ライフサイエンスコーパス: blueprint

1 e detection of deviations from this 'genetic blueprint'.

2 up of neurons reveals their shared branching blueprint.

3 order of which encodes an organism's genetic blueprint.

4 ely patterned dorsoventrally by a common Dlx blueprint.

5 e, using a sequence-structure alignment as a blueprint.

6 be far more complex than the more restricted blueprint.

7 t are able to assemble according to a master blueprint.

8 onstructed by means of a similar topological blueprint.

9 is first defined by a hypertrophic cartilage blueprint.

10 A as the first step in restoring the genetic blueprint.

11 ional design using protein structures as the blueprint.

12 alters genetic information from the genomic blueprint.

13 tors, patterning TFs prespecify sensory area blueprints.

14 transcription factor-mediated architectural "blueprints."

15 This protein blueprint also provides insights into potential mechanis

16 ural DNA nanotechnology, which uses DNA as a blueprint and building material to organize matter with

17 ted by mapping KF cases onto the examination blueprint and by judgments from expert colorectal surgeo

18 Instead, the innate cochlear blueprint and its actual ontogenetic variants were deter

19 30000-35000 human genes in the human genetic blueprint and provides a plethora of new details, the si

20 This work provides a blueprint and resources for the systematic genome-wide s

21 erstanding how cells interpret their genetic blueprint and their environment during development, and

22 ith free and open sharing of detailed design blueprints and accessible development tools, rapid proto

23 This blueprint approach, if extended to other flexible protei

24 development to be guided by both the genetic blueprint as well as the environmental context.

25 unique differences in levitation and density blueprints between breast, esophageal, colorectal, and n

26 Deliberate digression from this robust blueprint brought a first set of analogues into reach, w

27 hin vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information wi

28 ochemical studies have formulated a detailed blueprint concerning the apoptotic network, necrosis is

29 further intention to align their activities (blueprint, curriculum and centre visitation) with the UE

30 This blueprint describes the consensus from the workshop, ide

31 oded by its gene sequence and that molecular blueprint designs this kinase to be regulated by subcell

32 e complete description of the macaque genome blueprint enhances the utility of this animal model for

33 different hematopoietic cell types from the Blueprint Epigenome project.

34 explored pocket in Hsp70 and provide a novel blueprint for a cancer-oriented development of Hsp70-dir

35 ts excellent electronic properties provide a blueprint for a potentially rich area of exploration in

36 ironment interactions, a panacea refers to a blueprint for a single type of governance system (e.g.,

37 The present study provides a much needed blueprint for a systems-level understanding of EBPR and

38 to the isocyanoterpene family and provides a blueprint for a very direct synthesis of DICA and relate

39 Our work provides a blueprint for a wide variety of future chemical approach

40 the mammalian circadian clock and provides a blueprint for advancement in chronotherapy.

41 We provide a blueprint for analyzing capitation arrangements.

42 hat weakens bacterial fitness and could be a blueprint for antivirulence approaches.

43 These results are a blueprint for applying the 'node and strut' principles o

44 Here, we present a blueprint for aromatic carbon-hydrogen functionalization

45 uch, this study begins to provide a putative blueprint for base specificity among sugar nucleotide-de

46 hibition of PrL neurons, providing a circuit blueprint for behavioral manipulations.

47 tural plasticity furnishes a next-generation blueprint for CaV channel modulation.

48 Our study provides a blueprint for characterizing the role of bacteria in the

49 logical limitations and provides a strategic blueprint for chemical production.

50 lmarks of this signaling mechanism provide a blueprint for chemical sensing in small compartments, su

51 ine with a helicene-like motif to form a new blueprint for chiral systems with large and tunable nonl

52 for embryological studies, offering a simple blueprint for chordate development.

53 Our approach provides a blueprint for combining chemical exposures linked to com

54 may be regarded as a universally applicable blueprint for comprehensive exploitation of the substant

55 ty in this class of materials and serve as a blueprint for controlling charge transport in MOFs with

56 responsible for providing the master genetic blueprint for craniofacial development.

57 These multi-dimensional datasets provide a blueprint for delineating molecular mechanisms underlyin

58 itating inflammatory diseases and serve as a blueprint for developing highly potent and specific i3-l

59 c insights into BAX inhibition and provide a blueprint for developing inhibitors of BAX activation.

60 ses autoimmune diabetes, thereby providing a blueprint for development of novel therapies to cure aut

61 coordinated joint action, which serves as a blueprint for dialogue coordination, and the experience

62 a comprehensive, culture-independent genomic blueprint for ecosystem-wide analysis of protein functio

63 details of their generation could provide a blueprint for effective vaccination.

64 all together, this study provides a general blueprint for efficient optical screening of micro- and

65 Our results suggest a simple genetic blueprint for engineering defined nonreactogenic live-at

66 Our results provide a blueprint for engineering molecular anchors with finely

67 These insights provide a molecular blueprint for engineering selectively potentiating thera

68 robust across subjects and could serve as a blueprint for evaluating dynamic brain function.

69 for regulating anxiety states and provide a blueprint for examining how G-protein-mediated signaling

70 porter ion, we believe this work serves as a blueprint for expanding the multiplexing capacity of the

71 Lactococcus lactis GalK begins to provide a blueprint for further engineering of this vital class of

72 ycosylation and NRF2 signaling and provide a blueprint for future approaches to discover functionally

73 ts for cofactor recognition that represent a blueprint for future inhibitor design.

74 tions, the established framework serves as a blueprint for future large-scale water resource monitori

75 ives in some states could begin to provide a blueprint for future policy making.

76 of visual system regeneration and provides a blueprint for future progress in the field.

77 These important goals provide a blueprint for future research that may significantly imp

78 Here we attempt to make a blueprint for future studies in this field.

79 derstanding Tfp biology and provide a useful blueprint for future studies.

80 is rapid catalytic process provides a useful blueprint for future work in artificial photosynthesis.

81 Our transcriptome analysis may serve as a blueprint for gene expression pattern and provide functi

82 PCR Experiments" (MIQE) guidelines provide a blueprint for good PCR assay design and unambiguous repo

83 Our methods and findings provide a blueprint for how the increasing wealth of ecological, l

84 how the brain develops have provided a rough blueprint for how we may bring about regeneration in the

85 ghts into CARD9 variant proteins to create a blueprint for IBD therapeutics and recapitulated the mec

86 rived from metabolite datasets can provide a blueprint for improvement of water use efficiency and dr

87 ids plus six volatile molecules, providing a blueprint for improving the flavor of what has become an

88 The results presented here provide a blueprint for in-depth studies of the interactions of th

89 obabilistic tractography map as a connectome blueprint for individualized, patient-specific, determin

90 ectivity and molecular composition provide a blueprint for information processing in neural circuits.

91 the evolution of cooperation and provides a blueprint for intentional induction of cooperation withi

92 Our study provides a blueprint for investigating and prolonging drug-target k

93 observations, our data point to CENP-C as a blueprint for kinetochore assembly.

94 The DiscovEHR data set provides a blueprint for large-scale precision medicine initiatives

95 ene coexpression network analysis provides a blueprint for leveraging genomic data to identify key co

96 The key to this reaction is a conceptual blueprint for metathesis chemistry that forgoes the trad

97 Overall, this paper provides a blueprint for ML use with clinical data.

98 ssential biological processes and provides a blueprint for molecular mimicry that drives drug discove

99 , termed the 'daughter arrester', provides a blueprint for more advanced devices that mimic developme

100 These studies provide a blueprint for myriad N-heterocyclic methodologies.

101 lications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop

102 This concept may not only serve as a blueprint for new strategies in diversity synthesis but

103 provided by the committees helped to set the blueprint for one of the great success stories in modern

104 of life; in many ways they provide a general blueprint for organizing the building blocks of life.

105 The methods developed here provide a blueprint for parsing out the contribution of the four H

106 The larger model then acts as a blueprint for physical implementation at the DNA level.

107 Our proposal is the first blueprint for realizing topological phases of matter in

108 olubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanisms but unexpectedly showe

109 t pentose utilization in yeast and provide a blueprint for reprogramming transporter properties.

110 This design provides a realizable blueprint for scalable spin-based quantum computers in s

111 taining transcription factors that provide a blueprint for segmental identity along the body axis.

112 actions-but not single domains-can provide a blueprint for sensitive activation sensors within a narr

113 The PFKP structural blueprint for somatic mutations as well as the catalytic

114 hanisms of TRPA1 regulation, and establish a blueprint for structure-based design of analgesic and an

115 esented to the immune system, and provides a blueprint for structure-based vaccine design.

116 protective humoral response might provide a blueprint for successful vaccines and vaccination approa

117 DNA recognition by bHLH dimers as well as a blueprint for system-level studies of the DNA binding de

118 We established the molecular blueprint for target discrimination in vitro using spect

119 ed electrocatalyst, this study describes the blueprint for targeted improvement of fuel cell catalyst

120 We expect that this work will serve as a blueprint for the adaptation of ssDNA recombineering to

121 nd the approach provided here can serve as a blueprint for the analysis of traits and conditions link

122 he melanocortin system provides a conceptual blueprint for the central control of energetic state.

123 It will also serve as a blueprint for the construction of other brain-inspired m

124 works developed in this study can serve as a blueprint for the design of a broad range of tailor-made

125 ond electron transfer step, thus providing a blueprint for the development of a broad range of novel

126 They provide a blueprint for the development of advanced heterogeneous

127 ting to semiconducting, as well as provide a blueprint for the development of hybrid porous materials

128 ructured input from the retina may provide a blueprint for the early development of cortical maps and

129 A blueprint for the examination was developed.

130 volution of antigen receptors, and provide a blueprint for the experimental reconstruction of protein

131 nd physiological experiments have outlined a blueprint for the feedforward flow of activity in cortic

132 Therefore, our work provides a blueprint for the functional annotation of diverse bacte

133 logy for immunoengineering and can provide a blueprint for the future development of personalized, au

134 The reported method constitutes a blueprint for the high-throughput screening and future d

135 findings from the neural field can provide a blueprint for the identification of new molecular mechan

136 The overall approach provides a general blueprint for the integration of carbene catalysis with

137 ing of retinal inputs provides an anatomical blueprint for the integration of visual features in the

138 le-free networks, and may represent a common blueprint for the large-scale organization of interactio

139 nge inhibition of the reactants--that sets a blueprint for the location of the stereocilia.

140 This work provides a blueprint for the next generation of rapid microbial ide

141 ent techniques: an algorithm for computing a blueprint for the overall strategy, an algorithm that fl

142 PhotoETP thus provides a blueprint for the production of small-molecule class B G

143 An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs essential

144 e almost totally unknown, yet they provide a blueprint for the radiation of land plant forms.

145 Notably, this study provides a blueprint for the rational design and application of non

146 ution-based precursor approach creates a new blueprint for the rational design and controlled synthes

147 These findings may provide a blueprint for the rational development of new GalT inhib

148 We provide a blueprint for the realization of 16-plex reagents with 1

149 vegetative growth, but serves as the genetic blueprint for the somatic macronucleus (MAC), which is r

150 2)-like) of biogenic oxides, providing a new blueprint for the structural signature of biogenic Mn ox

151 e review the approaches taken that provide a blueprint for the study of other obesity-associated gene

152 rgent strategy was developed that provides a blueprint for the synthesis of many of the small yet com

153 social, and advocacy disciplines to create a blueprint for the training and development of health car

154 These results define a blueprint for the transition from stem cell self-renewal

155 transcription factor expression establish a blueprint for the vertebrate forebrain early in embryoge

156 iad other short peptide motifs and provide a blueprint for therapeutic applications in a variety of c

157 signs described here may serve as a possible blueprint for therapeutic development in fields other th

158 ely after arterial injury that establish the blueprint for this inflammatory program are largely unkn

159 en, and the usefulness of having the genetic blueprint for this small organism have been well worth t

160 Accelerating Progress Against Cancer: ASCO's Blueprint for Transforming Clinical and Translational Re

161 intrinsic ORF mRNA structure encodes a rough blueprint for translation efficiency.

162 This assay lays a blueprint for translation of these techniques to other t

163 nesis and tumor pathophysiology, providing a blueprint for understanding diverse astrocyte contributi

164 ar protein architecture provides a molecular blueprint for understanding focal adhesion functions.

165 The structural mechanism is a blueprint for understanding how phytochromes connect to

166 the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

167 racterized by NMR, and provides a structural blueprint for understanding the function of this channel

168 The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved

169 ivity, structure, and genotype may provide a blueprint for understanding the mechanisms governing tem

170 s charge state and may furnish a methodology blueprint for understanding the redox and magnetic behav

171 The MacB architecture serves as the blueprint for understanding the structure and mechanism

172 attributes of T44625, this report provides a blueprint for understanding the successful zoonotic pote

173 These observations provide a structural blueprint for understanding unique aspects of TRP channe

174 ctively, the results of this study provide a blueprint for using metabolomics as a platform to identi

175 atory elements that collectively provide the blueprint for using the protein-coding capacity of the D

176 patterns of their dendrites, which form the blueprint for wiring the brain.

177 In aggregate, our results provide valuable blueprints for altering nucleotidylyltransferase specifi

178 f antidepressant action in SERT, and provide blueprints for future drug design.

179 In addition to providing blueprints for Hmox1 expression in mice that provide nov

180 rovide high-fidelity, single-cell resolution blueprints for Hmox1 expression throughout the body of m

181 drug action pathways may provide informative blueprints for individualized chemotherapy.

182 for dynamic ion selectivity and provide the blueprints for new therapeutic agents.

183 se of genomics methods to reveal the genetic blueprints for not one but dozens of plant species, as w

184 s are crucial for gene regulation, providing blueprints for the assembly of transcriptional machinery

185 human-pig chimeric alpha-chains can serve as blueprints for the design of a new generation of variant

186 e organizing principles serve as topological blueprints for the entire gp130 family of cytokines.

187 tanding of the biological world by providing blueprints for the evolutionary and functional diversity

188 ling, and computational methods to construct blueprints for the initiation and maintenance of complex

189 or specific cancers is likely to provide the blueprints for the markers and targets to aid diagnosis,

190 crystal chemistry and are regarded as ideal blueprints for the rational design and construction of m

191 Klug derived a family of surface lattices as blueprints for the structural organisation of the protei

192 ial steps: pre-processing or development of "blueprints" for organs; processing or actual organ print

193 The amino acid sequence of a protein is the blueprint from which its structure and ultimately functi

194 an engineering' approach by drawing a single blueprint graph that represents all generated sequences.

195 ersification of proteomes beyond the genomic blueprint; however it is infrequently used among animals

196 Yet, the pursuit of such blueprints in the laboratory has failed thus far in enab

197 bat retina conforms to the general mammalian blueprint, in which light signals of intensities above r

198 To understand the transcriptional "blueprint" initiating inner ear development, we used mic

199 rns in a recent WHO research and development blueprint initiative for emerging infectious diseases.

200 s they allow the establishment of structural blueprints inspired by natural photosynthetic organisms

201 s essential to maintain and to translate the blueprints into functional sensory area properties in co

202 t as a linear entity within cells where this blueprint is actually utilized.

203 This blueprint is applicable for any sequenced organism with

204 mical structures suggests that their genetic blueprint is still present in the mouse genome but is no

205 REVIEW: Epigenetics dictate how the genetic blueprint is ultimately expressed and, therefore, is fun

206 rget article continues a critique of genetic blueprint models of development that suggests reconsider

207 program is likely to encode the basic neural blueprint, much evidence suggests that experience-driven

208 A new blueprint network for the design and synthesis of porous

209 As part of the NIH Blueprint Neurotherapeutics Network project we undertook

210 y 42 human healthy blood epigenomes from the BLUEPRINT, NIH ROADMAP and ENCODE consortia by their cel

211 Numerous blueprints now exist for stabilizing the simplest type o

212 le across nights and subjects and provides a blueprint of cortical excitability and connectivity.

213 A genetic-based blueprint of crucial developmental times for organs and

214 o abolish spontaneous activity, a functional blueprint of developing and regenerating hair cells.

215 belian quasiparticles and can be seen as the blueprint of fractional topological order.

216 Such concepts are helping to assemble a blueprint of how the myriad adaptors and kinases fit tog

217 The human genome encodes the blueprint of life, but the function of the vast majority

218 The DNA sequence of an organism is a blueprint of life: it harbors not only the information a

219 nitors are rapidly organized into a scalable blueprint of lost structures.

220 tensively characterize the resulting in vivo blueprint of metabolism in human blood by integrating it

221 The genetic blueprint of P. falciparum will ultimately need to be un

222 While the general blueprint of ribosome biogenesis is evolutionarily conse

223 Together, a blueprint of synapse formation is emerging into which th

224 in mammalian and yeast cells that serve as a blueprint of TA protein insertion.

225 Our recent studies have provided a proteomic blueprint of the 26S proteasome complexes in the heart,

226 nergistically to provide a unique structural blueprint of the assembly process of this intricate mole

227 Together, these findings provide a blueprint of the brain mechanisms by which neutral third

228 us closer to understanding the evolutionary blueprint of the brain, improving the detection and char

229 Here, we review the molecular blueprint of the desmosome and models for assembling its

230 These findings provide a blueprint of the developmental events associated with es

231 Although the cellular blueprint of the ENS is mostly in place by birth, the fu

232 This provides a blueprint of the events that lead to human cancer, allow

233 In 2000, when the genetic blueprint of the first plant species was revealed, the t

234 We map out a blueprint of the genetic architecture of rice (Oryza sat

235 y utilization to be gained by this proteomic blueprint of the ICM.

236 ubtypes relies heavily on defining a lineage blueprint of the normal human breast.

237 are coming closer to obtaining a structural blueprint of the polyadenylation machinery that explains

238 sting targets and the straightforward design blueprint of the sensors we expect their wide-ranging ap

239 The blueprint of this design is most easily accessible in th

240 it is imperative to delineate the molecular blueprint of this disease.

241 To establish a molecular blueprint of this dynamic complex, we first mapped the a

242 As the blueprints of cellular actions, biological pathways char

243 Genome sequences are the blueprints of diverse life forms but they reveal little

244 integrate flagellar gene control into master blueprints of global gene expression.

245 intain a harmonic family in light of genetic blueprints of individual couples.

246 s not only extended our understanding of the blueprints of many plant species but has also revealed t

247 bout the genetic landscape and architectural blueprints of various cancers.

248 ients with preeclampsia could function as a "blueprint" of causative factors, we describe a serum-bas

249 ell lineage and establish a high-resolution 'blueprint' of their development.

250 Deoxyribonucleic acid (DNA) is the blueprint on which life is based and transmitted, but th

251 nes to generate organelles with unique lipid blueprints on which they assemble replication complexes

252 on are envisioned to act as a supramolecular blueprint or template for metal-ion retroinsertion.

253 bundles as intended, matching the connectome blueprint previously defined.

254 His goal of outlining the blueprint principles for a universal model of reading is

255 pired by the relatively simple morphological blueprint provided by batoid fish such as stingrays and

256 is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have in

257 nesses that opponents have identified in the blueprint strategy.

258 t these circuits are part of the fundamental blueprint that all vertebrates use to select actions and

259 t recipients provide a cutaneous template or blueprint that instructs melanocytes where to place pigm

260 preting maps without an underlying cellular 'blueprint'; this could be supplied using contrast agents

261 needs to be defined; a nationally developed blueprint to deal with logistics of pandemic prevention

262 We then utilized this gea net as a blueprint to design and assemble another MOF (gea-MOF-2)

263 how the model can be used as a quantitative blueprint to design genetic modifications with predictab

264 rector with developing a focused and concise blueprint to guide the use of limited funding over the n

265 n nondynamic transcriptomes and to provide a blueprint to identify gene regulatory network involved i

266 prioritizing cell lines according to natural blueprint to streamline functional applications.

267 compared with mouse and provides a molecular blueprint to understand human embryogenesis and its rela

268 ace of ookinetes and provides the structural blueprints to design next-generation immunogens.

269 of voltage sensing and establish structural blueprints to design selective Nav channel antagonists.

270 ls have been characterized, establishing the blueprints to further engineer sophisticated function.

271 Natural structures provide blueprints to overcome this, however this approach intro

272 RA as a potential resource in retrosynthetic blueprints to reach highly challenging targets.

273 Antifungal Subcommittee followed the M23-A2 "blueprint" to develop interpretive MIC breakpoints for a

274 sed the four-bundle tractography 'connectome blueprint' to plan surgical targeting in 11 participants

275 o bioconjugation this methodology provides a blueprint toward the development of photoredox catalysis

276 esigned with respect to key issues including blueprinting, validity, reliability, and standard settin

277 can be similarly engineered using v-Src as a blueprint, we encountered one kinase, c-Abl, which when

278 With these design principles as a blueprint, we experimentally constructed artificial pola

279 Because of their distinctive genomic blueprint, we propose the classification of these giant

280 al condition categories from the examination blueprint, which balances examination content by conside

281 ction of our brain are governed by a genetic blueprint, which reflects dynamic changes over the histo

282 s that assume a topology or other structural blueprint will often fail.