream infection and meningitis.

118 rization was associated with a lower risk of bloodstream infection and symptomatic thrombosis and a h

119 The primary outcome was time to first bloodstream infection between 48 h after randomisation a

120 neutropenia, likely bacterial infection, and bloodstream infection by >/=70%.

121 S. aureus bloodstream infection cases and controls were equally ma

122 in severe sepsis/septic shock, patients with bloodstream infection could be discriminated by a decrea

123 ut bloodstream infection or catheter-related bloodstream infection during the ICU stay.

124 In two patients, an attenuated toxicity bloodstream infection evolved from an asymptomatically c

125 Current evidence on catheter-related bloodstream infection femoral risk, compared with the ot

126 ica is a leading cause of community-acquired bloodstream infection in Africa.

127 cin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients.

128 me sequencing of E. faecalis associated with bloodstream infection in the UK and Ireland over more th

129 Bacterial bloodstream infection is a common cause of morbidity and

130 Bacteremia or bloodstream infection is a frequent and costly complicat

131 Staphylococcus aureus bloodstream infection is associated with considerable mo

132 sion, these data suggest that S. epidermidis bloodstream infection is cleared in a highly efficient m

133 Bloodstream infection occurred in 18 (4%) of those in th

134 her catheter-related clinical sepsis without bloodstream infection or catheter-related bloodstream in

135 gdom identified 342 patients with E. faecium bloodstream infection over 7 years.

136 regression to examine trends in icidence of bloodstream infection over time.

137 eus bloodstream infection and in 268 E. coli bloodstream infection patients, respectively (1:1 match

138 Rates of bloodstream infection per 1,000 bed-days were estimated

139 Central catheter-associated bloodstream infection prevention bundle that included da

140 Incident bloodstream infection rate was 9.6 and 8.4 per 1000 hosp

141 d and Wales demonstrates a steady decline in bloodstream infection rates over time.

142 ty of America definition of catheter-related bloodstream infection remains the most precise definitio

143 racteristics were excluded, catheter-related bloodstream infection risk was comparable between the si

144 Catheter-related bloodstream infection risk was comparable for internal j

145 an may, similarly, decrease catheter-related bloodstream infection risk, when compared with femoral.

146 ssue infection, urinary tract infection, and bloodstream infection varied among the 3 sites.

147 The total hospital cost per bloodstream infection was lower in the intervention grou

148 Low-dose acetylsalicylic acid at the time of bloodstream infection was strongly associated with a red

149 Here we show that during a bloodstream infection with methicillin-resistant Staphyl

150 Bacteremia (bacterial bloodstream infection) is a major cause of illness and d

151 We tested 616 bloodstream infection, 185 pneumonia, and 110 sterile fl

152 remain the leading cause of catheter-related bloodstream infection, although an increase in Gram-nega

153 rtile range, 9-36 days), 61% of patients had bloodstream infection, and 59% died.

154 ssociated pneumonia, central line-associated bloodstream infection, and catheter-associated urinary t

155 total hospital costs decreased by $2,439 per bloodstream infection, for an approximate annual cost sa

156 ma; any ICU-acquired infection; ICU-acquired bloodstream infection, pneumonia, and urinary tract infe

157 2013 and June 2014 with suspected or proven bloodstream infection, pneumonia, or sterile fluid and t

158 omes (ICU mortality, central line-associated bloodstream infection, ventilator-associated pneumonia,

159 lis is a natural heme auxotroph and cause of bloodstream infection, we explored whether restoration o

160 s activating protease in the pathogenesis of bloodstream infection, which indicates a greater complex

161 uitable treatment in patients with S. aureus bloodstream infection.

162 mia, but TLR2(-/-)mice could still resolve a bloodstream infection.

163 83 for intra-abdominal infection and 45 for bloodstream infection.

164 llowing: pocket infection; endocarditis; and bloodstream infection.

165 estinal malignancy, yet are also isolated in bloodstream infection.

166 rt-term mortality in patients with S. aureus bloodstream infection.

167 isional surgical site infection, and primary bloodstream infection.

168 aureus (MRSA) is a frequent cause of lethal bloodstream infection; however, vaccines and antibody th

169 site infections, and 2 versus 0 for primary bloodstream infection; the effect was consistent across

170 Candida bloodstream infections (BSI) are associated with signifi

171 illin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) are classified epidemiologi

172 organism identification improves outcomes in bloodstream infections (BSI) but have not controlled for

173 ndida and multidrug-resistant (MDR) bacteria bloodstream infections (BSIs) and their crude death rate

174 in hospital-onset (HO) Staphylococcus aureus bloodstream infections (BSIs) and used whole-genome sequ

175 nation therapy on mortality of patients with bloodstream infections (BSIs) due to CPE.

176 ta-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum b

177 Yet, its impact on MRSA bloodstream infections (BSIs) has not been well studied.

178 We investigated Bcc bloodstream infections (BSIs) in a cohort of non-CF pati

179 the treatment of gram-negative bacilli (GNB) bloodstream infections (BSIs) in patients presenting wit

180 f blood culture (BC) volume for detection of bloodstream infections (BSIs) is documented.

181 To determine the magnitude of bloodstream infections (BSIs) related to their use, PubM

182 for multidrug-resistant Enterococcus faecium bloodstream infections (BSIs).

183 Cs) are the standard method for diagnosis of bloodstream infections (BSIs).

184 ly demonstrate improved clinical outcomes in bloodstream infections (BSIs).

185 ealthcare-associated central line-associated bloodstream infections (CLABSIs), using National Healthc

186 r complications of HPN were catheter-related bloodstream infections (CRBSIs) (1.7/1000 d of PN) and i

187 e parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) inflict health impairmen

188 ith increased incidence of enteric bacterial bloodstream infections (EB-BSI), this association has no

189 ropriate antibiotic therapy for enterococcal bloodstream infections (EBSI) can be delayed.

190 Vancomycin-resistant Enterococcus bloodstream infections (VRE-BSIs) are associated with si

191 cloacae isolated between 2001 and 2011 from bloodstream infections across hospitals in the UK and Ir

192 cation of Gram-negative organisms that cause bloodstream infections and can significantly impact pati

193 (ICUs) resulted in greater reductions in all bloodstream infections and clinical isolates of methicil

194 ated clinical infection syndromes (including bloodstream infections and community-acquired pneumonia)

195 Bloodstream infections are a leading cause of morbidity

196 Fungal bloodstream infections are a significant problem in the

197 Even with surgical and antibiotic therapy, bloodstream infections are associated with significant m

198 Infections acquired overseas and bloodstream infections are particularly important areas

199 e optimal preventive strategies for reducing bloodstream infections associated with arterial catheter

200 udies have shown that the occurrence rate of bloodstream infections associated with arterial catheter

201 theters are recommended for adults to reduce bloodstream infections but not for children because ther

202 We show here that the R domain enables bloodstream infections by directing fibrinogen to the st

203 ur knowledge, these are the first reports of bloodstream infections by Trichosporon inkin in patients

204 Community-acquired bloodstream infections cause substantial morbidity and m

205 taphylococci and protect mice against lethal bloodstream infections caused by a broad spectrum of MRS

206 patients with sepsis or septic shock due to bloodstream infections caused by GNB admitted between 20

207 acetylsalicylic acid therapy on mortality in bloodstream infections caused by S. aureus compared with

208 catheters significantly reduced the risk of bloodstream infections compared with standard and hepari

209 ed assay can rapidly detect F. tularensis in bloodstream infections directly in whole blood at the ea

210 lso available for E. faecium associated with bloodstream infections in 15 patients in neighboring hos

211 standard central venous catheters to prevent bloodstream infections in children needing intensive car

212 Candida is the third most common cause of bloodstream infections in hospitalized patients.

213 bial-resistant S. marcescens associated with bloodstream infections in hospitals across the United Ki

214 eate the impact of propofol sedation on MRSA bloodstream infections in mice in the presence and absen

215 4 most common gram-negative bacteria causing bloodstream infections in neutropenic patients.

216 central venous catheters could help prevent bloodstream infections in paediatric intensive care unit

217 Research on S. aureus bloodstream infections is a frontier for the characteriz

218 Identification of bloodstream infections is among the most critical tasks

219 cal infections of >0.3/1,000 patient days or bloodstream infections of >0.03/1,000 patient days shoul

220 Bloodstream infections remain a major cause of morbidity

221 Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due t

222 of MRSA, highlight the growing challenge of bloodstream infections that are effectively impossible t

223 , however, at high risk for catheter-related bloodstream infections that can result in substantial mo

224 The rate of catheter-related bloodstream infections was higher in the early-strategy

225 A total of 480 patients with bloodstream infections were included in the analysis: 24

226 Bloodstream infections were increased in patients with v

227 Bloodstream infections were the most common type of infe

228 is the single most prevalent cause of fungal bloodstream infections worldwide causing significant mor

229 All but 1 case-patient had bloodstream infections, and 6 presented with sepsis.

230 ulture contamination, health care-associated bloodstream infections, and rates of the primary outcome

231 arge proportion of E. coli urinary tract and bloodstream infections, and they differ markedly in thei

232 es in children should focus on prevention of bloodstream infections, particularly among neonates and

233 inical S. aureus isolates from patients with bloodstream infections, representing two globally import

234 ed pneumonia, intra-abdominal infections and bloodstream infections, respectively.

235 strategies for the pathogenesis of S. aureus bloodstream infections, which culminate in the establish

236 surface decolonisation reduced all-pathogen bloodstream infections.

237 t (ICU) patients may affect catheter-related bloodstream infections.

238 tant clone associated with urinary tract and bloodstream infections.

239 mine a worse outcome both in respiratory and bloodstream infections.

240 omising approach for combating P. aeruginosa bloodstream infections.

241 nd their role in the management of pediatric bloodstream infections.

242 ulatory system, capable of causing S. aureus bloodstream infections.

243 how this interaction impacts the outcome of bloodstream infections.

244 or the most commonly identified organisms in bloodstream infections.

245 tion about the role of PhoQ in P. aeruginosa bloodstream infections.

246 ention decreased mortality for patients with bloodstream infections.

247 improved clinical outcomes for patients with bloodstream infections.

248 nts with less frequent Gram-negative bacilli bloodstream infections.

249 um) may be an adaptation associated with the bloodstream-inhabiting lifestyle of this parasite for ro

250 that the bacterium is also able to enter the bloodstream, interact with host cells and tissues, and u

251 om the bloodstream and poor passage from the bloodstream into target tumours.

252 onance targeting guides macrophages from the bloodstream into tumours, resulting in increased tumour

253 sition from a mucosal commensal lifestyle to bloodstream invasion, we performed Tn-seq on GBS strain

254 oduction of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

255 y high rates of resistance to CAZ-AVI in CRE bloodstream isolates at our institution associated with

256 etobacter calcoaceticus-A. baumannii complex bloodstream isolates collected from a single hospital fr

257 However, recent studies report that bloodstream isolates differ systematically from those fo

258 le-genome sequencing (WGS) of 495 E. faecium bloodstream isolates from 2001-2011 in the United Kingdo

259 rodilution (BMD) assays were performed on 90 bloodstream isolates of the 4 most common gram-negative

260 uces a lethal failure of cytokinesis in both bloodstream (mammalian host) and procyclic (insect vecto

261 ofol significantly increases the severity of bloodstream MRSA infection, even when administered in co

262 lity is distinct between the nasopharynx and bloodstream of adult humans: glucose is absent from the

263 The fast bloodstream of animals is associated with large shear st

264 tors and the presence of the parasite in the bloodstream of chagasic patients.

265 oid colony-forming activity was found in the bloodstream of E10.5 embryos and in the fetal liver at E

266 Circulation tumor cells (CTCs) in the bloodstream of early-stage cancer patients carry the imp

267 , real-time measurement of four drugs in the bloodstream of even awake, ambulatory rats, achieving pr

268 Using intravital microscopy of the bloodstream of mice infected with Listeria monocytogenes

269 rotype V GBS strains (92%) isolated from the bloodstream of nonpregnant adults in the United States a

270 ei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquir

271 kely by contributing to PA14 survival in the bloodstream of the thermally injured mouse during sepsis

272 equently invades the skin, soft tissues, and bloodstreams of humans.

273 Using ligands of molecules exposed to the bloodstream on the endothelial surface enables design of

274 ged >/=18 years with a respiratory, urinary, bloodstream, or surgical site infection caused by a mult

275 Genetic knockout of GMPS in bloodstream parasites led to depletion of guanine nucleo

276 These bloodstream parasites use RNA polymerase-I (pol-I) to tr

277 Treatment of bloodstream parasites with cholesterol-specific methyl-b

278 Assay conditions simulated bloodstream (pH 7.5) or phagolysosomal (pH 5.5) pH conte

279 g particles continue to be secreted into the bloodstream remains controversial.

280 pt was extended to live rats with an induced bloodstream S. aureus infection.

281 PAR1 is proteolytically-activated by bloodstream serine proteases also involved in the format

282 In the host bloodstream T. brucei scavenges heme via haptoglobin-hem

283 ilus-1 mediate pneumococcal passage from the bloodstream through the BBB into the brain to cause leth

284 Leukocyte migration from the bloodstream to a site of infection is mediated by chemot

285 Homing of HSPCs from bloodstream to bone marrow (BM) is an important aspect o

286 man nasopharynx but occasionally invades the bloodstream to cause life-threatening infection.

287 se systemic disease often spread through the bloodstream to infect target tissues.

288 y release chemokine ligand 2 (CCL2) into the bloodstream to mobilize myeloid cells from the host bone

289 at it is able to rapidly disseminate via the bloodstream to tissue sites distant from the site of ini

290 Depletion of LC8 from mammalian-infective bloodstream trypanosomes affected cell cycle progression

291 anomolar potency against axenically cultured bloodstream trypanosomes.

292 The presence of trypanosomes in the bloodstream was assessed using RNAi target sequencing (R

293 n of bacteria overseas or isolation from the bloodstream was associated with a higher relative risks

294 nation of released merozoites throughout the bloodstream, we decided to explore which tyrosine kinase

295 d the respiratory epithelium and grew in the bloodstream were chains of variable lengths; however, th

296 so the most abundant amino acid in the human bloodstream, where it is assiduously maintained at appro

297 es relentless immune attack in the mammalian bloodstream, where it is protected by an essential coat

298 dozens of metabolites that accumulate in the bloodstream, where they can have systemic effects on the

299 ue to its ability to quickly access the host bloodstream, which it can accomplish through gastrointes

300 s continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence